|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for CD40(NM_001250.5) Search again
Product ID:
HQP116916
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
Bp50, CDW40, TNFRSF5, p50
Gene Description:
CD40 molecule
Target Gene Accession:
NM_001250.5(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
|
|
| A | B |
|
Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
|
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions.
Gene References into function
- Review. In some cases of CLL the malignant cells express both CD40 and CD154. Implications for autoimmunity and therapy are discussed.
- The capacity of natural killer cells to induce B cell activation is dependent on the interaction of CD40 with its ligand CD154.
- A CD40 molecule with mutated nonfunctional signaling domains acts as a dominant negative inhibitor and effectively prevents NF-kB activation and the induction of gene expression changes.
- Ceramide-rich membrane rafts mediate CD40 clustering in b lymphocytes
- CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways.
- CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes.
- CD40 and CD40L are important in autoimmunity and other immune processes. At least 5 signal transduction pathways are involved.
- CD40 activation induces p53-dependent VEGF secretion and cell migration in multiple myeloma cells.
- Critical role of tumor necrosis factor-alpha and NF-kappa B in interferon-gamma -induced CD40 expression in microglia/macrophages.
- Dissection of B cell differentiation during primary immune responses in transgenic mice expressing the human CD40 antigen
- The selective triggering of CD40 on keratinocytes in vivo enhances cell-mediated immunity.
- High constitutive expression of CD40 on salivary gland epithelial cells from Sjogren syndrome indicated their intrinsic activation. It was also expressed by lymphocytes, ductal epithelium and endothelium, but not other cells.
- Short-circuiting long-lived humoral immunity by the heightened engagement of CD40.
- Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic lymphocytic leukemia
- Absence of CD40/CD40L interactions results in increased susceptibility to disseminated infection with C. albicans through decreased NO-dependent killing of Candida by macrophages.
- clustering of CD40 ligand is required to form a functional contact with CD40
- IL-1 plays a prominent role in the inflammatory response initiated by CD40 ligation in intact human skin.
- Studies of the mechanism of CD40-mediated apoptosis of human Burkitt lymphoma cell lines revealed an increase in bax messenger RNA with a subsequent increase in Bax protein in the mitochondria.
- Endogenous Act1 is recruited to the CD40 receptor in human intestinal (HT29) and cervical (HeLa) epithelial cells upon stimulation with CD40 ligand, indicating that Act1 is involved in this signaling pathway.
- plasmin induction of CD40 in human monocytes
- mediates activation of NF-kappa B in airway epithelial cells
- CD40 and CD80 molecules were observed to play a specific role in the induction of cytotoxic function but not in IFN-gamma production of IL-2-activated NK effectors.
- Efficient generation of antigen-specific cytotoxic T cells using retrovirally transduced CD40-activated B cells.
- CD40-mediated p38 mitogen-activated protein kinase activation is required for immunoglobulin class switch recombination to IgE
- CD40 engagement enhances eosinophil survival through induction of cellular inhibitor of apoptosis protein 2 expression: implications for allergic inflammation
- results suggest that in DG75 cells, TRAF3-induced MEK1 activation may be involved in CD40-mediated upregulation of IL-4-driven germline C epsilon transcription
- Treatment of human gingival fibroblasts with human leukocyte elastase down-regulated CD40 expression & binding to CD40 ligand. CD40 reduction by direct proteolysis by HLE was seen in skin & lung fibroblasts (not monocytes, macrophages, & dendritic cells)
- CD27 and CD40 co-stimulatory signals regulated the p53-amplified apoptotic pathway in B cells through the inhibition of p53-independent apoptotic pathway primarily induced by BCR ligation
- CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling.
- CD40 is a surface receptor through which the activity of Btk can be stimulated in human B cells.
- CD40 ligation on monocytes accelerates the maturation of dendritic cells in the presence of GM-CSF/IL-4
- Incubation of vascular endothelium with CD40L resulted in increased expression of cell adhesion molecules. Consequently, the adhesion of activated CD4+ T lymphocytes to CD40L treated endothelium was increased.
