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Validated All-in-One™ qPCR Primer for HAVCR2(NM_032782.4) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.[supplied by OMIM].
Gene References into function
- Tim-3 gene associated with rheumatoid arthritis
- the -574T > G polymorphism of Tim-3 might be associated with the susceptibility of atopic diseases
- Human Tim-3 can promote HAV entry into target cells but itself may not function as a cellular receptor of HAV.
- Failure to up-regulate T cell expression of TIM3 in inflammatory sites may represent a novel, intrinsic defect that contributes to the pathogenesis of multiple sclerosis and other human autoimmune diseases.
- Stimulation of Tim-3 by its ligand galectin-9 results in increased phosphorylation of Y265, suggesting that this tyrosine residue plays an important role in downstream signalling events regulating T-cell fate.
- Expressed in melanoma cell lines at higher level than in isolated epidermal melanocytes, which can contribute to lower adhering capacity of tumor cells. TIM-3 in TGF-beta-stimulated mast cells and melanoma cells may support survival of this tumor type.
- High expressionof TIM-3 in in acute kidney transplant rejection makes it a promising noninvasive test for its diagnosis.
- T-cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) influences autoimmune diseases, and its role in other inflammatory diseases including allergies and cancer is becoming clear.
- data show that Tim-3 is highly expressed by cells of the innate immune system and that its expression on antigen-presenting cells promotes the secretion of proinflammatory cytokines from monocytes and dendritic cells
- Involved in the pathogenesis of systemic lupus erythematosus.
- multiple sclerosis may function in part by restoring TIM-3 immunoregulation of T cell function
- role of the rs10515746 (A/C), rs1036199 (A/C), and rs10053538 (A/C) SNPs within the TIM-3 gene in 186 German type 1 diabetes families and its interaction with human leukocyte antigen (HLA) high-risk haplotypes
- increase of TIM-3 expression on PBMCs, overproduction of IFN-gamma in the sera, and increased galectin-9 in PBMCs was observed in acquired aplastic anemia patients
- Data show that blockade of the Tim-3 pathway can enhance HIV-1 - specific T cell responses, and suggest that the Tim-3 pathway plays a critical role in suppressing the overall T cell response to HIV-1.
- Tim-3 messenger RNA evaluation in renal transplant recipients is a noninvasive method to evaluate graft dysfunction.