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Validated All-in-One™ qPCR Primer for IL1A(NM_000575.4) Search again
Product ID:
HQP100999
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
IL-1 alpha, IL-1A, IL1, IL1-ALPHA, IL1F1
Gene Description:
interleukin 1 alpha
Target Gene Accession:
NM_000575.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq].
Gene References into function
- The level of IL-1 alpha is significantly higher in sera of cicatricial pemphigoid patients with active disease before intravenous immunoglobulin therapy compared to the post-treatment level.
- Allele specific regulation of cytokine genes: monoallelic expression of the IL-1A gene. Review.
- Interleukin-1 alpha and beta system in testis--quantitative analysis. Expression of immunomodulatory genes in male gonad.
- Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression.
- data indicate that IL-1 gene polymorphisms known to affect the inflammatory response are highly related to plasma levels of CRP and fibrinogen in patients referred for coronary angiography
- Cloning and functional analysis of the allelic polymorphism in the transcription regulatory region
- Results suggest a role for the IL1A gene in modifying the clinical features of migraine.
- Interleukin-1 system plays a role in sex steroid receptor gene expression in human endometrial cancer.
- TNF-alpha promoter polymorphism is associated with Il-1 beta synthesis capacity in human leukocytees
- Association of the interleukin-1 gene cluster on chromosome 2q13 with knee osteoarthritis.
- Review.inheritance of a specific IL-1A gene polymorphism increases risk for development of Alzheimer's disease by as much as sixfold. Moreover, this increased risk is associated with earlier age of onset of the disease.
- The IL1A genotype associates with atopy in nonasthmatic adults
- Review. The IL-1 family consists of IL-1alpha and IL-1beta, 2 receptors, and a specific receptor antagonist, IL-1Ra. The balance between IL-1 & IL-1Ra in local tissues plays an important role in the susceptibility to & severity of many diseases.
- IL-1A allele 2 is a risk factor for Alzheimer's disease (AD) in a dose-dependent manner, the risk of developing AD with two copies of the IL-1A allele 2 being approximately double that of one copy of the IL-1A allele 2.
- relationship between interleukin-1A (IL-1A) gene polymorphisms and the susceptibility of chronic periodontitis in Uighur minority in Xingjiang province of China
- IL1-alpha induced during in vitro activation of mast cells by cystic fibrosis-associated Pseudomonas aeruginosa stimulates neutrophil transendothelial migration.
- investigated interleukin polymorphisms in ovarian cancer but did not find any association between common polymorphisms of interleukin 1A, interleukin 1B, and interleukin 1 receptor antagonist and the occurrence of ovarian cancer
- We have identified a novel regulatory sequence at -65 to -41 of the human IL-1alpha promoter
- a "defective" IL-1ra response to IL-1 may underlie, at least in part, the exaggerated prostaglandin-endoperoxide H synthase (PGHS)-2 induction in orbital fibroblasts
- the CTG haplotype of the IL1A gene may be an important marker for the susceptibility to, and the severity of, systemic sclerosis
- that a DNA binding protein containing the Ets domain is constitutively expressed in fibroblasts from the skin of systemic sclerosis patients and regulates transcription of the IL1A gene, contributing to the fibrogenic phenotype of fibroblasts
- soluble form of the IL-1 receptor accessory protein (AcP) increases the affinity of binding of human IL-1alpha and IL-1beta to the soluble human type II IL-1 receptor
- In conjunctiva of keratoconjunctivitis sicca patients.
- The association of the TN7(delTTCA)A haplotype with higher levels of IL-1 alpha expression and reduced risk for ESRD is consistent with involvement of cytokines in risk for developing nephropathy.
- may enhance the local production of CCL3, which may interact with CCR1 expressed on hepatoma cells, in an autocrine and/or paracrine manner
- Low levels of IL-1 alpha mrna expression are associated with an increased risk for cancer specific death in patients with bladder cancer.
- TNF-alpha & IL-1 produced by sickle leukocytes are the primary factors responsible for the observed CAM expression. This & the subsequent endothelial adherence of sickle erythrocytes play roles in the pathophysiology of sickle-related complications.
