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Validated All-in-One™ qPCR Primer for TNF(NM_000594.3) Search again
Product ID:
HQP110731
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F
Gene Description:
tumor necrosis factor
Target Gene Accession:
NM_000594.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq].
Gene References into function
- A high in vivo and in vitro production of TNF-alpha found in carriers of the common Caucasoid haplotype HLA-B8,DR3 is associated with multiple autoimmune diseases and immune response dysregulation in healthy subjects.
- Elevated tumour necrosis factor-alpha levels may play a role in the development of necrotizing enterocolitis. The A(-308) and A(-238) variants of the promoter region of the TNF-alpha gene are reportedly associated with altered TNF-alpha production.
- -A significantly reduced PGN-elicited tumor necrosis factor alpha (TNF-alpha) secretion by U937 cells and rat alveolar macrophages.
- Anti-TNF therapy for rheumatoid arthritis and other inflammatory diseases
- affects susceptibility to acute rejection after cardiac transplantation
- Interleukin-6, tumor necrosis factor alpha and interferon gamma serum levels in patients with anorexia nervosa.
- Postburn plasma TNF alpha level increased in all patients, especially obvious in those with sepsis.
- PAI-1 gene activation by TNF-alpha apparently is yet to be defined for the location of the response element and/or the signaling pathway, while TGF-beta is the most important cytokine for PAI-1 transcriptional activation through its 5' proximal promoter.
- effect on cell proliferation and apoptosis in conjunction with interferon-gamma
- CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways.
- Damage of the ehdothelial cells of placental blood vessels is associated with the abnormal increase in the maternal blood TNFalpha.
- role of PTEN in blocking induction of NF-kapp B-dependent transcription by inhibiting the transactivation potential of the p65 subunt
- TNF-alpha potentiates adhesion of C5a-stimulated eosinophils to human bronchial epithelial cells (HBEC) by a mechanism in which eosinophil contact with HBEC is essential for priming.
- The phagocytosis of platelets opsonised by anti-beta2GPI antibodies determined the release of TNF-alpha and IL-1beta by dendritic cells and macrophages.
- The role of TNF/TNFR in organ-specific and systemic autoimmunity is reviewed: implications for the design of optimized 'anti-TNF' therapies.
- Critical role of tumor necrosis factor-alpha and NF-kappa B in interferon-gamma -induced CD40 expression in microglia/macrophages.
- Transient exposure of human bronchial epithelial cells to TNFA leads to persistent increased expression of ICAM-1.
- Incubation of endothelial cells with conditioned media derived from stimulated macrophages modulates ICAM1 mRNA expression. Results suggest TNF-alpha and activation of the NF-kB pathway are involved.
- The A1 allele of TNF-alpha associates with rheumatoid arthritis.Genotypes A1A2 of TNF-alpha is associated with more severe disease.
- Breast cancer is not associated with SNPs in the TNFA promoters; TNFB*A allele induces some function(s) leading to the inhibition of tumorigenesis in breast cancer
- Genetic variation in TNFalpha production is unlikely to play a major role in risk of cutaneous malignant melanoma.
- association of TNF alleles with HLA-DR, -DQ and -B alleles in 216 healthy individuals from the north of England
- Genetic polymorphisms in the TNF-alpha gene at positions -376, -308, -238 and +489 could not be identified as susceptibility or severity factors in periodontitis
- TNF-deficient mice are protected from experimental allergic encephalomyelitis.
- TNF-alpha--accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspase-dependent mechanism.
- Carriage of ILbeta2 and IL1RN*2, together with non-carriage of TNF2is associated with increased susceptibility, but not with a prognosis of IgAN.
- Polymorphisms in or near tumour necrosis factor (TNF)-gene do not determine levels of endotoxin-induced TNF production.
- In dengue shock syndrome pts, TNF-alpha was significantly associated with D-dimer, an activation marker of fibrinolysis (p < 0.003), but not with activation markers of coagulation. TNF-alpha is involved in the onset and regulation of hemostasis.
- TNF alpha-mediated effect causes or contributes to defective bone marrow progenitor cell reserve and function and defective stromal cell function in rheumatoid arthritis.
- Ubiquitin/proteasome-dependent degradation of D-type cyclins is linked to tumor necrosis factor-induced cell cycle arrest.
- in semen of normal/infertile men
- no significant differences in basal TNFalpha levels were found between the growth hormone deficient, idiopathic short stature children and healthy controls
- ). TNF-alpha promoter polymorphisms are associated with severe, but not less severe, silicosis in this population.
- Stimulation of IRF-7 gene expression by tumor necrosis factor alpha: requirement for NFkappa B transcription factor and gene accessibility
- role in inducing interleukin-6 and interleukin-8 secretion in bronial epithelia cells
- the pathophysiological role of the tumor necrosis factor (TNF) system in insulin resistance in patients with gestational diabetes (GDM) and during the course of normal pregnancy
- promoter polymorphism in NIDDM in japan; relationahip to insulin sensitivity and abdominal fat
- Promoter polymorphism TNFalpha-308*2 increases risk of asthma.
- Polymorphisms of the TNF gene and the TNF receptor superfamily member 1B gene are associated with susceptibility to ulcerative colitis and Crohn's disease, respectively.
- Proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF.
- Inducer-specific enhanceosome formation controls tumor necrosis factor alpha gene expression in T lymphocytes.
- the C-terminal one third of DNA binding domain confers different binding specificity of NFATc and NFATp to an NFAT site in the TNF-alpha promoters
- In vascular endothelial cells co-treated with 15d-PGJ2 and TNF-alpha, the subsequent elevation of TF activity was synergistically increased over that of cells treated with TNF-alpha alone.
- role in Candida albicans-induced interferon-gamma production in human whole blood cultures
- insulin and TNF alpha regulate the expression of Foxc2 via a PI3K- and ERK 1/2-dependent pathway in 3T3-L1 adipocytes
- One hundred sixty-four unrelated healthy individuals from Chinese Han population were investigated in order to define the distribution of eight polymorphic loci within the tumor necrosis factor (TNF) gene cluster
- Tumor necrosis factor-alpha increases airway smooth muscle oxidants production through a NADPH oxidase-like system to enhance myosin light chain phosphorylation and contractility.
- Hyperoxia prolongs tumor necrosis factor-alpha-mediated activation of NF-kappaB: role of IkappaB kinase.
- Increased bioactive TNF in human systemic lupus erythematosus: associations with cell death
- Secretion levels of sIL-2R, IL-6, IL-8, IL-10, and TNF-alpha, but not IL-4 and IL-12, are elevated in activated T-cells in large granular lymphocytic leukemia associated with autoimmune disorders.
- Effect of the cannabinoid receptor ligand, WIN 55,212-2, on superoxide anion and TNF-alpha production by human mononuclear cells
- determine the cellular contents and concentrations of interleukin 6 (IL-6), interleukin 8 (IL-8) and tumour necrosis factor alpha (TNF-alpha) in fluids of patients with spermatocele or epididymal cyst
- Polymorphisms for interleukin-4 (IL-4) -590 promoter, IL-4 intron3, and tumor necrosis factor alpha -308 promoter: non-association with endometriosis.
- Correlation of p21 gene codon 31 polymorphism and TNF-alpha gene polymorphism with nasopharyngeal carcinoma.
- IGFBP-3 is essential for TNF-alpha-induced apoptosis in PC-3 cells
- These data strongly suggest that in TNF-induced apoptosis, Hsp72 specifically interferes with the Bid-dependent apoptotic pathway via inhibition of JNK.
- analysis of TNFa microsatellite polymorphisms in genetic susceptibility to juvenile idiopathic arthritis
- polymorphism is associated with the incidence of graft-versus-host disease and relapse rate in unrelated bone marrow transplantation (uBMT)
- TNF-alpha gene polymorphism is related to lumbar spine bone area in healthy female Caucasian adolescents.
- Increased erythrocyte glutathione peroxidase activity and serum TNFalpha in HIV-infected patients is related to pathogenesis of HIV infection and the hypercoagulable condition during HIV infection.
- production by different populations of erythroid cells derived from human embryonal liver
- novel regulation for the proteolytic activation of MMP-9 in human tissue (tissue-associated chymotrypsin-like proteinase, pM9A).
- The -308 G/A TNF-alpha gene variant conveys an increased risk for the development of insulin resistance in obese subjects
- Malignant B-cells in B-CLL are exposed to large numbers of T-cells able to synthesize and secrete TNF-alpha. The TNF-alpha production can be associated with progression of B-CLL.
- An association between young age of onset of psoriasis and HLA-Cw*0602 is confirmed in patients with psoriatic arthritis.
- Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors
- Tumor necrosis factor-alpha allele 2 shows an association with insulin-dependent diabetes mellitus in Latvians.
- Regulation of ecto-5'-nucleotidase by TNF-alpha in human endothelial cells.
- secretion from acute myelogenous leukemia blasts was up-regulated by leptin
- a decreased processing rate of mTNF-alpha in mature adipocytes combined with an increase in TNF-alpha production may be a potential mechanism resulting in elevated membrane-associated TNF-alpha in adipose tissue in obesity
- obese women, even those with morbid obesity, over-express TNFalpha in subcutaneous adipose tissue in proportion to the magnitude of the fat depot
- NF-kappaB-dependent MnSOD expression protects adenocarcinoma cells from TNF-alpha-induced apoptosis.
- role of TNF in promoting fetal membrane apoptosis
- TNF-alpha gene polymorphisms in sarcoidosis
- Overexpression of mucin genes induced by tumor necrosis factor-alpha in cultured tumor cells is inhibited by a retinoic acid receptor alpha antagonist.
- role in inducing AKT2
- post-transcription regulation during in vitro differentiation of monocytes/macrophages in primary culture
- Independent mechanisms for TNF alpha-induction of apoptosis and TNF alpha-suppression of steroidogenesis.
- Weight loss in obese subjects was associated with opposite changes in the secretion and transcription of IL-8 and TNF-alpha in the adipose tissue, as well as in plasma
- Polymorphism in the TNF promoter is strongly associated with the risk of diabetes but not cardiovascular mortality in old age.
- Human proteinase 3 can inhibits LPS-mediated TNF-alpha production through CD14 degradation
- TNF-alpha in rheumatoid arthritis synovium plays a role in the synovial hyperplasia of RA by suppressing apoptosis and promoting proliferation of synoviocytes through NF-kappaB-dependent signaling pathways mediated by up-regulated TNFR2 and TRAF1-6
- Lactic acidosis after cardiac surgery is associated with polymorphisms in tumor necrosis factor gene.
- detected a significant positive correlation between TNF-alpha (r=0.55) and interferon-gamma (r=0.54) mRNA expression and the Beck Depression Inventory sum scores during an acute attack in multiple sclerosis patients
- a predictor of insulin resistance in pregnancy
- hypothesis that ketosis increases the TNF-alpha secretion
- The -238 AG genotype is absent in severe RA but present in mild RA. The -238 GG genotype is present in 100% of severe cases. The +489 polymorphism does not segregate differently between responsive and unresponsive pts.
- TNFalpha and IL-8 regulate the expression and function of CD44 variant proteins in human colon carcinoma cells.
- TNFA polymorphism associated with development of asthma in Japanese population
- TNF-alpha-mediated apoptotic depletion of BM erythroid cells may account for Anemia of chronic disease in rheumatoid arthritis.
- Native LDL potentiate TNF alpha and IL-8 production by human mononuclear cells.
- High TNF-alpha levels are associated with an increased risk of periportal fibrosis in patients infected with Schistosoma mansoni.
- Anti-CD45 isoform antibodies enhance phagocytosis and gene expression of IL-8 and TNF-alpha in human neutrophils by differential suppression on protein tyrosine phosphorylation and p56lck tyrosine kinase.
- plays in the role in the pathogenesis of the otitis media with effusion (review)
- Promoter polymorphism cosegregates with another polymorphism and is associated with the interleukin-1 beta (IL-1 beta) synthesis capacity of human leukocytes.
- Impaired glucose tolerance is not associated with increased serum concentrations.
- TNFalpha is critically important in the regulation of T cell response in the absence of danger signals
- the role NF-kappaB plays in TNFalpha- or lipopolysaccharides (LPS)- induced chemokine secretion by human monocyte-derived macrophages was examined
- Data suggest an effect of the TNF(alpha)-308 polymorphism on the age at onset of late Alzheimer disease.
- role of p38 map kinase, NF-kappaB, and protein kinase c in TNF-alpha mRNA expression by human peripheral blood leukocytes, monocytes, and neutrophils in response to anaplasma phagocytophila
- TNF-alpha may play an important role in enhancing the biological response of bovine neutrophils to Mannheimia (Pasteurella) haemolytica leukotoxin
- acanthamoeba castellanii by release of ADP and other metabolites lead to human monocytic cell death through apoptosis and stimulate the secretion of TNF-alpha
- the excessive activation of cytokines as TNFalpha could be reduced by six-minute walking test training in congestive heart failure patients.
- TNF-alpha plays a role in the enhanced systemic and local production of NO in congestive heart failure and is elevated in proportion to the severity of CHF.
- The presence of TNF alpha expression was observed in all examined samples of differentiated thyroid carcinomas in comparison to surrounding tissue free from neoplastic infiltration
- There is a higher risk of relapse in poor prednisone responders expressing the TNF2 allele compared to those not expressing the TNF2 allele. TNF genotype seems to influence the risk of relapse in high risk ALL patients.
- cell survival and cell death signaling by TNF-alpha
- Polymorphism Nco1 is associated with fasting glycemia and lipid parameters in healthy non-obese caucasian subjects
- AHSG, TNF-alpha and leptin may contribute to insulin resistance during normal pregnancy and gestational diabetes
- TNFA downregulates angiotensin converting enzyme in differentiating human macrophages
- TNF-alpha has a role in activation of endothelial cell apoptosis along with TGF-beta1
- These results demonstrate that overexpression of Activating transcription factor 3 (ATF3) suppresses tumor necrosis factor-alpha-induced cell death of HUVECs, at least in part, through down-regulating the transcription of p53 gene.
- Tumor necrosis factor-alpha gene promoter polymorphism in coal workers' pneumoconiosis.
- REVIEW: genetic polymorphisms responsible for regulating the production of these proinflammatory cytokines and their role in modifying silicosis severity
- conclude that elevated TNF levels in myotonic dystrophy type 1 may lead to cardiac fibrosis affecting diastolic function, conduction, and automaticity.
- complement activation in the myocardium may contribute to the progression of dilated cardiomyopathy via TNF-alpha expression in cardiac myocytes
- IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts.
- TNFA acetylates p53, which attenuates the trans-activation by depleting CREB binding protein in rheumatoid synoviocytes
- In order to ensure an effective shutdown of the apoptotic pathway, TNF induces multiple NF-kappaB-dependent genes that inhibit successive steps in the TNFR1 death signaling pathway.
- activation of the ERK pathway is involved in the induction of IL-6 mRNA stabilization by IL-17 plus TNF-alpha.
- TNF plays a role in arachidonic acid release leading to cell death
- data suggest that although chronic lymphocytic leukemia (CLL) anemia is not characterized by inadequate Epo production, in some CLL patients this factor may be correlated; in these cases, levels of TNF-alpha were higher than in other anemic cases
- TNF-alpha sensitizes HT-29 colonic epithelial cells to intestinal lactobacilli, and induced IL-8 mRNA expression.
- APC inhibits TNF-alpha production by LPS-stimulated human monocytes in a concentration-dependent fashion by inhibiting the activation of both NF-kappa B and AP-1.
- Role in severity of Puumala Hantavirus infection
- Polymorphisms of the tumor necrosis factor-alpha gene promoter predict for outcome after thalidomide therapy in relapsed and refractory multiple myeloma.
- TNF-alpha levels were negatively correlated with the sperm motility and morphology.parameters. IL-6 and TNF-alpha may be involved in male fertility.
- Human TNF-alpha in transgenic mice induces differential changes in redox status and glutathione-regulating enzymes
- Reduction of tumor necrosis factor-alpha (TNF-alpha) related nuclear factor-kappaB (NF-kappaB) translocation but not inhibitor kappa-B (Ikappa-B)-degradation by Rho protein inhibition in human endothelial cells.
- Review. Recent evidence supports a dualistic, pro-inflammatory and immune- or disease-suppressive role for TNF in autoimmune diseases and inflammation.
- Associations of tumor necrosis factor alpha and HLA polymorphisms with adult dermatomyositis: implications for a unique pathogenesis.
- Results provide evidence that estrogen receptors repress Tax-activated tumor necrosis factor-alpha (TNF-alpha) transcription by interacting with a c-Jun and NFkappaB platform on the TNF-RE.
- Bone mineral mass is associated with interleukin 1 receptor autoantigen and TNF-alpha gene polymorphisms in post-menopausal Mediterranean women.
- A divergent role for TNF-alpha is shown in the killing of Toxoplasma gondii and Salmonella typhimurium in macrophages from patients with partial IFN-gamma receptor 1 deficiency, which explains the highly selective susceptibility of patients.
- tumor necrosis factor-alpha may contribute to the insulin resistance during the course of normal pregnancy
- Thalidomide and its analogues have distinct and opposing effects on TNF-alpha and TNFR2 during co-stimulation of both CD4(+) and CD8(+) T cells, suggesting a possible role for TNF-mediated events during co-stimulation.
- Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha.
- Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains
- TNF expression is modulated by hormone replacement therapy in postmenopausal women
- Bovine serum albumin induced an increase in the expression of this protein in human kidney proximal tubule cells in culture.
- results show that HCMV infection of villous trophoblasts leads to rapid loss of neighboring cells mediated by viral IE protein-induced TNF-alpha secretion
- results indicate that mouse IL-19 may play some important roles in inflammatory responses because it up-regulates IL-6 and TNF-alpha and induces apoptosis [IL-19]
- data suggest that the -238 promoter region TNF-alpha gene polymorphism is a determinant in the development of HIV-related lipodystrophy.
- Resection of pancreatic cancer normalizes the preoperative increase of gene expression.
- results suggest that tumor necrosis factor-alpha and interleukin-6 are involved in endotoxin-induced anorexia in humans
- role in inducing vascular cell adhesion molecule-1 expression in aortic endothelial cells
- The secretion of TNF-alpha from lung mast cells augments NF-kappa B activation not only of mast cells but also of surrounding inflammatory cells and thus has a considerable proinflammatory effect on its local microenvironment.
- The frequency of allele TNF2 in tuberculosis patients was significantly higher than in controls (chi 2 = 11.69, p = 0.001) in Bashkorstan
- TNF-alpha causes time-dependent accumulation of p53 and p21 in a cervical carcinoma cell line, which is inhibited by pre-treatment with insulin
- TNF-alpha can induce a "classical," caspase-dependent and a "nonclassical" caspase-independent cell death in neutrophils.
- TNF-alpha induces a caspase-independent but protein synthesis-dependent cell death signal.
- Results represent the first demonstration of an alternate usage of distinct signaling pathways by TNF-alpha to inhibit the expression of a given gene, COL1A2, depending on its activation state.
- three single-nucleotide polymorphisms of the TNFalpha gene in Japanese women
- single nucleotide polymorphisms in the TNFalpha gene in the Japanese population
- polymorphism of the tumor necrosis factor-alpha gene is unlikely to contribute to the risk of polycystic ovary syndrome
- TNF-alpha-mediated changes in cell cycle progression and apoptosis are mitigated by heme oxygenase 1 in vascular endothelium
- Extracellular ubiquitin specifically inhibits ex vivo secretion of tumor necrosis factor-alpha (TNF-alpha) and TNF-alpha mRNA expression from peripheral blood mononuclear cells (PBMNCs) in response to endotoxin in a dose-dependent manner.
- In contrast to preferential decrease in TNFalpha gene detected in dermis during the treatment phase, persistent/enhanced TNFalpha mRNA expression was detected in epidermis.
- TNF-alpha suppresses erythropoiesis by inhibiting the generation of glycophorin A positive (GPA+) cells derived from CD34+ cells as well as by inhibiting the proliferative capacity of GPA+ cells.
- Clinical relevance of the TNF-alpha promoter/enhancer polymorphism in patients with aplastic anemia.
- increased secretion in mucosal leishmaniasis
- TNF genotype associated with clinical outcome of Leishmania chagasi infection
- TNF-dependent arthritis in the absence of osteoclasts
- role in modulating thymus and activation-regulated chemokine/CCL17 and interferon-induced protein of 10kDA/CXCL10 release in HaCaT cell line
- Disruption of HSP90 function reverts the action of this protein from necrosis to apoptosis.
- IFN-gamma-mediated caspase-3 activation and C. burnetii killing depend on the expression of membrane TNF.
- tumor necrosis factor-alpha increases the number of melanoma cells attaching to collagen and polystyrene, increases ability to invade through fibronectin, and upregulates alpha3 (28%), alpha4 (90%), and beta1 (65%) integrin subunit expression.
- soluble proteins of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and IL-6 receptor subunit gp80 (sIL-6R gp80), as markers of multiple sclerosis
- A relationship exists between tumor necrosis factor-alpha and interleukin-10 promoter polymorphisms and the development of paucibacillary leprosy
- Vpr caused an HIV-1 reproduction in U1 cells through the induction of TNF
- levels of TNFA expression in normal and inflamed dental pulp are described
- the TNF-alpha-308A allele carrier state appears to be associated with lower systolic and diastolic BP values in diabetic adolescents
- potentiates IL-4/IL-13-induced IL-13Ralpha2 expression
- investigated whether TNFalpha can regulate Sertoli cell tight junction function via its effects on collagen alpha3(IV) and other proteins that maintain the homeostasis of the extracellular matrix
- placental TNF alpha associated with placental malaria and low birth weight in Malawian women
- The paracrine role of choriodecidual TNF-alpha appears to be pivotal in the elaboration of the inflammatory response to lipopolysaccharide.
- results show that TNF-alpha stimulated cytotrophoblasts modulate the expression of differentiation markers, down-regulating the autocrine signals that promote syncytialization, and increasing their invasive capacity through up-regulation of proteases
- Nur77, itself, is transcriptionally up-regulated by TNFalpha. This in turn upregulates PAI-1.
- The role of the TNF locus in the genetic background of RA is unclear, however, our data does not support the previous reported association of the TNF +489A allele with RA susceptibility or severity.
- that the MHC contains genetic elements outside the LTA-TNF region that modify the effect of HLA-DRB1 on susceptibility to rheumatoid arthritis
- TNF-alpha is secreted by fungi-prestimulated leukocytes from the lower respiratory tract and may be involved in the processes of exacerbation of asthma complicated by fungal infections
- polymorphisms of the TNF alpha-308 genes are unlikely to contribute to atopic disease risk in the Czech asthma population
- Treatment with TNF-alpha plus IFN-gamma induces gap junctional communication mediated by connexin43 between freshly isolated monocytes/macrophages that allows the intercellular conversation required for different cellular responses.
- It was impossible to evaluate whether in vitro cytokine production profiles really can be deduced from a particular cytokine gene polymorphism.
- Endogenous tumor necrosis factor promotes resistance to cellular stresses by inducing the metallothionein-1A gene.
- TNF alpha is an important modulator of CXCR4 and CCR5 expression in human fetal astrocytes.
- TNF-alpha can induce maturation of monocyte-derived dendritic cells and elicit sustained antiviral cytotoxic T lymphocyte responses, either alone or cooperatively with CD40L or RANKL.
- IL-6r and TNF-alpha increase in parallel to VEGF and FGF-2 with increasing stage of multiple myeloma.
- TNF-alpha -308 A allele is associated with increased PTFE graft thrombosis and failure in hemodialysis patients.
