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Validated All-in-One™ qPCR Primer for IL1B(NM_000576.2) Search again
Product ID:
HQP009641
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
IL-1, IL1-BETA, IL1F2, IL1beta
Gene Description:
interleukin 1 beta
Target Gene Accession:
NM_000576.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq].
Gene References into function
- The level of IL-1 beta is significantly higher in sera of cicatricial pemphigoid patients with active disease before intravenous immunoglobulin therapy compared to the post-treatment level.
- There were no significant differences in the distributions of the IL-1RN and IL-1B genotypes, allel frequencies or halotypes.
- These studies demonstrate that PEIPC and PECPC isomers are potent activators of endothelial cells increasing synthesis of IL-8 and MCP-1.
- data fall short of showing significant association between a variant of the promoter of interleukin-1beta, polymorphism of angiotensinogen, and the missense variant of endothelial nitric oxide synthase and occurrence of idiopathic recurrent miscarriage
- Repressed transcription of IL-1beta and rapid decay of IL-1beta mRNA in septic shock neutrophils correlated with reductions in levels of IL-1beta after stimulation with LPS
- Interleukin-1 alpha and beta system in testis--quantitative analysis. Expression of immunomodulatory genes in male gonad.
- IL-1 beta increases CD40 ligand-induced cytokine secretion by monocyte-derived dendritic cells (DC), CD34+-derived DC, and peripheral blood DC independently of T cell-derived cytokines.
- Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6
- role in upregulating VEGF in vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway
- Genotype A2A2 of IL-1beta is associated with severe forms of rheumatoid arthritis. The allelic combination A1 IL-1beta/A2 IL-1Ra is less often present in rheumatoid arthritis patients with severe disease.
- Test found no evidence of an association of mutations with hypertension.
- Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts
- Carriage of IL1beta2 and IL1RN*2 together with non-carriage of TNF2 is associated with increased susceptibility, but not with a prognosis of IgAN.
- differentiated articular chondrocytes are highly responsive to IL-1beta and that p38 MAPK mediates this response by inducing COX-2 gene expression.
- T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region
- In dengue shock syndrome pts, IL-1beta was significantly associated with t-PA (p < 0.03). IL1B is involved in the onset and regulation of hemostasis.
- in semsen of normal/infertile men
- Lidocaine inhibits secretion of IL-8 and IL-1beta and stimulates secretion of IL-1 receptor antagonist by epithelial cells.
- Up-regulation of IL1-beta is crucial for the pathogenesis of myeloma
- Il-1beta genotype carries asthma susceptibility only in men
- role in Candida albicans-induced interferon-gamma production in human whole blood cultures
- process of cervical dilatation during parturition at term is associated with an increased expression of interleukin-1 beta, interleukin-6 and interleukin-8 mRNA in the lower uterine segment
- Increased frequency of interleukin-1beta (-511) allele 2 in febrile seizures. polymorphism of interleukin-1beta at position -511
- Interleukin-1beta processing following Shigella flexneri infection of human monocyte-derived dendritic cells.
- results suggest that NFkappaB is involved in the IL-1beta-induced COX-2 expression in the mesenchymal cells of human amnion
- secretion from acute myelogenous leukemia blasts was up-regulated by leptin
- TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis.
- Interleukin 1 beta induces overexpression of mucin genes in cultured tumor cells which is inhibitable by a retinoic acid receptor alpha antagonist.
- role in inducing cyclooxygenase-2 and presenilin-1 gene expression potentiated by hypoxia in primary human neural cells
- expressed in human gastric carcinoma with Epstein-Barr virus infection
- Association of an interleukin 1B gene polymorphism with Parkinson's disease
- Tumors derived from a retroviral vector coding human IL-1BETA gene transduced into Lewis lung carcinoma cells secrete IL-1 beta into the tumor milieu, which promotes tumor growth through hyperneovascularization.
- role in NF-kappa B induction modulated by a novel PAAD-containing protein
- plays a role the pathogenesis of the otitis media with effusion (REVIEW)
- Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan.
- There are associations of spontaneous preterm delivery with the fetal carriage of IL1B+3953*1 and IL1RN*2 alleles in African and Hispanic populations, respectively.
- Association of interleukin-4 and interleukin-1B gene variants with Larsen score progression in rheumatoid arthritis.
- Association of the interleukin-1 gene cluster on chromosome 2q13 with knee osteoarthritis.
- role of p38 map kinase, NF-kappaB, and protein kinase c in IL-1beta mRNA expression by human peripheral blood leukocytes, monocytes, and neutrophils in response to Anaplasma phagocytophila
- Acanthamoeba castellanii by release of ADP and other metabolites lead to human monocytic cell death through apoptosis and stimulate the secretion of IL-1beta
- Induction of IL-1beta in THP-1 macrophages and human microvascular endothelial cells during Bartonella henselae infection
- IL-1 beta mRNA stability in monocytes is linked to cytoskeletal reorganization and the availability of mRNA degradation factors.
- The expression of IL-1beta mRNA and IL-8 mRNA was increased significantly in patients with ulcerative colitis UC
- The polymorphism of promotor region -31C/T of IL-1B gene is associated with the susceptibility of gastric cancer in Chinese.
- Inheritance of the G/G genotype of both IL-1B and IL-6 was a particularly strong predictor for the development of recurrent aphthous stomatitis.
- Review. Homozygosity for an Il-1 alpha polymorphism in combination with another in the IL-1B gene further increases the risk of Alzheimer disease.
- Japanese Brazilians with a polymorphism at C-31T of interleukin 1 beta have an increased susceptibility to Helicobacter pylori infection
- IL-1 functions to limit CMV spread by increasing the expression of IFN-beta, which in turn reduces production of infectious virus.
- inflammasome comprises caspase-1, caspase-5, Pycard/Asc, and NALP1; a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
- Data indicate that both COX-1 and COX-2 contribute to endothelial prostanoid synthesis in the neonatal human brain under basal conditions and in response to proinflammatory cytokine IL-1 beta.
- Review. The IL-1 family consists of IL-1alpha and IL-1beta, 2 receptors, and a specific receptor antagonist, IL-1Ra. The balance between IL-1 & IL-1Ra in local tissues plays an important role in the susceptibility to & severity of many diseases.
- The Interleukin 1-beta exonic (+3953) polymorphism does not alter in vitro protein secretion by blood mononuclear cells
- identified beta cells as the cellular source of glucose-induced IL-1beta in cultured human islets; role of such endogenously produced IL-1beta in beta cell glucotoxicity
- IL-1beta down-regulates TFF expression in human stomach neoplasm cells cultivated in vitro.
- the unique sIL1R-II binding ability of human IL-1beta is due to a single amino acid difference compared with monkey IL-1beta
- relationship between interleukin-1B (IL-1B) gene polymorphisms and the susceptibility of chronic periodontitis in Uighur minority in Xingjiang province of China
- IL1-beta induced during in vitro activation of mast cells by cystic fibrosis-associated Pseudomonas aeruginosa stimulates neutrophil transendothelial migration.
- detect the expression of interleukin-1beta (IL-1beta) on the surface of human luteinized granulosa cells and to understand its relation to the hormones in human follicular fluid and sera
- Retinoic acid induces expression of the interleukin-1 gene in cultured normal human mammary epithelial cells and in human breast carcinoma lines.
- in human pulmonary epithelial cells, IL-1beta activates ERK or p38 to induce COX-2 production, which in turn induces MUC2 and MUC5AC production.