- IL-1A was used to stimulate epidermal keratinocytes in organ culture.
- no one particular polymorphism in the IL-1 gene cluster yields an advantage for survival in the last decades of life
- Activation of vascular endothelial cells by IL-1alpha released by a pulmonary epithelial cell line infected with respiratory syncytial virus.
- the constitutively up-regulated expression of pre-IL-1 alpha in the nuclei of systemic sclerosis (SSc) fibroblasts up-regulates proliferation and matrix production of SSc fibroblasts through binding necdin
- Monoallelic expression of IL-1 alpha is observed in Th0, Th1, and Th2 cell clones from healthy individuals, as well as in synovial fluid of the knee joint derived from rheumatoid arthritis patients.
- confirm the role of uPA in acantholysis and suggest an involvement of IL-1alpha/TNF-alpha in uPA induction
- In pancreatic cancer, IL-1alpha enhanced alpha(6)beta(1)-integrin expression, probably via increased IL-1RI levels.
- Proapoptotic stimuli upregulate MCP-1 expression by vascular smooth muscle cells through release of interleukin-1alpha.
- IL-1alpha activity in chondrocytes is independent of any direct modification in UDPGD activity and manifests equally in human cartilage of all ages
- Cancer cell-derived cytokines, such as IL-1 alpha, induce cachexia by affecting leptin-dependent metabolic pathways.
- serum IL-1 alpha and IL-1 soluble receptor type 2 levels in women with ovarian cancers were significantly higher than those in cervical cancer, and in patients with benign disorders, and in healthy control
- In IL-1 alpha transgenic mice, which may overproduce membrane-associated (MA)IL-1 as well as soluble IL-1 alpha, severity of arthritis highly correlates with MA-IL-1 activity rather than with soluble IL-1 alpha activity or serum IL-1 alpha concentration.
- The IL-1alpha-889 polymorphism, previously shown to predispose to increased IL-1 protein expression, may be involved in susceptibility to systemic sclerosis
- Precursor form of IL-1alpha was overexpressed in various cells and assessed for activity in the presence of saturating concentrations of IL-1 receptor antagonist
- polymorphisms of IL1A (G/T at +4845) and IL4RA (T/C at +22446) show an epistatic effect on the risk of atopy
- cells of keratinocyte origin (SCC 12F) respond to a single physiologic dose of solar-simulated irradiation with both early (8 h) and late (72 h) peaks of IL-1alpha mRNA induction
- The presence of high amounts of intracellular IL-1alpha in human dermal fibroblasts suggests that these cytokines may carry out important function inside cells
- (125)I fibrinogen demonstrated no specific interaction of IL-1alpha with fibrinogen
- The results suggest a possible contribution of the IL-1 gene locus polymorphisms to the pathogenesis of LBP.
- IL-1beta is the critical regulator of tuberculosis-stimulated CCL5 secretion in the lung.
- IL-1 evokes a complex gene expression program in endothelial cells that includes positive but also negative (feedback) regulators of diverse endothelial cell functions.
- Potential in tissue repair for injured human keratinocytes
- Data show that interleukin 1-alpha (IL-1a) is an important autocrine fibrogenic factor in systemic sclerosis (SSc) and suggest that inhibition of intracellular IL-1a may be a novel strategy for the treatment of SSc.
- The polymorphism distributions of IL-1alpha (-889C/T) showed no differences between the essential hypertension group and control group.
- IL-1-inducible phosphorylation of p65 NFkB is mediated by multiple protein kinases including IKKalpha, IKKbeta, IKKepsilon, TBK1, and an unknown kinase and couples p65 to TAFII31-mediated IL-8 transcription
- A potent cytokine stimulus for IL-8 RNA stabilization in breast cancer cells.
- SHP-2 has a role in regulating IL-1-induced Ca2+ flux and ERK activation via phosphorylation of PLCgamma1
- serum IL-1 and TNF-alpha are reduced significantly by calcitriol during osteoporosis
- Cellular and subcellular expression of TNF-alpha, IL-1alpha and IL-6 in hepatocytes inx chronic hepatitis C.