- CD40 has pro- and anti-apoptotic functions in malignant B-cells and epithelial cancers [review]
- CD40 is present in ovarian cancer cells and can be used for targeted gene delivery in a Coxsackie adenovirus receptor-independent. manner
- Expression of this antigen may identify prognostically favorable subgroups of diffuse large B-cell lymphoma.
- the CD40 gene was a new susceptibility gene for GD within certain families because it was both linked and associated with Graves disease
- CD40 triggering enhances fludarabine-induced apoptosis of chronic lymphocytic leukemia B-cells through autocrine release of tumor necrosis factor-alpha and interferon-gama and tumor necrosis factor receptor-I-II upregulation.
- Expression of CD40, CD54 and HLA-DR were seen in the hair structure including the dermal papilla in alopecia areata.
- CD40L enhances the capacity of Mycobacterium tuberculosis-responsive CD8+ T cells to produce IFN-gamma by increasing the number of IFN-gamma-producing CD8+ T cells and the amount of IFN-gamma produced per cell.
- endothelial CD40, through activation of the PI3K/Akt signaling pathway, regulates cell survival, proliferation, migration, and vessel-like structure formation, all steps considered critical for angiogenesis
- CD40 can costimulate memory T cells and favors IL-10 secretion.
- CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation.
- CD40 ligation induced a rise in NF-kappaB activity in hepatocytes
- Patients with acute cerebral ischemia show upregulation of the CD40 system, which might contribute to the known proinflammatory, proatherogenic, and prothrombotic milieu found in these patients.
- A synergistic role is played by the TLR9/CD40 system in the orchestration of CpG-ODN-induced responses in B lymphocytes.
- REVIEW: positive feedback loop linking NFkappaB and CD40 plays an important role in the control of the adaptive immune response, with fundamental implications for immunity and tolerance in vivo.
- CD40 is processed by the tumor necrosis factor-alpha-converting enzyme
- expression profiles and relative contribution in the porcine-human xenogeneic response
- in B cells, Gadd45 beta is induced by CD40 through a mechanism that requires NF-kappa B and this induction suppresses Fas-mediated killing
- Interleukin-10 induction of endothelial nitric-oxide synthase expression attenuates CD40-mediated interleukin-12 synthesis in human endothelial cells.
- Treatment of cultured human endothelial cells with anti-CD40 antibody (to ligate CD40) results in the expression of several other angiogenesis factors, e.g., fibroblast growth factor-2 and vascular endothelial cell growth factor receptors Flt-1 and Flt-4
- CD40-deficient dendritic cells from patients with hyper IgM disease exhibit severe impairment of DC maturation that may contribute to the defect of T-cell-mediated immunity
- Immature dendritic cells engulfed apoptotic and necrotic neutrophils, resulting in up-regulation of CD83 and class II major histocompatibility complex molecules, but down-regulation of CD40, CD80, and CD86
- All the apoptotic events induced by BCR triggering are completely reversed by CD40 ligation with anti-CD40 antibody.
- LTbetaR, CD40 and TANK interact with TRAF3 at sites that promote molecular interactions driving specific signaling
- stoichiometry of TRAF1-TRAF2 heteromeric complexes ((TRAF2)2-TRAF1 versus TRAF2-(TRAF1)2) determines their capability to mediate CD40 signaling but has no major effect on TNF signaling
- A distinct response from naive and memory B cells is observed in vitro related to the duration of CD40 stimulation, reflecting the role of each subset in primary and secondary immune responses.
- 5'-untranslated region of the CD40 gene may confer genetic susceptibility to Graves' disease in Koreans
- CD40 expression on gastric carcinoma may be associated with cell survival and elevation of cell motility
- Results indicate that patients with active lupus nephritis exhibit B cell abnormalities that are consistent with intensive germinal center activity, are driven via CD154-CD40 interactions, and may be involved in the production of autoantibodies.
- CD40 may be involved in peritonitis and in the development of late phase mononuclear predominance.
