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Validated All-in-One™ qPCR Primer for RANBP9(NM_005493.2) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq].
Gene References into function
- RanBPM is the enzymic substrate for USP11 and is deubiquitinated specifically
- RANBPM has a role in the HGF-MET and Ras signal transduction pathways
- overexpressed wildtype HIPK2 and a kinase defective mutant of HIPK2 directly interact with RanBPM in the nucleus of mammalian cells.
- interacts with steroid receptors to selectively modify their activity
- demonstrates that CDK11(p46) directly interacts with RanBPM in vitro and in human cells
- RanBPM may constitute a molecular scaffold that contributes to coupling LFA-1 and other integrins with intracellular signaling pathways
- Expression of RanBPM inhibited the ubiquitination of p73alpha, and thereby prolonged its half-life.
- Results identify and characterise a novel interaction between RanBPM and the related receptor tyrosine kinases, Axl and Sky.
- Coexpression of RANBP9 with constitutively active Raf kinase synergistically inhibited myogenic regulatory factor MyoD-directed muscle reporter gene transcription
- CD39 associations with RanBPM have the potential to regulate NTPDase catalytic activity. This intermolecular interaction may have important implications for the regulation of extracellular nucleotide-mediated signalling.
- RanBPM is a potent novel coactivator for thyroid hormone receptors
- RanBPM, ARMC8alpha, ARMC8beta, Muskelin, p48EMLP, and p44CTLH form complexes in cells
- Studies in this review indicate that RanBPM acts as a scaffolding protein and is important in regulating cellular function in both the immune system and the nervous system.
- Results describe the enhancement of the transactivation activity of Epstein-Barr virus Rta protein by RanBPM.
- These novel findings identify a role for muskelin-RanBP9 complex in pathways that integrate cell morphology regulation and nucleocytoplasmic communication.
- These results suggest that RanBPM could be a key regulator of Ca(v)3.1 channel-mediated signaling pathways.