- This protein increases urine flow rate and inhibits protein expression of Na(+)-K(+)-exchanging ATPase.
- investigated interleukin polymorphisms in ovarian cancer but did not find any association between common polymorphisms of interleukin 1A, interleukin 1B, and interleukin 1 receptor antagonist and the occurrence of ovarian cancer
- Possible association of a polymorphism in the interleukin-1beta gene with the severity of Plasmodium falciparum malaria in Ghanaian children.
- study reports measurements of IL-1 thermodynamic and kinetic folding parameters between pH 5 and 7
- IL-1beta mediates MUC2 gene expression and mucin secretion
- An examination of quantitative gene expression of this protein in the renal artery wall of chronically rejected human renal allografts.
- IL-1beta-31 genotype T/T or the IL-1beta-511/-31 haplotype C-T is associated with the presence of HCC in Japanese patients with chronic HCV infection.
- a "defective" IL-1ra response to IL-1 may underlie, at least in part, the exaggerated prostaglandin-endoperoxide H synthase (PGHS)-2 induction in orbital fibroblasts
- the relationship between interleukin (IL)-8, IL-1beta and neutrophils in vaginal fluid obtained from 60 healthy women and 51 women who were bacterial vaginosis positive
- soluble form of the IL-1 receptor accessory protein (AcP) increases the affinity of binding of human IL-1alpha and IL-1beta to the soluble human type II IL-1 receptor
- role in inducing CXC chemokine GCP-2/CXCL6 in mesenchymal cells
- No association of the IL-1 beta and three IL-1 beta inducible gene polymorphism with ulcerative colitis was observed in Japanase population.
- allele 2 in the interleukin-1beta gene is more common in women with vulvar vestibulitis syndrome than in other women
- combined elevation of interleukin-1beta and interleukin-6, rather than the isolated elevation of interleukin-6 alone, independently increases the risk of type 2 diabetes
- results suggest that leptin regulates the IL-1 system and that the blockade of functional Ob-R impairs leptin and IL-1beta functions at the endometrial level.
- In the recurrent implantation failure group, the MMP score and IL-1beta concentration were significantly higher than those in the control group, whereas concentrations of IFN-gamma and IL-10 were significantly lower.
- IL-1beta, TNF-alpha, TGF-beta, and bFGF are involved in bone remodeling regulation, acting as local effectors, possibly under the control of PTH.
- IL-1beta has a role in inducing activation of Egr-1 binding, which is required for inhibition of COL2A1 proximal promoter activity
- allele 1 significantly increases the risk of external apical root resorption
- may enhance the local production of CCL3, which may interact with CCR1 expressed on hepatoma cells, in an autocrine and/or paracrine manner
- Low levels of IL-1 beta in combination with IL-17 can act on myoblasts and muscle tissue leading to the expression or production of factors involved in muscle inflammation.
- IL-1beta is an autocrine/paracrine stimulator of IL-6 release from human adipocytes
- TNF-alpha & IL-1 produced by sickle leukocytes are the primary factors responsible for the observed CAM expression. This & the subsequent endothelial adherence of sickle erythrocytes play roles in the pathophysiology of sickle-related complications.
- an association between the interleukin-1beta exon 5 polymorphism, endometriosis, or increased serum IL-1beta levels was not found
- No significant difference was found in genetic polymorphism for interleukin 1 beta between major depressive disorder patients and controls; however, patients homozygous for 511T allele had a trend of less severe depressive symptoms than 511C carriers.
- no one particular polymorphism in the IL-1 gene cluster yields an advantage for survival in the last decades of life
- IL-1beta polymorphisms were correlated with mucosal atrophy in Japanese and Chinese populations, but not in Thai and Vietnamese populations.
- In normal conditions and in the presence of IL-1beta, cathepsin B is involved in the activation of plasminogen activator in osteoblasts.
- parallel expression with cyclooxygenase-2, interleukin-6 and NF-kappaB in colorectal cancer
- Polymorphisms in interleukin (IL)-1 beta and its endogenous receptor antagonist are associated with risk of Helicobacter pylori-related gastric cancer
- IL1-beta induces GCMSF in lung fibroblasts.
- Polymorphism of this locus as related to the develpment of liver neoplasms in patients with chronic hepatitis C infection
- regulation of expression by ATP
- In multiple sclerosis primary progressive patients, the IL-1beta /IL-1ra ratio was significantly lower than in relapsing-remitting patients.
- The allele frequency of IL-1B -31 C was more prevalent in Korean (51%) than in Caucasian (30%). The CC genotype was not associated with an increased risk of gastric cancer or duodenal ulcer in the Korean population
- c-Fos expression induced by toxin B was reduced dose dependently by IL-1 receptor antagonist. Evidence of direct excitatory effect of IL-1beta on membrane potential was detected in minority of enteric neurons.
- Data show that angiogenin isolated from cow milk induces the production of cytokines interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha in human leukocytes.
- Paracrine actions involving ET-1, TNF-alpha and IL-1beta between human astrocytes and BMVECs may play a central role in BBB breakdown during CNS inflammation
- Results indicate that interleukin-1beta is involved in the pathogenesis of acute respiratory distress syndrome (ARDS). Early determination of IL-1beta level in bronchoalveolar lavage fluid may be more valuable in the evaluation of disease process of ARDS
- mechanism by which the important proinflammatory mediator, interleukin (IL)-1 beta, increases MUC8 gene expression levels
- role of polymorphism at this site as it relates to the severity of gastric mucosal pathology associated with H. pylori
- role for NF-kappaB in the co-ordinate induction of COX-2, mPGES and in the corresponding release of PGE2 by IL-1beta
- Proinflammatory cytokine IL-1beta specifically activates certain neurochemically defined neural pathways, and these changes may lead to disturbances in motility observed in inflamed bowel.
- The frequency of the E2 allele of the IL-1beta exon 5 polymorphism was high in POAG patients.
- This study reports on the polymorphism of exon 5 of interleukin-1B (IL-1B) in position +3953. The genotype distribution of IL-1B +3953 varied significantly between patients with early and late onset of Alzheimer's disease.
- When analyzed separately, none of the IL1B or IL1RN polymorphisms was associated either with inflammation or restenosis. However, when the IL-1B (-511) and the IL-1RN VNTR genotypes were combined, a highly significant relationship was observed.
- IL-1 beta activation of Fas ligand expression in astrocytes may participate in neuronal injury in HIV-1-associated dementia via the NF-kappa B pathway.
- polymorphisms causing hypersecretion from amniochorion
- Total bacterial DNA from feces collected after probiotic administration modulated the PBMC (peripheral blood mononuclear cells) response by a decrease of interleukin-1 beta
- Present data from a Chinese population fail to show a strong association of the variation at position -511 of the IL-1 beta gene promoter region in temporal lobe epilepsy patients with hippocampal sclerosis.
- The synchronous regulation of lung mucin and liquid metabolism triggered by IL-1beta may be an important defense mechanism of the airway epithelium to enhance mucociliary clearance during airway inflammation.
- Polymorphism of the promoter is found in Dutch patients with stomach neoplasms and Epstein-Barr virus.
- During Rhinovirus upper respiratory tract infection, significant increases in mean levels of nasal IL-1 (P = .02) were observed in symptomatic but not asymptomatic subjects
- Data show that gingival fibroblasts express interleukin-1 (IL_1) beta converting enzyme mRNA, but low levels of IL-1 beta mRNA, and do not secrete interleukin-18.