- natural CD40 signaling pathways in B cells
- Signal transduction and transcription factors inducing CD40 expression are described, as are the cis-elements in the CD40 promoter. Mechanisms underlying suppression of CD40 in macrophages/microglia by immunomodulatory agents are also discussed.
- in human renal proximal tubule epithelial cells, CD40 and its downstream MAPKs are located in membrane rafts and that disruption of caveolae or dislodgment of signaling proteins and diminishes MAPK activation and IL-8 and MCP-1 production.
- Patients with diabetes show increased coexpression of CD40 system, especially CD40L, which may create a proinflammatory and prothrombotic milieu for aggravating the development of atherosclerosis.
- Activation of the CD40/CD40L system in the gut mucosa may trigger a self-sustaining loop of immune-nonimmune cell interactions leading to an antigen-independent influx of T cells that contributes to chronic inflammation.
- beta2-AR agonists strongly inhibited the expression of ICAM-1 and CD40.
- Epstein Barr virus LMP1 drives bfl-1 promoter activity through interactions with components of the tumor necrosis factor receptor (TNFR)/CD40 signaling pathway; evidence presented that this process is NF-kappa B dependent
- Platelet activation modulates the constitutive expression of CD40 on the surface of platelets; CD40 expression remains constant as demonstrated by flow cytometric analysis.
- During an inflammatory response, CD40-CD154 mediated T helper cell-endothelial cell interaction results in an increased ciruclating monocyte recruitment & activation of these cells on their crossing of the endothelial cell barrier.
- The CD4+ T lymphocyte-dependent antibody response to pneumococcal capsular polysaccharides requires CD40-CD40 ligand interaction.
- After CD40-activation, acute lymphocytic leukemia cells released substantial amounts of interleukin-10 (IL-10) but were unable to produce bioactive IL-12.
- reduction in anti-IgM-induced growth inhibition due to altered N-glycosylation may enhance CD40-CD40L-mediated cell survival through TRAF2 which interacts with both IgM and CD40 in HBL-2 cells
- upregulated by HIV-1 vpu in endothelial cells
- CD40 has a role in progression of soft tissue sarcomas
- demonstrate that the strength and persistence of CD40 signaling can induce migration to lymph nodes and secretion of cytokines
- REVIEW: CD40-CD154 interaction can upregulate costimulatory molecules, activate antigen-presenting cells, influence T-cell priming and T-cell-mediated effector functions as well as participate in the pathogenic processing of chronic inflammatory diseases
- ligation of CD40 on EC increased association of Ras with its effector molecules Raf, Rho, and PI3K. But, it was determined that only PI3K was functional for Ras-induced VEGF transcription.
- CD40-CD154 interaction augments the expression of inflammatory cytokines and MMP in chondrocytes and contributes to an intrinsic process of cartilage degradation in rheumatoid arthritis.
- Soluble form of CD40 is increased in uremic patients (review)
- unable to confirm a role for CD40 in Graves' disease pathogenesis in our U.K. population
- Germinal cell expansion occurs in the absence of CD40 signaling, which may act only in the initial and final stages of the GC reaction.
- CD40 ligation induces CLL cells to express the proapoptotic molecule Bid and the death receptors CD95 and DR5
- Loss of CD40 expression is associated with prostate cancer progression
- Data show that specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation.
- These studies help to identify the TRAF binding domains in CD40 and to establish affinities between CD40 and the different TRAF proteins.
- These results indicate a distinction between TNF Receptor family members CD40 and TNFR1 in their utilization of MAP3Ks, and demonstrate TRAF-dependence of Tpl2 association with the CD40 receptor complex.
- CD40 may have a role in processes associated with islet autoimmunity and transplantation.
- CD40 ligation strongly synergized with Tax to activate NF-kappaB, suggesting that CD40 signals may costimulate Tax-mediated NF-kappaB activation.
- the majority of thyroid cancers express CD-40 and CD-40 ligand
- CD40/CD40L signaling contributes to inflammatory and prothrombogenic responses and brain infarction induced by middle cerebral artery occlusion and reperfusion.
