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Validated All-in-One™ qPCR Primer for CEACAM1(NM_001712.4) Search again
Product ID:
HQP016624
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
BGP, BGP1, BGPI
Gene Description:
CEA cell adhesion molecule 1
Target Gene Accession:
NM_001712.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily.
Gene References into function
- The expression ratio of the long-form and the short-form generated from CEACAM1 (C-CAM1) mRNA by alternative splicing differs significantly in primary NSCLC tissues.
- ability of N. gonorrhoeae to up-regulate its epithelial receptor CEACAM1 through NF-kappaB suggests an important mechanism allowing efficient bacterial colonization during the initial infection process.
- The expression of CD66a observed on NK cells from patients with malignant melanoma suggest the existence of a class I MHC-independent inhibitory mechanism of defense used by these cells to evade attack by CD66a-positive NK cells.
- Quaternary structure of coronavirus spikes in complex with carcinoembryonic antigen-related cell adhesion molecule cellular receptors
- Only the long cytoplasmic domain isoform of CEACAM1 is expressed in human granulocytes, B cells, and T cells, since GPI-linked CEA-related proteins have functionally replaced the short cytoplasmic domains in the human.
- High CEACAM 1 expression is associated with development of metastasis in primary cutaneous malignant melanoma patients
- inhibition of prostate tumor angiogenesis by the tumor suppressor CEACAM1
- Role of CEACAM1 protein in the inhibition of activated decidual lymphocyte functions.
- CEACAM1-4S mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture.
- CEACAM1 has a role in internalizing bacteria to epithelial cells
- CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II
- cholesterol is an essential membrane fusion cofactor that can act with or without CEACAMs to promote murine hepatitis virus entry
- The long and short cytoplasmic tails of CEACAM1 serve as inhibitory and costimulatory receptors, respectively, in T cell regulation.
- CEACAM1-4L (long), but not the -4S (short)isoform inhibits IL-2 production in transfected Jurkat cells, while CEACAM1-4S, but not the -4L isoform inhibits proliferation in transfected Kit-225 cells.
- the N-domain of CEACAM1 does not show evidence of recombination
- The sequential digestions clearly identified several different Lewis x glycan epitopes, which may modulate the cell adhesive functions of CEACAM1
- The amino-terminal end of CEACAM1 interacts with CEACAM5, but not with CEACAM6. Both CEACAM1 and CEACAM5 contain the Arg and Gln residues in positions 43 and 44, respectively, whereas CEACAM6 contains 43-Ser and 44-Leu.
- CEACAM1 and alpha(v)beta(3) integrin are functionally interconnected with respect to the invasive growth of melanomas
- constitutive expression of CEACAM1 in microvascular endothelial cells switches them to an angiogenic phenotype, whereas CEACAM1 silencing apparently abrogates the VEGF-induced morphogenetic effects during capillary formation
- failure of the maturing colon cell to express CEACAM1 is likely to contribute to the development of hyperplastic lesions
- role in developing of hyperplastic polyps leading to colon cancer
- CEACAM1 is up-regulated in endothelial cells of angiogenic blood vessels. This in turn is involved in the switch from noninvasive and nonvascularized to invasive and vascularized bladder cancer.
- transmembrane CEACAM1-L expressed on endothelial cells is implicated in the activation phase of angiogenesis by affecting the cytoskeleton architecture and integrin-mediated signaling
- Heterophilic interactions of carcinoembryonic antigen and CEACAM1 inhibit killing by natural killer (NK) cells. The N-terminal domain of CEACAM1 is crucial but not sufficient for both CEACAM1-CEACAM1 homophilic and CEACAM1-CEA heterophilic interactions.
- OPN and CEACAM1 may act as a functional complex involved in the regulation of placental invasiveness.
- Data show that variants of Neisseria gonorrhoeae that bind to human carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) 1 and 6 failed to induce detachment and, instead, promoted enhanced host cell adhesion to the ECM.
- Binding of DC-SIGN to both CEACAM1 and Mac-1 is required to establish cellular interactions with neutrophils.
- findings suggest that CEACAM1 participates in immune regulation in physiological conditions and in pathological conditions, such as inflammation, autoimmune disease, and cancer
- The expression of CEACAM1-L led to an increased phosphorylation of focal adhesions and to altered cytoskeletal rearrangements during monolayer wound healing assays.