- Neither IL-1B-511, IL-1B+3954 nor interleukin-1 receptor antagonist genotypes, allele or carrier frequencies showed significant association with tubal pathology or C.trachomatis post-infection-based tubal pathology.
- concomitant treatment of A549 cells with hyperoxia and IL-1beta augments activation of IKK, prolongs degradation of IkappaBalpha, and prolongs nuclear translocation and DNA binding of NF-kappaB
- IL-1 beta genetic polymorphism influences the impact of the CYP2C19 genotype on the cure rate of 1 week triple therapy for Helicobacter infections.
- IL-1 beta induces neutrophil gelatinase-associated lipocalin expression at the transcriptional level by an NF-kappa B-dependent pathway.
- superantigens from S. aureus activate the extrinsic coagulation pathway by inducing expression of TF in monocytes, and that the expression is mainly triggered by superantigen-induced IL-1 beta release
- IGF-1, IGFBP-2 levels were related to IL levels, disease activity and anatomical distribution, consistent with active inflammation modifying the IGF-IGFBP system, possibly relevant to disturbance of growth.
- Results suggest that interleukin-1beta-mediated up-regulation of macrophage inflammatory protein-1beta production in hepatic cells may contribute to continuous recruitment of inflammatory cells to the liver and maintenance of inflammation.
- no association with IL-1beta and TNF-alpha in childhood nephrotic syndrome
- In unselected patients with cutaneous vasculitis who fulfill classification criteria for Henoch Schonlein purpura, carriage of IL-1beta (-511) T allele appears to influence severity of renal involvement.
- Soluble IL-1 beta bioactivity and autocrine IL-1 beta-dependent IL-6 up-regulation are critical initiators of fibroblast activation and proliferation and most likely play a role in the fibroproliferative response seen in human acute lung injury.
- Polymorphisms of the interleukin-1 beta gene are associated with increased risk of non-small cell lung cancer
- possible direct effects of IL-1beta on the expression of thrombopoietin (TPO) and transcription factors c-Jun, c-Fos, GATA-1, and p45 nuclear factor-E2 (NF-E2) in MK cell lines CHRF and Meg-01
- polymorphic variants of the genes of the Il-1 cluster (IL-1A, IL-1B, IL-1RN, and IL-1F5-F10) are associated with schizophrenia and bipolar disorder
- IL-1beta levels were higher in patients with low sex hormone levels.
- Alveolar macrophage-derived TNF-alpha and IL-1 beta provide a major stimulus for the production of proinflammatory mediators by lung epithelial cells. Relative importance may depend on type of epithelial cell target.
- IL-1beta increases the invasive ability of gasstric carcinoma cells through activation of NF-kappaB and the resulting MMP-9 expression.
- Interleukin-1beta-511 polymorphism is one of the determinants of successful eradication of H. pylori using triple therapy with a PPI, amoxicillin, and clarithromycin, together with CYP2C19 genotype and bacterial resistance to clarithromycin.
- carriers of the IL-1beta (-511)*C allele were found to have lower systolic (P = 0.049) blood pressure levels compared with T homozygotes
- NF-kappaB activation and IL-1beta secretion are induced by cryopyrin with an increased ability to interact with ASC
- IL-1beta was only present in human dermal and synovial fibroblasts cell lysates after stimulation
- IL-1beta binds with high affinity to fibrin(ogen) and demonstrates increased activity in the bound form.
- hypothermia prolonged NF-kappaBeta activation, identifying a potential role for this transcription factor in mediating the effects of hypothermia on TNF-alpha and IL-1beta production
- IL-1 beta together with UGT1A7 polymorphisms has a role in hepatocellular carcinoma in Japanese Hepatitic C virus-infected patients
- IL-1 gene cluster polymorphisms may play a significant role in the pathogenesis of osteoarthritis of the hip.
- The results suggest a possible contribution of the IL-1 gene locus polymorphisms to the pathogenesis of LBP.
- IL-1 beta gene polymorphisms may affect susceptibility to Sjogren's syndrome, but not systemic lupus erythematosus.
- JNK signaling plays an important role in the inhibitory effects of cAMP on IL-1beta+IFNgamma-induced iNOS gene expression in cultured hepatocytes
- chronic exposure of human islets to leptin decreased beta cell production of IL-1Ra and induced IL-1beta release from the islet preparation, leading to impaired beta cell function, caspase-3 activation, and apoptosis
- basic calcium phosphate crystals may be an important amplifier of PGE(2) production through induction of the COX enzymes and the proinflammatory cytokine IL-1beta.
- There was expression of interleukin-1beta in abnormal muscle fibers. interleukin-1beta may play a role in the pathogenesis of myofibrillar myopathy.
- a significant and time-dependent increase in the amount of the active form of IL-1beta (17 kDa) secreted into the supernatant by epithelial cells infected with live C. albicans
- These findings show no evidence for an association between the IL-1B +3953 polymorphism and AD in the Jewish population.
- IL-1beta reduces the ability of IGF-I to activate Cdk2 and to induce E2F-1, cyclin A, and cyclin A-dependent phosphorylation of a retinoblastoma tumor suppressor
- polymorphisms within the promoter region of the IL1B gene contribute to observed differences in lipopolysaccharide-induced IL-1 beta protein secretion.
- There is an association between polymorphisms of the promoter region -511C/T of IL-1B and IL-1RN intron 2 and chronic hepatitis B virus infection
- IL-1beta can serve as a pivotal costimulus of inflammatory cytokine synthesis in human mast cells, and this may be partly mediated by IL-1 receptor-binding and subsequent signaling via nuclear translocation of NF-kappaB.
- molecular mechanism underlying IL-1 beta processing and release in human monocytes
- MAPK-AP-1 and ROS-NF-kappaB signaling pathways are involved in the IL-1beta-induced IL-8 expression and that these paracrine signaling pathways induce endothelial cell proliferation
- The IL-1beta +3953 polymorphism influenced survival in AD patients and those with the TT genotype and without the APOE epsilon4 allele showed the shortest cumulative survival
- interleukin 1, beta interleukin 1, beta proprotein catabolin preinterleukin 1 beta
- Data describe the association between interleukin-1beta promoter polymorphism and delusions and hallucinations in Alzheimer's disease.
- Together, these results suggest that IL-1beta induces HBD-2 mRNA expression in A549 cells, and the induction seems to be at least in part mediated through activation of signaling proteins PKC, p38 MAPK, JNK, and PI3K, but not ERK.
- S100B and IL-1beta in the cerebrospinal fluid may have a role in the progression of traumatic brain injury
- IL1B2 and IL1RN*2 genotypes of the IL-1 cluster genes are associated with diabetic nephropathy in Korean patients with type 2 diabetes mellitus
- This study suggests that host genetic constitution (particlularly, IL1B genetic polymorphism) and lifestyle may influence the protective effect for atrophic gastritis development.
- decreased glucose production by the liver and enhanced glucose disposal lead to the development of hypoglycemia in mice bearing IL-1beta-secreting tumor
- IL-1beta-dependent prolonged EGFR transactivation involves multiple pathways, including an IL-8-dependent pathway
- Dat show that -31, -511 and -1470 loci in the promoter region of IL-1 beta are in strong linkage disequilibrium. And this study provides a basis for searching disease-related IL-1 beta haplotye.
- interleukin-1beta regulates interleukin-6-induced suppressor of cytokine signaling 3 expression
- IL-1beta employs the NFkappaB pathway predominantly, while the spectrum of EGF signaling is broader and includes p38 kinase. Synergism occurs through differential use of independent response elements within the COX-2 promoter.