- role of recipient CD40 and CD154 in the rejection process of concordant and discordant islet xenotransplantation
- GPI(+) T lymphocytes showed a significant increase of all these parameters, and the analysis of CD40-dependent pathways revealed a functional persistence of CD154 expression on the CD48(+)CD4(+) lymphocytes.
- LOX-1 and CD40 synergistically, but through a distinct pathway, work to induce endothelin-1 expression in endothelial cells.
- Retinoic acid inhibits CD40 plus IL-4 mediated IgE production through alterations of sCD23, sCD54 and IL-6 production
- anti-CD40 monoclonal antibodies, by rapidly inducing apoptosis, may reduce the capacity of inflammatory signal-matured immunogenic dendritic cells to generate an effective T-cell response
- CD40 signals may simultaneously induce antiapoptotic genes for cytoprotection of renal proximal tubular epithelial cells
- study provides evidence to support a role for constitutive CD40 signalling in cell neoplastic transformation
- single nucleotide polymorphism of CD40 gene is associated with susceptibility to later onset of Graves disease in Japanese
- CD40 expression may have a role in cyclophosphamide resistance in cervical squamous cell carcinoma
- High CD40 expression in the ileal pouch mucosa could be implied in the pathogenesis of pouchitis following proctocolectomy for ulcerative colitis
- both mouse and human renal carcinoma cells (RCC) constitutively express functional CD40
- Platelets from patients with systemic lupus erythematosus can activate mesangial cells through CD40/CD154 interactions
- This binding was not competed by either HSP70 or the biotin entity itself. Interestingly, the biotinylated HSP70 also elicited the production of CC-chemokine RANTES independent of CD40 signaling.
- TRAF2-dependent CD40 signal transduction requires TRAF6 in nonhemopoietic cells
- results support the notion that CD40 C-1T polymorphism has a modest effect on genetic susceptibility to sporadic Graves disease
- CD40 expression stimulated by chylomicron remnants in THP-1 cells is dependent on ERK 1/2-mediated pathway
- Soluble CD40L was significantly elevated in patients with more advanced symptomatic PAD and might be an indicator for disease extent stratification.
- Possible use of CD40-B cells as cellular adjuvant for cancer immunotherapy.
- TRAF3 stabilization, JNK activation and caspase-9 induction define a novel pathway of CD40-mediated apoptosis in carcinoma cells.
- higher inflammatory status of coronary lesions as well as involvement of the CD40-CD154 signaling cascade in chronic renal failure patients, especially in cases of calcified atherosclerotic lesions
- Genetic variation of the CD40 gene is associated with coronary artery calcium in a diabetic population.
- CD40 is present not only in the plasma membrane and cytoplasm but also in the nucleus of normal and neoplastic B-lymphoid cells
- the CD40 gene may be involved in susceptibility for Graves' disease in the Japanese population
- 15d-PGJ2 significantly decreased CD40 and RANTES expression in HK-2 cells, which were partially mediated by PPAR-gamma-dependent pathways.
- Anti-apoptotic signaling of CD40 involves induction of c-FLIP proteins.
- Islet beta-cells responded to CD40-CD40L interaction by secreting IL-6, IL-8, MVP-1, & MIP-1beta. CD40-CD40L interaction activates extracellular signal-regulated kinase 1/2 & nuclear factor-kappaB pathways in insulinoma NIT-1 cells.
- Results suggest that hepatocyte over-expression of CD40 might play an important role in regulating hepatocyte survival and death in HCV-associated chronic liver diseases.
- results indirectly suggest that sCD40 concentrations are related to cellular cholesterol levels
- Single cytidine/thymine nucleotide polymorphism has no association with disease susceptibility or disease course in multiple sclerosis.
- Review discusses the important role of CD40 in the angiogenic process of tumor-prone transgenic mice that is coupled to carcinogenesis.
- BAFF-R and CD40 enhance B cell responsiveness to transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI)-mediated suppression.
