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Validated All-in-One™ qPCR Primer for DDR1(NM_013993.3) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq].
Gene References into function
- gene expression analysis with DDR1 overexpression, using microarrays specific for human and mouse genes coding for extracellular matrix proteins or ECM-interacting factors
- DDR1 activation markedly amplifies TNF-alpha- and LPS-induced phenotypic and functional maturation of dendritic cells (DCs) through activation of p38 mitogen-activated protein kinase.
- The interaction of DDR1b isoform with collagen up-regulates the production of IL-8, macrophage inflammatory protein-1 alpha, and monocyte chemoattractant protein-1 in macrophages in a p38 mitogen-activated protein kinase- and NF-kappa B-dependent manner.
- DDR1 and DDR2 have roles in the regulation of collagen turnover mediated by SMCs in obstructive diseases of blood vessels and the lung
- several residues within loop 1 (Ser-52-Thr-57) and loop 3 (Arg-105-Lys-112) as well as Ser-175 in loop 4 of DDR1 are critically involved in collagen binding
- up-regulation of DDR1, CLDN3, and epithelial cell adhesion molecule are early events in the development of epithelial ovarian cancer
- High discoidin domain receptor 1 expression is associated with pulmonary sarcoidosis
- The results demonstrate that collagen-evoked ectodomain cleavage of DDR1 is mediated in part by Src-dependent activation
- DDR1 contributes to fibroblast survival in the tissue microenvironment of idiopathic pulmonary fibrosis and its up-regulation may occur in other fibroproliferative lung diseases as well.
- dimeric receptor tyrosine kinase DDR1 requires a transmembrane leucine zipper for activation
- DDR1 signaling provides a novel target for therapeutic intervention with the prosurvival/antiapoptotic machinery of tumor cells.
- DDR1 contributes to the eosinophil survival in the tissue microenvironment of Churg-Strauss syndrome and that it might be involved in the development of CSS.
- Results strongly suggest that DDR1 mediates cell invasion-related signaling between collagen type I and MMP-2 and -9 in pituitary adenoma cells.
- Thus, DARPP-32 signaling downstream of DDR1 is a potential new target for effective anti-metastatic breast cancer therapy
- DDR1 knockdown decreased melanocyte adhesion to collagen IV and shifted melanocyte localization in a manner similar to CCN3 knockdown.
- altered expression of DDR1 may contribute to malignant progression of non-small cell lung carcinoma
- In the present study we screened for single nucleotide polymorphisms (SNPs) in the DNA from 100 schizophrenia patients. We identified mutation within exon 10 that produces the amino-acid substitution N502S in the a-d isoforms, and M475V in the e isoform.
- DDR1 gene may be regarded as a potential marker for some types of endometrial cancer.
- PCA-1-DDR-1 signaling is a new important axis involved in malignant potential prostate cancer associated with hormone-refractory status.
- There are significantly higher number of invading cells in DDR1a expressing hepatocellular carcinoma cells.
- DDR2 was differentially upregulated in nasopharyngeal carcinoma and modulated by EBV Zta protein
- The identification of DDR1 dimers provides new insights into the molecular structure of receptor tyrosine kinases and suggests distinct signaling mechanisms of each receptor subfamily.
- KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling.
- Initiation of the signal requires two collagen receptors, alpha2beta1 integrin and discoidin domain receptor (DDR). Each receptor propagates signals through separate pathways that converge to up-regulate N-cadherin.