- TNFa has a role in inducing VCAM1 expression in a pathway involving p38 MAPK
- TNF signaling leads to oligomerization, ubiquitination, and activation of GCKR and activation of the SAPK pathway in a manner that depends upon TRAF2 polyubiquitination and oligomerization and Ubc13 function
- abdominal obesity, adipocyte hypertrophy from visceral fat, serum TNF-alpha and C-peptide seem to be the best correlators of the lipoprotein disturbance characteristic of the metabolic syndrome
- Adenosine selectively suppresses TNF-induced NF-kappaB activation, which may contribute to its role in suppression of inflammation and of the immune system.
- relationship between recurrent pregnancy loss and polymorphisms of the genes coding for TNF-alpha (-308 G-->A), IL-10 (-1082 G-->A), IL-6 (-174 G-->C), and IFN-gamma (+874 A-->T)
- Levels of tumor necrosis factor-alpha were significantly higher in patients with hyperemesis gravidarum than in healthy pregnant and nonpregnant women
- TNFA haplotypes modify susceptibility to type I diabetes mellitus independently of HLA class II in a Moroccan population
- increased tumor necrosis factor-alpha and leptin levels may contribute to insulin resistance in gestational diabetes mellitus and in the third trimester of normal pregnancy and may negatively influence the anthropometric parameters of the newborns
- IL-1beta, TNF-alpha, TGF-beta, and bFGF are involved in bone remodeling regulation, acting as local effectors, possibly under the control of PTH.
- The TNF-1031C allele is independently associated with susceptibility to BD in Caucasoid patients.
- In a large cohort of patients a significant association between the occurance of IGA nephritis and the TNF alpha low producer phenotype was found.
- TNF-alpha mRNA was a target of translational repression by pVHL through the TNF-alpha 3'-untranslated region in renal cell carcinoma cells
- TNF-alpha/-308 A allele was overexpressed in patients with end-stage non-ischemic dilated cardiomyopathy.
- Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha: a novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3' kinase, and Akt.
- TNFalpha induces ICAM-1 expression
- This paper identifies and characterizes a binding site on this gene's promoter.
- TNF-alpha-induced expression of RANTES plays important roles in cell-mediated liver injury in alcoholic liver diseases.
- TNF-alpha & IL-1 produced by sickle leukocytes are the primary factors responsible for the observed CAM expression. This & the subsequent endothelial adherence of sickle erythrocytes play roles in the pathophysiology of sickle-related complications.
- Polymorphism of this protein is associated with acute biliary pancreatitis.
- synthesis of adipose tissue tumor necrosis factor alpha and leptin could induce the production acute-phase reactants, thus contributing to the maintenance of chronic low-grade inflammation
- TNFA has both adverse vasomotor & beneficial profibrinolytic effects on endothelial function, reflecting the complex & pleiotropic nature of TNFA, which functions as part of the normal host surveillance mechanisms & responses to tissue injury.
- TNF-alpha does not affect HCV protein and RNA synthesis in Huh-7 cells, nor does it synergistically enhance the inhibitory effect of IFN-gamma. These results demonstrate that HCV replication in Huh-7 cells is highly resistant to TNFalpha
- There is a possible relationship between the TNF-308 polymorphism and the development of allergic contact dermatitis.
- Haplotypic analysis of the TNF locus.
- Pretreatment of monocytic cells with low TNF doses inhibited TNF-induced (restimulation with a high dose) IL-8 promoter-dependent transcription as well as IL-8 production, which was prevented by overexpression of C/EBPbeta, but not p65 or Oct-1.
- In addition to activating the NF-kappa B-inducing kinase/IKK alpha/beta signaling pathway in vitro, TNF-alpha activates the protein kinase C-dependent c-Src pathway.
- No significant differences in the polymorphism of TNF-alpha promoter -238 and -308 between the patients and controls.
- no age-related allele or genotype frequencies were observed for polymorphic nucleotide.
- reduction of -308GG TNF homozygous individuals in tuberculosis patients
- TNF-alpha induces early-onset, protein synthesis-independent expression of endothelial adhesivity by PKCzeta-dependent phosphorylation of cell surface ICAM-1 that precedes the de novo ICAM-1 synthesis
- study suggests that both examined polymorphisms: the -308 G/A in the promoter region of TNF-alpha and K121Q amino acid variant of the PC-1 influence the development of insulin resistance as a prediabetic quantitative trait in a Polish population
- Weight loss was associated with changes in the circulating levels of IL-8, IL-6 and TNF-alpha indicating that these cytokines are influenced by weight loss.
- Proinflammatory genotypes of tumor necrosis factor alpha was associated with more than doubling of the risk of noncardia gastric cancer.
- TNFA induces GCMSF in lung fibroblasts.
- The TNFalpha -308 and TNFbeta +252 polymorphisms were significantly associated with age at psoriasis onset, presence of joint erosions in PsA, and progression of joint erosions in early PsA.
- tumor necrosis factor-alpha gene dimorphism is associated with unstable angina
- Fanconi anemia subjects have a marrow TNF-alpha activity that inhibits erythropoiesis so TNF-alpha has a relevant role in the pathogenesis of erythroid failure in these patients.
- role in genetic susceptibility of tuberculosis
- TNF-308*2 genotype might be more susceptible to diabetic complications such as atherosclerosis
- Data show higher SAA1 homozygosity in familial Mediterranean fever (FMF)-amyloidosis patients than in FMF patients, but no significant difference between controls and FMF patients with and without amyloidosis for the TNF-alpha-308 G-A allele.
- HCMV infection prevents TNFalpha external signaling to the cell by disrupting the function of TNFRI, the 55-kDa receptor for TNFalpha
- Histone acetylation and chromatin conformation are regulated separately at the TNF-alpha promoter in monocytes and macrophages.
- ATG-induced apoptosis in T cells involves both Fas and TNF pathways and TNF-alpha is produced much earlier than Fas and FasL expression.
- Certain specific cytokine genotypes for TGF-beta1, IL-10, and TNF-alpha are not associated with chronic allograft dysfunction.
- TNF alpha and DQB1*02 alleles in linkage disequilibrium in IDDM and NIDDM; TNF alpha promoter polymorphism associated with insulin-deficient phenotype in NIDDM only together with DQB*02
- Stimulation of conjunctival epithelium with TNF-alpha and/or IFN-gamma generated release of the chemotactic factors IL-8 and RANTES, which could act to prolong inflammation. May prolong inflammation by recruiting eosinophils to the ocular surface.
- Increased serum level of tumor necrosis factor-alpha is associated with children with Langerhans cell histiocytosis
- TNF-alpha-induced apoptosis is inhibited by EGF through activation of PKC-delta
- single nucleotide polymorphisms appear to be associated with severe adult periodontitis in Japanese populations
- evidence of undetectable levels of TNF-alpha and inducible inos enzyme in infants with congenital hypothyroidism
- Data show that angiogenin isolated from cow milk induces the production of cytokines interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha in human leukocytes.
- The TNF-alpha polymorphism was not associated with cervical incompetence or with delivery prior to 28 weeks in women who received an emergent cerclage.
- TNF-alpha-induced apoptosis has caspase 9 activating caspase 7 in the absence of the caspase 3-dependent pathway in MCF7 tumor cells
- Data show that overexpression of Bruton's tyrosine kinase results in the stabilization of tumor necrosis factor alpha mRNA via the 3' untranslated region.
- During leukocyte differentiation, time windows exist during which autocrine TNFalpha is active and then down-regulated by TNF receptor I, which may temper continuous up-regulation of synthesis of proteins involved in pericellular proteolysis.
- results suggest that overexpression of tumor necrosis factor (TNF)-alpha or exogenous TNF-alpha limits pulmonary fibrosis
- TNFA promoter polymorphism was strongly associated with narcolepsy.
- TNF2 allele was significantly decreased in MS patients (14%) in comparison with controls (24%; p = 0.044). The TNF2 allele had no influence on disease behavior, since it was not associated with the course and severity of MS in this group of patients.
- results demonstrate a decreased frequency of the -863CC TNF-alpha promoter genotype and an increased frequency of the -1082GG IL-10 promoter genotype in patients recovered from hepatitis C virus infection
- expression is inversely related to the expression of plasma adiponectin.
- Promoter polymorphism in this gene predicts the conversion from impaired glucose tolerance to type 2 diabetes.
- Common polymorphisms in this protein are associated with increased risk of colorectal cancer.
- TNFalpha production is induced by lipopolysaccharide, group B Streptococci and Staphylococcus aureus; G(i)-coupled and Src tyrosine kinase-coupled signaling pathways are involved
- In non-diabetic subjects, hypoglycaemia downregulated the production capacity of TNFalpha
- Carriage of the TNFA2 allele is associated with high risk of chroiamnionitis.
- Higher cytosol levels of TNFA were found in the walls of ruptured aneurysms than in the asymptomatic aneurysms.
- Production of TFNA was reduced after the second T-cell vaccination.
- In all three groups of patients significant correlation was seen between abundance of IL-2 vs. IL-4, IL-5, IL-10, or TNF-alpha, between IL-4 vs. IL-10, and between TNF-alpha vs. INF-gamma
- 308A allele of the promoter of tumor necrosis factor-alpha gene is associated with high rates of glucose oxidation in normal weight subjects and with effective lipid storage in overweight subjects
- A Gambian TNF haplotype matches the European HLA-A1, B8, DR3 and Chinese HLA-A33, B58, DR3 haplotypes.
- TNF-alpha production following whole-blood stimulation is increased in first-degree family members of patients with non-paraneoplastic Lambert-Eaton myasthenic syndrome.
- a key role for TNF-alpha in regulating the synthesis of hyaluronan-adhesive CD44 by inducing sialidase activity through p38 MAPK activation in LPS-stimulated monocytic cells
- TNF-alpha promotes macrophage-induced apoptosis in carotid plaque vascular smooth muscle cells by cooperative interactions with nitric oxide and Fas-Fas ligand.
- data demonstrate that basal circulating tumor necrosis factor-alpha is not elevated in patients with type 2 diabetes when matched for body mass index with control subjects
- serum and cyst fluid levels of interleukin (IL)-6, IL-8 and tumour necrosis factor-alpha (TNF-alpha) were evaluated in women with endometriomas and compared with those in women with benign or malignant ovarian tumours.
- adipose tissue mRNA of tumor necrosis factor-alpha, interleukin-6, and interleukin-8 was increased in HIV-associated lipodystrophy syndrome subjects
- induction of the MMP-13 gene by TNF-alpha is mediated by ERK, p38, and JNK MAP kinases as well as AP-1 and NF-kappaB transcription factors
- presence of high levels of biologically available TNFalpha, in susceptible individuals, may in turn play a role in the pathogenesis of systemic autoimmune diseases in HPV infected individuals
- p38 MAPK activation inhibited the deadenylation of reporter mRNAs containing either the cyclooxygenase-2 or tumor necrosis factor AU-rich elements
- In patients with heart failure, enhanced platelet O(2)(-) production is mediated by TNF alpha via activation of arachidonic acid and NADPH oxidase pathways.
- the presence of abnormalities in the TNF-alpha pathway could predispose to the development of diabetes mellitus in subjects at risk for the disease
- TNFA promoter polymorphisms are associated with the clearance of hepatitis B virus infection.
- TNF-alpha downregulates TLR-4, which is associated with LPS hyporeactivity for NF-kappaB formation
- TNFalpha-induced apoptosis is modified by 5/6 kinas, which interferes with the activation of TNF-R1-associated death domain
- Adding TNF at the onset of monocyte/fibroblast cocultures skews monocyte differentiation toward dendritic cells.
- confirm the role of uPA in acantholysis and suggest an involvement of IL-1alpha/TNF-alpha in uPA induction
- Tumor necrosis factor alpha is a key mediator of gut inflammation seen in amebic colitis in human intestine in the SCID mouse-human intestinal xenograft model of disease.
- up-regulated to a greater extent in patients with influenza-associated encephalopathy than in those without neurologic complications.
- No change in level during liver cancer surgery.
- TNFa is overexpressed in human fat cells from insulin-resistant subjects
- analysis of the association of NcoI polymorphism within the promoter/enhancer region of TNFalpha and the first intron of TNFbeta encoding gene with toxic complications following sten cell transplantation
- TNF, GM-CSF, and G-CSF induce actin depolymerization and morphological changes through activation of ERK and/or p38 MAPK, and cytokine-induced actin reorganization may affect inhibitory effect of these cytokines on neutrophil chemotaxis.
- PrPc protein was significantly increased when glioma spheroids were treated with TNF-alpha whereas mRNA levels remained unchanged; TNF-alpha raised intracellular ROS levels
- possible associations between common serological markers of celiac disease with the -1087 IL10 and -308 TNFA polymorphisms
- TNF alpha triggers different effector mechanisms to directly inhibit Leydig cell StAR expression and steroidogenesis, which ultimately contribute to the global reproductive failure associated with chronic inflammation and sepsis.
- TNFalpha and caspase 8 play roles in the regulation of MMP1 and MMP9 by interferon gamma
- There is a potential interplay between TNF-alpha-induced activation of p38 MAPK and NF-kappaB.
- A clear association of the -308A allele polymorphism of TNF-alpha in children with autoimmune-associated congenital heart block (CHB) cannot be made; TNF-alpha may be one of several factors that amplify susceptibility to CHB.
- -G308A tumour necrosis factor-alpha gene polymorphism may have a potential role for susceptibility to major depressive disorder in the Korean population.
- This study suggest that the various alleles of either the SNP or the microsatellites (TNF-alpha andTNF-beta) are not to be independent risk factor for sporadic AD.
- Polymorphisms in tumour necrosis factor are associated with risk of bladder cancer and grade of tumour
- TNF-alpha IL-6 and IL-10 expression in UVB-irradiated human keratinocytes via cyclic AMP/protein kinase A pathway and a possible reduction of deleterious inflammatory effects of cytokine following by using pharmacological agents.
- findings show that in peripheral blood mononuclear cells, in addition to the mitochondrial pathway, endogenous TNF- synthesis contributes to Staphylococcus aureus alpha-toxin-induced apoptosis
- polymorphisms causing hypersecretion from amniochorion
- Four polymorphisms (TNF-alpha -376 G/A, -308 G/A, -238 G/A, and +488 G/A) were investigated in two Sudanese populations living in an area in which S. mansoni is endemic.
- TNF-alpha down-regulates the transforming growth factor-beta receptor type II protein level through proteolysis in human dermal fibroblasts.
- role in upregulating gene involved in familial Mediterranean fever
- tumor necrosis factor-alpha promoter is regulated by angiotensin II and lipopolysaccharide in cardiac fibroblasts
- TNFalpha, via the autocrine action of IFNbeta, differentially regulates the expression of proinflammatory genes and DNA synthesis
- TNF-alpha could play a role in the development of insulin resistance in humans, both in muscle and in vascular tissue.
- NF-kappa B and AP-1 are required for basal MAT2A expression in HepG2 cells and mediate the increase in MAT2A expression in response to TNF-alpha
- An established line of follicular dendritic cells proliferates in response to TNF, which acts as a mitogenic growth factor, and displays a distinct persistent NF-kappa B activation mode that results in a sustained induction of NF-kappa B-inducible genes.
- Treatment of airway epithelial cells with TNF-alpha in combination with IL-4 increases the stability of eotaxin mRNA.
- TNF-alpha via its p55 receptor has additive effects with GM-CSF on the common p47phox phosphorylated site and on fMLP-induced NADPH oxidase activation in human neutrophils, which is evidence for a common priming pathway.
- TNF induces transactivation between Etk and VEGFR2, and Etk directly activates PI3K-Akt angiogenic signaling independent of VEGF-induced VEGFR2-PI3K-Akt signaling pathway.
- TNFalpha induces cell proliferation in renal cell carcinoma
- TNF-alpha causes a decrease in eNOS promoter activity that may be mediated by GATA-4 and Sp3.
- Specific alterations in TNF-alpha expression coupled with detection of numerous CD68-immunoreactive macrophages suggests activation of proinflammatory cytokine signaling pathways in the tuberous sclerosis complex brain that may culminate in cell death.
- TNFalpha stimulates binding of nuclear proteins to the nuclear factor kappa beta (NFkappaB) and the CAAT/enhancer binding protein (C/EBP) consensus sites in the ICAM-1 promoter in these cells
- TNF-alpha exerts transcriptional, as well as post-transcriptional, effects on eNOS gene expression
- 11,12-EET analogues were synthesized and compared using a human endothelial cell based TNF-alpha-induced VCAM-1 expression assay.
- We investigated two genetic polymorphisms in the TNF locus (TNF-alpha -308 G-->A and TNF-beta +252 A-->G) as risk factors for cerebral infarction (CI) by determining its prevalence in 294 survivors of CI, and in 581 age, gender, and race-matched controls
- polymorphisms influence implant failure after total hip arthroplasty; whether the TNF-238 polymorphism causes a biological change that predisposes to loosening or is in linkage disequilibrium with such a locus is not yet known
- MIF, TNF-alpha and IL-6 may participate in pathological process of chronic hepatitis B and cirrhosis. IL-6 may play important role in ascites formation. Serum MIF, TNF-alpha and IL-6 appear to reflect severity of tissue injury in hepatitis B.
- TNF-alpha, critical for antimycobacterial granuloma formation, is a key autocrine and paracrine regulator of matrix metalloproteinase-9 secretion.
- activation of reverse signaling by transmembrane TNF renders monocytes/macrophages refractory to a subsequent activation of the MAPK/ERK pathway by LPS
- The -850T polymorphism in the TNF-alpha promoter region may play a role in the pathology of Down syndrome (DS) in DS patients at high risk of dementia.
- Association of the common G allele of the -G308A TNFalpha gene polymorphism with schizophrenia in a sample of 207 families. However, linkage disequilibrium with a different allele of the TNFalpha gene or another gene in the MHC region cannot be excluded.
- The results of these investigations suggest that the TNF-alpha gene -308G/A variants do not play a major role in susceptibility to, clinical manifestations for, or clozapine response in, schizophrenia.
- Promoter of the TNFalpha gene does not influence the amount of weight lost in overweight and obese men and women on a 30% energy restricted diet.
- Enhanced TNF-alpha production may also promote atherosclerosis due to increased insulin resistance and the expression of adhesion molecules. (review)
- These data show an altered inducibility of tumour necrosis factor-alpha production by chronic granulomatous disease-mutant cells, suggesting a further defect in differentiated chronic granulomatous disease-mutant cells in addition to the known defect.
- TNF polymorphisms at position -308 and +252 are not a significant factor for BMI, but affect the WHR in obese Koreans
- ANG II, via AT(1)R, modulates the secretion of TNF-alpha and MMP-2 from vascular endothelial cells and TNF-alpha mediates the effects of ANG II on MMP-2 release.
- These results indicate that TNF-alpha and IL-4 synergistically up-regulate the expression of IL-13Ralpha2 decoy receptor on human fibroblasts.
- Activation of NF-kappa B by TNF-alpha is insufficient to increase expression of antimicrobial protein neutrophil gelatinase-associated lipocalin (NGAL) and indicates that an additional factor must synergize with NF-kappa B to upregulate NGAL synthesis.
- TNF-alpha plus fibronectin stabilizes granulocyte macrophage-colony-stimulating factor (GM-CSF) mRNA, increases GM-CSF secretion, and prolongs in vitro eosinophil survival.
- Epstein-Barr virus (EBV) immediate-early protein BZLF1 prevents TNF-alpha activation of target genes and TNF-alpha-induced cell death by down regulating TNF-R1
- results establish that tumor necrosis factor alpha targets insulin-like growth factor-I induced E2F-transcription facor 1 synthesis, leading to inhibition of accumulation in cyclin A and hyperphosphorylation of RB protein
- Ischemic tolerance in acute stroke is associated with increased plasma levels of TNF-alpha in the presence of reduced concentrations of IL-6.
- REVIEW: role of TNFalpha as a pathogen in congestive heart failure
- TNF-alpha acts as a potent stimulator of Actinobacillus actinomycetemcomitans Leukotoxin-induced HL-60 cell apoptosis via TNF receptor 1-mediated upregulation of LFA-1 expression.
- Although TNF-alpha levels were significantly elevated in acute stage of Kawasaki disease(KD), there was no significant difference in frequency of A allele at positions -238 and -308 between the KD and control groups in Korean patients.
- Pathways triggered by Tat in human monocyte induce TNF-alpha
- Basal cell carcinoma is associated with high TNF-alpha release but nor with TNF-alpha polymorphism at position--308
- Virtually all TNF-alpha-inducible genes were dependent on I kappa B kinase 2 (IKK2)/NF-kappa B activation, whereas a minor number was additionally modulated by p38; genes suppressed by IKK2/NF-kappa B were newly identified
- significantly higher in supernatants from Hepatitis C virus-infected primary human macrophage cultures.
- Homozygosity for the G allele of the -308 G/A polymorphism in the tumor necrosis factor-alpha gene associated with an increased risk of migraine without aura
- There is no association between TNF-alpha polymorphism and behcet disease.
- TNF-alpha may play an important role in the pathophysiologic mechanism of childhood active ulcerative colitis.
- TNF-alpha has a role in the regulation of growth and apoptosis in normal human prostate epithelial cells (NP) and prostate tumor cell lines
- Claudin-1 in cell is decreased with increasing amounts of TNFalpha. Lack of claudin-1 may cause relocation of ZO-1 away from tight junction. May play role in increased intestinal permeability seen in Crohn's disease and other diseases.
- The mechanism of TNF-alpha-induced apoptosis of macrophages following inhibition of NF-kappa B has been characterized, and a central role for the loss of mitochondrial function is demonstrated.
- TNF-alpha increases matrix metalloproteinase-9 and tenascin expression in bronchial fibroblasts via the transcription factor Ets-1.
- study demonstrates that overexpression of RORalpha1 and RORalpha4 inhibits TNF-alpha induced expression of VCAM-1 and ICAM-1 in human umbilical vein endothelial cells by inhibiting the NF-B signaling pathway
- Data report the mapping of a protein interaction network around 32 known and candidate tumour necrosis factor alpha/NF-kappa B pathway components.
- PrP(c) overexpression converts TNF-sensitive MCF7 cells into TNF-resistant cells.
- identify TNF-alpha, IL-6, and IL-10 pro-inflammatory genotypes as genetic factors that might be associated with graft rejection and recurrence of HCV in liver transplant recipients
- no association with IL-1beta and TNF-alpha in childhood nephrotic syndrome
- positive association of TNF-alpha polymorphism in position -308 with pemphigus foliaceus.
- CREB is activated by TNF/TNFR1 signaling through a p38MAPK/MSK1 signaling pathway.
- The effect of the TNF-alpha promoter -308G>A polymorphism on the development of schizophrenia is, if any, weak in this Japanese sample.
- genetic polymorphism of IFN-gamma may be an important risk factor to develop oral lesions of lichen planus, but an increase in the frequency of -308A TNF-alpha allele may best contribute to the development of additional skin involvement.
- identified a 5' distal TNFalpha-responsive enhancer of the PAI-1 gene located 15 kb upstream of the transcription start site containing a conserved NFkappaB-binding site that mediates the response to TNFalpha.
- G308A gene polymorphism is implicated in bipolar disorder in Korean population.
- a novel and important role for metalloprotease activation and EGFR transmodulation in mediating the cellular response to TNF
- Human TNF secreted by engineered murine cancer cells arrests tumor development through an endogenous pathway that is dependent on both bone marrow- and non-bone marrow-derived murine host cells expressing TNF receptor.
- Review. TNF alpha is an important stimulus of cells producing inflammatory mediators, which play a role in rheumatoid arthritis.
- Protein c activation may regulate TNFA levels and result in coagulation abnormalities and inflammation in diabetes.
- Tumor necrosis factor alpha may cause anemia by inhibiting erythropoietin production.
- TNFalpha promoter region polymorphism is responsible for susceptibility to CI in Koreans.
