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Validated All-in-One™ qPCR Primer for ADORA2A(NM_001278499.2) Search again
Product ID:
HQP149356
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
A2aR, ADORA2, RDC8
Gene Description:
adenosine A2a receptor
Target Gene Accession:
NM_001278499.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine. [provided by RefSeq].
Gene References into function
- A(1)- and A(2a)-adenosine receptor activation protects HK-2 proximal kidney tubule cells against H(2)O(2)-induced injury
- Removal of the entire carboxy terminus of human A2aRT blunts the ability of the receptor to constitutively elevate cyclic AMP in intact cells; in contrast, MAP kinase stimulation is not affected by the truncation.
- adenosine triggers a survival signal via A3 receptor activation and it kills the cell through A2A receptor inducing a signaling pathway that involves protein kinase C and mitogen-activated protein kinases.
- The A2A receptor mediates a negative feedback pathway to modulate cytokine expression in THP-1 cells
- No evidence for genetically determined reduction of adenosine A 2(A) receptors in schizophrenia. Role of adenosine A (2A) receptors in the molecular effects of antipsychotic drugs.
- The human D2 dopamine receptor synergizes with the A2A adenosine receptor to stimulate adenylyl cyclase in PC12 cells.
- adenosine A2A Receptor, either homomeric or heteromeric with dopamine D2 receptors, exists as an oligomer in living cells
- an alpha-actinin-dependent association between the actin cytoskeleton and A2AR trafficking
- molecular model
- In the most probable of two possible modes of interaction between D2R and A2AR, helix 5 and/or helix 6 and the N-terminal portion of I3 from D2R approached helix 4 and the C-terminal portion of the C-tail from the A2AR, respectively
- Adenosine binding to A(2A)AR counteracts stimulation of neutrophil CD49d integrin expression
- Evidence is found for a susceptibility locus for panic disorder, possibly including agoraphobia, either within the ADORA2A gene or in a nearby region of chromosome 22.
- Most damage after hepatic ischemia occurs during reperfusion and can be blocked by adenosine A2a receptor activation.
- adenosine-related gene variants do not appear to alter susceptibility to the disease in this group of essential hypertensives
- A2A receptor activation increases protein phosphatase activity, which blocks IP3 receptor-regulated calcium release and reduction of intracellular calcium inhibits TNF-alpha production in monocytes
- The tendency of some peptides of adenosine A2a receptor to self-associate, especially in aqueous environments, underscores the need to prevent improper interactions during folding and refolding of membrane proteins in vivo and in vitro
- Adenosine A2A and dopamine D3 receptors seem to form A2A/D3 heteromeric receptor complexes in which A2A receptors antagonistically modulate both the affinity and the signaling of the D3 receptors when they are colocalized in the plasma membrane.
- PBMC from CHF patients how an upregulation of A2AR-mediated inhibition of TNF-alpha, which may represent a mechanism of protection against inappropriate cytokine production.
- Our findings suggest that it is unlikely that the A2aAR 1976T > C polymorphism plays a major role in the pathogenesis of PD, schizophrenia, or antipsychotic-induced tardive dyskinesia in the Chinese population.
- Modeled pairs of A(2A)AR-derived neoceptor-neoligand, which are pharmacologically orthogonal with respect to the native species.
- The 1976C > T polymorphism of ADORA2A receptor may be in linkage disequilibrium with a functional variant that affects panic disorder, and the extent of this linkage disequilibrium is not similar for all ethnic populations.
- Evidence of an individual adenosine A2A receptor transmembrane domain self-association.
- Regulation of adenosine receptor expression, especially up-regulation of the A(2A)AR, is part of a delayed feedback mechanism initiated through NF-kappaB to terminate the activation of human and mouse macrophages.
- An increased platelet A2A receptor maximum receptor binding may belong in a cascade of toxic events leading to earlier onset of Huntington's disease.
- Modulation by A2AR in the production of inflammatory signals by neutrophils may influence the evolution of an inflammatory response by reducing the activation status of inflammatory cells.