- first report demonstrating that activators of PKC are able to specifically induce the expression of CEACAM1 in human carcinoma cells
- data show that disappearance of epithelial CEACAM1 in PIN is accompanied by its upregulation in adjacent vasculature which apparently correlates with vascular destabilization and increased vascularization of prostate cancer
- study shows the expression pattern of osteopontin in cellular populations of normal endometrium and in endometrial carcinoma and its correlation with the expression of CEACAM1
- This Review considers the evidence for CEACAM1 involvement in immunity, with emphasis on its functions as a regulatory co-receptor for both lymphoid and myeloid cell types.
- CEACAM1 may be an interesting progression marker in squamous intraepithelial lesions and cervical cancer, in particular due to reported immunoregulatory properties.
- the N-terminal domain of human CEACAM1 contains the binding target of the opacity proteins during invasion of Neisseria meningitidis and N. gonorrhoeae
- studies imply that distinct polymorphisms in human epithelial CEACAMs have the potential to decrease or increase the risk of infection by the receptor-targeting pathogens
- CEACAM1 functions as a key regulator of contact-dependent control of cell survival, differentiation, and growth by controlling both ERK/MEK and PI3K/Akt pathways
- High expression of CD66a was significantly correlated with tumor invasion, stage, and pre-operation serum carcinoembryonic antigen level.
- In conclusion, M. catarrhalis induced apoptosis in pulmonary epithelial cells--a process that was triggered by interaction between CEACAM1 and UspA1.
- Phosphorylation mimic mutants at either Thr457 or Ser459 (or both), but not null mutants in CEACAM1-4S were able to restore glandular lumen formation.
- Epithelial downregulation of CEACAM1 in superficial bladder tumors and in PIN of the prostate. Concurrently, CEACAM1 is upregulated in endothelial cells of tumor blood vessels.
- data reveal the dual role of CEACAM1 on hepatocarcinogenesis; CEACAM1 acts as tumor suppressor in HepG2 cells in anchorage-depend. growth conditions; in anchorage-independent growth cond it augments cell proliferation by potentiating cell-cell attachment
- Meningococcal outer membrane vesicle (OMV)preparations bind the immunoreceptor tyrosine-based inhibitory motif-containing coinhibitory receptor CEACAM1 and inhibit T-cell activation and proliferation.
- PDIP38 can shuttle between the cytoplasmic and the nuclear compartments and that its subcellular localization is regulated by CEACAM1
- interaction of CEACAM1 with Prox1 and VEGFR-3 plays a crucial role in tumor lymphangiogenesis and reprogramming of vascular endothelial cells to lymphatic endothelial cells
- The studies demonstrate the importance of CEACAMs as mediators of increased cellular invasion under conditions of inflammation and bring to light the potential role of NFkappaB pathway in Opa-mediated invasion by meningococci.
- Haplotypic diversity in CEACAM genes: effects on susceptibility to meningococcal disease.
- It is reported here that hCEACAM1-4L has a key function in downregulating the protein tyrosine Src kinase associated with hDAF signalling.
- These data argue for a functional role of lipid rafts in CEACAM1-mediated endocytosis that is promoted by the transmembrane domain of the receptor and that might be relevant for CEACAM1 function in physiologic settings.
- high CEACAM-1 expression is associated with an increased angiogenic activity in non-small-cell lung cancer and that the prognostic influence of CEACAM-1 might be derived from this association
- CEACAM1-dependent cell death pathway involves dual cleavage of CEACAM1 and caspase activation and can be activated by CEA.
- CEACAM1 orchestrate an inhibitory program that abrogates extremely proximal events downstream of the TCR/CD3 complex by focusing on the activation of ZAP-70.
- There is a functional role for the long cytoplasmic domain of CEACAM1 in regulation of beta-catenin activity.
- bacteria effectively harness the coinhibitory function of CEACAM1 to suppress the adaptive immune response at its earliest step.
- This explains how UspA1 can engage CEACAM1 at a site far distant from its head group, permitting closer proximity of the respective cell surfaces during infection.
- network of regulatory elements control the alternative splicing of CEACAM1
- Micrometastases of gastric cancer can be detected in circulating peripheral blood using quantitative real-time RT-PCR. CK19 is a better marker than CK18, CK20 and CEA
- CEACAM1 is a direct target of SOX9 in the colon epithelium
- This finding is of particular interest, as it identifies a strategy by which bacteria 'use' CEACAM1 to colonize the pulmonary epithelium.
- cytokine-induced cell-surface expression of CEACAM1 by keratinocytes in the context of a psoriatic environment might contribute to the persistence of neutrophils and thus to ongoing inflammation
- Data show that desensitization of neutrophils to any two CEACAMs, 1, 3, 6, or 8, results in selective desensitization to those two CEACAMs, while the cells remain responsive to the other two neutrophil CEACAMs.