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Validated All-in-One™ qPCR Primer for PRKCD(NM_006254.3) Search again
Product ID:
HQP014731
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ALPS3, CVID9, MAY1, PKCD, nPKC-delta
Gene Description:
protein kinase C delta
Target Gene Accession:
NM_006254.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members.
Gene References into function
- PKC-delta selectively inhibits H2 histamine receptor-mediated activation of nonselective cation channels in differentiating granulocytic cells.
- Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta.
- role in regulation of eosinophil NADPH oxidase activity
- that the PKC delta pathway plays an important role int the control of human keratinocyte migration
- activation by type I interferons and mediation of Stat1 phosphorylation on serine 727
- Calcium-dependent involucrin expression is inversely regulated by protein kinase C (PKC)alpha and PKCdelta.
- Switch chimeras, containing the C1B from epsilonPKC in the context of deltaPKC (delta(epsilonC1B)) and vice versa (epsilon(deltaC1B)), were generated and tested for their translocation in response to ceramide and arachidonic acid.
- Phosphorylation of MUC1 by PKCdelta increases binding of MUC1 and beta-catenin in vitro and in vivo.
- results indicate that PKCdelta plays a crucial role in activating anticancer drug-induced apoptosis signaling by amplifying the ceramide-mediated mitochondrial amplification loop.
- PMA activated the promoter activity of the 12(S)-lipoxygenase gene in cells PKCdelta but not PKCalpha, indicating that PKCdelta played the functional role in mediating the gene activation of 12(S)-lipoxygenase induced by PMA.
- intracellular Cl(-) (Cl) regulates the activity of protein kinase C (PKC)-delta and thus the activation of Na-K-Cl cotransport
- PLD1 is threonine-phosphorylated in human-airway epithelial cells by a PKCdelta dependent mechanism
- PKC delta expressed in human neutrophils can phosphorylate p47phox and induce both its translocation and NADPH oxidase activation as well as the binding of p47phox to the cytosolic fragment of p22phox.
- Novel isoforms regulate human keratinocyte differentiation by activating a p38 delta mitogen-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha.
- REVIEW:Interaction of protein kinase C isozymes with membranes containing anionic phospholipids utilizing fluorescent phorbol esters to probe the properties of the C1 domains
- contributes to apoptosis by regulating p73beta protein
- role for the PKC-delta isoenzyme in regulating HLA class II-mediated apoptosis of mature dendritic cells
- Data show that protein kinase C delta (PKC delta) is located downstream of RhoA and that active RhoA and PKCdelta are both necessary for leukotriene D(4)-induced stress-fibre formation.
- Role of nuclear PKC delta in mediating caspase-3-upregulation in Jurkat T leukemic cells exposed to ionizing radiation
- Activation is required for oxidant-induced disruption of both the microtubule cytoskeleton and permeability barrier of intestinal epithelia
- PKC delta associates with IL6ST via Stat3 and enhances Stat3-gp130 interaction
- PKC mediates VEGF-induced Akt activation in a novel signal transduction pathway through which Akt can be regulated by growth factors acting through receptor protein tyrosine kinases, and may play an essential role in VEGF-stimulated angiogenesis.
- PKCdelta functions in the activation of SAPK through a Lyn --> PKCdelta --> MEKK1 --> MKK7 --> SAPK signaling cascade in response to DNA damage
- inhibits p300 intrinsic histone acetyltransferase activity after phosphorylation at serine 89
- tyrosine phosphorylation and activity of PKCdelta were dependent on PI-3K activity in B-CLL cells, and survival signals might be mediated via PKCdelta
- Down-regulation of hydrogen peroxide-induced activation of this enzyme in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells
- Protein kinase C delta-NF-kappaB signaling regulates VCAM1 stimulation by thrombin in endothelial cells
- selective modulation of PKC delta may regulate TNF-R1 signaling in intestinal epithelium.
