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Validated All-in-One™ qPCR Primer for CDH11(NM_001797.3) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq].
Gene References into function
- The intracellular domain of cadherin-11 is not required for the induction of cell aggregation, adhesion or gap-junction formation
- CADH11 was evaluated as a biomarker at the protein level and was found to have increased expression in xenograft tumors after S11248 treatment.
- A 2.62 Mbp minimal region of genomic loss of chromosome 16q22 was found in retinoblastoma which contains a hotspot CDH11, implicating CDH11as a potential tumor suppressor gene in retinoblastoma.
- primary aneurysmal bone cysts are mesenchymal neoplasms exhibiting USP6 and/or CDH11 oncogenic rearrangements
- Review. Cadherin-11 expression confers upon cells a fundamental change in cellular behavior. Its expression on fibroblast-like synoviocytes may determine their behavior & differentiation.
- Together, these studies implicate cadherin-11 in synovial tissue and lining layer formation and provide an in vitro system to model fibroblast-like synoviocyte behavior and function in organizing the synovial tissue.
- Cadherin-11 is involved in the intercellular physical coupling of detrusor smooth muscle bladder cells and also of myofibroblasts.
- Overexpression of osteoblast cadherin is associated with breast cancer cell metastatic potential
- The results indicate that CDH11 may be useful as a prognostic marker of disease progression and survival in osteosarcoma.
- cadherin-11 promotes homing and migration to bone and osteoclastogenesis through mediating the homophilic interactions of breast cancer cells with marrow stromal/osteoblastic cells, thereby enhancing bone metastases.
- These findings suggest that cadherin-11 is involved in the metastasis of prostate cancer cells to bone.
- Tumor necrosis factor alpha drives cadherin 11 expression in rheumatoid inflammation
- Cadherin-11 and fascin might be useful markers for recurrence of pleomorphic adenomas.