- Our results reveal the higher levels of maternal and umbilical sCD40L serum levels in pregnancy complicated by pre-eclampsia with and without intrauterine growth retardation.
- reveal potent biologic functions for T cell CD40 and suggest an additional means for amplification of autoimmune responses
- Compared with healthy controls, CD4(+) T cells from HIV-1(+) patients had impaired induction of CD154 when T cell activation was mediated by CD40(+) APCs. In contrast, T cell activation in the absence of these cells resulted in normal CD154 expression
- Ligation of cell surface CCR5 receptors by CCL3 or CD40 by CD40L activated the ERK1/2 and p38 MAPK signaling pathways that induced APOBEC3G mRNA expression and production of the APOBEC3G protein
- CD40 gene polymorphisms exert a genetic effect on IgE production in patients with asthma through translational regulation of CD40 expression on B cells
- substitution of a D-prolyl residue for the glycyl within the Lys-Gly-Tyr-Tyr CD40-binding motif of CD40L leads to a complete loss of cooperativity in the interaction of the mimetic with its cognate receptor.
- CD40 Kozak SNP is specific for thyroid antibody production involved in the etiology of Graves' disease
- induction of the short c-FLIP isoforms inhibits the onset of CD95-induced apoptosis in primary CD40-stimulated ALL cells despite high CD95 expression.
- Data demonstrate that CD40 signals B cell survival in part via transcriptional activation of the RelB NF-kappaB subunit.
- CD40-40L signaling has a role in vascular inflammation
- CD40 ligation may represent a novel mechanism for elimination of CRC cells and render CD40 a promising therapeutic target for the eradication of colorectal tumours.
- These data together uncovers a new signaling pathway regulating APE/Ref-1 nuclear translocation involving CD40-crosslinking, TRAF2 and p38.
- upon CD40 ligand stimulation, endogenous and exogenous CD40 receptor is rapidly mobilized into lipid rafts compared with unstimulated Aortic Endothelial Cells.
- CD40 stimulation can transiently induce RANTES and MCP-1 expression in LMP1-negative epithelial cells.
- The CD40 gene seems to be not associated with Graves' disease in the Tunisian population
- A possible role of CD40-CD40L interactions between monocytes and T4 helper cells in the pathogenesis of bone marrow failure in myelodysplastic syndromes was shown.
- Chronic atrial fibrillation acutely upregulates CD40 expression as well as platelet adhesion to the endocardium
- CD40, CD80 and CD86 are upregulated in cultured monocyte-derived dendritic cells of patients with coronary artery disease
- For susceptible genes, the CC genotype in the CD40, the GG genotype in the CTLA-4 exon 1, and the CC genotype in the CTLA-4 promoter region have shown no significant association with clinical outcome after antithyroid drug withdrawal in Grave's disease.
- Cyclic stretch thus increases the abundance of CD40 in endothelial cells through transforming growth factor-beta1/Alk-1 signaling
- CD40 expression was up-regulated on the circulating monocytes in septic subjects on Day 1
- Activation of CD40 on cholangiocytes by activated macrophages provides a molecular mechanism to amplify chronic inflammation and bile duct destruction in liver disease.
- In acute phase of myocardial infarction (MI), the circulating level of CD40 ligand, an index of platelet activation, is predictive of angiographic morphologic features that indicate high-burden thrombus formation (HBTF) in infarct-related artery (IRA).
- Our results suggested that in the cardiovascular system, ghrelin not only has an anti-inflammatory effect, but also has a significant immunoregulatory effect that may be mediated through the GHSR-1a receptor.
- Women with the TT genotype in rs1883832 SNP affecting to Kozak consensus sequence of CD40 gene had lower BMD at FN and at LS sites and increased risk of osteopenia or osteoporosis.
- sCD40L level is similar in patients with aspirin-resistant and aspirin-sensitive platelet aggregation
- the CD40/CD154 interaction has a role in the pathogenesis of autoimmune process leading to inflammatory infiltration in Graves' ophthalmopathy
- Results suggest that anti-CD40 agonists decrease CD40 surface protein t(1/2) via a mechanism that involves TRAF6 but not TRAF2/3.