- protein kinase c delta regulates apoptosis [review]
- affects on JunB expression and monocyte differentiation
- Il-2 and polysaccharide K increased expression of protein kinase C delta.
- This protein is responsible for constitutive and DNA damage-induced phosphorylation of rad9 protein.
- Phosphorylated PKCdelta, but not total PKCdelta, in dorsal root ganglion was decreased in diabetic rats. Decrease in phosphorylated PKCdelta is partly causes impaired neurite outgrowth in diabetes, and PKCdelta plays role in diabetic neuropathy.
- PLS3 is a downstream effector of PKC-delta in the mitochondria.
- data suggest that nuclear translocation and kinase activity of protein kinase C-delta are both necessary for saturated fatty acid-induced apoptosis
- Data suggest that phosphorylation of protein kinase C delta may act as a negative feedback mechanism to limit the overall activation of the CD98 pathway.
- Mediation of tumor growth factor beta-1 induced collagen I expression in glomerular mesangial cells.
- PKC delta regulates airway epithelial cell expression of NF-kappa B-dependent proinflammatory genes IL-8, GM-CSF, RANTES, and ICAM-1.
- The novel varepsilon and eta and atypical zeta, but not the conventional alpha and beta and the novel delta PKCs, may be involved in the signaling pathways involved in thrombin-induced human platelet P-selectin expression
- PKC-delta has a role in EGF protection of tumor cells from TNF-alpha-induced apoptosis
- PKC delta is activated in a retinoic acid-dependent manner and plays a critical role in the generation of the biological effects of retinoic acid in malignant cells
- the genomic structure of PRKCD was analyzed; exon-intron genomic structure is highly conserved among mammals, while significantly diverged in C. elegans
- Protein kinase C delta is activated during engagement of the type II interferon receptor and participates in IFN-gamma signaling.
- Protein kinase C-delta is a key downstream effector in the induction of interferon-beta-mediated survival of functional neutrophils at sites of inflammation.
- results indicate that activation of PKC is responsible for GnRH-induced phosphorylation of both ERK1/2 and Pyk2, and that Pyk2 activation does not contribute to GnRH signaling
- overexpression of PKC delta induced cIAP-2 promoter activity and increased NF-kappa B transactivation, suggesting regulation of cIAP-2 expression by a PKC delta/NF-kappa B pathway
- activation of mGluR5 causes translocation of both gammaPKC and deltaPKC to the plasma membrane. deltaPKC, but not gammaPKC, phosphorylates mGluR5 Thr(840), leading to the blockade of both Ca2+ oscillations and gammaPKC cycling.
- PKCdelta plays a positive role in protease-activated receptor-mediated dense granule secretion, whereas it functions as a negative regulator downstream of glycoprotein VI signaling
- results indicate that PKCdelta inhibits TPA-induced PLD1 activation mediated by PKCalpha through the association with PLD1
- Protein kinase C, delta negatively regulated IL-4-dependent expression of CD86.
- PKCdelta and PKCepsilon may offer novel targets for development of cancer preventive or therapeutic agents that selectively inactivate PKCepsilon or stimulate PKCdelta.
- MMP-9 inhibition activity of resveratrol and its inhibition of JNK and PKC-delta may have a therapeutic potential in cancer.
- PKC delta has a role in activating p53 transcription
- the targeting mechanism of PKCdelta, dual regulation of both its activation and translocation to the Golgi complex, is critical for ceramide-induced apoptosis
- Induction of neurites by the regulatory domain of PKCD is counteracted by PKC catalytic activity and RhoA GTP-binding protein metabolism.
