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Validated All-in-One™ qPCR Primer for CHRM3(NM_001347716.2) Search again
Product ID:
HQP151556
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
EGBRS, HM3, PBS, m3AChR
Gene Description:
cholinergic receptor muscarinic 3
Target Gene Accession:
NM_001347716.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation.
Gene References into function
- potential role of endogenous GRK6 in the regulation of M(3) mACh receptor
- Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B
- We show that activation of these receptors leads to divergent growth responses: M(2) AChR activation causes an increase in DNA synthesis, whereas M(3) AChR activation causes a dramatic decrease in DNA synthesis.
- both G(q) and G(11) are involved in mediating the action of the M(3) receptor on cytosolic Ca(2+) in HT29 cells
- Single nucleotide polymorphisms not more frequent in asthma. No nonrandom transmission of short tandem repeat polymorphism haplotypes in asthma. Nonrandom transmission of haplotypes in skin test reactivity to cockroach allergens.
- the conserved poly-basic region in the C-terminal tail of the M3 muscarinic receptor contributes to the ability to mediate protection against apoptotic cell death
- the M3 receptor displays a major ARF1-dependent route of phospholipase D1 activation with an additional ARF6-dependent pathway to PLD1 or PLD2
- M3 mAChR desensitization is mediated by GRK6 in human SH-SY5Y cells, and receptor desensitization of phospholipase C signaling can be monitored in 'real-time' in single, living cells.
- The muscarinic acetylcholine receptor M3 is a mediator of bradycardia and bronchoconstriction due to vagal innervation.
- M3 up-regulates "sedentary" integrins alpha2beta1 and alpha3beta1. Inhibition of migration by M3 was mediated through Ca2+-dependent guanylyl cyclase-cyclic GMP-protein kinase G signaling pathway.
- M1- and M3- but not M2- or M4-AchR signals activate HIF-1 by both stabilization and synthesis of HIF-1alpha and by inducing the transcriptional activity of HIF-1alpha.
- (HEK) 293 cells expressing recombinant Galpha(q/11)-coupled muscarinic M3 receptors showed transient coexpression of RGS proteins
- demonstration of the antigenicity of a novel peptide fragment of the human muscarinic acetylcholine receptor 3 in primary Sjogren's syndrome
- binding of beta-arrestin-1 to muscarinic M(3) receptors requires paired stimulation of two receptor components within the same receptor dimer
- characterization of the muscarinic receptor in the spontaneously immortalized human keratinocyte cell line HaCaT and its role in cell migration
- Data demonstrate that M(1), M(2), and M(3) muscarinic acetylcholine receptors (mAChR)can form homo- and heterodimers in living cells, and suggest that heterodimerization plays a role in the mechanism of mAChR long term regulation.
- The muscarinic Ca2+ signaling pathway is not necessarily affected by depolarization and suggest that the M3 receptor itself is not sensitive to voltage.
- C allele as associated with a reduced acute insulin response and modestly associated with increased risk of early-onset type 2 diabetes in Pima Indians.
- affects endocrine and exocrine hormone and salivary secretion
- Resuts show that urothelium carries multiple cholinergic receptor subtypes, with predominant expression of M2R, M3R and alpha7-nAChR and suggest that this layer-specific distribution serves to stratify cholinergic regulation of urothelial function.
- alphaM3 belongs to a complex and diverse set of synchronously moving parts that change structure relatively late in the channel-opening process.
- M3R was involved in the up-regulation of H1R by activating H1R gene transcription through a PKC-dependent process
- Poly I:C caused increased M3R in airway smooth muscle cells by interacting with TLR3.
- These results indicate caveolae and caveolin-1 facilitate [Ca(2+)](i) mobilization leading to ASM contraction induced by submaximal concentrations of acetylcholine.
- the M(3)/M(5) subtypes appear to be the major contributor, leading to intracellular calcium mobilization from the internal store via an IP(3)-dependent pathway in the undifferentiated retinoblastoma cells.
- M3 employs two distinct mechanisms of chemical imitation to potently sequester chemokines, thereby inhibiting chemokine receptor binding events as well as the formation of chemotactic gradients necessary for directed leukocyte trafficking
- Neither the linear M3R peptide nor M3R transfectants represent suitable tools for discrimination of pathogenic from natural autoantibodies in Sjogren's syndrome.
- The observed effect of tau protein on neurons (in neuroblastomas and primary cultures of hippocampal and cortical neurons) is through M1 and M3 muscarinic receptors.
- The results demonstrate that multiple muscarinic receptor subtypes regulate mTOR, and that both MAPK-dependent and -independent mechanisms may mediate the response in a cell context-specific manner.
- Results demonstrate that the actions of pilocarpine and carbachol in salivary cells are mediated through two distinct signaling mechanisms via M3/M1 receptors.
- Muscarinic receptor M3 expression is associated with invasive migration of melanomas.
- airway M(2)Rs inhibit BK channels by a dual, Gbetagamma-mediated mechanism, a direct membrane-delimited interaction, and the activation of the phospholipase C/protein kinase C pathway
- M2 and M3 receptors are upregulated in a time-dependent and pressure-dependent fashion after as little as a 24 h exposure to increased hydrostatic pressure in bladder