|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for PDCD1(NM_005018.3) Search again
Product ID:
HQP117925
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1
Gene Description:
programmed cell death 1
Target Gene Accession:
NM_005018.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
|
|
| A | B |
|
Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
|
Summary
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation.
Gene References into function
- PD-1 may play an important role in germinal center reactions
- A regulatory polymorphism in this gene is associated with susceptibility to systemic lupus erythematosus in humans (p.666).
- Modulation of immune responses to hPD-1 will depend upon the type of costimulatory signal delivered, the cytokine milieu, and the signaling pathways activated in the responding cell, be it T- or B-cell or monocyte.
- Differential binding properties of B7-H1 and B7-DC to programmed death-1.
- We investigated the existence of single-nucleotide polymorphisms (SNPs) in the PD-1 gene in patients with type 1 diabetes in comparison with healthy control subjects.
- the association between lupus nephritis and PDCD1 was weaker in European American than in Swedish families
- The PD-1 gene is significantly associated with rheumatoid arthritis susceptibility, suggesting the possibility that PD-1 may contribute to the pathogenesis of RA.
- evidence of the involvement of the human PDCD1 gene in arthritis.
- Our data indicate polymorphism in intron 4 of the PDCD1 gene affects the occurrence of APA and may slightly modify the risk of sporadic SLE.
- 6867C/G sinsgle nucleotide polymorphism of the PD-1 gene is associated with lupus nephropathy in Caucasian SLE patients.
- The PDCD1 gene is associated with renal manifestations(but not with susceptibility to)in systemic lupus erythematosus patients from northern Sweden.
- description of four alternatively spliced PD-1 mRNA transcripts (PD-1Deltaex2, PD-1Deltaex3, PD-1Deltaex2,3, and PD-1Deltaex2,3,4) in addition to the full length isoform
- CTLA-4 and PD-1 inhibit T-cell activation through distinct and potentially synergistic mechanisms.
- dysfunction of the PD-1/PD-L1 pathway may be related to tolerance for lymphocytes, which causes Sjogren syndrome
- A novel role is demonstrated for PD-1 in inhibiting beta 1 and beta 2 integrin-mediated adhesion.
- PD-1 has potential as a marker to discriminate between resting regulatory T cells and activated T cells, and to allow more homogeneous purification of these cells.
- PD-1 in HIV-specific CD8+ T cells may have a role in reversible immune dysfunction
- PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection.
- most hepatitis C virus (HCV)-specific CD8 cells expressed PD-1 at time of acute illness; expression declined with acquisition of memory phenotype & recovery of CD8 cell function; high levels were present when HCV persisted & CD8 cells were dysfunctional
- Data suggest no association of polymorphisms with type 1 diabetes.
- the genetic evaluation by association study demonstrated that the PD-1 gene was a predisposing gene to the development of T1D mellitus in the Japanese population
- regulatory single nucleotide polymorphism PD1.3G/A was shown to be involved in susceptibility to childhood-onset systemic lupus erythematosus but not lupus nephritis.
- PD-1 up-regulation mediates HIV-specific CD8+ T-cell exhaustion
- Modulation of PD-1 system may play a role in the development of autoimmune liver diseases.
- These results suggest that PDCD1 genetic variation influences the risk and expression of systemic lupus erythematosus and that these associations vary according to ethnic background.
- We conclude that polymorphisms in the PDCD1 gene analyzed here are not associated with RA in a Japanese population.
- These results show that small effects within PDCD1 may contribute towards the development of GD, supporting the hypothesis that much of the currently unknown genetic contribution to GD could be due to several small genetic effects with ORs 1.2.
- Study demonstrates that the inhibitory molecule PD-1 is significantly upregulated on total and HCV-specific CD8(+) cytotoxic T cells in the peripheral blood and livers of patients with chronic infection.
- results indicate Hepatitis C virus core can upregulate a key negative T cell signaling pathway, PD-1/PDL-1, associated with viral persistence & expressed on T cells of infected individuals
- The interaction of PD-1 and its ligands is involved in the downregulation of autoreactive lymphocytes and the regulation of pathogenesis in autoimmune liver disease.
- PD-1 expression on HIV-specific CD4-positive T cells in increased in chronic HIV infection and can be used as a phenotypic marker of the disease.
- We demonstrated the expression of PD-1 on CD4+ neoplastic and non-neoplastic T-cells, and that of PD-L1 on the neoplastic cells in ATL patients. It is suggested that the PD-1/PD-L1 pathway may contribute to the marked immunodeficient state of ATL patient
- PD-1 upregulation on HBV-specific CD8 T cells is engaged in the dysfunction of T cells and high viraemia in CHB patients, and the antiviral T-cell responses could be improved by the blockade of this inhibitory PD-1/PD-L1 pathway.
- PD-1 expression on CD8 T cells, including those specific for HIV, can be related both to their differentiation stage and their activation status
- results suggest that the PD-1/PD-L1 pathway may play a regulatory role in memory T cell subsets in addition to its association with T-cell exhaustion
- PD-1 demonstrates kinetics of synaptic accumulation, suggesting that the process involves T cell receptor-triggered cytoskeletal reorganization followed by ligand binding.
- associated with susceptibility to systemic lupus erythematosus among Chinese
- PD-1 might have a natural regulatory property behind myasthenia gravis.