- PKCdelta plays an important role in regulating 15-lipoxygenase expression in human monocytes and subsequently modulates the inflammatory responses mediated by 15-LO products
- propose a previously unrecognized function of plectin as cytoskeletal regulator of PKC signaling (dislocation of PKCdelta and elevated enzymatic activity), and possibly other signaling events, through sequestration of the scaffolding protein RACK1
- stimulus-specific modes for PKC delta signaling identified in this study allow for distinct PKC delta-mediated phosphorylation events and responses during growth factor stimulation and oxidant stress in cardiomyocytes
- Data show that activation of protein kinase D in response to oxidative stress requires two sequential signaling events, mediated by protein kinase Cdelta.
- Thus, a deregulation in PKCdelta was associated with reduced cellular sensitivity to cisplatin.
- PKD activation plays a central role in NT peptide secretion; upstream regulators of PKD include PKC-alpha and -delta and Rho/ROK
- Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis
- PKC delta (nPKC delta) might be predominantly involved in regulating membrane functions and survival of neutrophils associated with post ischemia reperfusion injury-induced inflammatory oxidative stress.
- EGF-mediated induction of fibronectin expression occurs at the post-transcriptional level and involves PKCdelta signaling pathway.
- Protein kinase Cdelta has a role in lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells
- Results identify protein kinase C delta as the kinase responsible for inactivation of serum response factor both in vitro and endogenously in senescent cells.
- heightened ERK and PKCdelta activity in high ambient glucose conditions interact with the Smad pathway, leading to enhanced responsiveness to TGF-beta1 and increased extracellular matrix production in mesangial cells.
- despite being an apoptotic effector activated late in the apoptotic cascade, PKCdelta also activates upstream components of the death effector pathway to insure the demise of cells committed to apoptosis
- as a protein induced upon PKCdelta activation, PLSCR1 is required for ATRA- and PMA-triggered leukemic cell differentiation
- Protein kinase Cdelta regulates apoptosis via activation of STAT1.
- Overexpression of dominant-negative PKCdelta mutant supported an essential role in virus reactivation, yet overexpression of PKCdelta alone was not sufficient to induce lytic reactivation of KSHV.
- p38delta mitogen-activated protein kinase as a downstream carrier of the PKCdelta-dependent death signal in keratinocytes
- Results suggest that a protein kinase C delta-reactive oxygen species-NF-kappaB cascade plays a pivotal role in cytosolic phospholipase A(2)alpha induction by phorbol 12-myristate 13-acetate.
- results showed that PKC beta(II) and delta isozymes are essential for the activation of IL-10 production in human monocytes following stimulation by HIV-1 Tat protein
- These findings indicate that signaling via PKCdelta-p38 kinase-linked cascade specifically induces expression of VCAM-1 in lung epithelium in response to TNF-alpha and that this effect is both functionally and clinically significant.
- Inhibition of PKCdelta is sufficient to lead to caspase-3-independent apoptosis in the colon cancer line, COLO 205.
- Protein kinase C delta plays a pivotal role in stimulating monocyte NADPH oxidase activity through its regulation of phosphorylation and translocation of p47phox.
- The delta isoform of protein kinase C (PKC) functions downstream of Ca 2+ in the signaling pathway from FcepsilonRI to degranulation in RBL-2H3 mast cells.
- p53 is an essential effector of PKCdelta in human colon cancer cells
- PMA transactivates the EGFR and increases cell proliferation by activating the PKCdelta/c-Src pathway in glioblastoma cells
- The cleavage and activation of PKC-delta are critical components of UV-induced apoptosis in human keratinocytes, and the inactivation of PKC-delta can promote the survival of keratinocytes exposed to UV radiation.
- MARCKS-mediated neurotensin release occurs via protein kinase C-delta downstream of the Rho/ROK pathway
- Involvement of c-Src and protein kinase C delta in the inhibition of Cl(-)/OH- exchange activity in Caco-2 cells by serotonin.