- three polymorphisms in IL-1 gene cluster might not play a key role in Alzheimer disease pathogenesis in Chinese Mainland Han population.
- Genotype not altered in MALT lymphoma.
- Both IL-6 and LIF can be very efficiently induced by IL-1beta in articular chondrocytes in vitro, more so in osteosarthritis than in normal cells.
- TNFa, IL-1b and ifn-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK
- role of nuclear factor-kappaB (NF-kappaB) during the induction of IL-6 by IL-1beta in human trophoblast cells
- IL-1B(+3954)T is significantly associated with higher C-reactive protein levels in patients with coronary disease, suggesting that this polymorphism increases systemic inflammation and CRP production.
- MBL significantly augmented IL-1beta production after stimulation with LPS+ and LPS- meningococci, in a dose-dependent fashion
- negative regulation of CAR, a glucocorticoid-responsive gene, via proinflammatory cytokine interleukin 1beta (IL-1beta)
- IL-17 and IL-17F play a differential regulatory role in GM-CSF production by LMVECs stimulated with IL-1beta and/or TNF-alpha, which is sensitive to Th1 and Th2 cytokine modulation
- The differential effects of TNF-alpha and IL-1beta on proximal tubular MMP-9 and TIMP-1 expression are mediated through the TNF-RI, the IL-1-RI and the different signaling pathways of PKC, ERK1/2, and p38 MAPK.
- Data suggest that interleukin-1beta could provoke a series of responses in rheumatoid synovial fibroblasts leading to the pathologic status of rheumatoid arthritis.
- IL-1beta polymorphism influences the susceptibility to acquire systemic lupus erythematosus.
- P2X7R stimulation increased the production of IL-1-induced nitric oxide synthase activity by astrocytes in culture.
- The polymorphism distributions of IL-1beta (+3953C/T showed no differences between the essential hypertension group and control group, but the IL-1beta (-511C/T) exhibited a significant difference between the two groups.
- These findings indicate that these two IL-1B promoter variants may contribute to the risk of developing gastric cancer in the Chinese population, especially in individuals with H. pylori infection.
- airway fluid from mechanically ventilated premature infants contains soluble factors capable of inducing airway epithelial cell IL-8 expression via a NF-kappa B-dependent pathway, and that IL-1 beta plays a specific role in this process.
- interleukin-1beta has roles in direct and toll-like receptor 4-mediated neutrophil activation and survival
- The regulation in chondrocytes of Smad6 and Smad7 expression by IL-1beta suggests a potentially important role of IL-1beta signaling in chondrocytes, via indirect influencing of the bone morphogenetic protein/TGFbeta signaling cascade.
- The 511C/T IL-1[beta] gene polymorphism affects the risk of myocardial infarction and ischemic stroke at young age and the response of mononuclear cells to inflammatory stimulation.
- strong and early expression of interleukin-1 receptor antagonist(IL-1Ra) proves to be non-protective due to the robust expression of airway agonist interleukin-1beta seen by day 5 in premature infants who develop bronchopulmonary dysplasia (BPD)
- In a Mexican population, the IL-1B proinflammatory genotype increases the risk of distal gastric cancer.
- analysis of mechanism for selective inhibition of TNF but not IL-1beta-induced IKK activation
- interleukin-16 production is impaired in monocyte-derived dendritic cells from atopic dermatitis patients but is restored by inflammatory cytokines TNF-alpha and IL-1beta
- NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages
- IL-23 p19 mRNA is inducible in colonic myofibroblasts by IL-1beta and Tumor Necrosis Factor-alpha
- TNF-alpha and IL-1beta are secreted with macrophage-released signals that affect NF-kappaB translocation and endothelial cell activation
- IL-1beta- and TNFalpha-mediated induction of IL-6R shedding in osteoblast-like cells is at least partly dependent on tumor necrosis factor alpha-converting enzyme activation.
- X-ray crystallography was used to identify the structural consequences of mutants; no clear correlation between the hydrophobicities of the specific side-chains introduced and the resulting stabilities was found
- results suggest that IL-1beta-induced human renal proximal tubular cell (HK-2 cell line) transdifferentiation is mediated, at least in part, through the activation of the JNK and p38 MAPK signaling pathways
- susceptibility to Behcet's disease is increased in individuals carrying the IL-1beta+3953 T allele and TT genotype
- the IL-1beta+3953 polymorphism increases the risk of EBV-associated gastric corpus
- Interleukin 1beta represents an additional pathway through which metabotropic glutamate receptor 5 (mGluR5) expression and function can be modulated in astrocytes under different pathological conditions associated with an inflammatory response.
- A panel of novel TNF alpha- and IL-1 beta-regulated genes was identified, and these are promising candidates for further study in relation to rheumatoid arthritis and other inflammatory diseases
- polymorphisms may play an important role in determining generalized aggressive periodontits susceptibility in Chinese males
- IL-1b decreases expression of the ENaC alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway
- polymorphisms in chronic obstructive pulmonary disease patients
- The protein encoded by the interleukin 1 beta gene may be involved in susceptibility to alcoholism in Spanish men, probably through a different pathway from that involved in the regulation of the inflammatory response.
- TNF-alpha and IL-1beta enhance the TGF-beta-mediated up-regulation of COL7A1 expression in HaCaT keratinocytes
- IL-1beta plays an important role in regulating relaxation of the normal human colon via nitregic nerves.
- PYPAF3 is a feedback regulator of interleukin-1beta secretion, and PYPAF2 and PYPAF3, together with PYNOD, constitute an anti-inflammatory subgroup of PYRIN-containing apoptotic protease-activating factor-1-like proteins
- results provide mechanistic insight into how interleukin-1beta can differentially regulate cAMP generation and chloride efflux in response to different adenylyl cyclase-coupled ligands in the same cell
- Variation in the IL-1 beta gene and IL-1 receptor antagonist gene individually does not play a role in susceptibility to recurrent miscarriage.and genes individually does not play a role in susceptibility to recurrent miscarriage.
- IL-1RN*2+ genotypes are not associated with increased risk of gastric cancer in the Chinese population
- the mechanism of IL-1beta-induced-sAPP(alpha) release is dependent on MEK1/2- and JNK-activated alpha-secretase cleavage in neuroglioma U251 cells
- might be a significant association between IL-1beta gene polymorphism and outcome after head injury
- The identification of IL-6 and IL-1beta as activators of LT-beta supports their involvement in LT-beta signaling in liver regeneration associated with chronic liver damage.
- The present study suggests that the IL-1beta gene contributes to a genetic susceptibility to the development of simple FSs of sporadic occurrence.
- role of the IL-1 system, especially IL-1 beta, in the development of malnutrition and wasting in end-stage renal disease [review]
- epistatic interrelationship between IL-1beta -511 and IL-1RN confers protection against gastric cancer in low-risk Italian population
- IL-1beta-induced cPLA2 and COX-2 gene expression is modulated through the p38 MAPK pathway in both neuroglioma and neuroblastoma cells.
- There were no difference in the overall Il1B haplotype frequency distribution between cases and control subjects among whites or African Americans.
- Two polymorphisms within the IL-1 gene cluster are associated with ESRD independent of race
- Although all cell types expressed mRNA for the relaxin receptor (LGR7), only peripheral blood mononuclear cells responded to relaxin at physiologic levels by increasing tumor necrosis factor-alpha and interleukin-1beta secretion
- polymorphism in the locus +3954 of gene could be a risk factor for chronic periodontitis in a sample of Brazilian individuals
- H-ferritin mRNA, IL-1beta, and poly(C)-binding proteins may have roles in ferritin translation and iron homeostasis in human liver
- The opioid-induced increase in IL-1 beta was blocked by naltrexone in the group tested. TNF-alpha expression was also significantly stimulated by 60 and 600 ng/ml beta-endorphin after 15 min, an effect blocked by naltrexone in the group tested.