- IL-1alpha, TNF-alpha, CCL20, CCL27, and CXCL8 alarm signals are induced in human cells after allergen and irritant exposure
- polymorphisms may play an important role in determining generalized aggressive periodontits susceptibility in Chinese males
- essential role for soluble factors, mainly IL-1alpha and bFGF, in the stimulation of dermal fibroblasts by human melanoma cells to secrete MMP-1.
- The significant associations between VEGF and the levels of IL6 and IL1 alpha suggest an important role for these cytokines in the development of these tumours.
- White carriers of the (+484)T haplotype were at increase risk of spontaneous preterm birth.
- Two polymorphisms within the IL-1 gene cluster are associated with ESRD independent of race
- individuals carrying the positive genotype have significantly greater risk for developing periodontitis
- Polymorphisms associated with control of gene expression and protein levels were not associated with occurrence of chronic idiopaathic leukemia in adults and were not responsible for the increased cytokines.
- IKKbeta phosphorylates multiple p65 sites, as well as in an IkappaB-p65 complex, and S468 phosphorylation slightly reduces TNF-alpha- and IL-1beta-induced NF-kappaB activation
- Data demonstrates that IL-1alpha and COX-2 mRNA are frequently co-expressed in human gastric cancer tissues, and suggest that the IL-1alpha-COX-2 pathway might be involved in tumor progression by regulating cancer cell proliferation.
- N-terminal IL-1alpha propiece increases ECV304 tumor cell motility.
- The proteolytic activation of pro-MMP-9 in skin inflammatory diseases likely occurs via a pathway including IL-1alpha.
- GBF1 is recruited to the endogenous IRF-9 promoter, and interacts with C/EBP-beta, IL-1, and IL-6
- there is no genetic association between IL1A gene polymorphism and outcome after head injury
- enhances tissue type plasminogen activator production in human pulp cells
- induces alkaline phosphatase, osteonectin, and osteocalcin in tooth mineralization and may play a role in the cytoprotection of pulp cells via heme oxygenase-1 expression
- significantly increases infective endocarditis incidence due to a platelet releasate-susceptible Streptococcus oralis strain, with rapidly increasing numbers of bacteria within the vegetations.
- IL-1 alpha is secreted by middle ear epithelial cells upon exposure to NTHi components and that it can synergistically act with certain of these molecules to up-regulate beta-defensin 2 via the p38 MAP kinase pathway.
- Genetic variations in pro-inflammatory IL-1alpha may predict the clinical outcome of breast carcinoma.
- In conclusion, incubation of normal or GD thyrocytes with Th1 cytokines induces a significant reduction in TSH-increased expression of both TPO and ThOXs, an effect partially mediated by NO.
- IL-1alpha can induce selective upregulation of alpha6beta1-integrin and uPA/uPAR in pancreatic cancer cells and these changes may modulate the aggressive functions of pancreatic cancer.
- vitamin D modulates cutaneous inflammatory reactions, at least in part, by increasing the IL-1Ra to IL-1alpha ratio and suppressing IL-18 synthesis in keratinocytes
- icIL-1ra1 does not act at an intracellular level to alter IL-1 mediated signalling, and is effective in inhibiting IL-1 responses only when released in an ATP-dependent and cell type specific manner
- elevated production of IL-1alpha and TNF-alpha by in vitro stimulated whole blood cell cultures occurs in non-alcoholic fatty liver disease obese patients
- studies demonstrate a novel role for IL-1alpha in mediating a proliferative response to TGF-beta signaling
- Interleukin-1 alpha gene single nucleotide polymorphism is associated with negative response to cyclophosphamide therapy scleroderma patients with alveolitis
- NF-kappaB is probably the primary transcription factor by which cAMP counteracts the inhibition of erythropoietin gene expression by IL-1.