- PKC epsilon and delta are the main PKC isozymes involved in G alpha(q)-mediated signaling in human atria
- PKCdelta-dependent phosphorylation of caspase-3 is involved in the regulation of monocyte life span
- PKC-delta plays a major role in antiestrogen resistance in breast tumor cells
- NAG-1 expression is up-regulated by TPA in LNCaP cells through a PKC-dependent pathway involving the activation of NF-kappa B
- PKCdelta protects glioma cells from the apoptosis induced by TRAIL and implicate the phosphorylation of PKCdelta on tyrosine 155 and its cleavage as essential factors in the anti-apoptotic effect of PKCdelta
- extracellular signal-regulated kinase-mediated adhesion of beta(2)-integrin caused by IL-5 is mediated in human eosinophils by a class IA PI3K through activation of a PKCdelta pathway
- HSP25 downregulates PKCdelta, which is a key molecule for radiation-induced ROS generation and mitochondrial-mediated caspase-dependent apoptotic events.
- PKCdelta is a proproliferative factor in estrogen-dependent breast cancer cells.
- the C2 domain of PKCdelta directly binds to phosphotyrosine peptides in a sequence-specific manner
- PKC-mediated exclusion of LIMK2 from the nucleus might be a mechanism to relieve suppression of cyclin D1 expression by LIMK2
- the proteolytic fragment of PKCdelta does not play a critical role in the induction of apoptosis in human small cell lung cancer cells
- These results suggest that cisplatin-induced DNA damage results in activation of ERK1/2 via PKCdelta.
- results demonstrate a critical role for PKCdelta/NF-kappaB in the regulation of FLIP in human colon cancer cells
- results identify a novel link between PKCdelta and G1 arrest via p21 up-regulation and highlight the complexities in the downstream effectors of PKC isozymes in the context of cell cycle progression and proliferation
- the signaling network involving Smad-dependent TGFbeta, PKCdelta, and integrin alpha2beta1/alpha3beta1, regulates cell spreading, motility, and invasion of the SNU16mAd gastric carcinoma cell variant
- Results indicate that protein kinase C delta functions as a survival factor protecting MCF-7 cells from the apoptosis induced by recombinant soluble TRAIL.
- HNE stimulation of mucin release by human airway epithelial cells involves intracellular activation of PKC, specifically the delta isoform.
- PKC-delta inhibits transformed keratinocyte growth by inducing apoptosis, and may function as a tumor suppressor in human SCCs where its loss in cells harboring activated ras could provide a growth advantage by conferring resistance to apoptosis
- PKCdelta altered rates of alphaT663-hENaC biosynthesis and/or delivery to the plasma membrane. These data are consistent with PKC isoform-specific effects on the intracellular trafficking of alphaT663- vs. alphaA663-hENaC.
- protein kinase Cdelta and JNK have roles in Ifn-alpha induced expression of phospholipid scramblase 1 through STAT1
- GSK-3, acting through PKCdelta, is a negative regulator of ERK1/2
- These findings indicate that PKCdelta regulates p53 to induce apoptotic cell death in the cellular response to DNA damage.
- Results demonstrate a novel, central and exclusive involvement of PKCdelta in mediating the action of IGF-I on human skeletal muscle cells, with an additional yet PKCdelta-dependent contribution of the MAPK pathway on C2C12 myoblasts.
- activation of the c-Abl-PKCdelta-Rac1-p38 MAPK pathway in response to ionizing radiation signals conformational changes of Bak and Bax, resulting in mitochondrial activation-mediated apoptotic cell death in human non-small cell lung cancer cells
- results suggest that the protein complexes of PKCdelta through the association between the C1 and C2-like regions by different combinations.
- PKCdelta acts as a pro-survival kinase and that SYND2 inhibits the anti-apoptotic action of PKCdelta in osteoblast.
- curcumin activates antioxidant response element-mediated gene expression in human monocytes via PKC delta, upstream of p38 and Nrf2.
- Dexamethasone-induced Ras protein 1 does not alter the membrane translocation of PKCdelta.