- Alveolar macrophage-derived TNF-alpha and IL-1 beta provide a major stimulus for the production of proinflammatory mediators by lung epithelial cells. Relative importance may depend on type of epithelial cell target.
- Human dermal microvascular endothelial cells expressed the TNF-alpha gene following incubation with il-1, LPS and interferon gamma.
- a specific DNA complex binds preferentially the variant TNF allele, but activating protein (AP)-2, myeloid zinc finger gene 1 (MZF-1) and Sp1 are not involved in this complex
- TNF-alpha induced expression of fractalkine in fibroblasts, and subsequent monocyte chemotactic activity in the culture supernatant
- in this model of natural LPS release, the variation between individuals in TNF-alpha release can only modestly be determined by genetic background (TNF-alpha promoter, Nod2 and toll-like receptor-4) of the individual
- Mast cells could play a role in the production of cytokines such as TNFalpha
- TNFalpha polymorphisms and resting blood TNFalpha levels do not correlate with the propensity to recurrent pregnancy loss in Caucasian women.
- TNF-alpha and IL-10 gene polymorphisms are related to the risk of death among patients with acute renal failure who require dialysis
- Our results suggest that IL-1Ra and TNF-alpha gene polymorphism is associated with the susceptibility to ischemic stroke in a Korean population
- mRNA level of TNF-alpha was up-regulated by cytokine treatment,which points to an autocrine loop augmenting and/or stabilizing the TNF-alpha-MCP-1 pathway.
- Small for gestational age, premature, and twin children are insulin resistant and have low plasma TNF-alpha and cortisol levels.
- TNF-alpha has a role in up-regulation of matrix metalloproteases in breast cancer
- Moderate red wine intake improves post-glucose FFA profiles but does not modify the plasma concentrations of both TNF-alpha and of adiponectin concentrations: the latter is significantly and positively associated to the insulin action.
- human tumor necrosis factor-alpha has an alpha-helix from guanidine hydrochloride-induced unfolding
- polymorphisms associated with Graves' disease
- Serum pro-inflammatory cytokine IL-6 or TNF-alpha concentrations were neither increased in subjects with impaired glucose tolerance nor closely correlated with the components of the metabolic syndrome.
- functional polymorphisms in the tumor necrosis factor-alpha gene promoter at positions -308 and -238 do not play a dominant role in alcoholic chronic pancreatitis
- Analysis of polymorphism in chronic renal failure patients undergoing hemodialysis.
- hypothermia prolonged NF-kappaBeta activation, identifying a potential role for this transcription factor in mediating the effects of hypothermia on TNF-alpha and IL-1beta production.
- Some SNP's associated with either persistence or clearance of hepacivirus in African-Americans.
- In end-stage renal disease on long-term hemodialysis, single nucleotide polymorphisms in promoter of IL-6, TNF-alpha, and IL-10 show strong association with indices of comorbidity and function, and biological and nutritional markers.
- No correlation was observed between leptin and TNF-alpha levels, both in serum and in ascites. Serum and ascites TNF-alpha were not correlated.
- There is a functional effect of TNFA polymorphisms on myeloid engraftment in unrelated hematopoietic stem cell transplantation
- Tumor necrosis factor-alpha induces fractalkine expression preferentially in arterial endothelial cells
- Human recombinant TNF alpha demonstrates an inhibitory effect on P-glycoprotein transport activity in Caco-2 intestinal epithelial cells with rhodamine 123 as a substrate.
- TNF-alpha, as a principal proinflammatory mediator, is associated with multiple sclerosis-related fatigue
- Data show that tumor necrosis factor-alpha reduced CD28 expression through inhibition of transcription, and that ligation of CD28 by an antibody or by CD80 also down-regulated CD28 transcription through the same mechanism.
- Genotypes of TNF-alpha-308 did not affect the development or the severity of placental inflammation
- data suggest that the TNF-alpha -- 308 A allele does not affect the development of sepsis in ventilated premature infants but may increase mortality once sepsis develops
- TNF-alpha controls not only the inflammatory functions of dendritic cells, but also their survival.
- TNFalpha-stimulated MUC1 shedding occurs independently of increased de novo protein synthesis and TNFalpha-induced increase in MUC1 gene expression is mediated through the kappaB site in the MUC1 promoter.
- TNF-alpha inhibited the generation of GPA(+) cells and enhanced the generation of GPA(-) cells, which were excentric cell shape and displayed cell surface antigens indicating the codevelopment of dendritic cells along with erythroid differentiation
- tumor necrosis factor-alpha has a role in epidermal keratinocytes
- Promoter polymorphisms of tumor necrosis factor-alpha are associated with risk of gastric mucosa-associated lymphoid tissue lymphoma
- concetration in children with acute lymphoblbastic leukemia after chemotherapy
- tumour necrosis factor-alpha has a role in survival of human neutrophils
- These data suggest that TNF-alpha stimulates U937 cell apoptosis by forming a high-affinity nanomeric (TNF-alpha)(3)-(TNFR)(3)-(GPI-anchored glycan)(3) complex. The GPI-anchored glycoprotein involved remains to be identified.
- endogenous production of TNFalpha in macrophages/monocytes is required for NFkappaB activation by irradiation
- IVIG inhibits NF-kappaB activation induced by TNF-alpha in cultured endothelial cells of coronary arteries, thereby possibly modulating IL-6 production and E-selectin expression
- results support the hypothesis that a simultaneous increase in tumor necrosis factor-alpha production by bone marrow lymphocytes and sensitivity of stem cells to tumor necrosis factor-alpha leads to bone marrow failure in aplastic anemia
- The -238G/A polymorphism of TNF-alpha gene promoter region is independently associated with different outcomes of hepatitis B virus infection.
- SphK1 mediates TNF-alpha-induced MCP-1 gene expression through a p38 MAPK-dependent pathway and may participate in oscillatory flow-mediated proinflammatory signaling pathway in the vasculature.
- All 51 Terena Indians tested (100%) had the G/G genotype at position TNF-alpha -308.
- In Polish TNF-alpha (-308A) allele carriers, obesity correlated with insulin resistance in females.
- We believe that H. pylori-related cytokine activation becomes concentrated on gastric mucosa and this pathogen-induced local inflammatory cascade does not cause changes in circulatory levels of these cytokines.
- TNFA promoter polymorphism is associated with susceptibility to endometriosis.
- TNF treatment at 41 degrees C significantly reduced clotting activity, TF protein and mRNA as well as TFPI-2 mRNA.
- Increased in Weill-Marchesani syndrome.
- No difference in serum level of normal and hemodialysis or peritoneal dialysis patients.
- No significant difference in allele frequencies of the -308 TNFalpha polymorphism between obese patients and controls.
- anti-TNF alpha therapy may constitute an interesting candidate approach for treating lupus inflammatory disease. (review)
- Polymorphism of promotor region of the tumor necrosis factor-alpha gene in patients with viral hepatitis C.
- the activation of NF-kappaB pathway in human endothelial cells mediates the TNFalpha effects on arginine transport
- Subjects with nonalcoholic steatohepatitis had reduced adiponectin level and increased TNF-alpha.
- TNF-alpha-induced apoptotic signaling is regulated by aldose reductase in endothelial cells
- obese compared with non-obese adolescents exhibited higher concentrations of TNF-alpha associated with several components of metabolic syndrome
- high concentrations of leptin (100 nM) and/or PRL significantly (p<0.05) reduce the inhibitory effect of IL-6 (10 and 100 ng/ml) and TNF-alpha (10 and 100 ng/ml) on beta-casein gene expression in HC11 cells transfected with pbetacCAT
- potentially high TNF producers with the TNF2 allele do not have an increased risk for rejection episodes, but if rejection episodes occur, they have a significantly increased risk for early graft loss
- CD14 and CD16 in monocytes may have a role in development of coronary atherosclerosis and expression of TNF-alpha
- Serotype III Group b Streptococcus strain stimulated significantly greater tumor necrosis factor alpha (TNF-alpha) (P < 0.0001) production than did serotype VIII strain in A549 epithelial cells.
- TNFalpha or alternate molecules activating its pathways might be useful as sensitizers for chemotherapy in hematological malignancies.
- Cardiomyocyte necrosis and/or apoptosis via activated tumor necrosis factor (TNF) and the Fas/Fas ligand (FasL) system may be related to the development of ongoing myocardial damage.
- Peptide fragments of gliadin induced interleukin (IL)-8 and tumour necrosis factor-alpha (TNF-alpha) production in a monocytic cell line.
- Maternal carriers of the TNF allele has significantly increased risk of spontaneous preterm birth.
- Provided that TNF-R1 mediates the cytotoxic actions of TNFalpha, these results support the concept of dysregulated TNF alpha metabolism in alcoholic hepatitis.
- no statistically significant associations have emerged between C-850T polymorphism and either the risk for childhood ALL
- CCR7 expression was strongly dependent on TNF-alpha in the case of DNCB, however, neutralization of TNF-alpha only partially reduced CCR7 expression upon NiSO(4) treatment
- Our results indicate that TGF-beta(1) gene Arg(25)-->Pro, TNF alpha gene G-308A and IL-6 gene G-174C polymorphisms are not risk factors or markers of progression in focal segmental glomerulosclerosis.
- TNF is involved in the pathogenesis of gallbladder carcinoma induced by gallstones
- impaired IL-12 and TNF-alpha production in Sezary syndrome (SzS) is associated with defective CD4+ T lymphocyte CD40L induction and indicate that CD40L may have therapeutic potential in SzS
- TNF-alpha activates a distinct set of genes in chondrosarcoma cells, and gene expression in these cells is regulated by groups of genes related in part by their function.
- The variability of the -1031T/C polymorphism of the TNF-alpha gene may be associated with susceptibility to endometriosis.
- TNFalpha may induce senescence with important functional consequences, including sustained growth inhibition and genetic instability, and that this cellular response is efficiently regulated by hematopoietic growth factors
- advanced glycation end-products promote mRNA expression and secretion of TNF-alpha and reduce eNOS mRNA and protein expression in vascular endothelium
- IRS-4 is subject to regulation by TNF-alpha, and PP4 mediates TNF-alpha-induced degradation of IRS-4
- In African-Americans, the angiotensin converting enzyme, vitamin D receptor, and tumour necrosis factor-alpha genes are not significant risk factors for sarcoidosis susceptibility.
- TNFalpha does not have a role in FasL induction of NF-kappaB activation and IL-8 production by a novel mechanism
- There is evidence for association (P=0.026) of a specific TNFa haplotype (-308A, -238G) with schizophrenia and schizophrenia spectrum disorders with a family-based trimmed haplotype linkage disequilibrium test (Trimhap).
- This review summarizes the role of the TNF-alpha TNFA-308*2 allele which has been found to be independently associated with HLA-DP Glutamate-69 in the determination of berylliosis risk.
- TNFa, IL-1b and ifn-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK
- The data presented here demonstrate for the first time that TNF either promotes growth or induces apoptosis in human vascular smooth muscle cells depending on phenotype.
- HSV-2 antiviral effect of type II interferon and TNF-alpha is dependent on indoleamine 2,3-dioxygenase (IDO) activation
- TNF/LTA genotypes might play an opposite role in the pathogenesis of gastric cancer and duodenal ulcer.
- IL-17 and IL-17F play a differential regulatory role in GM-CSF production by LMVECs stimulated with IL-1beta and/or TNF-alpha, which is sensitive to Th1 and Th2 cytokine modulation
- The role of GM-CSF and TNF-alpha in the in vitro granuloma reaction of peripheral blood mononuclear cells (PBMC) from chronic intestinal schistosomiasis patients before and after chemotherapy treatment to S. mansoni recombinant Sm28 GST
- TNF-alpha was found to be related to the pregnancy loss.
- the tumor necrosis factor-induced apoptosis response is defective in I-cell disease fibroblasts
- The differential effects of TNF-alpha and IL-1beta on proximal tubular MMP-9 and TIMP-1 expression are mediated through the TNF-RI, the IL-1-RI and the different signaling pathways of PKC, ERK1/2, and p38 MAPK.
- expression upregulated in oral mucosa cells by Candida albicans and Streptococcus salivarius
- G homozygote and G allele for TNF-alpha promoter are related to a higher risk of leiomyomas.
- A significant correlation between BMI and leptin was found in the two fat tissue compartments of both genders, but the correlation between BMI and TNFalpha was found only in subcutaneous fat tissue of women.
- Ultraviolet beta rays augment CAT-2 expression through a TNF-alpha- dependent mechanism which essentially contributes to increased iNOS activity
- NAK is a component of the TNFalpha.TNFR1 signaling complex and has a physiological role in the TNFalpha-mediated response
- Study supports TNF as a genetic factor for susceptibility to ozone-induced changes in lung function in humans
- Tumor necrosis factor-alpha was more effective at inhibiting differentiation in subcutaneous cells, whereas insulin-like growth factor-I stimulated differentiation more effectively in visceral cells
- Notch activation induced by a recombinant Notch ligand, Delta-1, reduced the TNF-alpha-induced growth suppression and apoptosis in U937 cells.
- increased blood levels in kidney tuberculosis patients
- Caspases 3 and 8 were strongly activated while the amount of CDK6 was reduced by TNF-alpha
- role of TNF-alpha in the development of diabetic retinopathy
- In women with preterm labor, maternal homozygous carriage of the -863 polymorphism of the tumor necrosis factor-alpha gene may be associated with preterm delivery and adverse neonatal outcome.
- The tnf-alpha gene at position -308 is associated with preterm premature rupture of membranes in multifetal pregnancies.
- These results suggest that autocrine production of TNF-alpha plays a role in the cytotoxicity of depsipeptide against a subset of leukemias.
- TNF-alpha indirectly upregulates bone sialoprotein expression via a pathway which can be mediated through cyclooxygenase-2 and core binding factor a1 expression in Saos2 osteoblast-like cells.
- genotyping of 32 human leukocyte antigen (HLA)-homozygous workshop cell lines and 300 healthy control samples for 19 coding and promoter region SNPs spanning 45 kb in the central MHC near the TNF genes
- study shows that PBMCs of patients with advanced gastric cancer show poor production of TNF and IL-12p40 in response to stimulation with tumor cells in vitro & this unresponsiveness is associated in some patients with diminished IRAK-1 expression in vivo
- the amino acid residues from 141 to 146 of hTNF-alpha were specially recognized by Z12 antibody
- The additive concentration of cytokines in diabetes and CVD (cardiovascular disease)suggests a common inflammatory state in both diabetes and CVD.
- However, In the presence of TNF-alpha, melatonin promoted RANTES melatonin, respectively) expression in a dose dependent manner in A549 cells).
- No correlation of polymorphisms with gastric cancer.
- activation of p38 MAPK and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and TNFR1/TNFa expression
- LCH represents a cytokine-driven condition partially mediated by TNF, IL-11, and LIF. These three cytokines are all osteoclastogenic, suggesting a pathogenetic pathway for the osteolytic lesions in LCH.
- balance of TNF-stimulated cell death from apoptosis to necrosis can be shifted by JNK
- TNF-alpha mRNA in trauma patients was not increased on admission (1.7 +/- 0.9) and decreased even below baseline after 12 h
- TNF-alpha gene polymorphisms is associated with renal allograft rejection
- analysis of mechanism for selective inhibition of TNF but not IL-1beta-induced IKK activation
- TNF-alpha treatment significantly decreases the expression of VEGFR-2, VEGFR-3, and NRP-1, which may be responsible for TNF-alpha-induced reduction of endothelial cell proliferation in response to VEGF(165).
- Echinacea alkylamides modulate TNFA gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways.
- interleukin-16 production is impaired in monocyte-derived dendritic cells from atopic dermatitis patients but is restored by inflammatory cytokines TNF-alpha and IL-1beta
- IKK-beta/NF-kappa B transcription pathway is a key regulator of IL-6, IL-8, and TNF-alpha release from adipose tissue and skeletal muscle
- The mutated form TNFR2(196ARG) shows a reduction of inducible TRAF2 recruitment upon TNF-alpha stimulation
- interleukin-23 p19 mRNA is inducible in colonic myofibroblasts by interleukin-1beta and TNF-alpha
- serum IL-1 and TNF-alpha are reduced significantly by calcitriol during osteoporosis
- Role of TNF-alpha in tenascin-W expression in mammary cancer.
- TNF-alpha and IL-1beta are secreted with macrophage-released signals that affect NF-kappaB translocation and endothelial cell activation
- Diabetic nephropathy patients, molecular variants of TNF are more frequent than non-diabetic patients with renal failure.
- In the presence of IFN-gamma, TNF-alpha increased GTPCH I mRNA in a manner dependent on nuclear factor-kappaB. IFN-gamma and TNF-alpha exert distinct but cooperative roles for BH4 biosynthesis in endothelium.
- TNFalpha-induced cell cycle arrest through IKK can provide a mechanism for the development of drug resistance to anti-cancer drugs, purine and pyrimidine analogues
- induced and expressed in human alveolar epithelial cells by Legionella pneumophila after invasion
- There was no significant association for any of the TNF-alpha promoter polymorphism tested and CD in the Newfoundland population.
- tumor necrosis factor alpha is not involved in the initiation of disc degeneration, but may be associated with further promotion of degenerative disarrangement and pain induction
- While mitogen activated protein kinase 8 (JNK1) is a downstream effector of the Tumor Necrosis Factor (TNF) signaling, Zfra regulation of the TNF cytotoxic function is likely due to its interaction, in part, with JNK1.
- TNF induces activation of the FOXO1 transcription factor, which acts as a master switch to control apoptosis
- Cellular and subcellular expression of TNF-alpha, IL-1alpha and IL-6 in hepatocytes inx chronic hepatitis C.
- IL-17-stimulated TNF-alpha mRNA expression and promoter activity was dependent on Egr-1 expression.
- IL-1beta- and TNFalpha-mediated induction of IL-6R shedding in osteoblast-like cells is at least partly dependent on tumor necrosis factor alpha-converting enzyme activation.
- Inhibition of either or both of these cytokines may offer a useful therapeutic approach to management of osteoarthritis by reducing gene expression of matrix metalloproteases involved in cartilage matrix degradation and favoring its repair.
- isoprenylcysteine carboxylmethyltransferase regulates Rac1 activity by controlling the interaction of Rac1 with RhoGDI through TNFA
- gene polymorphisms may play an important role as a host factor in the progression of hepatitis B infection
- polymorphism at position -308 of the TNFalpha promoter is not a significant factor for body mass index, but affects waist-to-hip ratio in obese healthy Korean women
- Among host genetic factors contributing to H. pylori disease outcome, TNF-A -857 TT genotype favors duodenal ulcer.
- promoter polymorphisms associated with psoriasis vulgaris and psoriatic arthritis but not with pustulosis palmoplantaris
- N-myc is recruited to the EAAT2 promoter with TNFalpha
- levels correlate inversely with levels of pH in pleural fluid of patients with complicated parapneumonic effusions (CPPE)
- TNFalpha modulates the glycosylation of endothelial cells by a mechanism that directly enhances the stability of beta4GalT-1 mRNA transcripts
- Experiments using dominant-negative Tpl2 suggest this kinase functions distal to TRAFs but proximal to the TAK1/TAB1 signaling complex, within the IKK/NFkappaB activation pathway.
- These data demonstrate that TNF-alpha rather than IL-6 stimulates an increase in PAI-1 mRNA in the subcutaneous adipose tissue, suggesting that TNF-alpha may be involved in the pathogenesis of related metabolic disorders.
- IL-1alpha, TNF-alpha, CCL20, CCL27, and CXCL8 alarm signals are induced in human cells after allergen and irritant exposure
- IFN-gamma can prime intestinal epithelial monolayers to respond to TNF-alpha by disrupting tight junction morphology and barrier function via MLCK up-regulation and MLC phosphorylation
- Effects of membrane TNF elicited by infliximab should be important action mechanisms of this potent anti-inflammatory agent in addition to the neutralization of soluble TNF-alpha.
- TNF-alpha signals primarily through the p38, JNK, MAP kinase, and IKK pathways resulting in the activation of the transcription factors AP-1 and NF-kappa B.
- Our results also show that rhTNF-alpha facilitates annealing and strand exchange, and promotes the cleavage of a 17-nucleotide substrate S by hammerhead ribozyme HH16.
- TNFalpha-induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha-induced ASK1-JNK/p38 activation
- TNF-alpha specifically enhances brain-derived neurotrophic factor secretion in monocytes and provides evidence that TNF-alpha represents a specific link between monocyte infiltration and neuronal changes in inflammatory diseases.
- SK1 down-regulation by TNF is dependent on the lysosomal pathway of apoptosis and specifically on cathepsin B, which functions as an SK1 protease in cells
- increased expression in Cryptococcus neoformans-infected brains of immune mice compared to control mice
- Single nucleotide polymorphisms of TNF-alpha is associated with Lofgren's syndrome in Czech patients with sarcoidosis
- High frequencies of the HSP70-2 G and the TNF-alpha -308 A alleles were associated with risk of severe acute pancreatitis.
- TNF-alpha promoter single nucleotide polymorphisms (SNPs) associated with susceptibility to HPV-16 associated cervical cancer
- cFLIP/CFLAR is an essential NF-kappa B-dependent antiapoptotic gene in the tumor necrosis factor alpha-regulated pathway in epidermal keratinocytes
- specific genomic targets downstream of the nuclear factor-kappaB transcription factor mediate tumor necrosis factor signaling
- A panel of novel TNF alpha- and IL-1 beta-regulated genes was identified, and these are promising candidates for further study in relation to rheumatoid arthritis and other inflammatory diseases
- TNF polymorphism analysis showed a significant increased frequency of TNF -238 GG genotype in the whole group of rheumatoid arthritis patients when compared to healthy controls
- Mitochondrial ROS production is a physiologically relevant component of the TNF signal-transduction pathway during apoptosis, and a novel functional role for mitochondrial ROS as a temporal regulator of NF-kappaB activation and antiapoptotic signalling.
- Neutralization of endogenous TNF sustains IFN-alpha secretion by plasmacytoid dendritic cells
- cell membrane TNFalpha inactivated by gingipains from Porphyromonas gingivalis
- In the development of esophageal varices in portal hypertensive rats, increased TNF-alpha and VEGF may be not an early event, and probably play a role in weakening the esophageal wall and the rupture of esophageal varices.
- PKD is a critical mediator in H2O2- but not TNF-induced ASK1-JNK signaling
- TNFalpha-induced ROS cause oxidation and inhibition of JNK-inactivating phosphatases by converting their catalytic cysteine to sulfenic acid. This results in sustained JNK activation.
- polymorphisms in chronic obstructive pulmonary disease patients
- TNF alpha production is enhanced by lipopolysaccharides in heat-shocked human promonocytic cells
- This proinflammatory cytokine may play important roles in the development of T cell imbalance, cardiovascular disease and wasting in the uremic milieu. (review)
- decreased levels in HPV18+ cervical biopsies
- blood TNF alpha concentrations are elevated in non-obese, non-diabetic Mexican Americans
- TNF-alpha production by human peripheral blood cells shows high intra-individual variability over time
- TNF-alpha, VEGF, and the ECM collaboratively regulate extravillous trophoblast behavior, including cell survival and endovascular differentiation, through integrin signaling during establishment and maintence of successful humann pregnancies.
- recipient TNFA2 and TNFB2 homozygosity is associated with the development of CAV after heart transplantation.
- a potential role of genetic variation in TNFalpha in the etiology of osteoporosis
- study showed that plasma adiponectin and tumor necrosis factor alpha (TNF-alpha) were independently and reversely associated with insulin resistance and C-reactive protein levels were related to TNF-alpha and obesity
- CARD15 and TNFalpha promoter polymorphisms interact to exert functional effect on MDP-induced TNFalpha production; this gene-gene interaction may contribute to interindividual variation in susceptibility to Crohn's disease
- TNFA-308 genetic polymorphisms are associated with increased risk of Crohn's Disease displaying distinct clinicopathological profiles
- No association between TNF -238G-->A and lipoatrophy was observed in patients receiving anti-aids medication.