- These results suggest that the TNFRSF5 -1C>T polymorphism may increase follicular lymphoma susceptibility through mechanisms that hinder cellular immune responses.
- activated neutrophils release superoxides in a PI3 kinase-dependent manner, contributing to platelet activation and sCD40L release in a redox-controlled positive feed-back loop
- N-acetylcysteine may be considered as a useful tool to prevent immune and inflammatory responses in pancreatic disorders by interfering with the CD40 pathway in pancreatic duct cells.
- further evidence of the importance of the CD40 signal in developing efficient human DC vaccines for cancer immune therapy
- C/T polymorphism in CD40 gene is not associated with susceptibility and phenotype of Graves' disease in Taiwanese.
- CD40 signaling rapidly disrupts the ability of BCL6 to recruit the SMRT corepressor complex by excluding it from the nucleus, leading to histone acetylation, RNA polymerase II processivity, and activation of BCL6 target genes
- CD40 expression in tumors is associated with a poor prognosis and that the juxtacrine interaction of CD40-CD154 among cancer cells facilitates the development of malignant potential in nonsmall cell lung cancer.
- very high expression of CD40 on BCP-ALL blasts is an independent prognostic marker indicative of superior relapse-free survival that may in part be due to CD40-dependent death receptor up-regulation
- signaling via CD40-P227A stably expressed in B-cells led to increased phosphorylation of c-Jun, increased secretion of the pro-inflammatory cytokines interleukin (IL)-6 and TNF-alpha, and increased Ig production, compared with wild-type CD40
- reversion of Fas resistance is mediated through CD40/CD40L ligation rather than IFN-gamma stimulation by inhibiting synthesis of c-FLIP
- Theses results suggest that CD40 is present in colon cancer, and recombinant soluble human CD40 ligand may be of clinical use to inhibit human colon cancer growth.
- antiapoptotic signaling of CD40, which interferes with TRAIL-induced apoptosis in follicular lymphomas B cells, involves NFkappa-B-mediated induction of c-FLIP & Bcl-xL which can interfere with caspase 8 activation or mitochondrial-mediated apoptosis
- endothelial CD40 involvement in the transcriptional regulation of gene networks associated with adhesion and motility, immunity, cell fate control, hemostasis, and metabolism
- These data reveal a novel "feed-forward" mechanism induced by NF-kappaB which ensures that acutely synthesized IRF-1 operates in concert with NF-kappaB to amplify the immunoproteasome and antigen-processing functions of CD40.
- CD40 expression was detected in 60.3% of paraffin-embedded ovarian cancer tissues and 73.3% of fresh ovarian cancer tissues, but not in normal ovarian tissues. CD40 expression was significantly correlated with FIGO stage of ovarian cancer.
- maturation of human DC with OK432 induces direct tumor cell killing by DC by interaction of tumor cell CD40 with dendritic cell CD40L
- the T/T genotype and T allele in the CD40 gene are more likely to be associated with late-onset Graves disease in Taiwanese patients
- Variant at the CD40 gene locus is associated with rheumatoid arthritis.
- prolonged in vitro CD40 stimulation, resulted in up-regulation of antiapoptotic Bcl-xL, A1/Bfl-1, and Mcl-1 proteins, and afforded resistance to various classes of drugs
- study demonstrated that Abeta(1-40), levels of sCD40 and sCD40L are increased in Alzheimer's disease and declining MMSE scores correlated with increasing sCD40L, which in turn, correlated positively with Abeta(1-42)
- sCD40 natural isoforms encompassing either three or four CRDs might exert different antagonistic effects from known CD154 antibodies by recognition of only membranous CD154.
- mTORC2 and Akt facilitate CD40-inducible expression of VEGF in endothelial cells
- LPS induced CD40 expression on human PBMCs through activation of NFkappaB and JNK, and partially through the induction of IFNgamma production.
- Data show that there were non-association and non-additional effects of TLR4/CD40 gene polymorphisms and haplotypes upon asthma risk.