- Investigations of the structural basis of PKC_delta's unusual independence of activation loop phosphorylation for in vitro kinase activity demonstrates unique activation loop stabilization and selective maintenance of in cell function in the T507A mutant
- This study unveiled the specificity of PKCdelta in the control of dermal fibroblasts migration.
- Taken together, these findings suggest that Bax and caspase activation, together with PKCdelta signaling are involved in c-Myc-dependent etoposide-induced apoptosis.
- PKCdelta regulates topoisomerase IIalpha and thereby cell fate in the genotoxic stress response.
- CCL22 stimulates phosphatidylinositol-3 kinase-independent phosphorylation of the novel delta isoform of PKC at threonine 505, situated within its activation loop--an event closely associated with increased catalytic activity.
- These results indicated that the activation of PKCdelta induced cell growth arrest in NPA thyroid cancer cells, through an ERK MAPK-p27(Kip1)-cyclin E-pRb pathway.
- SUMOylation and activation of ataxia-telangiectasia-mutated protein, PKCdelta, caspase-3, and nuclear factor kappaB signaling pathways modulate salivary adaptive responses to stress in cells exposed to either 1% O(2) or DFO.
- pVHL does not directly promote the degradation of PKCd nor does it inhibit catalytic activity in cells, indicating that distinctive signalling role(s) for the cellular complex characterize this interaction
- lysophosphatidic acid-induced IL-8 secretion is partly dependent on EGFR transactivation regulated by PKCdelta-dependent activation of Lyn kinase and MMPs and proHB-EGF
- the role of RhoA GTPase in protein kinase D activation depends on the cellular localization of protein kinase D
- PKCdelta is involved in the regulation of mitochondrial mass and intracellular H(2)O(2) in human cells and may play a key role in the overproliferation of mitochondria in the affected tissues of patients with mitochondrial diseases such as MERRF syndrome
- following cell activation, deltaPKC-annexin V binding is a transient and an essential step in the function of deltaPKC
- It involves phosphatidylinositol 3-kinase, PKC delta, and p47(phox) translocation and promotes ERK1/2 phosphorylation
- PKC delta signaling, via MEK/ERK and p38 MAPK pathways, is required for the secretion of thromboxane A2 from platelets.
- Can phosophorylate MCL1, leading to its degradation and mediating its pro-apoptotic effects on mitochondria to amplify apoptotic signaling.
- Cdc42 is an important downstream factor in the pathway through which PKC mediates morphological and cytoskeletal effects
- beta and some other PKC isoenzyme, most likely delta, mediate cholesterol accumulation when macropinocytosis of LDL is stimulated in PMA-activated human monocyte-derived macrophages
- A novel IL-13-dependent cytosolic signaling complex of protein kinase C (PKC)delta and tyrosine-phosphorylated signal transducer and activator of transcription (Stat)3 is identified.
- These data suggest that IGF-1R and PKCdelta are required to stimulate PKB phosphorylation in response to BMOV in HepG2 cells.
- involucrin gene expression inhibition by apigenin is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311
- Overexpression of PKCdelta alternative splicing promotes apoptosis while PKCdeltaII overexpression shields the cells from apoptosis.
- These results suggest an important role of tyrosine 311 in the apoptotic function of PKCdelta and implicate c-Abl as the kinase that phosphorylates this tyrosine.
- Stimulation of collagen type I secretion by TGF-beta requires a PKCdelta-Src-ERK1/2 signaling motif
- A novel androgenic hormonal mechanism for the control of PKCdelta expression via transcriptional regulation that fine-tunes the magnitude of PKCdelta apoptotic responses in prostatic cancer.
- These observations suggest that Erk activation may be correlated in the cells with high expression of SOCS6.
- These findings indicate that phosphorylation of PLS3 by PKC-delta induces PLS3 activation to facilitate mitochondrial targeting of tBid and apoptosis.
- the PKC-delta signal is involved in Haptoglobin secretion.
