|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for HOXB13(NM_006361.5) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
|
|
| A | B |
|
Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
|
Summary
This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq].
Gene References into function
- Epidermal HOXB13 signal was detected over the entire body surface, but surprisingly, essentially all of the signal was cytoplasmic in developing skin.
- This study suggests that HOXB13, a transcription factor, functions as a cell growth suppressor by negatively regulating the expression of TCF-4, which eventually provides negative signals for cell proliferation in prostate cancer.
- HOXB13 functions as an androgen receptor repressor to modulate the complex AR signaling and subsequent growth regulation of prostate cancer cells.
- HOXB13 may have a role in the invasive ability of endometrial cancer cells through regulation by estrogen
- Loss of HOXB13 may be an important event for colorectal cell transformation.
- The HOXB13 protein expression increases during disease progression of breast cancer to hormonal therapy.
- The HOXB13 protein expression increases during disease progression of breast cancer to hormonal therapy.
- transcripts are differently expressed in normal mucous and serous acini [which] may reflect a different role in salivary gland carcinogenesis
- HOXB13 and IL17BR has a role in progression of early-stage breast cancer
- HOXB13 is downregulated by methylation and functions as a tumor suppressor in malignant melanoma.
- HOXB13 and IL17BR have roles in breast cancer
- These results support a pro-proliferative and pro-survival role for HOXB13 in ovarian cancer.
- HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer
- characterizeation of the promoter region of the HOXB13 gene
- Hypermethylation of HOXB13 is a late event of breast tumorigenesis.
- An index composed of inherited (CYP2D6) and tumor (HOXB13/IL17BR) gene variation identifies patients with varying degrees of resistance to tamoxifen.