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Validated All-in-One™ qPCR Primer for CD226(NM_001303618.2) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq].
Gene References into function
- CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells
- Data show that both PVR and Nectin-2 represent specific ligands for the DNAM-1 triggering receptor.
- CD226 is involved in LFA-1-mediated costimulatory signals for triggering naive T cell differentiation and proliferation.
- DNAM-1 regulates monocyte extravasation via its interaction with cd155 protein expressed at endothelial junctions on normal cells.
- PTA-1(CD226 antigen) is localized to membrane rafts and binds the carboxyl-terminal domain of isoforms of the actin-binding protein 4.1G and also can bind human discs large providing the structural basis for a regulated molecular adhesive complex
- Abnormality of CD226 expression on natural killer (NK) T cells causes sensitivity to anti-CD95-induced apoptosis and is responsible for reduction of NK T cell number in patients with active systemic lupus erythematosus.
- CD226 molecules play an important role in maturation of the megakaryocytes in combination with LFA-1
- Loss of Dnam-1 gene copy number and retention of Cadh-7 might be indicators of worse prognosis, and Dnam-1 deletion might predict for a beneficial response to adjuvant 5-FU-based chemotherapy in patients with colorectal cancer.
- CD226/CD112 (DNAM-1/Nectin-2) mast cell stimulation has a role in the allergic process
- CD226 promoters P1 and P2 are regulated by Ets-1 and AP-1
- expression on CD3+, CD4+, and CD8+ T cells and on CD3- CD16+ NK cells of HIV-infected patients was significantly higher than that of normal controls.
- NK cell-mediated killing of myeloma cell lines was dependent on either DNAM-1 or NKG2D but not both molecules.
- EWS tumor cells are recognized and lysed by resting and with higher efficacy by activated NK cells through NKG2D and DNAM-1 dependent pathways.
- CD226 Gly307Ser association with multiple autoimmune diseases is reported.
- CD226 is a multiple sclerosis susceptibility gene.