- TNF-alpha and IL-1beta enhance the TGF-beta-mediated up-regulation of COL7A1 expression in HaCaT keratinocytes
- transepidermal water loss was suppressed by TNF-alpha and IFN-gamma, and these effects were also inhibited by IL-4
- Minocycline decreases TNF-alpha levels produced in human T cell-microglia interaction. This effect is mediated by a direct action of minocycline on the activated T cells and on microglia.
- TNFa allele 97, and TNFa allele 103 alleles were higher in the high-risk than the low-risk group for coronary disease. TNFa 109 allele was associated with increased relative risk for elevated total cholesterol to high-density lipoprotein (HDL) ratios
- results show that the intracellular depletion of polyamines inhibits the response of chondrocytes to TNFalpha by interfering with the DNA binding activity of NF-kappaB
- -Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis factor-alpha are described.
- upregulated in macrophages by OMP P6 of nontypeable Haemophilus influenzae
- Together, our data suggest that inhibition of p38 MAPK may be an attractive target to limit inflammatory responses that are mediated by TNF-alpha.
- TNF-alpha plays a pivotal role in the pathogenesis of rheumatic symptoms in patients with human immunodeficiency virus
- Genetic variations in these proinflammatory mediators and their receptors appear to influence the susceptibility and severity of the inflammatory response within the eyes of patients during the development of IAU(idiopathic acute anterior uveitis).
- Findings suggest that the TNF-alpha gene polymorphism does not predispose to the development of refractory anemia.
- Infliximab, a TNF-alpha inhibitor effectively treats steroid and OKT3 resistant acute rejection episodes of intestinal transplantations.
- Significantly higher tumor necrosis factor-alpha expression levels are associated with serous adenocarcinoma
- Target genes involved in tumor necrosis factor alpha (TNFalpha) pathways in response to TGF-beta1 were found in cervix cancer cells.
- TNFalpha induces apoptosis in neonatal blood granulocytes
- TNF-alpha level has no correlation with the course of subacute sclerosing panencephalitis or its treatment, when the age, disease stage, and clinical condition of the patient are considered.
- Inheritance of the rs1799724-T allele appears to synergistically increase the risk of Alzheimer's disease in APOEepsilon4 carriers and is associated with altered CSF Abeta42 levels
- Polymorphisms of IL-6 and TNF-alpha can be used to identify subgroups of patients with higher risk of unsuccessful outcome.
- The local effects of TNFalpha (tumour necrosis factor alpha) on small bowel iron transport and on iron transporter expression in the absence of hepcidin are reported.
- The polymorphisms of the TNF-alpha gene shows a significant haplotype association with susceptibility to pre-eclampsia in the Finnish population.
- Increased serum TNF-alpha concentrations are specifically found in heavy drinkers with the -857 (C-->T) substitution (CT heterozygotes), indicating an interaction between alcohol consumption and that polymorphism on serum TNF-alpha concentration.
- Under physiological conditions vitamin D activates only the transcription of TNF-alpha gene, for TNF-alpha protein synthesis additional cofactors are required.
- polymorphism of TNF-alpha and milder expression i.e. non-neuronopathic form, of Gaucher disease (versus the neuronopathic forms) may be suggestive of an association between genetic variability in TNF-alpha and phenotypic expression in Gaucher disease
- TNF-alpha-induced CD44 expression was regulated by AP-1 through the activation of the CaMK-II pathway, whereas LPS-induced CD44 transcription was regulated specifically by Egr-1 through JNK activation.
- TNF-alpha --G308A G/G homozygosity was modestly associated with schizophrenia in male patients.
- Genotype and allele frequencies at the IL-1beta, IL-1RN, and TNF-alpha loci in gastric cancer cases were not significantly different from controls
- In H. pylori-infected patients, -1031C or -863A carriers of TNF-alpha promoter had more severe gastric neutrophil infiltration and TNF-alpha gastric staining than individuals with -1031TT or -863CC genotype, respectively (p<0.05).
- Several TNF variants may be part of the genetic determinants for maximum parasitemia and/or mild malaria attack.
- TNF-alpha may have a role in endothelial cell damage in dengue
- The TNF(-488)A constituent of the AGG haplotype was also strongly associated with increased risk of spontaneous preterm birth.
- Serum concentrations of IL-6 were significantly correlated with weight, body mass index, waist circumference, hip circumference, and waist-hip ratio
- TNF-alpha behaves as a trigger of platelet activation through stimulation of the arachidonic acid pathway.
- Although all cell types expressed mRNA for the relaxin receptor (LGR7), only peripheral blood mononuclear cells responded to relaxin at physiologic levels by increasing tumor necrosis factor-alpha and interleukin-1beta secretion
- TNF-alpha may up- or down-regulate the inflammatory skin reactions through Langerhans cells.
- TNF-alpha-308 promoter polymorphism is a risk factor for acute kidney allograft rejection.
- tumor necrosis factor (alpha)- and Fas-induced apoptosis is blocked by inositol hexakisphosphate in human cells
- TNFalpha can induce apoptosis of enterocytes in mice with fulminant hepatic failure
- TNF -308 single nucleotide polymorphism (TNF2) does not exhibit a significant influence on the disease course or immunological response in systemic lupus erythematosus and primary Sjogren's syndrome.
- simultaneous inhibition of RANKL and TNF-alpha is necessary to reduce acid-induced, cell-mediated net Ca efflux from bone
- There were no differences in genotypes and allele frequencies of IL-10 and TNF-A polymorphism between study group with gastric cancer and peptic ulcer diseases and control group
- The opioid-induced increase in IL-1 beta was blocked by naltrexone in the group tested. TNF-alpha expression was also significantly stimulated by 60 and 600 ng/ml beta-endorphin after 15 min, an effect blocked by naltrexone in the group tested.
- Higher frequency of -308A tumour necrosis factor alpha, both in hetero and in homozygosis and mostly whether simultaneous, plays a role in predisposing to gluten intolerance and an increased risk for coeliac disease.
- Polymorphisms in the TNF-alpha promoter may independently modulate growth and disease severity in pediatric onset Crohn's disease. The effect of these polymorphisms does not appear to be mediated via weight loss, and is relatively modest.
- An increase in abdominal adiposity and increased TNFalpha release from mononuclear cells after hyperglycemia may contribute to insulin resistance in lean polycystic ovary syndrome patients.
- Polymorphisms associated with control of gene expression and protein levels were not associated with occurrence of chronic idiopaathic leukemia in adults and were not responsible for the increased cytokines.
- Lactocillus rhamnosus reduced TNFalpha-induced IL-8 production by affecting the NFkappaB/IkappaB pathway in Caco-2 cells.
- TNF-alpha inhibition of endothelial gene expression depends on NF-kB.
- The observations suggest TZDs inhibit TNFalpha-mediated PAI-1 induction independent of inducible PPARgamma activation.
- This is the first report demonstrating induction of TNF-alpha-mediated death by oxysterol in cells.
- Data show that lipoprotein lipase suppressed tumor necrosis factor-alpha-induced gene expression, and enhanced interferon-gamma-induced gene expression, in human aortic endothelial cells.
- IL-4 regulates TNFalpha-induced IL-8 expression at a transcriptional level and this mechanism involves STAT6 and NF-kappaB transcription factors
- IL-6 and TNFalpha are involved in the production of HGF by endometrial stromal cells and may be involved in the growth of endometriosis by an autocrine mechanism
- In conclusion, our study suggests that the presence of the high producer allele -308A in the TNF-alpha gene appears to be associated with an increased risk for the development of ICC.
- both c-Jun and NF-kappaB are required for basal and TNFalpha-mediated induction of GSH synthetic enzymes in H4IIE cells
- TNF-alpha polymorphism is associated with the development of acute coronary syndromes
- Single nucleotide polymorphism is associated with age of onset of schizophrenia.
- Cigarette smoke may directly cause the release of IL-8 from HASMC, an effect enhanced by TNF-alpha which is overexpressed in COPD
- The pro-inflammatory nature of hResistin was further evident from the ability of this protein to induce the nuclear translocation of NF-kappaB transcription factor as seen from electrophoretic mobility shift assays.
- MC159 protein may act to prolong virus survival by preventing the infected cell from responding to TNF-alpha, ultimately preventing the cellular production of proinflammatory and immunoattractant molecules.
- Association of a high responder TNF-alpha-308A allele may be a genetic factor in increasing susceptibility to rheumatic fever.
- IKKbeta phosphorylates multiple p65 sites, as well as in an IkappaB-p65 complex, and S468 phosphorylation slightly reduces TNF-alpha- and IL-1beta-induced NF-kappaB activation
- A proteasome inhibitor, lactacystin, enhances TNFalpha cytotoxicity in p53-positive and -negative cells .
- fibrin can support the wound healing process of the epidermis via the TGF-alpha/EGF-R pathway
- the apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by TNF
- TNFA promoter polymorphisms are important host genetic factors affecting the outcomes of HBV infection.
- Plasma levels may be a marker for chronic hepatitis C infections.
- These results suggest that hypoxia is an important negative regulator of monocyte chemotaxis to the renal inflamed interstitium, by reducing MCP-1 expression
- Synergistic interactions between the coagulation factor Xa (fXa) and the proinflammatory cytokines TNF, IL-1beta, and CD40L, leads to enhanced expression of Tissue Factor and E-selectin in endothelial cells.
- By using murine fibrosarcoma L929 cells, in which tumor necrosis factor (TNF) alpha induces accumulation of reactive oxygen species (ROS) and cell death, study shows that TNFalpha induces the unfolded protein response in a ROS-dependent fashion
- TNF-alpha expression is upregulated in paretic leg muscle, suggesting inflammatory pathways are accelerated in stroke muscle
- Globular adiponectin (gAd) is a powerful inducer of TNF-alpha and IL-6 secretion in primary human peripheral macrophages, in the THP-1 human macrophage cell line, and in primary mouse peritoneal macrophages.
- IKKbeta has an important role in TNF-alpha-mediated mucus production in airway epithelium in vitro and in vivo
- During tuberculosis, predisposition of CD4 T-cell subsets to apoptosis may involve both low expression of Bcl-2 and excessive expression of tumor necrosis factor(TNF)-alpha.
- phosphorylation of CREB is increased by 8-bromo-cAMP, which has opposite effects on TNF and TNFR1 mRNA expression
- signaling pathways activated by LPS and its receptor TLR4 and TNFalpha have roles in septic shock [review]
- Low levels of TNF-alpha, comparable to those present physiologically, induced nucleus pulposus degradation. TNF-alpha may contribute to the degenerative changes that occur in disc disease.
- A PCR method for identifying polymorphism.
- Our results demonstrate that SM-7368 is a synthetic compound that inhibits TNF-alpha-induced MMP-9 expression, and thus SM-7368 should be useful for the development of chemotherapies targeting TNF-alpha-mediated tumor invasion and metastasis.
- GG genotype of TNF-alpha G-308A polymorphism or a genetic variant in close linkage disequilibrium may interact with obesity to increase the risk of nephropathy in Chinese Type 2 diabetic patients.
- TNFalpha genotype modulates the activity of the TNFalpha pathway, influences insulin sensitivity and the severity of HCV chronic hepatitis.
- melphalan elicits membrane TNF on Kupffer cells due to inhibition of TNF processing and thereby initiates apoptosis of hepatocytes via obligatory activation of both Tnfr1 and Tnfr2
- TNFalpha correlated inversely with insulin secretion in pregnancy and is significantly hiher in gestational diabetes.
- TNF-alpha promoter region polymorphism is responsible for susceptibility to cerebral infarction in Koreans
- SP600125, a pharmacological inhibitor of JNK, predominantly suppressed UV-induced up-regulation of TNF-alpha expression in keratinocytes.
- IL-1beta, IL-6 and TNF-alpha are all significantly increased in hypoxic ischemic encephalopathy infants when compared to controls.
- GCF2/LRRFIP1 appears to act as a repressor and occupies the -308 site in cells that do not make TNF-alpha.
- A positive association was found in the G-308A TNF-alpha variant and systolic arterial BP Z score and HOMA index in adolescents harboring features of metabolic syndrome.
- plasma levels of adiponectin and TNFalpha are upregulated in acute myeloid leukemia
- Transgenic human TNF preferentially activates p38MAPKalpha and ERK in synovial membrane.
- There is a significant dose- and time-dependent increase in MIF secretion by human endometrial stromal cells in response to tumour necrosis factor-alpha.
- Aortic valve calcification may be actively regulated by an inflammatory process involving TNF-alpha.
- TNFalpha/TGFbeta combination as well as M. leprae infection triggered an increase in the apoptosis rate in the cultured Schwann cells.
- TNF-alpha could cause intracellular iron sequestration, which may participate importantly in the pathophysiology of atherosclerosis and cardiovascular disease.
- TNFalpha is heritable in tuberculosis (narrow sense heritability = 34-66%); the effect of shared environment is minimal (1-14%), but gene-environment interaction may be involved.
- PAK4 has a role in TNF-alpha induced cell survival pathyways by facilitating TRADD binding to the TNF Receptor
- once activated by TNFalpha, acute myeloid leukemic cells display NKG2D-mediated cytolytic activity toward various cellular targets including CFU-GM by a mechanism dependent on stimulation of the granzyme B/perforin system
- Elevated TNF-alpha levels are associated with increased myocardial infarction risk
- The TNF-alpha-308 allele may be related to susceptibility to ulcerative colitis. The TNF-alpha-308 gene polymorphism is not involved in pathogenesis of Crohn's diseas.
- These data show that inhibition of TNF-alpha processing by acute ethanol is a direct affect of ethanol on the cell membrane and is reversible upon cessation or metabolism.
- IL-1beta + TNF-alpha elicited innate immunity responses similar to those of flagellin.
- No associations between individual polymorphisms and schizophrenia were found. However, marginal association between subjects with both TNFA -238 A allele and 5-HTTLPR s allele and presence of family history was found.
- Our results suggest that IFN-alpha and TNF-alpha have a significant role in priming epithelial cells for higher cytokine and chemokine production in influenza A virus infection.
- High serum TNF-alpha level in Type 2 diabetic patients with microangiopathy is associated with eNOS down-regulation and apoptosis in endothelial cells
- In normotensive subjects with type 1 diabetes mellitus(T1DM) activation of TNF-alpha system is positively associated with pulse pressure. Possible pathogenic role of TNF-alpha system in development of cardiovascular disease in T1DM.
- TAK1 is recruited to the TNF-R1 complex via RIP and likely cooperates with MEKK3 to activate NF-kappaB in TNF-alpha signaling
- TNF has inhibitory effects on granulocyte-macrophage progenitors in vitro and on committed and primitive hematopoietic progenitors in vivo. However, in adult organism TNF deficiency is mostly compensated and controlled.
- Only women carrying at least one mutant allele of both polymorphisms (tumour necrosis factor-alpha A and interleukin-6 C) have a significantly elevated mean systolic blood pressure and diastolic blood pressure at the end of pregnancy.
- trophozoite-parasitized RBCs/hemozoin-fed adherent monocytes produced TNF-alpha time-dependently
- IL-10, but not TNF-alpha, TNF-beta, or IL-6 polymorphisms are associated with lung cancer
- Gene expressions of TNF-alpha and ICAM-1 in the pancreas rose at 1 hour and peaked at 7 hours after severe acute pancreatitis.
- NPCs express receptors for TNF-alpha, that trigger via a p38 MAPK signaling pathway production of two chemokines, MCP-1/CCL2 and IP-10/CXCL10, which are involved in infectious and inflammatory diseases of the brain.
- TNF-alpha and IFN-gamma regulate gene transcription mediated by NF-kappaB-Stat1 interactions
- TNFalpha plays an important role in coronary restenosis
- Our study shows a significant association between the TNF-alpha -308 polymorphism and the occurrence of STEMI, and suggests that the tumor necrosis factor-alpha -308 polymorphism could play a role in the pathogenesis of cardiac ischemic damage.
- a TNF-alpha SNsingle-nucleotide polymorphism may be associated with increased risk of new intracranial hemorrhage in the natural course of brain arteriovenous malformations
- TNF-alpha is an important regulator of the adenosine 2b receptor, and during inflammation, upregulation of TNF-alpha may potentiate adenosine-mediated responses.
- data suggest that Haemophilus somnus lipooligosaccharide-mediated apoptosis may be due, in part, to activation of a TNF alpha/TNR-R1-dependent death pathway
- TNF-alpha exerts a mitogenic effect, inducing cyclin D1 expression and activation of the transcription factor NF-kappaB in estrogen receptor-positive T47D breast ductal tumor cells
- TNF-alpha induced PTX3 expression in human lung cell lines and primary epithelial cells; knockdown of either JNK1 or JNK2 with small interfering RNA also significantly reduced the regulated PTX3 expression
- overproduction of TNF-alpha leads to aberrant expression of hnRNP-A2 in the rheumatoid joint and subsequently to autoimmune reactions, which may enhance the inflammatory and destructive process.
- We propose that during TNFalpha-induced apoptosis, PKCdelta-mediated phosphorylation of p21(WAF1/CIP1) at (146)Ser attenuates the Cdk2 binding of p21(WAF1/CIP1) and thereby upregulates Cdk2 activity.
- Our findings indicate that human airway smooth muscle cells express and secrete MMP-12 that is up-regulated by IL-1beta and TNF-alpha.
- TNFalpha G-308A polymorphism determines postoperative TNFalpha serum levels. Increased TNFalpha levels are associated with less favorable outcome after coronary revascularization.
- Loss of tnf-alpha production indicates an inadequate immune response to viral progression in the liver transplant recipient with relapsing hepatitis c virus infection.
- Promotor polymorphism in the TNF-alpha gene is associated in the development of primary gastric B-cell lymphoma.
- human neutrophils, TNF-alpha-induces a caspase-independent cell death signal, which is related to calpain and oxidative activities and cannot be rescued by the growth factor-related signaling mechanism
- high TNF secreting haplotypes, a2b3c1d1e3 and a2b5c2d4e3 were under-represented in chronic pancreatitis compared to healthy controls; a reduced capacity to produce TNF may be responsible for the induction of chronic pancreatitis
- may inhibit tooth mineralization
- The inhibitory effect of human TNF on osterix expression in murine pre-osteoblastic cells suggests a potential decrease of osteoblast differentiation in arthritis and osteoporosis.
- Suramin inhibits TNF-alpha and IL-6 production through the suppression of NF-kappaB activity from macrophages
- the TNF-alpha promoter -308 A/G polymorphism may confer susceptibility to systemic lupus erythematosus [meta-analysis]
- TNF-alpha is associated with insulin-mediated suppression of free fatty acids and net lipid oxidation in HIV-infected patients with lipodystrophy.
- Increased TNF-alpha protein expression in lesional psoriatic skin is associated with normal TNF-alpha mRNA expression, demonstrating for the first time that TNF-alpha expression in lesional psoriatic skin is regulated posttranscriptionally.
- TNFA (-308 G/A) promoter single nucleotide polymorphism (SNP) was determined. Our results suggest that TNFA (-308) alleles are not involved in the predisposition to the development of B-CLL.
- Conjugated linoleic acids inhibit TNFalpha-induced NF-kappaB DNA-binding & dose-dependently inhibits production of PGE2 & PGI2 in vacular smooth muscle cells.
- The effects of TNF polymorphisms on the survival of Chagas' cardiomyopathy patients who progress to end-stage dilated cardiomyopathy is reported.
- TNF is a chemokinetic and chemoattractant agent for Entamoeba histolytica
- On the basis of the present and previous results we propose that ARE-containing TNFalpha mRNA requires phosphorylation of eIF4E for initiation of translation.
- This review hypothesizes that the evolutionary participation of single-nucleotide polymorphisms and their effects on the TNFalpha gene is an element that could mediate increased susceptibility to rheumatoid arthritis.
- Results report the induction of TNF-alpha via the calcium/calcineurin/NFAT pathway in PC12 neural cells.
- Down-regulates NF-kappa B inhibitory proteins IkappaBalpha and IkappaBbeta in Burkitt lymphoma cells in vitro.
- IL-6 polymorphism is associated with age of onset of type 1 diabetes only in the presence of a high IL-1beta and tumor necrosis factor-alpha producer genotype.
- Role of TNFalpha in acute rheumatic fever may be in linkage disequilibrium with some other severity genes not yet genetically determined.
- male carriers of TNF2 allele are less susceptible for the development of lacunar subtype of ischemic stroke than the non-carriers.
- intracellular and molecular mechanisms that mediate the TNF-alpha-induced increase in intestinal epithelial tight junction permeability
- TNF alpha-related apoAI promoter inhibition was reduced in cells transfected with JNK1 siRNA. TNF alpha suppresses apoAI promoter activity through both MEK/ERK & JNK pathways but is not mediated by either p38 MAP kinase activity or NF-kappaB activation.
- TNF-alpha polymorphism is associated with susceptibility and severity of non-small cell lung cancer
- No evidence was found to implicate TNF gene polymorphisms for schizophrenia risk in a Caucasian sample
- TNF-alpha is differentially regulated in ovarian cancer cells compared with untransformed cells and modulates production of several cytokines that may promote ovarian tumorigenesis.
- Antimalarial downregulation of TNFalpha levels in systemic lupus erythematosus is influenced by polymorphisms at IL-10 and TNFalpha promoters. May identify patients likely to benefit from antimalarials.
- least in Caucasians, the TNF gene is a disease modifier gene in patients in which Alzheimer's disease is rising
- levels of interleukin-6 & tumor necrosis factor-alpha were significantly higher in patients with fatal Crimean-Congo hemorrhagic fever (CCHF)than nonfatal CCHF; findings demonstrate that proinflammatory cytokines play a major role in the mortality in CCH
- elevated salivary levels during acute recurrent aphthous ulcer and especially during the remission period are of importance
- APN/CD13 regulates TNFalpha-induced apoptosis via inhibition of TNFRI shedding
- This study provides the first genetic evidence that the ubiquitination of RIP is required for TNFalpha-induced NF-kappaB activation.
- Both the variants of TNF-alpha (-308 and +488) polymorphism had significant association and may thus be a strong predisposing risk factor for end-stage renal disease in a cohort of north Indian population
- TNF-alpha -238 G/A genotype may contribute to insulin resistance in renal transplant recipients.
- Ciprofloaxin may regulate the TNF-alpha production induced lipopolysaccharides in monocytes.
- Results suggest that, in human myocardial infarction, TNF-alpha produced by cardiomyocytes does not play a critical role in their apoptosis.
- TGF-beta1 dose-dependently inhibited TNFalpha-induced production of RANTES protein and mRNA from rheumatoid arthritis fibroblast-like synoviocytes
- elevated production of IL-1alpha and TNF-alpha by in vitro stimulated whole blood cell cultures occurs in non-alcoholic fatty liver disease obese patients
- the risk of CD in children with type 1 diabetes is significantly modified both by the presence of HLA-DQB1*02-DQA1*05 and by a variant of another gene within the major histocompatibility complex, the TNF -308A
- Immune complexes from rheumatoid arthritis sera and synovial fluid influence tnf-alpha production by peripheral blood mononuclear cells.
- TNF-alpha-induced CD38 expression involves NF-kappaB expression and its activation and dexamethasone inhibits CD38 expression through NF-kappaB-dependent and -independent mechanisms.
- SEPS1 may regulate cytokine production in macrophage cells and there may be a regulatory loop between TNF-alpha, IL-1beta and SEPS1 that plays a key role in control of the inflammatory response
- tumor necrosis factor alpha and TNFR1 and TNFR2 have roles in cellular differentiation
- in the women with menorrhagia TNF-alpha content was increased in menstrual effluent.
