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Validated All-in-One™ qPCR Primer for CXCL9(NM_002416.2) Search again
Product ID:
HQP011220
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CMK, Humig, MIG, SCYB9, crg-10
Gene Description:
C-X-C motif chemokine ligand 9
Target Gene Accession:
NM_002416.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The function of this gene has not been specifically defined; however, it is thought to be involved in T cell trafficking. This gene has been localized to 4q21 with INP10, which is also a member of the chemokine family of cytokines. [provided by RefSeq].
Gene References into function
- The IFN-gamma inducible MIG protein behaves as a homing chemokine constitutively expressed in human brain microvascular endothelial cells and astrocytes.
- Gene expression is predictive for the individual response of children with chronic allograft nephropathy to mycophenolate mofetil.
- that IFNgamma stimulates the production of IP-10 and Mig in the SS ductal epithelium, and that IP-10 and Mig are involved in the accumulation of T cell infiltrates in the Sjogren syndrome salivary gland.
- A higher amount of MIG mRNA is expressed after exposure of keratinocytes to interferon-gamma, leading to migration of T cells from the dermis to the epidermis and representing a second step of chemotaxis following T cell recruitment from blood.
- CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11.
- Constitutive NF-kappaB activity is required for the induced gene expression of CXCL9 in tumour cell lines in response to IFNgamma.
- Peak of expression of CXCL9 and CXCL10 occurred 4 days before CD8+ T cells infiltrated infected tissues. CXCL9 and CXCL10 may play role early during immune response against rickettsial infections.
- MIG and IP-10 are cleaved by gelatinase B and neutrophil collagenase
- The chemokine CXCL9, usually associated with Th1 cells, is elevated in serum of patients with acute Syndenham's chorea.
- Serum Mig levels in atopic dermatitis patients were significantly higher than those in control subjects
- CXCL9, CXCL10, and CXCL11 functions are mediated by intracellular domains of CXCR3
- Increased expression of the interferon-induced angiostatic ELR- CXC chemokines is a feature of juvenile DM that parallels the degree of vasculopathy in patients with the disease
- This CXCR3 ligand has the ability to activate biochemical (e.g., PtdIns 3-kinase and MAP kinase activation) and functional events (actin reorganization) in intestinal myofibroblasts.
- Increased plasma monokine induced by gamma interferon (MIG) levels in daughters and sisters of primary biliary cirrhosis (PBC) patients demonstrates involvement of MIG interaction with its receptor CXCR3 as a familial risk factor for PBC.
- Both a Th1 chemoattractant (CXCL9) and Th2 chemoattractants, CCL17 and CCL22, cooperatively play a role in the development of autoimmune blistering disease.
- prolactin may enhance IFN-gamma-induced CXCL9, CXCL10, and CXCL11 production in keratinocytes
- A novel innate defense mechanism against invasive bacteria on epithelial surfaces is reported in pharyngeal cells expressing.
- Data suggest atherosclerotic inflammation may be a trigger for sclerosis in calcified stenotic aortic valves through upregulation TGF-beta, VAP-1, MIG and Eotaxin3, which is only partially inhibited by previous statin therapy.
- During treatment of ulceretive colitis with corticosteroids CXCL1/CXCL9 were decreased.
- serum IP-10 and MIG levels were significantly higher in lymphoproliferative disease of granular lymphocytes patients than in healthy donors, and MIG expression was associated with the number of circulating LGLs
- Data may contribute to a better understanding of the pathophysiology underlying Crohn's disease.
- In summary, both GGS (Streptococcus dysgalactiae subsp. equisimilis) and GAS (Streptococcus pyogenes) evoke MIG/CXCL9 expression but they differ in susceptibility to its antibacterial effects.
- Inflammatory chemokine CXCL9 triggers lymphocyte function-associated antigen-1 (LFA-1) adhesiveness in a RhoA-independent manner and without triggering integrin extension.
- finding a constitutive expression of MIG/CXCL9 in the male urogenital tracts suggests roles for this chemokine both in host defense and during early phases of fertilization
- Graves' disease patients who relapsed or went into remission had significantly different levels of CXCL9.