- allele-specific expression of IL-1alpha in CD4+ cells is achieved, at least in part, by differential methylation of the promoter
- the 4G/5G PAI-1 genotype influences the PAI-1 response to IL-1alpha and the modulatory effect of pravastatin
- results suggest elevation of IL1 in myometrium at the end of pregnancy initiates process of down-regulation of oxytocin receptors in advanced labour resulting in desensitization of the myometrium to elevated levels of oxytocin in blood during lactation
- Tyr-542 of SHP-2 modulates IL-1-induced Ca2+ signals and association of the ER with focal adhesions
- composite genotype was found to be significantly associated with severe chronic periodontitis
- a common polymorphism of the interleukin-1alpha gene is associated with the presence of polycystic ovary syndrome
- These findings reveal that nuclear localization of pre-IL-1alpha depends on the binding to HAX-1 and that biological activities might be elicited by the binding to both HAX-1 and IL-1RII in SSc fibroblasts.
- IL-1, FN, and FN-derivatives have interrelated roles in determining biomaterial-modulated macrophage function [review]
- This study proposes a novel mechanism of TIMP-1 regulation, which ensures an increased supply of the inhibitor after brain injury, and limits extracellular matrix degradation.
- Through the study of IRAK modification mutants, two parallel IL-1-mediated signaling pathways for NFkappaB activation, TAK1-dependent and MEKK3-dependent, were uncovered. These two pathways bifurcate at the level of IRAK modification.
- All the polymorphisms within the IL-1alpha gene are in strong linkage disequilibrium and not convincingly associated with fracture risk, BMD, or bone turnover.
- IL1 induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta
- PARP-1 haplotypes increased the risk of AD by interaction with the IL-1A -889 allele 2.
- Autocrine actions of endogenous IL-1 alpha, mediated via IL-1RI signaling, contribute to a proproliferative and proinflammatory phenotypic shift in toll like receptor-activated human vascular smooth cells.
- the gene polymorphisms of the promotor region of IL-1 alpha at position (-889) are likely to play a pathogenic role in idiopathic pulmonary fibrosis and in modification of its clinical presentation and severity
- IL-1 genotypes are associated with cytokine levels in patients with aggressive periodontitis and chronic arthritis
- +4845 alleles may influence post-scaling values of salivary aspartate aminotransferase and alanine aminotransferase
- Constitutively expressed IL-1alpha is critical for numerous interferon-gamma activities.
- Data showed that the frequencies of IL-1alpha(C-889) alleles are more than 0.95.
- PGE(2) induces the expression of proinflammatory cytokine IL-1alpha, which may potentially enhance the proneoplastic actions of the cyclooxygenase-2/PGE(2) signaling pathway.
- there is insufficient evidence to establish if a positive genotype status contributes to progression of periodontitis
- Stimulation of SW1353 cells with activin A suppressed IL-1alpha-induced, but not TNFalpha-induced, MMP-3 expression
- The SNP at +4845 affected enzymatic efficiency of the protease in cleaving pre-IL-1alpha. Pre-IL-1alpha with Ala, which was high in frequency in systemic sclerosis, was more resistant to be cleaved by proteases in human sera than pro-IL-1alpha with Ser.
- role in triggering NF-kappaB is negatively regulated by RBCK1
- study did not find an association between IL-1 gene cluster polymorphisms and glaucoma in this sample of Chinese subjects
- C/T polymorphism at position -889 of the IL-1alpha gene promoter region does not increase the risk of developing normal tension glaucoma
- A repeated measures two-level model of the proportion of sites bleeding on probing, which was adjusted for gender, average plaque index, probing depth, calculus, revealed a significantly lower proportion of bleeding sites in genotype-positive subjects.
- IL-1RAcP, MyD88, and IRAK-4 are the stable components of the endogenous type I interleukin-1 (IL-1) receptor signaling complex
- Dihydrotestosterone inhibits TNF-alpha-induced IL1A mRNA expression in rheumatoid synovial cells.
- The autonomous keratinocyte cytokine, IL-1alpha, selectively upregulates the expression of AMPs which may modulate innate epithelial cell immunity in skin and mucosa.