- Membrane TNF-alpha is induced upon activation on the cell surface of CD4+ T cells and CD8+ T cells in patients with systemic lupus erythematosus.
- Study demonstrated a positive correlation between high TNF-alpha expression and favourable prognosis in non-small cell lung cancer in terms of overall survival.
- GSK-3beta selectively regulates NFkappaB-mediated inflammatory gene expression of IL-1beta and TNF-alpha by controlling the flow of NFkappaB activity between transcription of inflammatory and survival genes
- -857 polymorphism does not contribute to susceptibility of inflammatory bowel disease, nor does it define the phenotype of Crohn's disease in Israeli Jewish patients with inflammatory bowel disease.
- IL-1beta- and TNF-alpha-stimulated expression of GRO-alpha from airway smooth muscle is regulated by independent pathways involving NF-kappaB activation and ERK and JNK pathways
- The TNF-308 promoter polymorphism is not a disease-modifying gene in homozygous delta F 508 cystic fibrosis patients.
- The results indicate that estrogen plus overexpressed ERalpha induce LoVo cell apoptosis might mediate through the increase of hTNF-alpha gene expression, which in turn activate caspase-8, -9 and caspase-3 and lead to the DNA fragmentation and apoptosis.
- overexpressed hER-beta but not hER-alpha may induce caspase-8-mediated apoptosis by increasing the hTNF-alpha gene expression in a ligand-dependent manner in poorly differentiated HA22T cells
- The concentration of TNF-alpha in CSF was below that in plasma and both remained stable during exercise.
- TNF-alpha-308 single-nucleotide polymorphism is not a genetic risk factor for vitiligo susceptibility.
- IL-10 or TNF-alpha expression variation is not associated with alterations in HCV clearance or ALT levels, but TNF-alpha polymorphisms may be associated with hepatic fibrosis
- Some alleles may affect outcome of bone marrow transplantation.
- significant correlation of TNFd microsatellite polymorphisms with mortality after unrelated stem cell transplantation.
- Lower antibody titer to influenza A virus was observed in elderly individuals, and the seroconversion factor was found to be correlated inversely with IL-10 production and correlated directly with TNF-alpha production.
- although not necessarily dictating inflammatory bowel disease initiation, the TNF-alpha 308 A polymorphism may play a role in modifying the Crohn disease phenotype
- The cytokines TNFalpha and GM-CSF activate CAEV transcription, and this effect occurs independently of AP-1.
- Gene expression alterations indicate a sophisticated regulation of counteracting tumor necrosis factor-alpha and transforming growth factor-beta cytokine expression in peripheral blood leukocytes after acute myocardial infarction
- two inhibitors of p38 MAPK and protein tyrosine kinase pathways could be used as combined targets for inhibiting matrix metalloproteinase-9 expression in inflamed tissues
- TNFalpha induces chromosomal abnormalities independent of ROS through IKK, JNK, p38 and caspase pathways
- We conclude that gas6 signaling through the Axl receptor and the PI3 kinase/Akt1 survival pathway protects oligodendrocytes from growth factor withdrawal and TNFalpha-mediated cell death.
- Thus, the TNFA-863C > A polymorphism in the promoter region of TNFA may influence TNF-alpha expression and affect TsIgE levels and susceptibility to asthma.
- TNF-alpha is widely distributed in the myocardium of patients with dilated cardiomyopathy.(
- Exosomes produced by synovial fibroblasts obtained from individuals with rheumatoid arthritis contain a membrane-bound form of TNF-alpha that may contribute to the development of apoptosis resistance.
- TNFalpha can lead to the induction of NFkappaB signaling with a concomitant increase in spermidine/spermine N(1)-acetyltransferase (SSAT) expression in non-small cell lung cancer cells
- Data indicate that adenosine increases the release of IL-19 from bronchial epithelial cells via activation of adenosine A(2B) receptors, and IL-19 in turn activates human monocytes to release TNF-alpha, which upregulates A(2B) receptor expression.
- TNF-induced NF-kappa B p65 subunit phosphorylation is markedly decreased in TNF-tolerant monocytic cells, accompanied by formation of C/EBPbeta-p65 complexes that contribute to the unresponsiveness seen in patients with sepsis.
- TNF-alpha in the placental environment increases HIV-1 expression and could facilitate mother-to-child transmission of HIV-1.
- data implicate PKCzeta as a necessary component of TNF signaling pathways in chondrocytes that result in catabolic destruction of extracellular matrix proteins in osteoarthritic cartilage
- LITAF has a role in the pathophysiological regulation of the TNF-alpha gene
- A functional polymorphism within the TNF bloc could modulate MCP-1 concentration and seems more likely to be near to the LTA 252A>G polymorphism than to the TNF -308G>A one
- Results describe the gene expression of tristetraprolin, T-cell intracellular antigen and Hu antigen R in synovial tissues from rheumatoid arthritis and osteoarthritis patients.
- The carriers of the -308G/-238G haplotype homozygotes in the TNF-alpha promoter region have higher risk of persistent HBV infection.
- Compared to active coal miners without coal workers' pneumoconiosis (CWP) (8.23 microg/mL), TNF-alpha concentration was gradually decreased when dust exposure was stopped (5.90 microg/mL).
- TNF-alpha promoter variants are likely to play a substantial role in influencing the outcomes of hepatitis B virus infection.
- TNF, phox, NOS2, and MyD88 are activated during granulocytic anaplasmosis, and these contribute to inflammation and hepatic injury more than A. phagocytophilum pathogen load.
- TNF-alpha increases the stability of BMP-2 mRNA through the pentameric motifs via NF-kappaB
- Data show that either AP-1 or NFkappaB can up-regulate long MLCK transcription, but the mechanisms by which TNF up-regulates intestinal epithelial long MLCK transcription from exon 1A are differentiation-dependent.
- inhibition of TNF-alpha-induced autophagy is a novel mechanism of the antiapoptotic function of NF-kappaB activation
- Anti-TNFalpha strategies may be useful in the management of abdominal compartment syndrome.
- apoptotic mature neutrophils release MIF upon short term TNF-alpha stimulation
- serum IL-1beta and TNF-alpha are increased, and IL-2 and IL-6 are decreased in newly diagnosed IDDM patients
- Meta-analysis revealed that the TNF-308G/A polymorphism was statistically significantly associated with asthma.
- Carriers of the TNF-alpha appeared to have an increased risk of stroke in association with a febrile episode prior to strokes.
- TNF-alpha impairs fibrinolytic capacity in vascular endothelial cells by a NF-kappaB and p38 MAPK-dependent suppression of t-PA
- Single Nucleotide Polymorphisms in TNFA is associated with gastric cancer
- Findings indicate that TNFA haplotypes in the promoter response elements may exert significant influence on susceptibility to Behcet's Disease.
- a genetically programmed imbalance between serum levels of tumour necrosis factor and interleukin-10 exists in patients with poly- or dermatomyositis and this imbalance is related to the presence of disease-associated autoantibodies
- TNF-alpha down-regulates human Cu/Zn superoxide dismutase 1 promoter via JNK/AP-1 signaling pathway
- data suggest TNF-alpha decreases hCG-beta mRNA & protein expression by reducing gene transcription & trophoblast cell fusion.
- TNF-alpha production by peripheral blood monocytes in Behcet's disease patients who reported "bad" or "very bad" global well-being over the last month (n=4) was higher compared to other patients with better self-rating (p=0.03).
- TNF-alpha differentially modulates the expression of CD44 in TNF-alpha-resistant ovarian cancer cells, affecting their in vitro migration, invasion, and binding to hyaluronic acid.
- Variation in the TNF-alpha promoter region, or possibly polymorphisms in nearby genes, could affect cerebral inflammatory response and the risk of late-onset Alzheimer disease.
- the intrahepatic TNF-alpha production induced by HCV is transcriptionally up-regulated by HCV NS3. Therefore, HCV NS3 may have a potential role in the induction of intrahepatic inflammatory processes that occur during acute and chronic hepatitis C.
- Evidence suggests a direct role for TNF-alpha in muscle cell destruction and a possibility of muscle cell damage via an autocrine fashion.
- glucose intake induces an immediate increase in intranuclear NF-kappaB binding, a fall in IkappaBalpha, an increase in IKKalpha, IKKbeta, IKK activity, and messenger RNA expression of TNF-alpha in MNCs in healthy subjects.
- Serum TNF-alpha may be involved in the improvement of beta-Cell function and the decrease of insulin resistance by insulin therapy with an insulin pump in type 2 diabetes.
- Some TNF alpha genotypes play an important role in the pathogenesis of Crohn's disease in Koreans.
- Detailed studies on IL-10 regulation of TNF-alpha mRNA expression identified AU-rich elements (ARE) in the 3' untranslated region as a necessary determinant of IL-10-mediated TNF-alpha mRNA destabilization.
- TNF-alpha can induce anti-apoptosis signaling and production of matrix metalloproteinases through activation of nuclear factor-kappaB and JNK in rheumatoid arthritis Fibroblast-like synoviocytes
- Tumor necrosis factor alpha stimulates triglyceride hydrolysis by multiple intracellular pathways acting on insulin signaling, G proteins and perilipins, and might contribute to enhanced plasma fatty acid levels in obesity.
- Crucial role for the intracerebral control of Listeria monocytogenes and survival of cerebral listeriosis, not responsible for the destruction of brain tissue.
- CARD15-TNFalpha circuit that might play a role in mucosal immune surveillance
- Anti-TNF-alpha therapy reduced aortic stiffness to a level comparable to that of healthy individuals. Therefore, effective control of inflammation may be of benefit in reducing cardiovascular risk in patients with RA.
- TNF-alpha genetic polymorphisms are not associated with susceptibility to coronary artery disease.
- Our results indicate that insufficient systemic endogenous control of TNF-alpha seems to contribute to TMJ pain and tissue destruction in RA.
- The data suggest that Beryllium exposure induces transcription-dependent TNF-alpha production, potentially due to upregulation of specific transcription factors.
- Severe malaria was not associated with polymorphisms located at positions -308A and -238A in the TNF alpha gene promoter or with a high TNF level in plasma in children from Bamako, Mali.
- findings suggest that the increased levels of tumor necrosis factor-alpha and corticotropin-releasing hormone found in pregnant women presenting with preterm labor may be involved in the pathophysiological mechanism of the latter
- genetically determined low production of TNF-alpha was associated with a more severe clinical course of Puumala Hantavirus infection in humans.
- flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells
- This study indicates the possible roles of tunor necrosis factor alpha and other polymorphisms in the immune system in the susceptibility to asthma in children infected with Chlamydophila pneumoniae.
- Pro-inflammatory cytokines derived from surgical trauma may enhance tumor cell adhesion to microvascular endothelial cells and thus bring about more successful tumor cell implantation resulting in an increased risk of metastasis formation.
- TNF-alpha and IL-1beta enhance IL-8 expression in term decidual cells, suggesting that these cytokines are important regulators of chorioamnionitis-related decidual neutrophil infiltration.
- Isolation induced a twofold increase in TNFalpha expression between days one and three and reduced by inhibitor RDP58.
- TNF-alpha induces Lnk expression through PI3K-dependent signaling pathway in umbilical vein endothelial cells
- TNF-alpha promoter polymorphism may significantly increase susceptibility to aspirin-intolerant asthma by gene-to-gene interaction with HLA DPB1*0301
- These data suggest that reverse signaling through mTNF-alpha may exert a double role in modulating sTNF-alpha bioactivity.
- Perturbations in inflammation stemming from common genetic variants in TNF-alpha (like G-308A) could contribute to the development of non-Hodgkin lymphoma.
- In pathophysiological conditions, generation of TNFalpha at high levels leads to the development of inflammatory responses that are hallmarks of many diseases.
- Findings demonstrate that polymorphisms of high IL-1beta and TNF-alpha production were associated with an increased risk of RAS development.
- results suggest that wogonin effectively suppresses TNF-alpha-induced HASMC migration through the selective inhibition of MMP-9.
- Our data suggest that overexpression of TNFalpha leads to topical GC insensitivity by reducing GR nuclear translocation in keratinocytes.
- TNF-alpha -308 polymorphism appears to be associated with the genetic susceptibility for undifferentiated spondyloarthritis.
- TNF-alpha/238 and TNF-alpha/308 promoter polymorphisms do not seem to be major genetic risk factors for susceptibility to FMF and severity of the disease
- this study demonstrates an association of tumor necrosis factor-alpha (-308A) carriage with MWA, suggesting that carrying a high responder TNF-alpha-308A allele may be a genetic factor in increasing the susceptibility to develop migraine without aura.
- Cellular release of TNFalpha from stimulated leukocytes is mediated by the CRM1-dependent nuclear export mechanism.
- TNFalpha/CHX-induced cell death was significantly lowered in cells overexpressing PLD1
- TNFalpha production may have a role in chronic lymphocytic leukemia progression in low-risk individuals
- TNF mRNA is elevated in human psoriatic skin; TNF alone, however, is not sufficient to induce epidermal hyperplasia.
- Elevated TNF-alpha in normal-appearing white matter in multiple sclerosis (MS) may be responsible for the nuclear translocation of peptidylarginine deiminases leading to irreversible changes in oligodendrocytes in MS.
- Expression of the adenosine A2A receptor in human epithelial A549 cells is up-regulated by TNF-alpha and IL-1beta within 24 h at the mRNA and protein level.
- In summary, binding of transcription factor NF-kappaB to the TNF-alpha promoter is associated with allele-specific remodeling of chromatin structure.
- Comparison of the -308TNF genotypes between NHL patients & controls showed a significant excess of A/A genotype previously associated with higher TNF production. This polymorphism could lead to an increased NHL susceptibility in Tunisian populations.
- analyzed the expression of Toll-like receptors 1 to 9 on myeloid dendritic cells generated from X-linked agammaglobulinemia patients and evaluated their response to activation by specific Toll-like receptor agonists
- Polymorphisms of TNF-alpha, IFN-gamma, TGF-beta1, IL-10 and IL-6 do not appear to influence the onset of broncholitis obliterans syndrome or graft survival in recipients.
- Pemphigus vulgaris patient IgG works together with tumor necrosis factor-alpha and FAS-L in experimental cell cultures to induce acantholysis via basal cell shrinkage.
- These results suggest that genetic variations in the TNF-alpha gene and its receptor genes may not be involved in individual vulnerability to METH dependence.
- The biliary IL-6 and TNF-alpha levels were positively correlated with serum DBIL, TBA and gamma-GT levels in infantile hepatitis syndrome subjects.
- SphK-dependent Akt activation plays a significant role in TNF-alpha-induced cyclin D expression and cell proliferation
- Single nucleotide polymorphism in promoter at -308 is associated with type 1 diabetes in North Indian subjects.
- vaginal TNF-alpha concentration was elevated in TNFA-308A carriers only in the presence of abnormal vaginal flora
- Primary role for IL-1beta and TNF-alpha in the triggering of preterm labor associated with inflammation or infection.
- TNF-alpha induced expression of c-IAP1 and c-IAP2 via MAP kinases, but not via NF-kappaB, and that MAP kinases participated in the inhibition of apoptosis by induction of c-IAPs in TNF-alpha-stimulated endothelial cells
- ADMA accumulation in human cultured endothelial cells is influenced by both insulin and adiponectin, and both mediators counteract the TNFalpha-induced accumulation of ADMA through the DDAH pathway
- TNFalpha and IL-8 play an important role in monocyte atherogenic activity
- results show no significant differences either between Chagas disease cardiomyopathy (CCC) and asymptomatic patients, or among CCC patients according to severity of cardiomyopathy with respect to TNFa or -308 TNF promoter polymorphisms
- This metaanalysis demonstrates that the TNF-alpha -308 A/G polymorphism may represent a significant risk factor for RA in Latin Americans, but not in Europeans.
- Putative role of TNF-alpha -1031 polymorphism in the development of gastroenteropancreatic neuroendocrine tumors.
- TNF-alpha -1031C allele and its associated haplotypes in Koreans may enhance susceptibility to secondary hemophagocytic lymphohistiocytosis
- Association to schizophrenia is largely restricted to a 30 kb high Linkage Disequilibrium region/block in TNF-alpha/MHC locus.
- Glutaredoxin activity is significantly upregulated by tumor necrosis factor (TNF)-alpha in endothelial cells. Glutaredoxin association with caspase-3 is decreased by TNF-alpha.
- SNP -1031C-863A in TNF-alpha promoter may act as a risk haplotype among Parkinson's disease cases.
- TNF-alpha is released into fetal circulation after LPS stimulation and this may be relevant to the etiology of chorioamnionitis.
- CD14+ cells producing TNF-alpha, IL-6, IL-10, MCP-1, and IL-8 were significantly higher in peripheral blood than peritoneal fluid mononuclear cells of women with endometriosis.
- Our data demonstrated that TNF-alpha G-238A and G-308A genotypes were strongly associated with Graves' disease incidence.
- TNF promoter variants are not risk factors for chronic beryllium disease or beryllium sensitization.
- We found that TNF-alpha is, indeed, released into the aspirate of stented SVG (9 +/- 1 and 28 +/- 3 pg/ml before and after stent implantation, respectively, P < 0.0001).
- This study failed to observe a significant difference in the -308TNF-alpha single-nucleotide polymorphism between chronic periodontitis patients and controls.
- The TNFA2 and TNFd2 alleles were strongly associated with occurrence/initiation of IMN and should be considered as susceptibility genes for this disease.
- Data from 5,269 cases and 4,982 controls suggested that the rs361525 A allele, located in the TNF promoter region, was associated with a modest increase in breast cancer risk.
- Macrophages and dendritic cells infiltrate the islets and produce inflammatory cytokines (TNF-alpha and IL-1beta) during the development of type 1A diabetes.
- Increasing levels of tumor necrosis factor alpha(TNFalpha) were significantly associated with a higher regional cerebral blood flow
- MAP4K4 silencing prevents TNFa-induced insulin resistance in human skeletal muscle and restores appropriate signaling inputs to enhance glucose uptake
- high expression genotypes at any of the three SNP polymorphisms were more frequent in invasive breast carcinoma
- replication case-control association study showed the TNF-alpha A allele conferred an increased susceptibility for schizophrenia only in males, and the association became more specific when only patients of paranoid subtype were compared to controls.
- No significant association between episodes of acute rejection of kidney transplantation and single nucleotide polymorphisms.
- in comparison to non-diabetics, LPS endotoxin treatment produced a higher protein expression of TNFalpha and IL-6 proinflammatory cytokines in primary cultures of monocytes from recent onset type 2 diabetic patients with low fasting glucose levels
- In the study populations, the TNF-alpha-308 polymorphism may play a role in multiple sclerosis susceptibility.
- In this review, TNF-alpha induces sequential formation of Complex I and II, leading to activation of reactive oxygen species-dependent Jun kinase pathway, NF-kappa B pathway, or caspase-8.
- in human airway smooth muscle cells: TNF-alpha transactivation of the EGF receptor, with subsequent raf-1 kinase-mediated activation of adenylyl cyclase are two linked signaling pathways
- NTAL acts as a negative regulator of TNF-alpha and IL-8 production after stimulation via TREM-1.
- The TNF-alpha genes are not associated with susceptibility to tuberculosis in Thais.
- TNFA gene polymorphisms are associated with lead-induced inflammatory response in a student population.
- the common -148 C/T polymorphism is associated with differences in the TNFalpha release in response to systemic LPS infusion in humans
- induction of TNF gene transcription by virus or LPS does not depend upon NF-kappaB binding to the proximal promoter; rather, a stimulus-specific post-induction mechanism involving NF-kappaB is involved in the maintenance of maximal TNF mRNA levels
- Interferon-gamma and bacterial lipopolysaccharide act synergistically on human neutrophils enhancing interleukin-8, interleukin-1beta, tumor necrosis factor-alpha, and interleukin-12 p70 secretion and phagocytosis via upregulation of toll-like receptor 4
- the impact of the TNF-alpha -308 G/A polymorphism on systemic endotoxin-triggered inflammation seems to be limited
- expression in inflamed human dental pulp tissue is positively associated with the severity of clinical symptoms
- Immature enterocytes have more rapid IkappaBalpha degradation than mature enterocytes in response to TNF-alpha.
- The TNF and IL1 gene polymorphism studied did not seem to be associated with response to anti-TNF treatment.
- IL-7 and, to a limited extent, TNFalpha, both of which are produced by activated monocytes and were detected in synovial fluid, abrogated the CD4+,CD25+ Treg-mediated suppression.
- study found evidence that sequence variation within and close to the TNF locus was associated with risk of trachomatous trichiasis
- TNF-alpha stimulates GlcAT-P and GlcAT-S gene expression in brain endothelial cells and promotes T-cell adhesion via SGPG-L-selectin recognition, a preliminary step for onset of neuroinflammation.
- A relationship between DAS28 (Disease Activity Score in 28 joints) improvement, the -308 G/G polymorphism, and increased circulating TNFalpha levels was found in Chilean rheumatoid arthritis patients treated with adalimumab.
- a possible involvement of TNF -308G/A promoter polymorphisms in the predisposition to the development of coronary artery disease
- TNF-alpha gene polymorphism (C-857T) is likely associated with higher serum LDL-C levels and carotid plaque formation in Japanese patients with type 2 diabetes.
- TNF-alpha may contribute to the prolonged survival of inflammatory cells by suppression of Fas-mediated apoptosis, the process involved with NF-kappaB transactivation, anti-apoptotic XIAP up-regulation and caspase suppression.
- hydroxyapatite crystal stimulation of macrophage TNFalpha secretion depends on NF-kappaB activation and is inversely related to particle and pore size
- Polymorphism in allele 2 of the 308 gene is not associated with an increased risk for peri-implant bone loss following prosthetic reconstruction
- screen of coronary heart disease phenotypes against polymorphism in TNF locus is presented; no evidence for an effect of TNF polymorphism on plasma TNF levels, but an effect on plasma PAI-1 levels emerged in post-myocardial infarction patients
- Interaction of alpha-toxin with alpha5beta1-integrin and overproduction of TNF-alpha may contribute to destruction of epithelial cells during S. aureus infection.
- cell-specific alterations in TNF-alpha expression may promote clonal selection in the evolution of neoplastic hematopoietic disease
- Data showed that the frequencies of TNFalpha (A-238) alleles are less than 0.05 and the haplotype frequency of the high-producer-types AG and AA in the TNFalpha gene is 0.055, while of the low-producer-types GG and GA is 0.945.
- results suggest that FFA and possibly TNF-alpha levels are closely related to the development of insulin resistance in subjects with metabolic disorders
- the A allele of the -308 TNF SNP might be a potential factor for venous leg ulcer susceptibility
- A crosslinking-coupled affinity purification method was used to isolate TNF-alpha AU-rich element-associated proteins: two microRNP-related proteins, FXR1 and AGO2 were found that associate during translation activation.
- TNF-induced TRAF2-RIP1-AIP1-ASK1 complex formation and for the activation of ASK1-JNK/p38 apoptotic signaling.
- TNF polymorphisms, which influence TNF production, might be associated with the progression of non-alcoholic fatty liver disease
- Taken together, these results confirm the role of TNF-alpha and the three adhesion molecules in pathogenic processes associated with severe malaria in children, and suggest an association between sICAM-1 and severe malarial anemia.
- Collectively, TNF-alpha elicits BMP-induced osteogenic inhibition by suppressing BMP-Smad signaling pathway, at least in part, through SAPK/JNK activation and Smad6 upregulation.
- In co-culture, human vaginal epithelial cells expressed tumor necrosis factor-alpha (TNF-alpha) inhibiting the growth of Candida albicans.
- 1alpha,25-(OH)2DHT(3) blocks TNF-induced monocytic tissue factor expression by inhibition of AP1 and NF-kappa B.