- Site-restricted expression of IL-6 and its receptor by IL-1 beta-treated orbital fibroblasts might determine the profile of immunocompetent cells infiltrating the orbit in Graves' disease.
- The aim of this study was to test whether the IL-1-beta gene promoter region and exon 5 and IL-1 receptor antagonist (IL-1Ra) gene intron 2 polymorphisms could be useful genetic markers for susceptibility to Graves' disease.
- both IL-1B +3954 (C-->T) and C reactive protein +1059 (G-->C) polymorphisms influence baseline CRP values and act independently of each other in male subjects
- The frequencies of IL-1beta+3 594T, IL-10-1082G and CD14-159T allele were similar in patients with mild or severe pancreatitis and in controls.
- IKKbeta phosphorylates multiple p65 sites, as well as in an IkappaB-p65 complex, and S468 phosphorylation slightly reduces TNF-alpha- and IL-1beta-induced NF-kappaB activation
- The -511T/T genotype is a marker demonstrating that late onset AD in Chinese patients in Taiwan is genetically determined.
- VLDL induces IL-1beta mRNA expression, caspase-1 activation, and IL-1beta release from macrophages
- Glucocorticoids inhibit transcription directed by the IL-lbeta gene (IL1B) upstream induction sequence (UIS) enhancer.
- PAR-2 activation in intestinal epithelial cells potentiates IL-1beta-induced chemokine secretion via MAP kinase signaling pathways
- This study reports that IL1B -31C>T and IL1RA VNTR polymorphisms do not play a crucial role in susceptibility or resistance to cerebral malaria.
- results indicate that individuals homozygous for the IL1RN*1 allele and carrying the IL1B-31T allele had increased risk of non-small cell lung cancer; findings support the significance of IL1 gene cluster polymorphisms and risk of lung cancer
- The TT genotype of the IL-1beta gene may be associated with an increased risk of small vessel disease stroke
- A PCR method for identifying polymorphism.
- IL-1 beta has a role in control of stimulatory and inhibitory growth of cancer cells [review]
- IL-1beta, IL-6 and TNF-alpha are all significantly increased in hypoxic ischemic encephalopathy infants when compared to controls.
- thioredoxin-1 inhibits lipopolysaccharide-induced interleukin-1beta expression in human monocyte-derived macrophages
- a single residue in site A of IL-1beta can impact stability and function through perturbations in both local and long-range contacts
- These results suggest it unlikely that locally produced IL-1beta is an important mediator of glucotoxicity to human islets and argues against the IL-1beta-NF-kappaB-Fas pathway as a common mediator for beta-cell death in type 1 and type 2 diabetes.
- IL-1beta + TNF-alpha elicited innate immunity responses similar to those of flagellin.
- The combination of homozygosity for both IL1B-511*1 and CD46H*2 alleles is a high risk factor for recurrent pregnancy loss.
- IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism.
- endogenous ceramides are important second messengers in IL-1beta-induced apoptosis in pig thyroid cells through inhibition of adenylyl cyclase and ERK1/2 activities
- Results report changes in the transcriptome profile of HepG2 cells exposed to interleukin (IL)-6 alone, or IL-1beta and IL-6.
- Our findings indicate that human airway smooth muscle cells express and secrete MMP-12 that is up-regulated by IL-1beta and TNF-alpha.
- IL-1beta induces nitric oxide which has antagonistic effects on argininosuccinate synthetase gene and on the activity of argininosuccinate synthetase
- IL-1B-511 T allele does not decrease gastric acid output, although it has a stimulated influence on IL-1B expression.
- data indicate a novel two-step mechanism for IL-1beta transcription: 1) formation of a poised chromatin architecture, and 2) phosphorylation of an enhancer-bound factor that recruits other activators
- The association between the interleukin-1 polymorphisms and gastric cancer risk depends on the family history of gastric carcinoma in the study population.
- persistent IL-1beta signaling causes sustained activation of NFkappaB in a promoter-specific manner in human glial cells, leading to prolonged induction of selective pro-inflammatory genes
- Genetic variations in pro-inflammatory IL-1beta may predict the clinical outcome of breast carcinoma.
- IL-6 polymorphism is associated with age of onset of type 1 diabetes only when detected in patients with a high IL-1beta and tumor necrosis factor-alpha producer genotype.
- Complex folds of IL-1 beta like the beta-trefoil fold and functional loops like the beta-bulge can make some of the configuration space unavailable to the protein and cause topological frustration.
- cortisol up-regulates 11beta-HSD1 expression through induction of promoter activity, and the effect is enhanced by IL-1beta
- Levels of IL-1beta high or low activity in myeloma cell lines define groups of patients with smoldering multiple myeloma (MM): high producers are similar to patients with active MM; low producing levels resemble those with benign monoclonal gammopathies.
- chylomicron remnants stimulated IL-1beta mRNA expression and IL-1beta protein production probably via caspase-1 and NF-kappaB activation in THP-1 cells.
- IL-1B-511C allele, which may be associated with high IL-1B production in the liver, is a genetic marker for the development of HCC in chronic hepatitis B patients in a Thai population.
- +3953 single nucleotide polymorphism was associated neither with increased cervical fluid concentrations of IL-1beta nor with risk of preterm delivery.
- IL-1alpha and IL-1beta gene polymorphisms do not act as a strong susceptibility factor for MTLE-HS in individuals of Turkish ancestry
- Association between IL1B gene promoter polymorphisms and Helicobacter pylori associated duodenal ulcers.
- SEPS1 may regulate cytokine production in macrophage cells and there may be a regulatory loop between TNF-alpha, IL-1beta and SEPS1 that plays a key role in control of the inflammatory response
- Increased circulating levels of interleukin-1-beta is associated with Hepatitis C virus positive patients and with those affected also by non-Hodgkin's lymphoma
- GSK-3beta selectively regulates NFkappaB-mediated inflammatory gene expression of IL-1beta and TNF-alpha by controlling the flow of NFkappaB activity between transcription of inflammatory and survival genes
- IL-1beta- and TNF-alpha-stimulated expression of GRO-alpha from airway smooth muscle is regulated by independent pathways involving NF-kappaB activation and ERK and JNK pathways
- IL-1beta reduced the Young's modulus of human tenocytes by disrupting the cytoskeleton and/or downregulating the expression of actin and upregulating the expression of tubulins
- Polymorphism in the IL1B gene is associated with tuberculosis
- IL-1beta and IL-1Ra haplotype influences the impact of allograft outcome in renal transplant patients.
- IL-1beta increased ADAMTS-1 mRNA and protein levels in decidual stromal cell cultures in a concentration- and time-dependent manner.
- Elastin fragments induce NF-kappaB activation, leading to IL-1beta upregulation in invasive melanoma cells
- Functional microtubule network is required for IL-1beta secretion and suggest that disruption of tubulin is the mechanism by which inhibitors of histone deacetylasess reduce the secretion of IL-1beta.
- IL-1beta directly affects intracellular Ca2+ concentration in teleost fish leukocytes through a receptor-mediated mechanism, but not in human cells
- Polymorphism does probably not contribute to the variation in postoperative morphine consumption.