- in silico complete mRNA structures of the IL-1alpha and IL-1beta mRNAs in humans.
- results of the present study suggest that the IL1 gene complex does not play a major role in conferring susceptibility to schizophrenia in the Japanese population
- Fetal, but not adult, human cardiac tissues expressed detectable IL-1alpha mRNA.
- the IL1A (4845 GT and 4845 TT), IL1B (-511 CC), and TNFA (-238 AA and -308 GA) genotypes were associated with susceptibility to nasal polyposis in our study population
- There is an association between the IL-1 polymorphisms and chronic periodontitis.
- study suggests that the IL1RN VNTR, IL1A+4845, IL1B+3953 genes polymorphisms are not genetic markers of susceptibility to knee osteoarthritis in Turkish patients & are unrelated to clinical, radiological & laboratory characteristics of knee osteoarthriti
- The cellular colocalization of glutathione S-transferase omega-1 and interleukin-1 alpha suggests a functional interaction between both proteins which in part might explain the function of glutathione S-transferase omega-1 in cerebral atherosclerosis
- Statistical analysis revealed no difference in allele distribution for either gene. No association was observed between Generalized Aggresive Peridontitis and IL-1A (-889) gene polymorphisms in Brazilian patients.
- Defect in the local control of IL1 may be involved in the pathophysiology of endometriosis and related infertility.
- Association of interleukin-1A, interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms with multiple myeloma.
- Transcriptional responses of hman epidermal keratinocytes to cytokine IL1 are reported.
- In contrast with the adult tissues discussed above, which did not express IL-1alpha mRNA, commercially available human fetal tissue expressed IL-1alpha mRNA.
- IL-1RAcP687 functions in the IL-1 signal transduction and response. Furthermore, IL-1RAcP687 can associate with proteins involved in the upstream IL-1 signaling pathway such as IL-1RI, Tollip, and MyD88.
- Periodontitis-induced autoinflammatory response also may play a role in the development/severity of Behcet's disease and recurrent aphtous stomatitis via IL-1 alpha and beta gene alteration.
- B19 capsid antigen did not promote positive response for production of IL1A.
- higher serum IL1beta but not IL1alpha in postmenopausal mastalgia
- Pellino isoforms may be the E3 ubiquitin ligases that mediate the IL-1-stimulated formation of K63-pUb-IRAK1 in cells, which may contribute to activation of IKKbeta and transcription factor NF-kappaB, as well as signalling pathways dependent on IRAK1/4
- the IL-1 alpha -889 C allele may be involved in response failure and sequential progression into the development of hemophagocytic lymphohistiocytosis.
- combination of IL-1A+4845 T and IL-1+3954 T alleles yielded a strong association with rheumatoid arthritis and periodontitis
- These results suggest that the IL-1alpha-mediated deterioration of insulin signaling is largely due to the IL-6 production and SOCS3 induction in 3T3-L1 adipocytes.
- The paper demonstrates that the proinflammatory cytokine interleukin-1 (IL-1) plays an essential role in chlamydial induction of the chemokine IL-8.
- Specific cytokines (IL-1alpha, IL-4, and IL-6) are acutely elevated during hyperglycemia in children with type 1 diabetes, and these elevations persist for hours after hyperglycemia has been corrected.
- Set-association analysis did not reveal an independent or an interactive effect of these IL-1 alpha on the PD risk.
- interleukin-1 gene polymorphisms may have roles in lymphoid follicle development in patients with gastritis
- Constitutive suppression of IL-1alpha maintains quiescence of endothelium and that terminal complement complexes remove that suppression, allowing IL-1alpha transcription and, ultimately, activation of endothelium to proceed.
- In Korean women, an association was found between -889C/T polymorphism in the regulatory region of the IL-1alpha gene and body mass index.
- Subjects with type 2 diabetes have an increased risk for periodontitis, which is aggravated further if combined with the variant IL-1A/1B genotype.
- IL-1alpha may play a role in liver metastasis of gastric cancer via enhanced vascular endothelial cell proliferation and angiogenesis.