- CTLA4 AND PDCD1 are genes encoding coinhibitory immunoreceptors that harbor polymorphisms with demonstrated associations to multiple autoimmune disorders.
- We conclude that PDCD1 is unlikely to be a major susceptibility gene for T1DM.
- High levels of PDCD1 is associated with tongue cancer
- IL1R2 was greatly decreased with future rejection and FLT3, ITGAM, and PDCD1 showed borderline changes in future cardiac rejections.
- an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection
- in liver transplant patients PD-1 (programmed cell death 1) up-regulation was significantly associated with incipient and overt Cytomegalovirus disease and with viremia
- Induction and maintenance of T cell tolerance requires PD-1, and its ligand PD-L1 on nonhematopoietic cells can limit effector T cell responses and protect tissues from immune-mediated tissue damage.
- deficient cellular immunity observed in Hodgkin lymphoma patients can be explained by "T-cell exhaustion," which is led by the activation of PD-1-PD-L signaling pathway
- The programmed death-1 pathway is active in beryllium-induced disease and plays a key role in controlling beryllium-induced T cell proliferation.
- B7-H1, PD-1 and FOXP3 may have roles in progression of breast neoplasms
- Analysis of the functional relevance of a putative regulatory SNP of PDCD1 associated with systemic lupus erythematosus is reported.
- Together these results indicate that productively infected cells are resistant to early apoptosis by downregulating PD-1, whereas PD-1 enhances the susceptibility of effector T cells to apoptosis suggesting a dual role for PD-1 during HIV-1 infection.
- PD-1 up-regulation may efficiently mitigate pathogenic CD8 T-cell responses and liver damage, correlating with disease progression of acute hepatitis b virus infection.
- study found increased expression of PD-1 on HIV-specific CD107a-positive CD8+ T cells was associated with the presence of suppressor IL-10-positive CD8+ T cells
- expression of PD-1 defines a reversible defect of CMV-specific CD4 T cells that is associated with viremia
- Hepatitic C virus-specific CD8 T-cell dysfunction and responsiveness to PD-1/PD-L blockade are defined by their PD-1 expression and compartmentalization.
- The PDCD1:CD274 pathway functions in modification of maternal decidual lymphocyte cytokine secretion during pregnancy.
- PD-1 has a key regulatory role during the immune response of the host to the pathogen
- The programmed cell death 1 gene 7209 C>T polymorphism is associated with the risk of systemic lupus erythematosus in the Polish population.
- PD-1 is an immunomarker of follicular T-cell rosettes in nodular lymphocyte-predominant Hodgkin lymphoma and in a subset of lymphocyte-rich classic Hodgkin lymphomas.
- B7-H3 is highly expressed in urothelial cell carcinoma across tumor stages, whereas B7-H1 and PD-1 expression are associated with advanced disease
- HBV specific CD8+ T-cell response in the peripheral blood is more intense in patients with acute exacerbation of hepatitis B than in chronic hepatitis B with persistent viral infection.
- data showing regulatory T cell expression of PD-1 from non-responders increased after immunization while there was no change in post-immunization levels in high responders suggest PD-1/PD-L1 pathway plays a role in Treg induction of non-responsiveness
- PD-1 plays a crucial role in the attrition of cytomegalovirus-specific CD8-positive (CD8+) T cells in acute hepatitis B virus infection, which in turn, influences the preexisting homeostatic virus-specific CD8+ T cell pool.
- ISRE, STAT1, and STAT2 have essential roles in the regulation of constitutive and IFN-alpha-mediated PD-1 expression in macrophages
- p38 MAPK activation is an important initiating event in Nef-mediated PD-1 expression in HIV-1-infected cells.
- PD-1/PD-L1 expression on cells from asymptomatic HTLV-1 carriers and ATLL patients in comparison with cells from healthy donors.
- PD-ligand 1 regulates graft-versus-host-reactive CD8 T cells after liver transplantation
- gamma c cytokine-induced PD-1 does not interfere with cytokine-driven peripheral T cell expansion/survival, but may suppress certain effector functions of cytokine-stimulated cells upon TCR engagement
- high frequency of autoimmune diseases and autoantibodies in systemic lupus erythematosus multicase families; PD-1.3A and C4AQ0 are part of a predisposing genetic background
- PD-1 up-regulation precedes epitope mutation and correlates inversely with viral clearance independent of viral load.
- this meta-analysis demonstrated an association of the PD1.3A allele with lupus nephritis in European and systemic lupus erythematosus in Latin-American populations; the PD1.5C allele was associated with SLE susceptibility in Europeans
- The similar pattern of expression of CXCL13 and PD-1 in angioimmunoblastic T-cell lymphoma provides further evidence that AITL is a neoplasm derived from germinal-center T-helper cells.
- The expression of PD-1/PDL-1 in renal tissue and during mixed lymphocyte reactions suggests an important role in regulating peripheral T cell tolerance
- Patients with grade 3 follicular lymphoma, poor performance status, and high serum lactate dehydrogenase showed lower numbers of PD-1-positive cells.
- findings show PD-1.3 & PD-1.6 polymorphisms are not associated with the susceptibility to Vogt-Koyanagi-Harada (VKH) syndrome in the Chinese Han population; PD-1.5 may be negatively associated with occurrence of extraocular manifestations of VKH syndrome