- TNF-alpha seems to be activated (by the converting enzyme TACE) and biologically active through its receptors in human lumbar disc tissue
- 308G/A promoter polymorphism isassociated with susceptibility to polymyositis/dermatomyositis in a Chinese Han population
- An association was found between some TNF-alpha promoter SNPs and systemic manifestations, radiological progression, HAQ score, work disability, and joint surgeries
- higher "stress index" was associated with higher expression of total LPS-stimulated TNF-alpha and IL-6 between rest and 60min post-stress
- Collectively, these results suggest that TSLP, as a downstream molecule of TNF-alpha, may be involved in the pathophysiology of inflammatory arthritis.
- Finds no association between TNF-alpha polymorphisms at promoter regions -238 and -308 and either chronic beryllium disease or sensitization to beryllium
- balance between TNFalpha and IL-10 seems to determine the occurrence of post-operative complications
- analyzed candidate genes related to TNFalpha regulation and found that interleukin (IL)-10, interferon-gamma receptor 1 (IFNGR1), and TNFalpha receptor 1 (TNFR1) genes were linked and associated to both tuberculosis and TNFalpha
- Accumulation of AGE may have a role in the development of osteoarthritis by increasing MMP-1, -3, and -13, and TNF-alpha.
- polymorphic variations of pro-inflammatory cytokines play an important role in susceptibility to multiple sclerosis
- We approached the question of mechanisms and amino acid motifs directing newly synthesized TNF for storage in mast cell cytoplasmic granules.
- Tumor necrosis factor alpha -238G>A genotype alters postprandial plasma levels of free fatty acids in obese individuals with type 2 diabetes mellitus.
- role in triggering NF-kappaB is negatively regulated by RBCK1
- results suggest that genetic variation in TNF may contribute to childhood asthma and that associations may be modified by parental smoking
- Study results suggest that the G-308A polymorphism is unlikely to be associated with the development of ischemic heart disease, whereas it might be a protective factor for ischemic stroke in Asians only.
- HOXA9 coexpression augments TNFA activation of the SELE promoter.
- It suggests that single nucleotide polymorphisms at -308 (G/A) of TNFalpha promoter may represent an increased risk for Human Papillomavirus infection and development of cervical cancer in Indian women.
- reduced adiponectin and increased TNF-alpha may be involved in the pathogenesis of gestational diabetes mellitus
- Psychosine mediates increased TNF-alpha production by peripheral immune cells of Krabbe patients.
- In cultured Caco-2 cells, tumor necrosis factor-alpha (TNF-alpha) dose-dependently increased expression of Secretory component (SC) of immunoglobulin A.
- Here, we report that expression and consequent activation of TNK1 enables tumor necrosis factor alpha (TNFalpha)-induced apoptosis by selectively inhibiting TNFalpha-induced activation of nuclear factor-kappaB (NF-kappaB).
- TNF-alpha genotype was found to be an ambivalent determinant of IgE-mediated hypersensitivity to betalactams.
- The TNFalpha locus was reconfirmed and showed association with susceptibility to Ankylosing Spondylitis. It may be independent of HLA-B27. A range of 58 kb covering TNFalpha had strong linkage disequilibrium to AS.
- TNF-alpha can promote tumor immune escape by stimulating the production of apoptogenic/immunosuppressive glycosides by renal cell carcinoma.
- Data show that low-dose irradiation stimulates TNF-alpha-induced ICAM-1 mRNA expression in human coronary vascular cells.
- No significant associations of serum CRP levels with the genotypes of CRP C1444T and IL-1B C-31T were observed. TNF-A -1031CC polymorphism was significantly associated with high CRP values.
- CD8+ T cells engineered to secrete TNF-alpha may be useful when designing strategies for adoptive T-cell therapy of solid tumors in mice.
- Results suggest that inhibition of phosphatase activity by calyculin A stimulate the phosphorylation of Akt at Ser473 by PI3K/Akt signaling pathway, resulting in the expression TNF-alpha mRNA.
- This study found that the TNF2 allele was associated with increased risk of GBS (OR = 1.876, 95% CI = 1.144-3.075, p = 0.008), particularly for AMAN, the main subtype
- frequency of the TNF U04 allele designated -1031C, -863C, and -857C was found to be significantly greater in patients with cerebral malaria than in patients with mild malaria
- TNF is the master regulator of other inflammatory cytokines in the synovial membrane and the major cytokine in the pathogenesis of chronic inflammatory disease [review]
- Cutaneous T-cell lymphoma (CTCL) cell lines revealed pronounced resistance to death ligands (TRAIL and TNF-alpha) as compared to cell lines of T-cell acute lymphoblastic leukemia (T-ALL).
- We studied polymorphic allele variants of the cytokine genes tumor necrosis factor-alpha (C-863A and G-308A) patients with Hodgkin's lymphoma and analyzed for associations with treatment outcome
- Results show that TNF-alpha levels were significantly increased in symptomatic periapical lesions compared to control.
- Results show obsessive compulsive disorder patients showed increases in TNF-alpha levels compared to the healthy controls.
- integrated effect of tumor necrosis factor (TNF) alpha with other cytokine genes in IDDM
- association of a nonsynonymous change within the AIF-1 gene with systemic sclerosis, and linkage with TNFA alleles within 50 kb of this gene
- Increased serum levels of glycated albumin, C-reactive protein and tumor necrosis factor-alpha are associated with the presence and severity of coronary artery disease and renal impairment in patients with type 2 diabetes mellitus
- A TNF region haplotype offers protection from typhoid fever in Vietnamese patients.
- in peripheral blood mononuclear cells, C5a activates the p38 cascade, and this pathway plays a major role in the C5a enhancement of LPS-induced IL-6 and TNF-alpha production
- Endothelial dysfunction is a selective feature of Crohn's disease and is beneficially affected by intravascular TNF-alpha neutralization.
- 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling
- These studies demonstrate the importance of epigenetic regulation in the control of TNF-alpha expression.
- Diabetic carriers of the TNF-alpha -308A allele might benefit more from a prophylaxis with low dose aspirin than non-carriers.
- Reduced activation of NF-kappaB via impaired PI3K/Akt activation under increased TNF-alpha levels could result in increased apoptosis of vitiliginous keratinocytes.
- While the previously reported association between TNF*-238A and psoriasis seems to primarily reflect linkage disequilibrium with PSORS1, TNF*-857T may represent a risk factor for psoriatic arthritis that is independent of the PSORS1 allele.
- As neutrophils enter the site of inflammation, they release surface-expressed BLyS in a TNFalpha-dependent manner, and thus may contribute to local stimulation of autoimmune B cell responses.
- Down regulation of HuR expression by siRNA prevents atazanavir-induced increase of TNF-alpha and IL-6, suggesting that HuR might have an impact on pathophysiological processes of HIV PI-induced atherosclerosis
- SARS-coronavirus spike protein upregulated IL-6 and TNF-alpha release in murine macrophages via NF-kappaB pathway.
- TNF-alpha transcriptional repression by altering levels of acetylated histone H3 and H4 at its promoter.
- Involved in prevalence of hyperinsulinemia and insulin resistance in pediatric patients with chronic kidney disease in children.
- TNF-alpha significantly decreased PKC-zeta expression in PT osteoblasts, suggesting that proinflammatory cytokines can modulate its expression in osteoblasts in a way similar to changes detected in arthritic patients.
- Higher levels of IL-10, IL-8 and TNF-alpha were found in fibromyalgia patients than in controls.
- Heterozygocity for the gene polymorphisms did not occur more often in preeclamptic women compared with controls (TNF-alpha: 29.0% versus 24.3%, p>0.05; IL-6: 46.7% versus 51.4%, p>0.05; or IL-10: 49.5% in each).
- Carriers of TNF (-308)A allele do not seem to have an increased risk for celiac disease in type 1 diabetes./
- study confirming the association between -238 G/A TNF-alpha promoter polymorphism & early-onset psoriasis vulgaris in northern Polish population suggests the -238A variant may contribute to predisposition to psoriasis vulgaris and to the disease phenotyp
- TNF-alpha suppresses TGF-beta1-induced myofibroblast (fibroproliferative) phenotypic genes, for example, alpha-SMA, collagen type 1A, and fibronectin at the mRNA level.
- Our results suggest that the above four polymorphisms in the promoter region of the TNF-alpha gene appear not to confer increased susceptibility for schizophrenia in a Japanese population.
- The G308A polymorphism of the TNF-alpha gene did not affect levels of inflammatory markers in patients after surgery for head and neck cancer who were treated with early nutrition.
- TNFalpha mRNA expression is absent in nearly half of the cervical tumors analyzed. Neither promoter methylation nor genetic causes for lack of expression were evident.
- These results suggest an association of the -308 G/A polymorphism of the TNF-alpha gene with the severity of rheumatoid arthritis.
- Smaller magnitude of Parkinson disease risk increase among carriers of the heterozygous genotype for either or both polymorphisms suggests a gene-dosing effect.
- The association between serum levels of FAS, FLAG, and TNFA and the severity of the pathophysiological condition in patients with multiple organ failure with complicating peritonitis.
- study has identified a novel protective association between a TNF-alpha haplotype and bone mineral density in Crohn's disease
- The IL-10 G-1082A and CYP3A5()3 polymorphisms may influence the interindividual variability of tacrolimus pharmacokinetics in Chinese liver transplant patients.
- mRNA and protein structures and identities of the present known mammalian TNFA.
- There was no evidence of a statistically significant association in the allelic distribution of IL4, IL10, IL16 and TNF polymorphism that were tested,nor in the haplotype frequencies in patietns with CD.
- Tumor necrosis factor (TNF)-alpha causes death of large periportal Kupffer cells, the cells responsible for bacterial clearance during bacteremia.
- LTB(4) may enhance TNF-alpha-induced CCL27 production by activating NF-kappaB via the BLT1/G(i/o)/PI3K/ERK pathway in human keratinocytes.
- TNF-alpha allele correlates with increased risk of coronary artery disease in British population.
- The results show that Hcy activated both ERK(1/2)/p38MAPK pathway and NF-kappaB-DNA-binding activity.
- IL-7 stimulates osteoclastogenesis by inducing TNF-alpha release by T and B cells
- TNF-308A and -1031T alleles are significant risk factors in the idiopathic inflammatory myopathies (IIMs); in the IIMs, the TNF-308A allele is part of the common ancestral haplotype, but is not independent of HLA-B*08
- The -308 allele of the TNF-alpha gene does not affect differential tuberculosis susceptibility.
- Allelic composition at the examined SNPs in genes coding for TIMP-1 and MMP-3 affect Crohn's disease susceptibility and/or phenotype, i.e., fistulizing disease, stricture pathogenesis and first disease localisation.
- Contributes to inflammatory bone loss in transgenic mice by enhancing the osteoclastogenic potential of osteoclast precursor cells through inducing paired Ig-like receptor-A (PIR-A), a costimulatory receptor for receptor activator of NF-kappa B (RANK).
- Polymorphism in the promotor region of TNF-alpha gene may lead to altered expression and a possible suboptimal activity of TNF-alpha in persons with GG genotypes, and these data suggest a link with infection following major surgery.
- The TNF-alpha-238G > a single-nucleotide polymorphism protects against memory decline in older adults with type 2 diabetes.
- An association has been demonstrated between TNFA polymorphisms and pre-eclampsia susceptibility.
- TNF and LTA genes are not major susceptibility genes for endometriosis.
- TNF-alpha was elevated in colostrum of mothers of neonates with jaundice.
- These findings support a novel p53 --> CDIP --> TNF-alpha apoptotic pathway that directs apoptosis after exposure of cells to genotoxic stress.
- Positive correlations between TNF-alpha gene expression in patients with rheumatoid and healthy persons.
- replication of our results in a second independent population of children with sickle cell anemia provides evidence for a true association between the TNF(-308) G/A variant and large vessel stroke risk
- These data establish that TTP mediated TNF-alpha mRNA decay is inhibited by the combined activation of ERK and p38 and not by p38 activation alone
- Predisposition to rheumatic heart disease is influenced by cytokine gene polymorphisms esp. composite polymorphism (TNF-alpha(-308 )A/A and IL-10(-1082) A/A) and (TNF-alpha(-308 )A/A and IL-10(-1082) G/G).
- TNF-alpha, IL-1beta and IL-1Ra are produced after selective activation of mast cells in rheumatoid synovial tissue
- Finds that the TNF-308A polymorphism was associated with an increased susceptibility to multibacillary leprosy.
- In healthy young adults a 12-wk high-intensity aerobic training program downregulates blood monocyte production of TNF.
- Crohn disease myofibroblasts showed higher transmembrane TNF expression than control myofibroblasts
- Polymorphisms of the IL-4 (promoter-590 and intron 3) and TNF-alpha promoter-308 genes are not related to gout in Chinese patients in Taiwan.
- The TNF locus exerts a primary influence on both susceptibility to and the severity of rheumatoid arthritis.
- Persistent elevation of TNFA serebrospinal fluid levels may be one of the causes of treatment refractory daily persistent headache.
- Association between 15 single nucleotide polymorphisms in the coding and promoter regions of lymphotoxin A and TNFalpha geneswith risk of migraine.
- Brucella alters the maturation and functions of DCs through Omp25-dependent control of TNF-alpha production.
- the IL1A (4845 GT and 4845 TT), IL1B (-511 CC), and TNFA (-238 AA and -308 GA) genotypes were associated with susceptibility to nasal polyposis in our study population
- A tumor necrosis factor (TNF)-dependent differentiation pathway of dendritic cells evokes T helper 1 (Th1) cell and T helper 17 (Th17) cell responses.
- Result suggested that there may be susceptible sites of ankylosing spondylitis in this 15 kb region, which may be TNF-alpha-850 C-->T mutation or other sites that around the TNF-alpha-850.
- These results suggest that IL-10, TNF-alpha and TGF-beta1 gene polymorphisms may affect host susceptibility to lung cancer and the outcome of the patients.
- The novel -646A TNFalpha allele was associated with the expression of HLA-B51 in Korean Behcet disease, although no genetic role of TNFalpha promoter polymorphisms was found in the susceptibility to Behcet's disease.
- CB2 receptor agonists attenuated TNF signaling in inflammation models.
- Specific TNF variants may identify systemic lupus erythematosus patients who are at particularly high risk of developing pneumonia.
- the combination of bacterial iceA1 and TNF-alpha 238 G to A polymorphism may be a risk factor for peptic ulcer disease in children infected with Helicobacter pylori
- These results suggest that PKCepsilon mediates its effects on TNFalpha- based apoptosis partly by preventing activation and translocation of Bax to the mitochondria.
- interleukin-8 (CXCL-8) is induced by tumor necrosis factor-alpha and leukemia inhibitory factor in pancreatic carcinoma cells
- The levels of intralesional expression of mRNA of tumor necrosis factor-alpha, interferon, interleukin-10, RANTES, and indoleamine-2,3-dioxygenase in Mediterranean spotted fever are reported; levels of inducible nitric oxide synthase are also reported.
- observations suggest that the TNFa-308 G/A promoter SNP is not a genetic marker for type 1 diabetes (T1D), but that the TNFa microsatellite may have an added value to further refine the immunogenetic risk conferred by HLA-DQ region in Belgian population
- Berberine suppressed Il-1beta/TNF-alpha production in lung inflammation models. Suppression was dependent on inhibition of IkappaB-alpha phosphorylation and degradation.
- there were no differences in the -308 TNF-alpha (tumor necrosis factor-alpha) gene promoter polymorphism alleles or geneotype frequencies among patients with or without osteoporosis
- TNFA homozygous genotypes were significantly more often detected in Oral Lichen Planus patients.
- In a population of children in Norway, TNF-alpha-308 allele was associated with non-allergic asthma.
- TNFalpha was significantly correlated with amount of HIV-1 RNA but not with CD4 cell number in HIV-1-infected patients; patients with oral manifestations showed higher TNFalpha in saliva and HIV-1 RNA copies in serum than those without oral manifestation
- Results revealed that TNF-alpha could increase cholesterol content by down-regulating ABCA1 expression, IL-10 time-dependently decreased cholesterol accumulation by up-regulating ABCA1 expression.
- In psoriatic plaque skin, both CD68+ macrophages and CD11c+ dermal dendritic cells expressed TNFalpha and decreased following initiation of therapy with adalimumab, a TNFalpha inhibitor.
- in OLP (oral lichen planus)-HCV+ve (chronic hepatitis C) patients, the frequency of genotype -308 G/A of the TNF-alpha was decreased, whereas the genotype -308 G/G was increased compared with OLP-HCV-ve
- Omental TNF-alpha may play a key role in contributing to cardiovascular risk in central obesity subjects.
- Data demonstrate that non-lethal mechanical trauma causes significant TNFalpha production that in turn stimulates myocardial apoptosis via oxidative/nitrative stress.
- results indicate that TNF-alpha did not modulate steroidogenesis in cultured human granulosa luteal cells; however, NF-kappaB was activated by TNF-alpha
- Optineurin competitively antagonized NEMO's binding to polyUb receptor-interacting protein, and its overexpression inhibited TNFalpha-induced NF-kappaB activation.for its association with glaucoma.
- These results demonstrate for the first time that the A allele of the TNF -308 polymorphism is associated with cardiovascular disease in hemodialyzed end-stage renal disease patients.
- OPG but not OPN stimulated a dose-dependent increase in the expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin by endothelial cells in the presence of TNF-alpha
- significant augmentation of IL-8 production by endothelial cells during short-term hyperglycemia, and a similar but significantly stronger augmentation was obtained through TNF treatment
- An association is demonstrated among TNFalpha gene polymorphism, Koreans with hypertension, and iris constitution.
- did not find any association between the G-308A and C-850T polymorphisms and the risk for preeclampsia
- The TNFalpha-308A/TGFbeta1 25C genotype may be one component of genetic susceptibility to SLE in Colombian population.
- High innate production capacity of TNF-alpha precedes a steeper decline in muscle strength over time.
- There is a relationship between VEGF, TNF-alpha, IL-6 and the development of the diabetic retinopathy in children with diabetes mellitus type 1.
- -308 A allele may increase risk of gastritis and lymphoid follicle formation
- These data thus provided good evidence that the MAPK signaling pathways are required for the regulation of P. intermedia lipopolysaccharide-induced TNF-alpha synthesis at the level of translation more than at the transcriptional level.
- there is a strong association between the maintenance of highly functional CD4 T cells producing IFNgamma, IL-2, and TNFalpha and control of HIV-1
- The inflammatory markers, hsCRP, ESR, WBC, fibrinogen, and TNF-alpha, were raised in all patients but were significantly higher in rheumatoid arthritis patients with coronary artery disease who also had periodontal disease.
- The results showed that the TNF-alpha genotype could be a significant risk factor for sarcoidosis, whereas the risk of sarcoidosis due to the ACE genotype was not substantially elevated.
- Pre-treatment rheumatoid factor positivity or negativity does not influence response to TNF-alpha blocking therapy
- Transmembrane tumor necrosis factor (TNF) and TNF receptor (TNFR)1/2 are interaction partners contributing to TNF-alpha production in monocytes.
- Statistical analysis revealed no difference in allele distribution for either gene. No association was observed between Generalized Aggresive Peridontitis and TNFA (-308) gene polymorphisms in Brazilian patients.
- Serum TNF-alpha levels in the patient group before and after treatment, were lower than those in the control group.
- A novel mechanism for involvement of TNF-alpha in cell-cell interactions in RA synovium and for the effectiveness of TNF-alpha blockade in the treatment of RA is illustrated.
- TNFalpha gene G-308A polymorphism is not a major risk factors in renal transplantation
- polymorphism not associated with an increased risk of benign migratory glossitis development
- A case-control study found no association between the TNF-alpha-238 polymorphism and colorectal cancer in Iranian patients.
- proteasome inhibition augmented interleukin-1 beta- and tumor necrosis factor-alpha-induced activation of the IkappaBalpha kinase and MKK4/JNK/c-Jun pathway along with TAK1 activation
- Single nucleotide polymorphism is a genetic risk factor for ischemic cerebrovascular disease.
- TNF-alpha mediated downregulation of catalase expression and accordingly sufficient H(2)O(2) is required for appropriate function of the NF-kappaB dependent survival pathway.
- Three classes of inflammatory repressors act synergistically in modulating PAF-induced up-regulation of COX-2, TNFalpha, and PGE(2) by quenching oxidative stress or inflammatory signaling, resulting in increased HN cell survival.
- TNFalpha might be a negative regulator of breast cancer stem cell-like cells
- the lack of TNF-alpha potentiates pathogenic excess inflammation, fibrogenic response, and neovascularization in an alkali-burned mouse cornea.
- TNF-alpha causes different effects on human mesangial matrix metalloproteinase MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1 expression in vitro, indicating an important role for pro-inflammatory TNF-alpha in renal disease progression.
- The CC homozygote genotype of the peroxisome proliferator-activated receptor gamma (PPAR gamma) gene had increased tumor necrosis factor alpha levels compared with T allele carriers.
- HMGB1 can induce expression of TNF-alpha and IL-1beta, and formation of a pro-inflammatory loop between HMGB1, TNF-alpha, and IL-1beta may be responsible for the prolonged and sustained inflammation in CLE.
- Incubation in the presence of TRAIL enhanced the caspase-dependent and chymotrypsin-like-protease-dependent apoptotic cell death in A549 cells exposed to X rays
- Results indicate a role for NF-kappaB activation and TNF-alpha in the activation of monocytes of patients with rheumatoid arthritis (RA), and suggest an important role of circulating monocytes in RA pathogenesis.
- In in vitro PHA activated PBLs IL-6 was the most induced with a maximum increase of 1110-fold after 4 h of PHA stimulation, followed by TNF-alpha and IL-1beta as well as interferon-gamma (IFN-gamma).
- tumour necrosis factor polymorphisms are not associated with susceptibility to COPD
- We hypothesized that polymorphisms in inflammatory response genes contribute to the increased susceptibility to acute otitis media. In the patient group, TNFA promoter genotypes -238 G/G and -376 G/G were associated with an otitis-prone condition.
- Increase in TNF-alpha after cesarean section resulted in suppression of the nocturnal melatonin surge.
- There's a relationship between inflammatory activation of peripheral blood mononuclear cells (enhanced mRNA expression of TNF-alpha and IL-6) and renal involvement (increased urinary albumin excretion) in type 2 diabetic patients.
- A statistically significant increase of IL-2, TNF-alpha, and leptin concentr. was observed in patients from stage I to stage III of NSCLC. These findings suggest that IL-2, TNF-alpha, and the leptin play an important role in the cancerogenesis of NSCLC.
- Position -308 [-308 guanine/adenine] of the TNF-alpha promoter is not a genetic marker for identifying women at increased risk of common pregnancy complications.
- Both PD98095 and dicoumarol were capable of blocking TNFalpha production but had only a small effect on p21Waf1 expression
- Cells not expressing TNF-R1 were insensitive to TNFalpha, whereas those treated with DA showed a further decrease in viability when subsequently treated with TNFalpha.
- Human cardiac cells constitutively express M-CSF and its expression is up-regulated by TNF-alpha.
- Decreased osteogenic potential of mesenchymal stem cells of myeloma patients was in part due to TNF-alpha suppressed TAZ expression.
- TNF-alpha plays a significant role in the pathogenesis of chronic insulin resistance in humans.
- TNF-alpha expression in omental adipose tissue could play a key role in contributing to cardiovascular risk in central obesity subjects.
- n-3 PUFAs treatment effectively prevented the redistribution of occludin and ZO-1 and distortion of TJ morphology, reduced transepithelial electrical resistance induced by IFN-gamma and TNF-alpha
- Among farm workers frequently exposed to cement in southern Taiwan, those with TNF alpha promoter-308 heterozygous genotype had increased risk of chromate sensitization.
