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Validated All-in-One™ qPCR Primer for SIGLEC9(NM_001198558.1) Search again
Product ID:
HQP066242
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CD329, CDw329, FOAP-9, OBBP-LIKE, siglec-9
Gene Description:
sialic acid binding Ig like lectin 9
Target Gene Accession:
NM_001198558.1(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- Binding studies on recombinant human Siglec-9 show recognition of both Neu5Ac and Neu5Gc; in striking contrast, chimpanzee and gorilla Siglec-9 strongly prefer binding Neu5Gc.
- Siglec-7 and Siglec-9 are capable of negative regulation of TCR signaling and ligand binding is required for optimal activity
- Siglec-9 can inhibit Fc epsilon receptor I-mediated serotonin release from rat basophilic leukemia cells and recruit the tyrosine phosphatases SHP-1 and SHP-2.
- data suggest that apoptotic (ROS- and caspase-dependent) and nonapoptotic (ROS-dependent) death pathways are initiated in neutrophils via Siglec-9
- Siglecs-9 did not interact with sulfate derivatives of LacNAc and sulfated oligosaccharides containing sialic acid.
- The Siglec-9 provides not only a useful marker for certain subsets of AML, but also a potential therapeutic target.
- These results demonstrate that Siglec-9 enhances the production of the anti-inflammatory cytokine IL-10 in macrophages.
- A review of the cytotoxic effects of natural anti-Siglec9 autoantibodies on both neutrophils and eosinophils.