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Validated All-in-One™ qPCR Primer for ADORA1(NM_001048230.2) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene.
Gene References into function
- Human A1 adenosine receptor overexpressed in adipose tissue of transgenic mice protects them from obesity-related insulin resistance.
- A(1)- and A(2a)-adenosine receptor activation protects HK-2 proximal kidney tubule cells against H(2)O(2)-induced injury
- Putative sites for palmitoylation and phosphorylation within the A1-subtype adenosine receptor's carboxyl terminus do not play a key role in controlling agonist-stimulated changes in subcellular trafficking of the receptor.
- the membrane-proximal carboxyl terminus of the A1 adenosine receptor in receptor folding and G protein coupling
- data suggest that protein kinase C mu plays an important role in the ability of the adenosine A(1) receptor to signal to the nucleus
- building of a human A(1) adenosine receptor (hA(1)AR) model, based on the X-ray crystal structure of bovine rhodopsin, and its use as a basis for the investigation of some important structural characteristics of the receptor
- adenosine-related gene variants do not appear to alter susceptibility to the disease in this group of essential hypertensives.
- G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor requires c-Src, protein kinase C, and ERK signaling
- Stimulation of adenosine A(1) receptors on HBSMC rapidly mobilizes intracellular calcium stores by a mechanism dependent on PTX-sensitive G proteins, and IP(3) signaling.
- Robust constitutive myocardial A1-AR overexpression induces a dilated cardiomyopathy, whereas delaying A1-AR expression until adulthood ameliorated but did not eliminate development of cardiac pathology.
- The binding sites of ADORA1 reengineered for orthogonal recognition by tailored nucleosides were probed.
- Genetic variants in the adenosine A1/A3 receptor genes may predict the heart's response to ischemia or injury and might also influence an individual's response to adenosine therapy.
- A1 AR-selective agonist CPA stimulated a 1.7-fold increase in VEGF release from the mononuclear cells
- Adenosine A1 receptor-adenylyl cyclase transduction pathway is specifically up-regulated and sensitized in frontal cortex brain in Pick's disease.
- Adenosine A1 receptor gene expression is proportional to the extent of stent-induced neointimal proliferation.
- With 300 MBq of injected (18)F-CPFPX a subject receives an effective dose (ICRP 60) of 5.3 mSv.
- The interaction between A(1) and P2Y(1) receptors may play an important role in the purinergic signaling cascade in astrocytes
- Human ADA, apart from reducing the adenosine concentration and thus preventing A(1)R desensitization, binds to A(1)R behaving as an allosteric effector that markedly enhances agonist affinity and increases receptor functionality.
- The ability to increase synchronized slow-wave activity from waking to slow-wave sleep is significantly attenuated by the loss of adenosine A1 receptor expression in AdoA1R(f/f) floxed mice.