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Validated All-in-One™ qPCR Primer for PVR(NM_006505.4) Search again
Product ID:
HQP015954
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CD155, HVED, NECL5, Necl-5, PVS, TAGE4
Gene Description:
PVR cell adhesion molecule
Target Gene Accession:
NM_006505.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication.
Gene References into function
- We propose that the cytoplasmic domain may target CD155-containing endocytic vesicles to the microtubular network
- activation of expression of sonic hedgehog protein
- Data show that both PVR and Nectin-2 represent specific ligands for the DNAM-1 triggering receptor.
- CD155 may have an important role in cellular function
- These data indicate that Tage4 represents the functional orthologue of CD155 in mouse.
- that DNAM-1 regulates monocyte extravasation via its interaction with CD226 expressed at endothelial junctions on normal cells.
- These results suggest that CD155alpha plays a role in the regulation of cell adhesion and cell motility.
- cytoplasmic domain of PVR directly interacts with Tctex-1 and plays an important role in retrograde transport of poliovirus-containing vesicles along microtubules in vivo
- Upregulation of the molecular target CD155 renders explant cultures of high-grade malignant gliomas highly susceptible to a prototype oncolytic poliovirus recombinant.
- Analysis of the ligands for triggering NK receptors revealed the consistent expression of cd155 and cd112 in myeloid leukemias, and less frequent expression in lymphoblastic leukemias
- Evasion of NK cell killing was mediated by human cytomegalovirus UL141 blocking surface expression of CD155
- Necl-5 has a critical role in integrin alphavbeta3 clustering and focal complex formation
- Results describe the establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptor.
- no statistically significant association between this marker allele and non-syndromic clefting
- CD155, at least in part, enhances the proliferation of ras-mutated cells
- crystal structure of C155 D1D2 has been determined to 3.5-A resolution and fitted into approximately 8.5-A resolution cryoelectron microscopy reconstructions of the virus-receptor complexes for the 3 PV serotypes
- CD96-driven adhesion to CD155 may be crucial in developmental processes