- the genotype AA at polymorphism -863C/A in a recessive model showed a significant association with developing gout independent of hyperuricaemia, abnormal creatinine, higher TG, GPT and alcohol consumption
- While TNFalpha had no effect on MCL-1 transcription, it induced expression of another antiapoptotic molecule, BFL-1.
- These findings demonstrate for the first time that IRF-1 is a novel alternative GRbeta-independent mechanism mediating steroid dysfunction induced by pro-asthmatic cytokines.
- Visfatin, TNF-alpha, and IL-6 mRNA expressions are increased in peripheral mononuclear-monocytic cells from women with type 2 diabetes.
- TNFalpha may play a key role in cooperation with HB-EGF and AREG in the proliferation of epidermal keratinocytes at the psoriatic skin lesions.
- TNF-alpha gene polymorphism in patients infected with HBV would result in relatively inefficient inhibition of HBV and development of end-stage liver disease
- Present an atypical case of leukemic transformation in myelofibrosis associated with diffuse osteolytic lesions and extremely elevated TNF-alpha and lactate dehydrogenase (LDH). Parathormone was not disturbed.
- B19 capsid antigen did not promote positive rsponse for production of TNF-alpha.
- TNF-alpha genotype may contribute a common phenotype of enhanced vascular instability that increases the risk of hemorrhagic outcome.
- A significant association between the TNF-alpha-308G-->A polymorphism and processing speed was observed, indicating better performance for heterozygous or homozygous carriers of the A allele.
- MMP-1 and TNF-alpha correlate well with the severity of the disease, and therefore, can be used clinically as biological markers to judge the severity of ulcerative colitis.
- In response to autocrine TNFalpha signaling, the Smac mimetic promotes formation of a RIPK1-dependent caspase-8-activating complex, leading to apoptosis
- evaluation of TNF level and its polymorphisms in the promoter region may be considered to be reliable molecular and immunological markers, possess promising rational for diagnostic potential and immunotherapeutic interventions in clinical vivax malaria.
- SP D and TNF-alpha are significantly increased in CF compared with AFRS, suggesting activation of both innate immunity and Th1-mediated inflammation and potential correlation between SPs and downstream adaptive immune responses
- NAFLD and NASH patients have elevated plasma LBP.This increase is related to a rise in TNF-alpha gene expression in the hepatic tissue which supports a role for endotoxemia in the development of steatohepatitis in obese patients.
- The -863A allele of TNF-alpha gene and the extended haplotype of -863A, -308G, -238G can be used as a genetic marker for systemic lupus erythematosus susceptibility in Thai populations
- TNF-alpha sensitizes primarily resistant endometrial stromal cells to Fas-mediated apoptosis.
- Short-term TNF-alpha cell treatment caused A(2B) AR phosphorylation inducing, in turn, impairment in A(2B) AR-G protein coupling and cAMP production
- a novel, promoter-specific signaling interaction between estrogen and TNFalpha signaling is likely to be important for prolactin regulation in vivo.
- the polymorphism of promoter gene TNFA-238GA is associated with the occurrence and severity of chronic GVHD. The probability of chronic GVHD in patients with GA genotype at pos. -238 of TNFA gene is 91.7%; 59.4% in patients with GG genotype
- IL-10 modulated the pro-apoptotic capacity of TNF-alpha in chondrocytes as shown by the decrease in caspase activities and bax/bcl-2 ratio
- A relatively low dose of tnf-alpha induces systemic lipolysis but skeletal muscle metabolism is unaffected.
- Carriage of the TNF308.2 allele correlates with disease severity and hepatic fibrosis, which may contribute to a higher risk for HCC.
- FOXO3a (forkhead box O3) induces TNF alpha expresion and promotes apoptosis in human umbilical venin endothelial cells
- Autocrine TNF-alpha secretion resulting from IgE/FcepsilonRI-dependent activation plays a critical role in suppressing TLR9-dependent responses in plasmacytoid dendritic cells that normally promote T(H)1 activity
- In this review, TNF-alpha orchestrates a diverse array of functions involved in immune surveillance and defense, cellular homeostasis, and protection against certain neurological insults; however, paradoxical effects of this cytokine have been observed.
- Coincubation of platelets with monocytes induced EMMPRIN-mediated nuclear factor kappaB activation in monocytes with increased MMP-9, interleukin-6, and tumor necrosis factor-alpha secretion by monocytes
- These results suggest that P. acnes stimulates hDF to produce TNF-alpha, which mediates the expression of proMMP-2 through the NF-kappaB pathway.
- no significant differences in genotype and allele frequencies were found in Argentinean patients with MS. The A/G genotype was found in 4.4% of pts (n=90) and in 4.8% of healthy individuals (n=84; p=0.92; odds ratio=0.93; confidence interval: 0.23-3.84).
- Proinflammatory cytokines seem to be only partly involved in the pathophysiology of complex regional pain syndrome 1, as indicated by the lack of coherence between TNF-alpha and IL-6 levels and the signs and symptoms of inflammation and disease duration
- monocytes show reduced expression of LPS-stimulated tumor necrosis factor-alpha in term and preterm labor
- Fanconi anemia is characterized by an overproduction of the myelosuppressive cytokine TNF-alpha through unknown mechanisms.
- acute myocardial infarction from information on functional gene variants that favor inflammation or modulate cholesterol metabolism: IL6 -174 G/C, TNF -308 G/A, IL10 -1082 G/A, SERPINA3 -51 G/T, IFNG +874 T/A, HMGCR -911 C/A, and APOE epsilon2/3/4
- exposure to LPS evoked a weak and transient induction of TNFalpha mRNA whereas induction of IL-6 and IL-8 mRNA were pronounced
- TNF-alpha stimulated tenascin-C expression through NF-kappaB signaling with RelA activation in cultured OA chondrocytes, suggesting involvement of tenascin-C in OA cartilage remodeling.
- Taken together, these results show an association between severity of depressive symptoms and expression of pro-inflammatory cytokines in patients with HCV.
- HMEEC exposed to IL-1beta and TNF-alpha demonstrated significant upregulation of mucin secretion in a dose-dependent fashion.
- Data show that older Type D chronic heart failure patients have a higher mean TNF-alpha level as compared to patients who were younger or who were not Type D.
- in patients with chronic hepatatitis B infection, the TNF-alpha -863 A allele was significantly increased in the hepatocellular carcinoma group compared to healthy controls
- No statistically significant association is found between 308 G/A, -238 G/A, -376 G/A polymorphisms, or functional TNFalpha/interleukin-10 genotypes and tuberculosis.
- role of G(-308)A promoter polymorphism in myocardial ishemia
- results suggest that TNF-alpha and the local renin-angiotensin system coordinately stimulate PAI-1 production in hepatocytes
- Activated mast cells induce endothelial cell apoptosis by multiple mechanisms: chymase inactivates the FAK-mediated cell survival signaling, and TNF-alpha triggers apoptosis
- TNF activated ERK in an EGFR and Src dependent and an EGFR and Src independent modes
- Polymorphisms associated with increased expression in the cytokines TNFalpha and TGFbeta1 are overrepresented in the Myelodysplastic syndromes (MDS) population.
- TNF-alpha induced apoptosis of SYM-1 cells within 24h and decreased OPG levels
- The increase of plasma TNF-alpha in amyotrophic lateral sclerosis (ALS) patients in the presence of a slight increase of sTNFR-1 & -2 supports a functionally significant activation of the TNF system in ALS.
- These results suggest the mechanisms underlying chronic insulin resistance in gestational diabetes may be driven by increased inflammation in skeletal muscle.
- role of TNF-alpha-308 G/A and IL-4-589 C/T polymorphisms in susceptibility to and severity of asthma.
- Antithrombin might inhibit LPS-induced production of TNF-alpha by inhibiting the increase in Egr-1 expression in monocytes via interaction with heparin-like substances expressed on the cell surface
- noticed the largest number of mRNA copies for TNFalpha and TNF R2/R7 in healthy cells at stage III of the disease
- IL-1beta and IL-6 were found increased in plasma and tuberculous pleural fluid, indicating an inflammatory status
- Ioniing radiation signaling in a lung tumor cell line is due to activation of NF-kappaB signaling by TNF-alpha.
- Acute lung transplant rejection is associated with decreased intracellular T-cell TGFbeta in blood and increased intracellular IFNgamma and TNFalpha
- Protein levels of NOD2, TNFalpha, and nuclear NF-kappaB, as well as the binding activity of NF-kappaB to a consensus DNA sequence, were significantly increased in inflamed mucosa of patients as compared to controls.
- plasma total homocysteine is a determinant of TNF-alpha in hypertension
- NGF and NGF-induced TNF-alpha cooperate to activate Akt, promoting survival of normal neural cells.
- SAMD9 may have a role in the TNF-alpha signaling pathway and in the regulation of extra-osseous calcification
- The promoter/enhancer activity of the NFAT-binding site in the TNF-alpha gene was up-regulated by NFATc2 but not by NFATc1, whereas both NFATs associated similarly with this region.
- TNF-alpha affects cholesterol efflux and ABCA1 expression of adipocytes, and the pathway of PPARgamma-LXRalpha-ABCA1 is probably involved
- TNF-alpha unveils a previously unknown capacity of neutrophils to migrate to CCL3 through the intervention of Mac-1.
- The genotype distribution and allele frequencies of TNF-alpha G/A polymorphism were significantly higher in the thrombotic children without infection and in the control group than in the thrombotic children with an infection history
- protein kinase C synergistically enhances the secretion of uPA in TNF-alpha-stimulated human dental pulp cells
- observations suggest that Glucagon-like peptide-1 (GLP-1) inhibits tumour necrosis factor-alpha (TNF-alpha)-mediated plasmogen activator inhibitor-1 (PAI-1)induction in vascular endothelial cells
- processing of pre-TNF alpha in LPS-stimulated macrophages is regulated by TPL2-mediated activation of ERK1 and ERK2
- Results showed an association of specific TNF SNPs with cytokine levels and disease severity/resistance in patients from areas with differential disease endemicity.
- study does not support an association between TNF variants and prostate cancer risk
- Tumor necrosis factor-alpha induced changes in the mechanical properties of ECs, which included a decrease in the average shear moduli that occurred in all regions of the ECs and an increase in distensibility in the central regions.
- a significant association between TNF (-308A) SNP and both development of MC and diminished immune responsiveness
- Changes in peripheral blood of TNF transgenic mice are reflected in alterations in cell kinetics, transferrin receptor expression and increased apoptosis and cell death in the bone marrow indicating that TNF-alpha may contribute to myelodysplasia in ACD.
- TNF-alpha-308 G/A may be related to susceptibility, whereas -609 TT TNFR1 and 1690 C/T TNFR2 SNPs may be protective to tobacco-related oral squamous cell carcinoma.
- These findings support preclinical evidence that the local administration of tumor necrosis factor inhibitors may prove to be a safe and effective treatment for challenging pain conditions.
- The basis for interactions between tumor necrosis factor and insulin-like growth factor-1 is discussed in this Review with specific reference to clinical consequences for myofiber necrosis of skeletal muscle.
- SENP1 mediates TNF-induced desumoylation and translocation of HIPK1, leading to an enhanced ASK1-dependent apoptosis.
- Taken together, we demonstrate that EPA inhibits TNF-alpha-induced MMP-9 expression through inhibition of p38 and Akt activation.
- No particular tumor necrosis factor alpha genotype was associated with CAID.
- TauBr inhibited degradation of IkappaBalpha and TNFalpha-induced NF-kappaB activation.
- TNFalpha produces a nasal inflammatory response in humans that is characterised by late phase (i.e., 24 hours post challenge) neutrophil activity and plasma exudation.
- An altered pattern of TNF-alpha release was observed in trauma patients treated with catecholamines.
- TNF-alpha may participate in the pathogenesis of NAFLD.
- A direct effect of TGF-beta signaling via ALK5 on the regulation of TNF-alpha synthesis in macrophages
- THE TNF alpha (TNf) -308 minor allele (A) had a higher odds ratio (OR) of being associated with COPD; 237 minor allele (A) had a lower OR, ;In COPD patients, the -857 minor allele was associated with severe COPD
- TNFA-308G/A polymorphism is associated with gallbladder cancer.
- These data suggest that TNF-induces autophagy through ERK1/2 and that inhibition of autophagy increases cellular sensitivity to TNF.
- genotype frequencies at the TNF:g.[-1031T > C] and the TNF:g.[-863C > A] sites may be associated with advanced stage endometriosis in the Korean population
- TNF-alpha overrides the G2/M checkpoint in keratinocytes and allows for some cells containing unrepaired cyclobutane pyrimidine dimers to enter the cell cycle. TNF-alpha seems to be dependent on PI3K-Akt activation.
- highly significant contribution of TNF-alpha in the occurrence of oral squamous cell carcinoma
- Serum IL-1beta, IL-6, IL-8, and TNF-alpha are mediators of inflammation in neonatal sepsis
- Ghrelin, TNF-alpha, and IL-6 may have roles in cyanotic and acyanotic congenital heart disease in children
- Amniotic fluid TNF-alpha may promote the onset of labor at term and/or term labor contributing to subsequent delivery may induce the production and secretion of TNF-alpha into the amniotic cavity
- TGF-beta1/TNF-alpha levels and endothelial cell activation are interrelated in kidney transplant patients.
- Childhood obesity contributes to higher PAI-1 and TNFalpha and lower TGFbeta levels, which may accompany insulin resistance and dyslipidemia.
- In blacks we detected a significant association between higher amniotic fluid concentrations of TNFalpha and preterm birth this may be indicative of a TNF-alpha mediated pathological process of preterm birth in blacks but not in whites.
- In heart failure patients, platelet CD40L is upregulated by TNFalpha via a cyclooxygenase-1-independent, arachidonic acid-mediated oxidative stress mechanism.
- There is a trend to increase in TNF alfa and IL-10 values in Alzheimer's disease.
- Set-association analysis did not reveal an independent or an interactive effect of these TNF-alpha on the PD risk.
- TNF-alpha-positive cells are more frequent, while IL-4-positive cells are less frequent in tissues from lung neoplasms
- association between SNPs in the promoter of the TNF-alpha gene and ulcerative colitis and colorectal cancer
- The differential responses of human umbilical artery and vein endothelial cells to TNF in organ culture correlate with transcription factor/co-activator binding to DNA and converge during cell culture.
- Adiponectin protects the endothelial monolayer from Ang II or TNF-alpha-induced hyperpermeability by modulating microtubule and cytoskeleton stability via a cAMP/ PKA signaling cascade.
- TLR2/TLR4 stimulation was associated with NF-kappaB p65 nuclear translocation and proinflammatory cytokine production (TNF-alpha and IL-6) in adipose tissue
- TNF-alpha, can enhance invasion and the EMT of renal cancer cells, which provides a therapeutic target to prevent and treat advanced renal cell carcinoma.
- Suggest that reinioside C could attenuate the increase of TNF-alpha induced by exogenous asymmetric dimethylargining through inhibition ROS/NF-kappaB pathway in monocytes.
- These results identify JNK, and not NFkappaB, as a critical mediator of TNF-alpha repressory effect on connexin 43 gene expression.
- TNF-alpha -238G/A and -238A/A, and LT-alpha+252G/G genotypes were positively associated only with exclusively early RM. This supports the concept of the association of TNF-alpha (-238G/A) and LT-alpha (+252A/G) polymorphic variants in idiopathic RM.
- Our results suggest that TGF-beta1 gene Arg(25)-->Pro, TNFalpha gene G-308A, and IL-6 gene G-174C polymorphisms are not risk factors or markers of progression in Caucasian patients with IgA nephropathy.
- TNF-alpha, and also extracellular ATP, may contribute to cell activation following allergen stimulation and might reflect the mechanism by which dendritic cells respond to allergens
- The distribution of IL-10 and TNF-alpha genotype did not differ among patients with or without access failure.
- These results indicate that bile acid performs a critical function in the regulation of the induction of inflammatory-related genes in gastric cells
- Leptin induced functional TF and increased TF mRNA and protein expression in neutrophils and mononuclear leukocytes
- golgin-245 is a key regulator of TNF secretion; LPS activation of macrophages results in increased Golgi carriers for export, up-regulating the transport pathway for TNF export.
- STC1 maintains endothelial permeability in TNF-alpha-treated HCAECs through preservation of tight junction protein expression, suppression of superoxide anion production, and inhibition of the activation of NFkappaB and JNK
- study assesses whether and how immune complexes formed by the interaction of disease-specific autoantibodies to citrullinated proteins with their main synovial target antigen, citrullinated fibrin, contribute to TNFalpha production by macrophages
- Blood oxygenation affects exercise-induced TNF-alpha response in hypoxemic chronic obstructive pulmonary disease patients.
- SNPs of TNFalpha gene may not associate with SARS-CoV infection and may not affect interstitial lung fibrosis; however, the -1031CT/CC and -863 AC genotypes may be risk factors for femoral head necrosis
- p38 MAP kinase down-regulates extracellular signal-regulated kinase via activation of MKP-3 in human monocytes exposed to asbestos to enhance TNF-alpha gene expression.
- tumor cell-derived TNFalpha plays a profound role in malignancy of pancreatic ductal adenocarcinoma
- Results revealed significant differences between TNF-alpha concentrations in teeth with periapical pathosis with larger lesions, as well as between control and canals with small lesions.
- polymorphic variations may play an important role in susceptibility of Iranian multiple sclerosis patients
- Levels of tumor necrosis factor-alpha and high sensitivity C-reactive protein have a cumulative effect on the mean values of carotid artery intimal medial thickness in Asian Indian subjects with normal glucose tolerance.
- The IVS1G + 123A polymorphism of the TNF-alpha gene, which seemed to be functional, was associated with DM in the Japanese population.
- TNF-alpha induces renal tubular cell damage and AT1/AT2 receptor blockers showed cytoprotective effects probably via at least partly different mechanisms.
- Both CC and LC are associated with the HLA-DR3-DQ2 haplotype and with TNF2 allele carriage. These associations are present also in MC patients without CD.
- rhIL1beta and rhTNF alpha inhibited glucagon-stimulated signal transduction at the site of cAMP formation.
- exogenous Nef and TNFalpha synergistically activate NF-kappaB and AP-1 in U937 cells and primary macrophages resulting in enhanced stimulation of the HIV-1 long terminal repeat (LTR), and subsequently in enhanced viral replication
- The TNFalpha-308 allele A frequency was significantly lower in acute alcoholic hepatitis(AAH) (0.09) than cirrhosis (0.28) and healthy groups. AAH and cirrhosis groups did not differ for the frequency of TNFalpha-238, -863 polymorphisms.
- results suggest that in A549 cells, phosphorylation of p42/p44 MAPK, JNK, and transactivation of NF-kappaB are essential for TNF-alpha-induced MMP-9 gene expression
- the temporal expression of TNF is critical: it delays angiogenesis initially by blocking signaling through VEGFR2, and by inducing a tip cell phenotype through an NFkappaB-dependent pathway, it concomitantly primes ECs for sprouting
- The TNF-alpha promoter polymorphism (-308G/A) may be associated with asthma susceptibility and BHR in Korean children with asthma, and there appears to be a combined effect with IL-13 polymorphisms in this population.
- Initiates an interferon-beta-mediated autocrine loop that sustains expression of inflammatory genes and induces delayed expression of interferon-response genes.
- TNFalpha level is high in patients with end-stage heart failure on medical therapy but higher in patients on left ventricular assist device support; high TNFalpha plasma levels are not correlated with TNF2 allele but seem to be associated with TNF1 allel
- Results suggest that the simultaneous presence of IL-1B and TNF-alpha two-positions risk haplotypes enhances the susceptibility for celiac disease.
- Data show that JNK modulates the effect of caspases and NF-kappaB in the TNF-alpha-induced down-regulation of Na+/K+ATPase in HepG2 cells.
- TNFA-308 locus of TNF-alpha is a risk factor for gastric cancer, especially in Caucasian populations.
- IL-6 and TNF-alpha, and the level of an anti-inflammatory cytokine IL-10, but not their gene polymorphisms, provide novel and important prognostic information in patients with ADHF.
- HMGB1 plays an important role in Gram-negative sepsis by catalyzing movement of LPS monomers from LPS aggregates to CD14 to initiate a TLR4-mediated proinflammatory response
- These results indicate the involvement of NRDc in ectodomain shedding of TNF-alpha.
- Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), MIF, and matrix metalloproteinase-9 (MMP-9), decreased significantly after weight loss.
- Although the genetic background of TNFalpha could be shown to be associated with subgingival colonization with Prevotella intermedia, there is no evidence that it is an independent risk factor for periodontitis
- Data suggest that Moraxella catarrhalis lipooligosaccharide selectively upregulates ICAM-1 expression on human monocytes and stimulates adjacent naive monocytes to produce TNF-alpha through cellular cross-talk.
- study suggests polymorphisms of IL10, TNFalpha & TGFbeta1 do not have major independent role in acute rejection (AR)& hepatitis B virus(HBV)recurrence after liver transplantation & may not be risk factors of AR & HBV recurrence after liver transplantatio
- Activation of HLA-B27 promoter is a sequential event, and that TNF-alpha and IFN-beta are major participants at different timepoints.
- The role of BAT1 in the regulation of tumor necrosis factor-a suggests that BAT1 may regulate the inflammatory response observed in patients with rheumatoid arthritis.
- Increased mucosal tumor necrosis factor-alpha is associated with segmental colitis associated with diverticula.
- in gingival crevicular fluid and peri-implant crevicular fluid did not change significantly after a period of de novo plaque accumulation
- tumour necrosis factor-alpha gene nucleotide -308 polymorphism is associated with a moderately increased risk of asthma and bronchial hyperresponsiveness, but not with atopy
- PKCzeta is an important transduction molecule downstream of TNF-alpha signaling and is associated with increased expression of CD1d that may enhance CD1d-natural killer T cell interactions in psoriasis lesions.
- Plasma TNF-alpha was elevated in multiple sclerosis patients at the end of an 8 week exercise program.
- the concentration of cerebrospinal IL-10 and TNF-alpha was below the sensitivity of the measurements in cervical spondylotic myelopathy
- Increased concentrations of TNF-alpha in cord blood and of IL-6 in cord blood were associated with psychomotor developmental index <85; Increased concentrations of TNF-alpha in cord blood and IL-8 in cord blood were associated with cerebral palsy.
- High levels of IL-1beta, IL-10, IL-17 and TNF-alpha (in the serum and synovial fluid) were observed in arthritis compared to the healthy controls
- although the meta-analysis demonstrated a lack of an overall association between TNF-alpha G-308A polymorphism and preeclampsia, our results suggest a role of this SNP in the risk of severe IUGR-complicated preeclampsia
- Variants among promoter of TNF-alpha are unlikely to play major role in susceptibility to diabetic retinopathy in Chinese patients with type 2 diabetes.
- Serum adiponectin level was decreased and serum CRP and TNF-alpha levels were increased in obese children. Our findings suggest that childhood obesity is associated with inflammatory processes.
- Allelic distribution of -308 G>A (TNF 1/2) polymorphism of the TNF-alpha gene was determined in multiple myeloma patients.
- DC-SIGN enhances the production of IFN-alpha and TNF-alpha in cells that infected by glycosylated West Nile virus.
- The association between TNF-alpha and proliferative retinopathy in type 1 diabetic patients suggests that inflammation might play a role in the pathogenesis of proliferative diabetic retinopathy.
- Polymorphism of 308 (G/A) TNFalpha and TNFa depended, first of all, on patterns of breast and, secondly, on the elevated TNFalpha expression as a factor of pathogenesis of hereditary breast cancer.
- This case-control study evaluated polymorphisms in cytokine genes and the occurrence of occupational chronic irritant contact dermatitis. The results suggested a TNFA-induced increase of susceptibility (TNFA -308 variant genotypes)
- The TNFalpha -308 C-->T and -863 C-->A polymorphisms are not associated with spermiogram characteristics and do not represent molecular markers for genetic susceptibility to male infertility.
