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Validated All-in-One™ qPCR Primer for NTSR1(NM_002531.3) Search again
Product ID:
HQP157920
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
NTR
Gene Description:
neurotensin receptor 1
Target Gene Accession:
NM_002531.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq].
Gene References into function
- Neurotensin induces mating in Saccharomyces cerevisiae cells that express human neurotensin receptor type 1 in place of the endogenous pheromone receptor
- investigation of its binding to neurotensin
- Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line.
- constant activation of NT1 receptor generates an oncogenic regulation
- neuropeptide neurotensin (NT) binds to freshly isolated Sezary malignant cells and induces through NT1 receptors the cell migration of the cutaneous T cell lymphoma cell line Cou-L.
- NT and NTR1 are part of network activated after mucosal injuries, and NT stimulates epithelial restitution, at least in part, through a COX-2 dependent pathway.
- Ca2+ mobilization elicited by R-NT is via NTR1
- this report establishs a novel link in vitro between the Tcf/beta-catenin pathway and NT1 receptor promoter activation
- NMU & its cancer-specific receptors NTSR1 & GHSR1b, as well as its target genes, are overexpressed in lung cancer and in cell lines, and that those gene products play indispensable roles in the growth and progression of lung cancer cells.
- Binding of NTSR1 in a prostatic neoplasm cell line is sensitive to metabolic stress.
- results suggest that increased NTSR1 expression may be an early event during colonic tumorigenesis and also contribute to tumor progression and aggressive behavior in colonic adenocarcinomas.
- NTR1 and NTR2 mRNA were not detected in either pituitary adenomas or normal tissue.
- Investigating prototypical interactions between NT(8-13) and the human neurotensin receptor 1 (hNTR1), we created a receptor-ligand model that was validated by site-directed mutagenesis and structure-activity relationship studies