- Patients with irritant contact dermatitis with the polymorphism IL1A-889 (C-->T)had lower concentrations of IL-1 alpha. authors conclude that altered expression may lead to differences in the inflammatory response of the skin.
- This case-control study evaluated polymorphisms in cytokine genes and the occurrence of occupational chronic irritant contact dermatitis. For IL1A -889, prevalence of dermatitis was lower with T/T or C/T genotype suggesting a protective effect.
- activation of the TRPM8 variant in human lung epithelial cells leads to increased expression of IL-1alpha, -1beta, -4, -6, -8, and -13, granulocyte-macrophage colony-stimulating factor (GM-CSF), and TNF-alpha.
- polymorphism is not associated with the presence of pulmonary aspergillosis infection; but in combination with IL1Ra and IL1b genotypes may predict disease susceptibility
- These data do not suggest that genetically determined changes in the IL-1 or TNFalpha genes confer increased susceptibility to suicidal behavior.
- genetically determined IL-1alpha levels may modulate transcription of calpain and calpastatin. This could reduce the impact of IL1A genotype on IL-1alpha secretion
- Our results provide evidence that, in the majority of cases, polymorphism in IL1A and IL1B is not a major contributor to genetic susceptibility to RA.
- Higher prevalence of heterozygosity for IL-1alpha(+4845) was found in cases (65%) when compared to controls (35%) (P < 0.05). In this Turkish population, susceptibility to LAgP is increased by heterozygosity for allele 1 of IL-1alpha(+4845)
- IL-1alpha in skin differentially modulates the immune response to scarification with vaccinia virus
- IL-1 alpha was intensively expressed throughout the epithelium in all cases, while mild expression of IL-1 alpha was detected in the subepithelial layer endothelial cells and fibroblasts of keratocystic odontogenic tumors.
- IL-1alpha released by epithelial cells triggers the production of IL-1alpha by stromal cells in a paracrine amplification loop during menstruation and dysfunctional bleeding.
- To test whether polymorphisms in IL-1, NF-KB, FAS, and FASL genes are associated with risk of silicosis.
- Fibroblasts that overexpress ST18 by transient transfection exhibit significantly increased apoptosis and increased expression of TNF-alpha, interleukin (IL) -1alpha, and IL-6.
- The results reveal that it is not likely that the IL-1A C(-889) T polymorphism is involved in Alzheimer's disease pathogenesis in the Chinese population.
- We found no evidence that the gene polymorphism of IL-1A (p = 0.082) and overall gene polymorphism in any of the genes (p = 0.752) correlate with periodontitis.
- in a coronary heart disease population IL-1 alpha and beta gene polymorphisms may be involved in increased central obesity, and the genetic influences are more evident among patients who have a higher level of obesity or inflammatory markers
- In a Canary Island population, IL-1 alpha promoter polymorphism -889 C/T is not associated with Alzheimer disease.
- Single nucleotide polymorphisms in genes of the IL1 cluster: IL1A and IL1B are not associated with aggressive periodontitis in northern European Caucasian patients.
- There was no significant difference in the genotype or allele distributions of the IL1A -889 C/T and IL1B +3954C/T polymorphisms in patients with toxoplasmic retinochoroiditis when compared with controls.
- Results suggest that interleukin-1 receptor type II overexpression is likely, through activation of the IL-1alpha precursor pathway, to enhance cell migration.
- TNFalpha and IL-1 genetic polymorphisms contribute to the development of juvenile dermatomyositis and may also be indicators of disease severity
- The expression of this gene and its polymorphism directly influence activity or the expression level of its protein product.
- Report downmodulatory effect of the antihistaminic drug bepotastine on IL-1alpha expression in human keratinocytes.
- No overall association was found between prostate cancer risk and IL1-A or MCP-1 polymorphisms.
- our preliminary data support the hypothesis the IL1A variants are not associated with Alzheimer's disease
- Interleukin-1 and tumor necrosis factor-alpha induce collagenolysis and bone resorption by regulation of matrix metalloproteinase-2 in mouse calvarial bone cells.