- The C-terminal B30.2 domain of pyrin is necessary and sufficient for the interaction with caspase-1 to modulate IL-1beta production.
- These results suggest that lysophospholipid released by activated platelets might enhance the IL-8- and MCP-1-dependent chemoattraction of monocytes toward the endothelium through an IL-1-dependent mechanism.
- data implicate PKCzeta as a necessary component of the IL-1 signaling pathways in chondrocytes that result in catabolic destruction of extracellular matrix proteins in osteoarthritic cartilage
- Secretion of bioactive IL1B from decidualizing endometrial stromal cells was investigated by in vitro stimulation of decidualizing cells with lipopolysaccharide, interferon gamma or human chorionic gonadotropin.
- TLR2, IL-6 and IL-1beta may have roles in inflammatory reactions in the course of Lyme disease
- serum IL-1beta and TNF-alpha are increased, and IL-2 and IL-6 are decreased in newly diagnosed IDDM patients
- glucocorticoids and IL-1beta upregulate the synthesis and translocation of annexin I in rheumatoid synovial cells, but interdependent signalling pathways are involved
- IL-1 regulates human trophoblast growth by induction of cell cycle delay and cell death
- The IL1 locus appears to be a high-priority susceptibility locus in psoriatic arthritis (PsA), with at least 2 independent regions that confer increased risk.
- composite genotype was found to be significantly associated with severe chronic periodontitis
- IL-1beta can stimulate cell proliferation through activation of NF-kappaB and AP-1 transcription factors in human synovial sarcoma
- neuro-immune activation in neuropathic pain conditions includes supraspinal brain regions, suggesting preinterleukin 1 beta modulation of supraspinal circuitry of pain in neuropathic conditions
- Pro-inflammatory cytokines derived from surgical trauma may enhance tumor cell adhesion to microvascular endothelial cells and thus bring about more successful tumor cell implantation resulting in an increased risk of metastasis formation.
- TNF-alpha and IL-1beta enhance IL-8 expression in term decidual cells, suggesting that these cytokines are important regulators of chorioamnionitis-related decidual neutrophil infiltration.
- IL1B-31TT and IL1B-511CC are associated with progression of gastric adenocarcinoma
- In countries with a low prevalence of gastric cancer, risk groups carrying cagA+ strains and IL-1 genetic polymorphisms should be identified and treated.
- importance of IL-1beta-induced HIF-1alpha in regulation blood-brain barrier permeability and angiogenesis
- pathways up-regulated by IL-1 in intestinal epithelial cells
- IL-1beta may interfere with the cholinergic signal transduction cascade by inhibiting transcription factor activation, thus providing another mechanism by which IL-1beta may induce cholinergic dysfunction in Alzheimer's disease.
- In a meta-analysis, the overall associations between IL-1B proinflammatory polymorphisms and gastric cancer were null but several studies showed an association. The sources of this variation are unclear.
- pannexin-1 is required for processing of caspase-1 and release of mature IL-1beta induced by P2X(7) receptor activation.
- Findings demonstrate that polymorphisms of high IL-1beta and TNF-alpha production were associated with an increased risk of RAS development.
- increased frequency of polymorphism associated with high production in recurrent aphthous stomatitis patients
- IL-1 beta-induced sLeX expression on HuH-7 cells was suppressed by transfection of gene-specific small interference RNAs against FUT VI and ST3Gal IV but not against FUT IV and ST3Gal III.
- IL-1beta (-511C/T) and interleukin-1 receptor antagonist(VNTR) polymorphisms are significantly associated with increased risk of Type 2 diabetes mellitus as well as associated complications in North Indians
- a shortage of geranylgeranylated proteins, rather than an excess of mevalonate, is likely to cause increased IL-1beta secretion by mononuclear leukocytes of patients with mevalonate kinase deficiency
- Expression of the adenosine A2A receptor in human epithelial A549 cells is up-regulated by IL-1beta and TNF-alpha within 24 h at the mRNA and protein level.
- Induces transcription-dependent lower airway epithelial cell-specific CCL5 secretion.
- This is the first report describing the association between IL-1B polymorphism and HBV-related hepatic fibrosis, and our data suggest that IL-1B polymorphisms may be related to disease progression of HBV-related hepatitis in Japan.
- Primary role for IL-1beta and TNF-alpha in the triggering of preterm labor associated with inflammation or infection.
- gene cluster polymorphisms are related to velocity of tooth translation
- The present results demonstrate that PI3Ks are involved in the inhibition of IL-1beta secretion and in the induction of sIL-1Ra production in human blood monocytes.
- MAPK and PI3K pathways regulate the synergy of IL-17 and IL-1beta to enhance CXCL-8 promoter activity, mRNA induction, and protein synthesis in HASMC via the cooperative activation of AP-1 and NF-kappaB trans-acting elements.
- IL1-BETA SNPs 0794C>T, 1274C>T, and 2143T>C are associated with gastric cancer.
- Interleukin-1B gene polymorphisms is associated with rheumatoid arthritis
- The mucosa of esophagitis patients produced significantly greater amounts of IL-1beta and IL-6 compared with those of control patients
- Haplotype T-E1-I was significantly associated with higher risk of pediatric nephrolithiasis.
- rapid IL-1 release and signaling through IL-1R represent key steps in the innate immune response to P. aeruginosa infection, and this process is deficient in cells lacking functional CFTR
- IL-1B-511 T allele is associated with H. pylori infection in non-cardiac gastric cancer in a Chinese population. The IL-1B-511 gene polymorphism appears to play an important role in gastric carcinogenesis in Chinese patients with H. pylori infection
- Interferon-gamma and bacterial lipopolysaccharide act synergistically on human neutrophils enhancing interleukin-8, interleukin-1beta, tumor necrosis factor-alpha, and interleukin-12 p70 secretion and phagocytosis via upregulation of toll-like receptor 4
- Upon exposure to higher concentrations of IL-1beta, S. aureus expressed significantly higher levels of MSCRAMMs mRNA and had significantly lower expression of mRNAs for bicomponent leukotoxins.
- a proinflammatory polymorphism at IL-1B promoter gene is associated with increased host susceptibility to H. pylori infection in Chinese
- data show that host genetic variants at the IL-1beta locus predispose to bacterial vaginosis among Caucasian non-pregnant women
- polymorphism of the interleukin-1 beta gene (IL-1beta Taq C-->T)is associated with sperm pathology in Caucasians
- The polymorphism of IL-1beta may at least partially explain the genetic predisposition to an aggressive course of the disease with the development of terminal stage.
- rhIL-1ss stimulated human lung fibroblasts to enhance matrix stiffness & augmented TGF-ss1-induced stiffening. It increased collagen III and CTGF expression & decreased collagen I and alpha-SMA.
- inductive expression of IL-1beta in fibroblast-like synoviocytes(FLS) is under specific inhibitory control. Increased production of IL-1beta in FLS of susceptible individuals may lead to a higher risk
- Finds an association between a polymorphism in the promoter of the IL1B gene and the development of squamous cell carcinoma of the pharynx
- The IL-1B+3954 T allele is a major risk for cachexia from locally advanced gastric cancer.
- analysis of cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways
- This study demonstrated that platelets are incapable of synthesizing detectable amounts of IL-1beta on their own; any IL-1beta synthesis detected is a by-product of leukocytes contaminating the platelet preparations
- Data showed that the frequencies of IL-1beta(C +3962) alleles are more than 0.95.
- Understanding of the cross-talk between NF-kappaB and MAPKs signaling in CF lung epithelial cells may help in developing new therapeutics to reduce lung inflammation in patients with CF.