- establish a novel direct biochemical mechanism for acid sphingomyelinase activation in which protein kinase Cdelta serves as a key upstream kinase
- deregulation of cross-talk between mitogen-activated protein kinases and PKCdelta signaling may contribute to the etiology of osteoarthritis in human patients
- PKC-delta antagonizes apoptosis through phosphorylating Ebp1 and protects it from apoptotic degradation.
- These results revealed that PKCdelta plays a critical role in the expression of TG2, which in turn regulates autophagy
- study demonstrates that PKCdelta-mediated phosphorylation of 146Ser residue of p21WAF1/CIP1 is a novel mechanism for enhancing the cellular stability of the inhibitor protein by blocking caspase-3-mediated degradation
- PRKCD-mediated CREB activation regulates ghrelin-induced COX 2 expression and dinoprostone production in colonic epithelial cells.
- The specific PKCdelta inhibitor rottlerin markedly decreased bortezomib plus ATO-induced apoptosis, suggesting that PKCdelta plays an important role in bortezomib plus ATO-induced apoptosis
- Data provide the first evidence that Protein kinase C -delta play pivotal role in the regulation of AA production and cellular proliferation of human monocytoid MonoMac-6 cells.
- generation of the PKC delta catalytic fragment is a critical step for commitment to apoptosis and nuclear import and export of PKC delta plays a key role in regulating the survival/death pathway
- Activation of PKCdelta in response to Camptothecin treatment requires Myc and is important in CPT-mediated apoptosis signaling.
- the subcellular localization of PKCdelta plays important roles in its proapoptotic and antiapoptotic functions and in the activation of downstream signaling pathways
- PKCdelta is phosphorylated upon activation and that phospho-S299 represents a useful marker of the activated enzyme
- Protein kinase C-delta is activated by hypoxia, increases the stability and transcriptional activity of hypoxia-inducible factor-1 alpha and demonstrates a new role as regulator of hypoxia-induced angiogenesis.
- analysis of direct binding and activation of PKCalpha and PKCdelta by steroid hormones and the molecular mechanisms involved
- activation of PKCdelta regulates the phosphorylation of heat shock protein 27 via p38 mitogen-activated protein kinase
- These results demonstrate that lysophosphatidic acid regulates c-Met function through PKC delta and E-cadherin.
- study provides key molecular insights into activation of ASMase in response to UV light, the role of PKCdelta in this activation, and the role of ASMase in mediating apoptotic responses
- study concludes that the activation of novel protein kinase Cs, PKC delta and theta, by Nef is required to increase viral replication/infectivity and direct the subcellular localization of Nef
- The induction of IFIT4 transcription by IFN-alpha depends upon sequential activation of PKCdelta, JNK and STAT1, and the influence of PKCdelta or JNK on IFN-alpha-mediated induction of IFIT4 is dependent upon the phosphorylation of STAT1 at Ser-727.
- These findings provide evidence that activation of TP53 gene transcription by PKCdelta triggers TP53-dependent apoptosis in response to DNA damage.
- These findings indicate that PKCdelta activity for activation of involucrin promoter requires Y(311) and a second tyrosine residue; however, any one of the several tyrosine residues can serve in the secondary role.
- Our results indicate that loss of PKC delta is an indicator of endometrial malignancy and increasing grade of cancer.
- study reports identification of five novel Ser/Thr phosphorylation sites: Thr 50, Thr 141, Ser 304, Thr 451, and Ser 506 following overexpression of PKCdelta in HCT116 human colon carcinoma cells
- PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism
- PKC delta plays an important role in mucin secretion by airway epithelium via regulation of MARCKS phosphorylation.
- Data suggest that foreign body giant cell formation is supported by PKCbeta, PKCdelta, and PKCzeta in combined diacylglycerol-dependent (PKCbeta and PKCdelta) and -independent (PKCzeta) signaling pathways.
