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Validated All-in-One™ qPCR Primer for TNFSF4(NM_003326.4) Search again
Product ID:
HQP018329
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CD134L, CD252, GP34, OX-40L, OX4OL, TNLG2B, TXGP1
Gene Description:
TNF superfamily member 4
Target Gene Accession:
NM_003326.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells. [provided by RefSeq].
Gene References into function
- Expression of CD134 and CD134 ligand in lesional and nonlesional psoriatic skin.
- combined use of a vector driving the expression of OX40L with three other costimulatory molecules (B7-1, ICAM-1, and LFA-3) both enhances initial activation and then further potentiates sustained activation of nai;ve and effector T cells.
- An OX40L-dependent mechanism is demonstrated in plasmacytoid dendritic cell-mediated T helper cell responses; OX40L selectively induces Th2-type immune responses by promoting CD4+ T cells to secrete IL-4, IL-5, and IL-13.
- Elucidation of cross-talk between OX40 and OX40L could be very important in understanding interaction of cells present in inflamed airways of asthma.
- an increasing amount of gp34/OX40L expression leads to an increasing level of up-regulation of the allogeneic CD4+ T-cell response by dendritic cells
- Activated human natural killer (NK) cells are able to help T-cell receptor-stimulated autologous CD4+ T cells by a process that involves both OX40 ligand and B7 antigen costimulation.
- T cell proliferation by direct cross-talk between OX40 ligand on human mast cells and OX40 on human T cells.
- Single Nucleotide polymorphism in TNFS4 increase the risk of Arteriosclerosis
- OX40L costimulates human antiviral memory CD8 T cell responses largely through indirect effects and can enhance anti-influenza, anti-EBV, and anti-HIV responses, particularly in combination with 4-1BBL or B7.
- OX40L on thymic stromal lymphopoietin-activated dendritic cells triggers T helper type 2 (Th2) cell polarization in the absence of IL-12, and can switch IL-10-producing regulatory Th cell responses into TNF-alpha-producing inflammatory Th cell responses.
- OX40 ligand (OX40L) completely inhibited the generation of IL-10-producing CD4(+) type 1 regulatory T (Tr1) cells from naive and memory CD4(+) T cells induced by the immunosuppressive drugs dexamethasone and vitamin D3.
- the quantitation of sOX40L was correlated with the age and among these subjects, those of 70s and 80s have much higher sOX40L concentration than those of 60s
- The demonstrate rapid infiltration of activated (OX40(+)) CD4(+) T cells into HSV-1-infected corneas and expression of OX40L on MHC Class II-negative cells, which are present in the infected corneas and required for HSK.
- study findings indicate that functional OX40L is inducible on human activated CD4+ and CD8+ T cells, and that the expression is enhanced by TGF-beta1
- TSLP-induced molecule on dendritic cells that triggers inflammatory T(H)2 differentiation in the absence of IL-12. Review.
- OX40 ligand (OX40L) is a critical in vivo mediator of TSLP-mediated Th2 responses.
- Our present findings, if corroborated in other prospective investigations, suggest that the TNFSF4 variants tested may be useful indicators for assessing the risk of venous thromboembolism.
- Results show that the OX40-OX40L interaction suppresses IL-17 production by PHA-stimulated human PBMC and purified CD4 and CD8 cells.
- human primary T cells are programmed to rapidly express functional OX40L molecules after stimulation under DNA-damaging conditions, demonstrating that the induction of OX40L by T cells is independent of cell proliferation.
- thymic stromal lymphopoietin (TSLP) and human DCs plays an essential role in evoking inflammatory Th2 responses in allergy through OX40 ligand expression on DCs.
- allele frequencies and genotype distributions of TNFSF4 SNPs were not substantially different between the control group and the myocardial infarction group.