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Validated All-in-One™ qPCR Primer for NCR3(NM_147130.3) Search again
Product ID:
HQP192120
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
1C7, CD337, LY117, MALS, NKp30
Gene Description:
natural cytotoxicity triggering receptor 3
Target Gene Accession:
NM_147130.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Natural cytotoxicity receptors (NCRs), such as NCR3, are activating natural killer (NK) cell receptors that belong to the immunoglobulin (Ig) superfamily. NCR3 is expressed in all resting and activated NK cells and forms a complex with CD3-zeta (CD3Z, or CD247; MIM 186780) (Sato et al., 2001 [PubMed 11782277]).[supplied by OMIM].
Gene References into function
- Selective cross-talk among natural cytotoxicity receptors (NKp46, NKp30 and NKp44) in human natural killer cells.
- CD59 is physically associated with NKp46 and NKp30 and activate human nk cell-mediated cytotoxicity.
- NKG2D, NKp30, NKp44, and NKp46 acitvation affected by ligand-negative phenotype in bone marrow-derived progenitor cells, acquisition of cell-surface ligands during myeloid differentiation, defective expression of ligands on malignant transformation
- NKp30 is not only a triggering molecule essential for antitumor activity but is also a surface receptor involved in natural killer cell suicide.
- NK cell-mediated induction of dendritic cell maturation is dependent on NKp30.
- heparan sulfate glycosaminoglycans are not ligands for NKp30, leaving open the question as to the nature of the cellular ligand for this important NK cell activation receptor
- NKp30, among natural cytotoxicity receptors, appeared to be primarily involved in triggering NK cells upon interaction with bone marrow stromal cells
- The expression of LST1, specifically splice variants encoding soluble isoforms and NCR3, was increased in rheumatoid-arthritis-affected blood and synovium and was associated with more severe inflammation in the synovium.
- defect in cytotoxic effector function is associated with a reduced surface expression of activating NK receptors (NKp30, NKp46, and NKG2D) on CD56(dim) NK cells compared with uninfected newborns.
- evidence reported of an association between mild malaria and NCR3 -412G>C polymorphism located within the promoter
- Shown that NKp30-immunoglobulin recombinant fusion protein is Duffy binding-like proteins, natural cytotoxicity receptors are involved in naturual killer cell-Plasmodium- parasitized erythrocytes.
- Determined expressions of NKp30 in decidual natural killer cells in patients having spontaneous abortions.
- HLA-B-associated transcript 3 (BAT3) was released from tumor cells, bound directly to NKp30, and engaged NKp30 on NK cells. BAT3 triggered NKp30-mediated cytotoxicity and was necessary for tumor rejection in a multiple myeloma model.
- Expression of NKp30 and NKp44 ligands was variable and did not correlate with the origin of the cell line. Expression of NKp30 and NKp44 ligand correlated with NKp30 and NKp44-mediated NK cell lysis of tumor cells, respectively
- transcription and translation of the novel form of NKp30 can be induced by progesterone treatment
- in NK cells cultured with IL-15, we observed an up-regulation of the activating receptors NKG2D, NKp30, and NKp46, associated with an increase in anti-tumor lytic activity.
- differential, controlled role of NKp46- and NKp30-activating receptors expressed by uterine dNK that could be critical for the outcome of pregnancy
- NKp30 is the only functional cytotoxicity receptor expressed on a small number of freshly isolated umbilical cord blood T cells, as demonstrated by degranulation, IFN-gamma release, redirected killing, and apoptosis.
- NKp30-mediated NK cells/dendritic cells cross talk resulting either in iDC killing or maturation was BAT3-dependent