- the critical role of PLD1 in the intracellular signaling cascades initiated by TNF-alpha and its functional role for coordinating the signals to inflammatory responses.
- A positive temporal interaction between tumour necrosis factor-alpha and interlukin-6 on cell growth was identified with the combination significantly increasing total cellular protein, extracellular signal-regulated kinase phosphorylation and S-phase
- a relationship between the TNFalpha -1031T/T genotype and colorectal cancer (CRC) (64.5% for controls vs 74.7% for CRC cases above 70 yrs)
- Common TNF gene variants are associated with sepsis syndrome and death after severe injury
- Tumor necrosis factor-alpha inhibits chondrogenic differentiation of synovial fibroblasts through p38 mitogen activating protein kinase pathways.
- The level of functional circulating TNFalpha is partially genetically determined and is predictive of the clinical response to infliximab
- These findings suggest that JNK1 and JNK2 are involved in TNF-alpha-induced neutrophil apoptosis and GM-CSF-mediated antiapoptotic effect on neutrophils, respectively.
- activation of the TRPM8 variant in human lung epithelial cells leads to increased expression of IL-1alpha, -1beta, -4, -6, -8, and -13, granulocyte-macrophage colony-stimulating factor (GM-CSF), and TNF-alpha.
- TNF-alpha-induced ICAM-1 up-regulation in the airway epithelium is mediated by Rac1-ROS linked cascade via NF-kappaB-dependent manner
- The TNF-alpha gene promoter polymorphism G/A at position -308 does not influence TNF-alpha plasma levels during cardiac surgery, is not associated with greater oxidative stress, and does not result in a greater incidence of perioperative complications.
- T allele at -857 locus of Tumor necrosis factor (TNF) gene is a marker for more extensive disease in Turkish sarcoidosis patients
- low levels of TNFalpha increase the Ca(2+) sensitivity of the heart via a TNFR1-mediated mechanism
- Tumor necrosis factor-alpha levels in gingival crevicular fluid were positively correlated with probing depth and clinical attachment loss in children with gingivitis.
- documents role of reactive oxygen species in TNF-alpha signaling cascades in human keratinocytes used as a model of inflammatory skin disease and psoriasis
- TNF-alpha gene polymorphisms at positions -308 (G-308A), -863 (C-863A), and -1031 (T-1031C) are associated with Graves' disease.
- Data show that the TNF alpha may partly regulate the growth of MCF-7 breast cancer cells through the down-regulation of ER alpha expression, which is primarily mediated by a PI3K/Akt signaling.
- IL-10, IL-4 and TNF-alpha genetic polymorphisms were not related to the risk of developing drug induced liver injury
- These findings revealed that TNF-alpha is able to induce apoptosis via two distinct caspase-8 activation pathways that are differentially regulated by cIAP1/2 and c-FLIP.
- Data show that TNF-alpha is overexpressed in experimental models of seizures in brain areas of seizure generation and propagation, prominently by glia and to a lesser extent by neurons.
- These data do not suggest that genetically determined changes in the IL-1 or TNFalpha genes confer increased susceptibility to suicidal behavior.
- BMP-7 ameliorates IgA nephropathy-derived polymeric IgA-induced TNF-alpha and TGF-beta synthesis in human mesangial cells through multiple mechanisms involving inhibitory Smads and PPAR-gamma.
- Neural stem cell self-renewal is controlled by bi-directional cross-talk between the endocannabinoid system and the tumor necrosis factor signalling pathway.
- Interleukin 1beta and tumor necrosis factor- alpha regulate interleukin 6-type cytokines in gingival fibroblasts
- Production of both TNFalpha and IL-10 in COPD lung tissue following exposure to bacterial LPS may have important biological implications for both episodes of exacerbation, disease progression and amelioration.
- TNF is associated with with life expectancy
- Suppressor activity among CD4+,CD25++ T cells is discriminated by membrane-bound tumor necrosis factor alpha
- ATP and ADP at high-micromolar concentrations reduce secretion of the main Th1 cytokines Tumor necrosis Factor (TNF)alpha, IL-12(p70) and Interferon (IFN)gamma in LPS stimulated human blood
- Human immunodeficiency virus infection alters tumor necrosis factor alpha production via Toll-like receptor-dependent pathways in alveolar macrophages and U1 cells
- Report frequency of S and Z alleles for alpha-1-antitrypsin and tumor necrosis factor alpha -308 promoter polymorphism in northeastern Mexico.
- TNF-alpha-308(G-->A) G/G genotype may be contributing factor in susceptibility as well as in severity of asthma among Egyptian children
- CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from pDCs; CD300a/c RNA and surface expression were downregulated after stimulation of pDCs with TLR7 and TLR9 ligands
- Discuss the role of AQP3 in TNF-alpha-mediated inflammation and the development of periodontitis.
- oxidative stress promotes TNFR receptor (TNFR1- and TNFR2) self-interaction and ligand-independent and enhanced ligand-dependent TNF signaling
- TNF[alpha] -308, -238, and TGF [beta]1 -509 SNPs and the TNF[alpha] -308A/-238G haplotype were associated with age-related decline in FEV1 in a group of firefighters.
- Detail the role of Bax translocation, cytochrome c release, and perinuclear clustering of the mitochondria in the killing of HeLa cells by TNF.
- The synthesis and characterization of a thermally-responsive tumor necrosis factor antagonist are reported.
- the anemia of chronic kidney disease was associated with up regulation of TNF-alpha, and possibly IL-6 and IL-8 along with increased levels of these proinflammatory cytokines in patients treated with epoetin.
- TNF-alpha production in monocytes induced by centrifugation-mediated mechanical stress is dependent on MyD88-dependent TLR2 signaling that is associated with Ca(2+) release. TNF-alpha production induced by mechanical stress also affects TLR2 production.
- Transmembrane TNF-alpha when highly expressed on tumor cells and acting as a receptor, promotes NF-kappaB activation through reverse signaling, which is helpful to maintain tumor cell survival.
- TNF-alpha, an inflammatory cytokine, disrupts the localization of polycystin-2 to the plasma membrane and primary cilia through a scaffold protein, FIP2, which is induced by TNF-alpha
- Comparative proteomic analysis of TNF-alpha-derived endothelial microparticles is reported.
- Inflammatory markers associated with the acute-phase response (IL-6, TNF-alpha, C-reactive protein, and fibrinogen, but not IL-18) are associated with risk of recurrent stroke
- intracellular cathepsin B activity is involved in the TNF-alpha-containing vesicle trafficking to the plasma membrane
- The results of present study suggest that the TNF-alpha -308 and the IL-6 -174 promoter polymorphisms may be the genetic factors influencing the renal allograft survival.
- unfavorable genetic profile in the TNF-alpha gene may be involved in sudden infant death by exposing the infant to both a high level of and prolonged exposure to TNF-alpha
- Data show that coronary artery calcification, arterial stiffness, and renal insufficiency associate with circulating levels of TNF-alpha in type 2 diabetic patients.
- association between diabetic complications and LTA, TNF and AGER polymorphisms is complex, with partly different alleles conferring susceptibility in type 1 and type 2 diabetic patients
- TNF-alpha gene polymorphism (-308G/A) does not seem to be associated with the occurrence or recurrence of Ttoxoplasmic Retinochoroiditis.
- study found no evidence of an interaction between alcohol consumption and TNF-alpha gene polymorphisms in relation to TNF-alpha levels; carriers of the TNF -238A allele tended to have a higher prevalence of advanced liver disease than -238G homozygotes
- TNF polymorphisms studied seem not to play a role in determining the severity of alcoholic pancreatitis or the risk of developing alcoholic pancreatitis.
- The inhibition of TNF-alpha appears to be mediated primarily by exercise and not hyperthermia induced by protective clothing
- choline suppresses TNF production from endotoxin-stimulated macrophages
- Homozygous allele 1 was the most common TNF-alpha genotype in both groups, however no significant difference in TNF-alpha genotypes was found between groups.
- We found that the women with preeclampsia had significantly higher serum TNF-alpha concentrations compared with the women in the control group; urinary levels of TNF-alpha were significantly decreased in the women with preeclampsia compared with controls
- Results indicate that IL-6 and TNF-alpha are only partially responsible for the signs and symptoms of complex regional pain syndrome type 1.
- The variant allele of THBS2 is a risk factor for TAA in hypertensive patients, whereas the variant alleles of HSPA8, GPX1, AGT, and TNF are protective against this condition.
- Lysosomal degradation of cIAP1-TRAF2 by TWEAK/FN14 therefore critically alters the balance of life/death signals emanating from TNF-R1 in immortalized cells.
- during hyperglycemia, the increase in tumour necrosis factor (TNF)-alpha was larger in patients with type 1 diabetes than in non-diabetic volunteers
- NF-kappaB, but not p38, is critical for TNF-alpha-induced expression of ICAM-1, VCAM-1 and E-selectin
- TNFA-308 G/A polymorphism may contribute to a predisposition to acne in Turkish population
- Variation in TNFalpha is associated with chronic bronchitis in alpha 1 antitrypsin deficiency.
- c-IAP1 and c-IAP2 are required for TNFalpha-stimulated RIP1 ubiquitination and NF-kappaB activation.
- Serum TNF-alpha levels were significantly decreased in patients with burning mouth syndrome compared with controls.
- Dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats
- Pravastatin immunomodulates IL-6 and C-reactive protein, but not IL-1 and TNF-alpha, in cardio-pulmonary bypass
- All SIDS cases were homozygotic for TNF-alpha.
- Concentrations of adhesion molecules and TNF-alpha are associated with coronary atherosclerosis in SLE independent of the Framingham risk score.
- In patients with RA, genetic variability in the TNF-alpha gene is associated with smaller LDL particles that have a greater affinity for extracellular matrix and higher susceptibility to oxidation.
- Tumor necrosis factor-alpha can provoke cleavage and activation of sterol regulatory element-binding protein in ethanol-exposed cells via a caspase-dependent pathway that is cholesterol insensitive
- Results indicate that genetic variation in the TNF locus may contribute to the interindividual variation in muscle phenotypes in men.
- There is association between the -308 G/A and -238 G/A TNFA polymorphisms and OCD in our Brazilian sample.
- No association was detected between the TGFB1, IL10, TP53, and HMOX1 genes and DGF. The G allele of the TNF polymorphism rs3093662 was associated with DGF in an adjusted analysis.
- Data show that THF-alpha is not significantly elevated in both the treatment responders and the non-responders with major depression.
- Patients homozygous for the A allele at position -308 had a higher mortality than those carrying the G allele (P = 0.01)
- TNFalpha was elevated in a large portion of community heart failure patients and was associated with a large decrease in survival
- Haplotypes of the TNF gene influence tracheal aspirate fluid levels of TNF-alpha. Diplotypes of TNF are associated with fetal chorioamnionitis.
- TNF-alpha can play a crucial role in the immunopathogenesis of nephritis by the induction of CCL2, ICAM-1 and VCAM-1 expression via the activation of the intracellular MAPK signaling pathway, which may contribute to macrophage and lymphocyte infiltration
- Expression of sphingosine-1-phosphate receptor-3 is enhanced in human fibroblast-like synoviocyte of the inflamed synovium by TNF-alpha.
- Heme oxygenase-1 expression decreased LPS-stimulated secretion of MCP-1, IL-6, IL-10, and TNF-alpha at both 4 and 24 h in murine and human macrophages
- Report the influence of increased training volume on TNF-alpha concentration in college level male rowers.
- High levels of sVCAM-1, associated with systemic tumour necrosis factor-alpha (TNFalpha) activity, were identified as a novel discriminator for systemic lupus erythematosus-related cardiovascular disease.
- necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin
- Thalidomide suppressed IL-1beta while enhancing TNF-alpha and IL-10, when cells in whole blood were stimulated with lipopolysaccharide.
- CCL23, M-CSF, TNFRSF9, TNF-alpha, and CXCL13 are predictive of rheumatoid arthritis disease activity and may be useful in the definition of disease subphenotypes and in the measurement of response to therapy in clinical studies.
- The role of the Early Growth Response-1 transcription factor in TNFalpha autoregulation in HaCaT human keratinocytes was investigated.
- P38 is a critical mediator of BLP induced TNF-alpha release and NFkappaB activation, whereas PKC is only partially responsible for its response. P38 and PKC are both critical mediators of PMA induced TNF-alpha release and NFkappaB activation.
- Fibroblasts that overexpress ST18 by transient transfection exhibit significantly increased apoptosis and increased expression of TNF-alpha, interleukin (IL) -1alpha, and IL-6.
- Data show that basal level of TNF-alpha is higher in Parkinson's disease patients than in healthy control subjects.
- gAcrp treatment profoundly suppressed the ability of LPS to increase TNF-alpha transcription and reduced the stimulus-induced stabilization of TNF-alpha mRNA in response to LPS.
- Serum levels of sTNFR1 and sTNFR2 were increased in schizophrenic patients when compared with controls (all p < 0.05), but there was no difference in TNF-alpha levels.
- Middle aged hypertensives with obstructive sleep apnea had increased levels of CRP, IL-6, IL-18, TNF-alpha, and asymmetric dimethyl-arginine.
- patients with low sperm count exhibiting TNFalpha A allele, compared with those with G allele, alteration in hormonal balance was observed with increased inhibin B levels & subsequent reduced FSH plasma levels.
- TNF-alpha is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for inflammatory bowel diseases.
- Results indicate that ghrelin inhibits both basal and TNF-alpha-induced PAI-1 production via NF-kappaB pathway in HepG2 cells.
- TNFA (-238) variant may be a risk factor in both development and the severity of coal workers' pneumoconiosis, while TNFA (-308) variant seems to be important only in disease severity.
- findings would support the concept of contribution of TNF-alpha and IL-10 gene polymorphisms in the pathogenesis of pre-eclampsis in this Iranian population
- CRP +1444 C-->T and TNF-alpha -308 G-->A polymorphisms are associated with predisposition to Kawasaki disease and, in patients with Kawasaki disease, increased carotid arterial stiffness and intima-media thickness in the long-term.
- APOE epsilon4 was associated with an independent increase in risk for Alzheimer's disease (AD) in individuals with TNFA -850*2, while carriage of BAT1 -22*2 reduced the risk for AD, independent of APOE epsilon4 genotype
- TNF appears to be a risk factor for iron deficiency and IDA in children in a malaria-endemic environment and this is likely to be due to a TNF-alpha-induced block in iron absorption.
- Alveolar epithelium down-modulates endotoxin-but not tumor necrosis factor alpha-induced activation of endothelium and selectively inhibits neutrophil transendothelial migration.
- 2 conflicting TNF-alpha mechanisms exist: a downregulated TNFR1-dependent one in plateau-phase acute inflammatory demyelinating polyradiculoneuropathy & an upregulated TNFR2-dependent one in acute-phase motor axonal neuropathy.
- TNF is related to inflammation; its immunoexpression increases in prostatic carcinoma.
- S100A6 is induced by tumor necrosis factor-alpha via an NF-kappaB-dependent mechanism, serving a role in homeostasis to limit tumor necrosis factor-alpha-induced apoptosis by regulating p53 phosphorylation
- GbetaL is involved in the negative regulation of TNFalpha-stimulated NF-kappaB signaling through a direct interaction with IKK.
- CD4(+)TNFalpha(+)IL-2(-)T cells are intrathecally upregulated in multiple sclerosis
- IL6 (-174) and TNFA (-308) promoter polymorphisms are associated with systemic creatine kinase response to eccentric exercise.
- Expression of TNF-alpha might play an important role in the angiogenesis, tumour cell proliferation and metastasis of Invasive micropapillary carcinoma of the breast .
- Data suggest tha TNFalpha polymorphism might play a role in IUGR aetiology and influence TNF-alpha expression in maternal serum, but also show that polymorphism is not related to Doppler velocimetry or perinatal outcome.
- The association between the TNFA-308G>A polymorphism and increased risk of gastric carcinoma is dependent on linkage disequilibrium with an as yet unidentified locus.
- TNF-alpha -308 G to A TNF-alpha gene promoter polymorphism at position -308 might be associated with a predisposition to anorexia nervosa and initiate the disease.
- The TNFalpha-308 polymorphism is a susceptibility marker to rheumatoid arthritis. The G/G genotype is associated with a high mRNA and soluble TNFalpha expression.
- The association of TNF polymorphisms in Turkish scleroderma patients with lung involvement.
- These studies demonstrate a synergistic role between TNFalpha and IL-1 family members, including IL-1beta, in the induction of interferon-gamma production.
- amniotic fluid TNF-alpha and soluble TNF receptor concentration regulation is affected by race and preterm birth
- G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance
- Results describe the therapeutic effect of a TNF receptor-1-selective antagonistic mutant of TNF-alpha in acute hepatitis using two independent experimental models, induced by carbon tetrachloride or concanavalin A.
- the 308 G/A polymorphism is a susceptibility factor towards the development of vitiligo in female (but not male) Iranian patients
- Tumor necrosis factor alpha drives cadherin 11 expression in rheumatoid inflammation
- Upregulated in response to ultraviolet (UVB)by keratinocytes; an important component of the inflammatory cascade in skin
- PI3K activation (by HIV proteins such as Nef) may contribute to reduced TLR4-mediated TNF-alpha release in HIV+ human macrophages and impair host cell response to infectious challenge.
- -308 gene promoter G-->A substitution confers a significant risk for developing ulcerative colitis in East Asians but not Europeans
- Thus, the present investigation does not support the proposal that common nucleotide variations in the TNF-alpha gene can influence the development of AD at least in Italian population.
- bid Overexpression of FLIP reduced TRAIL and TNF-alpha-induced apoptosis in ML-1 cells. However, while FLIPL completely abrogated apoptosis, FLIPS allowed for BID cleavage and caspase-3 activation.
- Activation of the TNF-alpha system may potentially exert independent effects on ln albumin:creatinine ratio and eGFR in type 2 diabetes
- TNF-alpha-308 G/A genotype is not associated with pseudoexfoliation glaucoma.
- Urinary excretion of TNF-alpha might be an early marker of preclinical target organ damage in hypertensive patients.
- tested hypothesis that methylation state of the TNF-alpha promoter contributes to increased expression of TNF-alpha in Parkinson's disease; compared DNA from substantia nigra pars compacta & cortex of PD patients and neurologically healthy controls
- Finds lack of association between functional polymorphisms in TNF-alpha gene at position -308 and silicosis and pulmonary tuberculosis in Chinese iron miners
- Tautomycetin suppresses the TNFalpha/NF-kappaB pathway via inhibition of IKK activation.
- claudin-1 expression is responsible for TNF-alpha-dependent growth signals and the proliferation of pancreatic cancer cells.
- the myelosuppressive cytokines TNFalpha and IL-1beta are secreted by bone marrow (BM) cells in a p38 MAPK-dependent manner
- Polymorphisms in the cytokine genes TNFA and IL1B may increase the risk of preterm birth, possibly by a dysregulation of the immune system in pregnancy.
- S6K1 directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2.
- TNF-alpha plays a critical role in regulating human Vgamma2 Vdelta2 T cell immune responses.
- Evidence is provided for the role of genetic variation in TNF SNPs and haplotypes with risk of NHL.
- Polymorphisms in TNF-308G/A may be important modulators of pain treatment and control.
- These results suggested that the TNF-alpha gene G-308A polymorphism might be a risk factor for SAD in Southern China. A-allele might play a role in the susceptibility of SAD.
- Data show that overexpressed PARP-1 promotes PARP-1/NF-kappaB/DNA complex formation, enhancing the expression of TNF-alpha and IL-6 in circulating mononuclear cells of unstable angina patients.
- In patients with acute coronary syndrome, atorvastatin increases lumbar spine BMD solely in patients with the G/G genotype of the TNFalpha-308 G/A polymorphism.
- The TNF-alpha gene G308A polymorphism may contribute to the development of idiopathic dilated cardiomyopathy but does not significantly affect pump function or adverse cardiac remodelling.
- TLR8 may play a role in driving TNF production in rheumatoid arthritis
- High-producing TNF-alphA - 308/LT-alpha + 250 heterozygous haplotype is associated with high NHL incidence; influence of TNFG/A genotype and A alleles in the susceptibility to NHL and the association of LT-alphaG/G genotype with CL
- No significant association was found between TNF-alpha 238 polymorphisms and nationality or in Behcets disease or health controls.
- there was no association between TNFA (tumor necrosis factor alpha) -308G/A, -238G/A, -857C/T or -863C/A polymorphisms or the -10131C allele and Behcet's disease
- TNF-alpha impedes neutral lipid turnover in macrophage-derived foam cells.
- Polymorphisms in the IL6, LEPR, TNF and ADIPOQ genes are not associated with prostate cancer, while allelic variants in the LEP gene are related to prostate cancer risk, supporting a role for leptin in prostate carcinogenesis
- TNFalpha and IL-1 genetic polymorphisms contribute to the development of juvenile dermatomyositis and may also be indicators of disease severity
- Mortality after burn trauma is primarily determined by clinical factors, but the TNF-alpha-308 A allele seems to contribute to an increased mortality risk.
- E2 increases the angiogenic activity of TNFalpha. This could potentially worsen the stability of complex atherosclerotic plaques and increase cardiovascular events.
- Data showed that ADAM17 and its specific inhibitor TIMP3 were co-expressed in the human intestinal barrier and ADAM17 inhibition, either physiologically or pharmacologically, amplified TNF-alpha-mediated hyperpermeability.
- genistein protects human vascular endothelial cells against tumor necrosis factor-alpha-induced apoptosis through the p38beta mitogen-activated protein kinase
- The results suggested that R31A and R32G mutations strongly influenced electrostatic interaction with TNFR2, and that L29K mutation contributed to the binding of R1-6 to TNFR1.
- Involvement of p38 MAPK in the TNF-alpha-mediated 11beta-HSD1 regulation; TNF-alpha stimulates enzyme activity in vivo.
- A alleles in TNF-A and RANTES influenced prostate cancer susceptibility and acted independently of each other in these subjects. No epistatic effect was found for the combination of different polymorphisms studied.
- NF-kappaB pathway activation by CARD11 or tumor necrosis factor-alpha, compensatory IKKalpha activity was also observed with IKKbeta
- Posttraumatic stress disorder was associated with low cortisol and higher levels of DHEA and greater production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) compared to traumatized and healthy controls.
- TNF-alpha secreted by host cells other than antigen-specific cytotoxic T lymphocytes (CTL) plays a critical role in the acute progression of necroinflammatory liver disease, and it may cause acute hepatitis to develop into lethal liver disease.
- Defects in TNFalpha signalling pathways rather than distribution of TNF receptors (TNFRs) probably explain the enhanced apoptosis in systemic lupus erythematosus.
- Seven SNPs in the TNF genes (TNFA and TNFB) were genotyped in a Korean cohort (398 T1D patients and 1422 nondiabetic controls).
- Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells.
- Polymorphisms related to TNF-alpha and IL-1Ra genes may be considered genetic markers for Type 1 diabetes (T1D) among Egyptians.
- Circulating levels of 2-arachidonoylglycerol may downregulate TNF-alpha production.
- An association between the TNF-alpha haplotype GCAT, which was present significantly at a higher frequency in H.pylori infected individuals with duodenal ulcers, was observed.
- CD16 cross-linking activated PI3K and that active PI3K limited TNF-alpha production by inhibiting GSK-3beta activity, that blocked the action of NF-kappaB.
- Interleukin-1 and tumor necrosis factor-alpha induce collagenolysis and bone resorption by regulation of matrix metalloproteinase-2 in mouse calvarial bone cells.
- The production of IL-12, IL-18, and TNF-alpha by alveolar macrophages was increased in patients with both acute and chronic forms of Hypersensitivity pneumonitis in either the absence or presence of lipopolysaccharide compared with controls