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Validated All-in-One™ qPCR Primer for TGFA(NM_001099691.3) Search again
Product ID:
HQP161948
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
TFGA
Gene Description:
transforming growth factor alpha
Target Gene Accession:
NM_001099691.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Transforming growth factors (TGFs) are biologically active polypeptides that reversibly confer the transformed phenotype on cultured cells. TGF-alpha shows about 40% sequence homology with epidermal growth factor (EGF; MIM 131530) and competes with EGF for binding to the EGF receptor (MIM 131550), stimulating its phosphorylation and producing a mitogenic response.[supplied by OMIM].
Gene References into function
- autocrine TGF-alpha functions by facilitating re-entry into the cell cycle from sub-optimal growth states rather than promoting or controlling the proliferation of actively cycling cells.
- expression in pancreatic endocrine tumors
- mRNA expression in atrophic gastritis before and after Helicobacter pylori eradication
- Activation of the human transforming growth factor alpha (TGF-alpha) gene by the hepatitis B viral X protein (HBx) through AP-2 sites.
- if overexpressed in the pancreas causes the development of tubular structures and fibrosis
- expression and role of TGFA in fat cells and insulin resistance in humans
- findings suggest an increase in functional TGF-alpha and activation of the EGFr in response to IFN-gamma
- TGF-alpha is released from epithelial cells in the upper compartment of the crypt into the adjacent lamina propria and then diffuses to the epithelial cells in the lower part of the crypt, resulting in expansion of the proliferative compartment.
- bile acids activate EGFR via a TGF-alpha-dependent mechanism, and this EGFR activation promotes cellular growth.
- Comparative study in the expression of p53, EGFR, TGF-alpha, and cyclin D1 in verrucous carcinoma, verrucous hyperplasia, and squamous cell carcinoma of head and neck region.
- These results argue for growth factor-dependent hepatocellular carcinoma development and provide novel and combined prognosis markers after HCC surgery.
- role in activating extracellular signal-regulated/mitogen-activated protein kinase and implication in metastatic spread of colon cancer cells
- role in mediating proliferation into differentiation in neuroblastoma cells controlled by estrogen receptor alpha
- TGF-alpha has a role in epidermal tissue regeneration
- Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing human transforming growth factor-alpha
- The growth factor independence of HCT116 cells was shown to be dependent on autocrine transforming growth factor (TGF)-alpha activity.
- Western blot analysis showed increased TGF-alpha protein expression in ethanol-treated HepG2 cells. TGF-alpha in conditioned medium from ethanol-exposed HepG2 cells stimulated type-I collagen messenger RNA expression in rat hepatic stellate cells.
- The immunophenotype of colorectal neuroendocrine tumours regarding hormone markers is heterogeneous. The expression of TGF-alpha corresponds to the immunohistological profile of normal neuroendocrine L-cells.
- Overexpression of TGF-alpha in liver may be associated with regeneration of hepatocytes injured by HBsAg. Continued expression of TGF-alpha might lead to dysplasia of liver cells and development of hepatocellular carcinoma.
- not a relevant modifier locus for the occurrence of cleft lip/cleft palate
- autocrine TGFalpha regulates cell adhesion function by multiple signaling pathways via specific phosphorylation sites of S6K in cancer cells
- TGF-alpha up-regulates keratinocyte toll-like receptor (TLR)5 and TLR9 expression and function, augmenting host defense mechanisms at epithelial surfaces.
- Production of IL-15 and/or TGF-alpha was also associated with amphoterin mRNA expression in colon cancer tissues with tumor-associated macrophages depletion
- TGFA is probably a genetic modifier of clefting in humans, which is consistent with the oligogenic model suggested for nonsyndromic oral clefts.
- TGFalpha is the physiologic human keratinocyte pro-motility factor in human serum
- the production of TGF-alpha by HRCC cells leads to the activation of EGFR on tumor-associated endothelial cells that serve as an essential target for therapy with tyrosine kinase inhibitors
- TGFA is up-regulated in tumor cells of SCC but not BCC of the skin. TGFA is also overexpressed in asymptomatic epidermis adjacent to both SCC and BCC, relative to normal skin.
- Naked2 acts as a cargo recognition and targeting (CaRT) protein to ensure proper delivery, tethering, and fusion of TGF-alpha-containing vesicles to a distinct region at the basolateral surface of polarized epithelial cells.
- Inhibition of Ski through RNA interference restored TGF-beta signaling and growth inhibition in vitro, and decreased tumor growth in vivo.
- the tumorigenic growth effects of MYC in TGFalpha-expressing liver progenitor cells are not solely dependent on its apoptotic activity.
- The presence of neuroendocrine cells may have an effect on the expression of TGF-alpha and EGFR in gastric adenocarcinoma, and the autocrine mechanism between TGF-alpha and EGFR plays an important role in the prognosis of gastric carcinoma.
- High expression is related to the biological aggressiveness of breast cancer. TGFA is preferentially expressed in tumours co-expressing EGFR/HER3.
- decreasingly expressed in unaffected, cleft of the lip, alveolus with or without cleft palate, and patient with cleft palate only and thus further strength has been given to its role in the onset of the disease
- The transforming growth factor-alpha (TGF-alpha)is a members of the polypeptide growth factor family. The moderate immunoreactivity of TGF-alpha was detected in serous-mucinous adenocarcinoma of the ovary.
- Subsequently, ROS generation by PA-LPS releases transforming growth factor-alpha (TGF-alpha), which in turn, leads to up-regulate MUC5AC expression.
- At early stages, immunoreactivity to TGF-alpha was detected in all metanephric structures and from the 7th week onward, it decreased in differentiating nephrons.
- PRL expands the pool of cells susceptible to tumorigenesis, which is then facilitated by PRL and TGF-alpha cross talk
- Silibinin impairs constitutively active TGFalpha-EGFR autocrine loop in advanced human prostate carcinoma cells.
- We found a higher protein expression of TGF-alpha in human hepatic cirrhosis (HC) tissues, suggesting that there was autocrine circulation of TFG-alpha in HC tissues.
- changes in cell adhesion and migration resulting from coexpression of TGFalpha with CD9
- identify an EGFR-independent action of TGF-alpha, in which it protects Naked2 from proteasomal degradation, thus ensuring its delivery to the basolateral surface of polarized epithelial cells
- Mutations in TGFA gene have no association with nonsyndromic cleft lip and palate in the sample from Rio Grande do Sul. Therefore, based on this study, it is not possible to determine the role played by TGFA in the expression of cleft lip and palate.
- serum TGF-alpha positivity were significant independent prognostic factors in patients with advanced non-squamous, non-small cell lung cancer
- Src and ADAM-17-mediated shedding of transforming growth factor-alpha is a mechanism of acute resistance to TRAIL.
- No association was found between Taq1 polymorphism and cleft lip and/or palate in this study