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Validated All-in-One™ qPCR Primer for CDR2(NM_001802.1) Search again
Product ID:
HQP000470
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CDR62, Yo
Gene Description:
cerebellar degeneration related protein 2
Target Gene Accession:
NM_001802.1(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Gene References into function
- Identifies cdr2-specific T cells in patients with paraneoplastic cerebellar degeneration; cells are evident by standard CTL, and by cross-presentation of apoptotic cdr2-expressing cells.
- Identifies c-Myc interaction with cdr2 by co-IP and co-localization in cytoplasm of cerebellar Purkinje neurons. Sera from 6/6 patients with cdr2 autoantibodies and paraneoplastic cerebellar degeneration block this interaction.
- In patients with paraneoplastic cerebellar degeneration and anti-Yo antibodies, IFN-gamma-secreting cell responses towards Cdr2 isoforms are not detected, suggesting a limited role for cytotoxic T lymphocyte-mediated tumor immunity in this patient group.
- Mycoplasma fermentans, in infecting human B cells, generates a Mycoplasma component that interacts with CD21, which is involved in B cell proliferation.