- Under high glucose conditions, monocytes release significantly higher amounts of IL-1beta through multiple mechanisms.
- Salivary interleukin-1-beta measured at baseline may predict future alveolar bone loss.
- IL1B gene polymorphisms may be involved in susceptibility to systemic sclerosis.
- a pro-inflammatory genotype did not increase the colorectal cancer risk associated with H. pylori infection
- The regulation of three major mitogen-activated protein kinases phosphorylation, ERKp44/p42, p38, and JNK, was determined. The influence of specific mitogen-activated protein kinase inhibitors on IL-1 beta protein levels during beta-endorphin stimulation
- The study revealed no association of IL-1B polymorphism and the risk of aggressive and chronic periodontitis.
- study did not find an association between IL-1 gene cluster polymorphisms and glaucoma in this sample of Chinese subjects
- intermittent hypoxia ameliorates eosinophil- and platelet-related thrombosis, proinflammatory IL-1beta secretion, and lipid peroxidation enhanced by strenuous exercise.
- Inhibition of ERK phosphorylation decreased expression of IL1B.
- No significant associations of serum CRP levels with the genotypes of CRP C1444T and IL-1B C-31T were observed. TNF-A -1031CC polymorphism was significantly associated with high CRP values.
- A repeated measures two-level model of the proportion of sites bleeding on probing, which was adjusted for gender, average plaque index, probing depth, calculus, revealed a significantly lower proportion of bleeding sites in genotype-positive subjects.
- Interleukin-1beta gene functional polymorphism on dorsolateral prefrontal cortex activity is associated with schizophrenic patients
- The results in this study suggest that IL-1beta may act as a defense/survival factor in response to applied mechanical loading.
- Hand osteoarthritis risk is conferred by homozygous state for the IL1B haplotype characteristic of the extended risk haplotype.
- In neonatal infection, IL-1beta adversely affects breathing and its control by mPGES-1 activation and PGE(2) binding to brainstem EP3 receptors, resulting in increased apnea frequency and hypoxia-induced mortality.
- IL-1 beta significantly decreased PKC-zeta expression in PT osteoblasts, suggesting that proinflammatory cytokines can modulate its expression in osteoblasts in a way similar to changes detected in arthritic patients.
- ST2825 interfered with recruitment of IRAK1 and IRAK4 by MyD88, causing inhibition of IL-1beta-mediated activation of NF-kappaB transcriptional activity.
- Smaller magnitude of Parkinson disease risk increase among carriers of the heterozygous genotype for either or both polymorphisms suggests a gene-dosing effect.
- No evidence for association between IL-1beta (-511) and IL-1beta (+3953) polymorphisms and normal tension glaucoma(NTG). May not play key role in NTG pathogenesis in Chinese.
- mRNA and protein structures and identities of the present known mammalian IL1B.
- The IL-1beta C+3962T SNP is associated with the presence of severe restrictive lung physiology in Italian systemic sclerosis patients.
- an autocrine factor regulating compressive force-induced Receptor Activator of Nuclear Factor-kappaB Ligand expression in periodontal ligament cells [during tooth movement]
- essential for Interleukin 8 induction [during tooth movement]
- Supershift experiments implicated binding of both the CCAAT-enhancer binding protein beta transcription factor and the TATA-box binding protein to the interleukin-1beta SNP region.
- data from the present study show that the IL-1b+3954 allele is associated with a significantly increased risk for rheumatoid arthritis in females in the Chinese population
- IL-1 beta was elevated in colostrum of mothers of neonates with jaundice.
- necessity of inflammasome components for the UVB-induced secretion of IL-1beta by keratinocytes
- TNF-alpha, IL-1beta and IL-1Ra are produced after selective activation of mast cells in rheumatoid synovial tissue
- Staphylococcal enterotoxin C1 may act through an NADPH oxidase mechanism to release reactive oxygen species
- results of the present study suggest that the IL1 gene complex does not play a major role in conferring susceptibility to schizophrenia in the Japanese population
- Interleukin-1beta stimulation resulted in induction of HAS1 and HAS2 transcription but did not induce phenotypic differentiation or induce hyaluronan coat assembly
- IL-1beta -511C/T and IL-1 RN 86 bp VNTR do not contribute to the aetiology of essential hypertension in the Pakistani Pathan population investigated here
- Results show that IL-1B-511C/T and T carrier state may indicate less risk for gastric and colorectal carcinoma in the Japanese population.
- The content of IL-1beta decreased after the femoral neck injury. These results confirm mutual changes of activity between examined cytokines in the area of fractured bone.
- This study investigated the association between common IL1beta genetic polymorphisms, inflammation, and the MetS, and the modulation of diet-related variables (i.e., erythrocyte membrane fatty acid composition) in a white U.S. population.
- the IL1A (4845 GT and 4845 TT), IL1B (-511 CC), and TNFA (-238 AA and -308 GA) genotypes were associated with susceptibility to nasal polyposis in our study population
- Results describe the activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage.
- IL-1beta is highly inducible under different forms of stress, such as excitatory neurotransmitter excess occurring during seizures, in infection and inflammation, and during neurotrauma.
- The Shope Fibroma virus-encoded PYD-only protein 1 homolog (vPOP) impairs the host response by blocking Cryopyrin and ASC inflammasome-mediated activation of pro-Caspase-1 and subsequent processing of pro-interleukin (IL)-1beta.
- Endometrial mRNA levels of IL-1 beta and RANTES were increased in women with endometriosis compared with control subjects.
- Berberine suppressed Il-1beta/TNF-alpha production in lung inflammation models. Suppression was dependent on inhibition of IkappaB-alpha phosphorylation and degradation.
- Data suggested (-511)T>C SNP in IL-1beta gene be one of the susceptible alleles for Lumbar disc disease.
- IL-1beta polymorphisms were not related to oral lichen planus development.
- study suggests that the IL1RN VNTR, IL1A+4845, IL1B+3953 genes polymorphisms are not genetic markers of susceptibility to knee osteoarthritis in Turkish patients & are unrelated to clinical, radiological & laboratory characteristics of knee osteoarthriti
- results showed that the requirements of ATP stimulation for IL-1beta release observed in healthy individuals are bypassed in patients bearing CIAS1 mutations
- These results support the concept that FcgammaRIIa genotype may affect IL-1beta production, possibly leading to interindividual differences in periodontitis risk.
- polymorphism +3954 is associated with an increased risk of benign migratory glossitis development
- proteasome inhibition augmented interleukin-1 beta- and tumor necrosis factor-alpha-induced activation of the IkappaBalpha kinase and MKK4/JNK/c-Jun pathway along with TAK1 activation
- IL-1B +3954 and IL-1RN genetic polymorphisms are associated with a significantly increased risk of RA in this Chinese population
- Compared to TNF-alpha, IL-1 beta treatment results in a dose-dependent increase in the latent form of mesangial matrix metalloproteinase (MMP)-9 and a decrease in tissue inhibitor of metalloproteinase (TIMP)-1 production in mesangial cell line T-HMC.
- HMGB1 can induce expression of TNF-alpha and IL-1beta, and formation of a pro-inflammatory loop between HMGB1, TNF-alpha, and IL-1beta may be responsible for the prolonged and sustained inflammation in CLE.
- In in vitro PHA activated PBLs IL-6 was the most induced with a maximum increase of 1110-fold after 4 h of PHA stimulation, followed by TNF-alpha and IL-1beta as well as interferon-gamma (IFN-gamma).
