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Validated All-in-One™ qPCR Primer for ABCB6(NM_005689.3) Search again
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily.
Gene References into function
- study of C-terminal nucleotide-binding domain of ABCB6 in nucleotide-free & ADP-bound states by NMR & homology modelling; results revealed localised dynamic cooperativity, which was proposed for a prokaryotic ABC MJ1267, also exists in a eukaryotic ABC
- ABCB6 is uniquely located in the outer mitochondrial membrane and is required for mitochondrial porphyrin uptake
- ABCB6 exists in two molecular weight forms, is localized to both the outer mitochondrial membrane and the plasma membrane, and plays a functional role in the plasma membrane.
- ather, it localized in the ER-derived and brefeldin A-sensitive perinuclear compartments, mainly in the Golgi apparatus.