- Activation of the A(2A) receptor might have a beneficial effect by inhibiting inflammatory cell influx and downregulating inflammatory cell activation in asthma and COPD, respectively.
- Adenosine A2a receptor is involved in bronchial epithelial cell adenosine-stimulated wound healing.
- Galpha(olf) variant XLGalpha(olf) interacts with the human adenosine A2A receptor
- A2A upregulation in prefrontal cortex may contribute to memory dysfunction in depression
- adenosine inhibits MMP-9 secretion by neutrophils; this effect involves the A2a receptor and is mediated through the cAMP/PKA/Ca(2+) pathway
- The changes in peripheral A(2A) receptor expression suggest a significant inflammatory response to HD and heart or kidney failure.
- a common variation in ADORA2A contributes to subjective and objective responses to caffeine on sleep
- The G(alphas)-coupled adenosine A2A receptor closes KCa3.1, providing a clearly defined mechanism by which adenosine inhibits human lung mast cell migration and degranulation.
- A(2A) receptor B(max) values are robustly increased at all Huntingon disease stages as well as in 32 pre-symptomatic subjects
- the 1976C>T polymorphism does not affect the vasodilator response to adenosine and caffeine in vivo
- Results describe the isolation and spectroscopic characterization of functional human adenosine A2a receptor.
- an increased number and an up-regulation of adenosine A2A receptors in patients with spontaneous syncope and a positive head-up tilt, which in the context of high APLs may play a role in the recurrence of syncopal episodes
- Findings show that the probability of having the ADORA2A 1083TT genotype decreases as habitual caffeine consumption increases. This observation provides a biologic basis for caffeine consumption behavior
- Adenosine A2A receptors signal for increased collagen production by multiple signaling pathways, promoting the hypothesis that adenosine receptors promote hepatic fibrosis.
- A2A receptors open Cl- channels in pancreatic ducts cells with functional cystic fibrosis transmembrane regulator (CFTR).
- although there is a protein-protein interaction in the brain, there is no genetic association of the ADORA2A, either alone or in epistasis with DRD2, and the risk of schizophrenia
- linear and nonlinear 3D-QSAR methods and LBHM computational techniques has been used to depict the hypothetical antagonist binding site of the human adenosine A2A receptor
- A(2A) receptor is the first example of a G protein-coupled receptor documented to select signaling pathways in a manner dependent on the lipid microenvironment of the membrane.
- adenosine A2a receptor may function as a coincidence detector and a signal integrator--REVIEW
- These findings provide support for an association between an ADORA2A polymorphism and self-reported anxiety after a moderate dose of caffeine. It is likely that other ADORA2A and DRD2 polymorphisms also contribute to responses to caffeine.
- results identify stabilizing contacts that are likely related to the stability of the receptor and that are consistent with what is known about the three-dimensional structure and stability of rhodopsin and the beta(2) adrenergic receptor
- stimulation with IL-4, IL-13 & subsequent stimulation with AMP/NECA decreased A2AR expression accompanied by increased histamine secretion; results suggest role for decreased A(2A)R expression in enhanced adenosine responsiveness as observed in asthma
- Pharmacological data do not advocate for a clear implication of the A2A receptor in axiety. [REVIEW]
- These observations support the hypothesis that long-term drug exposure differentially alters A(2A)/D(2) receptor oligomerization.
- In resting human PMNs, mainly A(2A)R transcripts with long 5'-UTRs are expressed, whereas in stimulated PMNs and PMNs of septic patients, short 5'-UTRs predominate.
- The adaptations in the heart of highly trained endurance athletes lead to relative myocardial 'overperfusion' at rest. On the other hand hyperaemic perfusion is reduced, but is not explained by A2AR density.
- At least three A(2A) receptors assemble into higher-order oligomers at the plasma membrane in differentiated neuronal cells.
- Extracellular adenosine induces apoptosis in Caco-2 cells by activating caspase-9 and the downstream effector caspase caspase-3 in association with mitochondrial damage via A(2a) adenosine receptors