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Validated All-in-One™ qPCR Primer for PDCD1LG2(NM_025239.3) Search again
Product ID:
HQP112924
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
B7DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2, bA574F11.2
Gene Description:
programmed cell death 1 ligand 2
Target Gene Accession:
NM_025239.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- Blockade of PD-L2 during T cell responses initiated by allogenic dendritic cells increases T cell proliferation and cytokine production, showing that PD-L2 functions to inhibit T cell activation.
- Binding properties of B7-DC to programmed death-1.
- regulatory role of PD-1 and the differential roles of B7-H1 and B7-DC in hapten-induced immune responses.
- Administration of anti-PD-L2 mAb did not significantly affect the prolongation of graft survival.
- Two novel splice variants of PD-L2 were cloned and identified.
- Data suggest that PD-L2 status may be a new predictor of prognosis for patients with esophageal cancer.
- Via its interaction with programmed death-1 (PD-1) on human T cells, PD-L2 acts only as a negative regulator of T cell activity, inhibiting proliferation, IL-2 production, and IFN-gamma production.
- PD-L2 negatively regulates human T cell activation and thus might be a candidate molecule for immunotherapeutic approaches aimed to attenuate pathological immune responses.
- data do not support an association between systemic lupus erythematosus and SNP's within the genes of the PDCD1 ligands PD-L1 and PD-L2
- Modulation of PD-L2 system may play a role in the development of autoimmune liver diseases.
- PD-L2 47103 T may be associated with susceptibility to SLE in Taiwan
- Polymorphisms of PD-L2 are not associated with susceptibility to rheumatoid arthritis in Taiwan.
- deficient cellular immunity observed in Hodgkin lymphoma patients can be explained by "T-cell exhaustion," which is led by the activation of PD-1-PD-L signaling pathway
- HRV-16 infection or exposure to dsRNA induces epithelial B7-H1 and B7-DC
- Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia.
- PD-1 has a key regulatory role during the immune response of the host to the pathogen