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Validated All-in-One™ qPCR Primer for LGALS9(NM_009587.2) Search again
Product ID:
HQP010602
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
HUAT, LGALS9A
Gene Description:
galectin 9
Target Gene Accession:
NM_009587.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin.
Gene References into function
- ecalectin is a novel eosinophil-activating factor
- overexpression of galectin 9 is associated with cell aggregation and apoptosis of melanoma cells
- IFN-gamma-induced production of galectin-9 by endothelial cells may play an important role in immune responses by regulating interactions between vascular wall & eosinophils. In situ endothelium from inflammatory diseases expressed galectin-9.
- Galectin 9 in IFN-gamma-stimulated fibroblasts plays a crucial role as a physiological modulator at inflammatory sites.
- Gal-9 induces the apoptosis of various immune cells, including activated CD4+ and CD8+ T cells, through the Ca2+-calpain-caspase-1 pathway, playing a role not only in thymocyte maturation but also in immunomodulation by inducing apoptosis of those cells.
- Changes in the expressions of galectin-9 are potentially important for myeloid cell differentiation into specific lineages.
- REVIEW: role in a variety of physiological and pathological conditions
- Galectin-9 is a possible prognostic factor with antimetastatic potential in breast cancer.
- Data suggest that galectin-9 is correlated with oral cancer cell-matrix interactions and may therefore play an important role in the metastasis of oral squamous cell carcinomas.
- Gal-9 plays a role not only in innate immunity but also in acquired immunity by inducing DC maturation and promoting Th1 immune responses.
- Stimulation of Tim-3 by its ligand galectin-9 results in increased phosphorylation of Y265, suggesting that this tyrosine residue plays an important role in downstream signalling events regulating T-cell fate.
- Nasopharyngeal carcinoma cells can release HLA class-II positive exosomes containing galectin 9 and/or LMP1.
- Galectin-9, consisting of two carbohydrate recognition domains (CRDs) induced Jurkat T-cell apoptosis, however, a single CRD had no effect, suggesting the stable dimeric structure of two CRDs is required for the activity.
- Gal-9 inhibits allergic inflammation of the airway and airway hyperresponsiveness by modulating CD44-dependent leukocyte recognition of the extracellular matrix
- TLR3, PI3K, and IRF3 are involved in the poly IC-induced galectin-9 expression in HUVECs
- Galectin-9 represents a novel surface marker which might be employed for molecular targeting to the Peyer's patches.
- These results suggest that galectin-9, but not other galectins, induced proliferation of human osteoblasts through clustering lipid rafts on membrane and subsequent phosphorylation of the c-Src/ERK signaling pathway.
- Structural analysis of LGALS9 terminal carbohydrate recognition domain reveals unexpected properties that differ from the mouse orthologue, Lgals9.
- Gal-9-induced apoptosis of hyperproliferative rheumatoid arthritis fibroblast-like synoviocytes may play a critical role in the suppression of rheumatoid arthritis.
- Galectin-9 and galectin-1 require different glycan ligands and glycoprotein receptors to trigger T cell death.
- decreased Gal-9 expression is inversely associated with malignant potential or differentiation of cervical cervical intraepithelial neoplasia and squamous cell carcinoma as a differentiation biomarker.
- increase of TIM-3 expression on PBMCs, overproduction of IFN-gamma in the sera, and increased galectin-9 in PBMCs was observed in acquired aplastic anemia patients
- the crystal structure of the human galectin-9 N-terminal carbohydrate recognition domain in complex with N-acetyllactosamine dimers and trimers.