- The novel human PKCdeltaVIII splice variant functions as an antiapoptotic protein in NT2 cells.
- Cx43Hc electrical conductance is inhibited after PKC activation. Inhibition is predominantly mediated by PKC-epsilon. Partial inhibition may be provided by PKC-beta II/PKC-delta.
- phosphorylation of IRS-1 Ser(357) mediates at least in part the adverse effects of PKC-delta activation on insulin action
- Posttranslational modification of HuR by PKCdelta represents an important novel mode of HuR activation implied in renal COX-2 regulation
- Thrombin contributes to the tissue remodeling in inflammatory airways and lung diseases at least partially through PKCdelta activation.
- Syk signals downstream of PKC-delta to mediate thrombin induced ICAM-1 expression in endothelial cells by increasing transcriptional capacity of NF-kappaB via a mechanism that relies on tyrosine phosphorylation of RelA/p65
- Rottlerin induces down-regulation of caspase-2 via PKC delta-independent but ubiquitin proteasome-mediated pathway.
- Show a critical role of PKCdelta in the regulation of renal carcinoma cell migration, which seems to be caused by affecting the expression and activity of beta1 integrins and focal adhesion kinase.
- distinct phosphorylation of PKCdelta on tyrosines 64 and 187 specifically activates the Erk1/2 pathway by the down-regulation of MKP-1, resulting in the persistent phosphorylation of Erk1/2 and cell apoptosis
- Phorbol 12-myristate 13-acetate -induced NF-kappaB-dependent transcription is driven by novel PKC isoforms, particularly PKCdelta and epsilon.
- 3BP2 acts downstream of SAP, increases CD244 phosphorylation and links the receptor with PI3K, Vav, PLC gamma, and PKC downstream events in order to achieve maximum natural killer cell killing function.
- PKCbetaII (protein kinase C beta2) and PKCdelta (protein kinase C delta) counter-regulate coronary endothelial barrier properties by targeting distinctive subcellular sites.
- Data describe the role of PKC-delta and p38 MAP kinase in HIV-1 Tat protein-induced IL-10 production by an alternative TNF-alpha-independent pathway in monocytes.
- PKCdelta acts upstream of SPAK to increase activity of NKCC1 during hyperosmotic stress
- endothelial PKC delta activation eliminates neutrophil transendothelial migration through a mechanism unrelated to endothelial barrier integrity
- PKCdelta is a key regulator in X-ray-induced apoptosis of keratinocyte
- Regulation of NSMAF by TNF-alpha involves PRKCD in lung epithelial cells.
- Histamine-induced Egr-1 expression is dependent on the activation of the H1 receptor, and rapidly and transiently activates PKCdelta, ERK1/2, p38 kinase, and JNK prior to Egr-1 induction.
- VEGF-induced secretion is largely dependent on PKC-delta and significantly less on [Ca2+]c.
- PKCdelta-dependent signaling has roles in the cell fate determination upon hypoxic exposure
- Enhanced ECE-1 expression induced by hyperglycemia is partly due to activation of the PKC-delta isoform. Thus, inhibition of this PKC isoform may prevent diabetes-related increase in ET-1.
- thrombin-induced p65/RelA, AMPK, and PKCdelta activation were markedly reduced by knockdown of the TRPC isoform TRPC1 expressed in human endothelial cells and in endothelial cells obtained from Trpc4 knock-out mice.
- Our results are consistent with a role for PKCdelta in breast cancer progression.Increasing concentrations of PKCdelta mRNA were associated with reduced overall patient survival.
- PKCdelta alters hedgehog signaling by inhibition of Gli protein transcriptional activity
- The phosphorylation-acetylation cascade triggered by PKC delta represents the primary mechanism whereby TGF-beta regulates the transcriptional activity of Fli1 in the context of the collagen promoter.
- Regulatory role of IRS-2 on the expression of IGF-I receptor through Protein kinase c-delta in pancreatic cancer cells.