- Our results suggest that there is an interaction between the Interleukin-1 beta and neuregulin-1 genes in schizophrenia
- interleukin-1 beta plays a central role in gout
- Association of interleukin-1A, interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms with multiple myeloma.
- The frequency of IL-1B-511 II/II was significantly higher among patients in early marginal bone loss (+) group than those in early marginal bone loss (-) group (P < .05).
- Periodontitis-induced autoinflammatory response also may play a role in the development/severity of Behcet's disease and recurrent aphtous stomatitis via IL-1 alpha and beta gene alteration.
- the IL-1 gene cluster may harbour susceptibility genes for AITDs and GD pathogenesis in the Tunisian population
- B19 capsid antigen slightly increased IL1B.
- Jak2 ordinarily dampens and limits the duration of the PGHS-2 induction by IL-1beta.
- higher serum IL1beta but not IL1alpha in postmenopausal mastalgia
- A significant association between the IL-1beta-1418C-->T polymorphism and memory performance was found with carriers of the T allele (dominant model) having worse memory performance than those with the C allele.
- ATP induced significantly higher levels of IL-1beta in LPS-activated rheumatoid arthritis blood samples.
- Our data suggest that IL-1beta elicits the rapid activation of a cellular network of genes particularly implicated in inflammatory response that may create a cellular environment favorable for myometrial cell contraction
- In atrophic body gastritis patients IL-1B-511 polymorphism does not appear to be associated either with specific clinical, biochemical or histological features or with the development of gastric neoplastic lesions at long-term follow-up.
- estradiol and progesterone are involved in PTX3 induction and regulation during implantation. Also, of the factors secreted by trophoblast, IL-1beta induces PTX3 in human endometrial stromal cells.
- distributions of IL-1B+3954 genotypes and IL-1A+4845 and IL-1B+3954 haplotypes were unique to the patients with rheumatoid arthritis and periodontitis.
- IL-1beta and MIF cytokine network induce MMP-1 and contribute to the loss of interstitial collagen in skin photoaging
- Taken together, these results show an association between severity of depressive symptoms and expression of pro-inflammatory cytokines in patients with HCV.
- HMEEC exposed to IL-1beta and TNF-alpha demonstrated significant upregulation of mucin secretion in a dose-dependent fashion.
- Strong association was observed with three single nucleotide polymorphisms (SNPs) in the IL1A gene (rs2856836, rs17561, rs1894399, p = 0.0036, 0.000019 and 0.0003, respectively).
- The production of GRO-alpha, IL-6 and IL-8 was shown to account for the ability of the HeLa cell culture medium to stimulate the migration of monocytes/macrophages, suggesting a key role for p38 MAPK and ERK1/ERK2.
- confirms the protective role of hydrostatic pressure which stimulates prostaglandin production and counteracts IL-1beta induced NO release in osteoarthritic chondrocytes
- When hCG-coated beads were applied to human endometrial epithelial cells in the presence of IL-1beta, endometrial cells acquired strong trophinin expression and the ability for apical cell adhesion with trophinin-expressing human trophoblastic cells
- effects of glucosamine on the regulation of the expression of MMPs (MMP-1, -2, and -13) and chemokines (IL-8, MCP-1, and RANTES) as well as the involvement of MAPK signal pathways (JNK, ERK, and p-38) and NF-kappaB on the present or absence of IL1B
- IL-1beta and IL-6 were found increased in plasma and tuberculous pleural fluid, indicating an inflammatory status
- Hyaluronan inhibited interleukin-1beta-induced metalloproteinase production from osteoarthritic synovial tissue by a process that was not solely dependent on hyaluronan molecular mass but that was partly mediated by hyaluronan binding to CD44.
- IL-1beta mRNA were upregulated in CD children.
- This study provides evidence of an association between lL-1beta +3953 polymorphism and risk of cervical cancer.
- studies suggest that IL-1beta, BK, and TGF-beta1 impair IP receptor-mediated cAMP accumulation by multiple effects on different components of the signaling pathway and that these effects are PKA and p38 MAP kinase dependent.
- synergy in IL-1beta production between NOD2 and TLR is mediated at post-translational level in a caspase-1-dependent manner.
- up-regulation of Smad7 by IL-1beta is mediated through the NF-kappaB pathway, especially the p65 subunit in chondrocytes
- Investigation of cellular responses to experimental phonation may provide insight into how matrix metalloproteinases and other extracellular matrices contribute to maintenance of the vocal fold and development of pathology.
- intracellular HMGB1 synergizes with a macrophage/monocyte-specific E26 transformation-specific sequence (Ets) transcription factor PU.1 to transactivate the promoter of the IL1B gene
- A combination of IL-1beta and IL-1RA associations exhibiting gene-gene interaction further substantiates the finding of risk.
- Data suggest that IL-1beta is involved in the regulation of various cytoskeletal components in human chondrocytes including the multifunctional protein FHL2, which might be relevant for the pathogenesis of osteoarthritis.
- the IL-1beta +3953 C/T polymorphism, was not found to be associated with risk for oral cancer; it seems that IL-1beta does not play a primary role in oral oncogenesis
- Il-1 beta gene polymorphisms were found to be associated with fat, but not lean, mass in elderly men.
- Tissue samples at different points showed a significant reduction in IL-1beta mRNA expression, and a significant increase in Foxp3 mRNA expression in ulcerative colitis.
- findings show IL-1beta NFkappakappaB- & C/EBPbeta-dependently induces IL-6-synthesis in hepatocytes; IL-6 consecutively stimulates C-reactive protein production; this mechanism may be crucial for acute phase response in general & CRP production in part..
- Interleukin-1B (IL1B) and interleukin-6 (IL6) gene polymorphisms may have a role in chronic lymphocytic leukaemia
- IL-1 beta polymorphism was not a primary predictor of oral squamous cell carcinoma development
- Serum IL-1beta, IL-6, IL-8, and TNF-alpha are mediators of inflammation in neonatal sepsis
- Transcriptional activation of the EGR-1 promoter by JNK-MKK7 or by IL-1 required a single upstream AP-1 site and three distal serum-response elements (SRE).
- There is a modest association between IL-1 beta-511T polymorphism and temporal lobe epilepsy with hippocampal sclerosis.
- the activity of JIP1-JNK complexes is downregulated by VRK2 in response to interleukin-1beta
- The researchers found an association between IL-B polymorphisms and the development of nasopharyngeal neoplasms in a Chinese population.
- These studies provide further evidence of a complex regulatory pathway that modulates the expression of granulocyte apoptosis during inflammation, and point to a specific role for IL-1beta as an autocrine survival factor.
- These data identified the NO/Ca(2+)/CaM/ERK signalling pathway as a novel mechanism mediating the mitogenic effect of IL-1beta in human astrocytes
- IL-1RN gene polymorphism has no association with acute coronary syndrome, but the allele 1 (C) of IL-1B (-511) may be a risk factor for susceptibility to USAP in the Turkish population
- compound SNPs in the NALP3 and CARD-8 genes may explain increased IL-1beta levels and inflammatory symptoms
- FlaA of V. cholerae could induce IL-1beta expression by recognizing TLR5 that activate NF-kappaB and MAP kinase in Int407 cells.
- Increased expression of IL-1beta and myofibroblast recruitment in the subacromial bursa in rotator cuff lesions are linked to shoulder stiffness
- Our data indicate that the induction of IL-1beta plays an important role in mediating the release of other proinflammatory cytokines from primary human epithelial cells following challenge with P. gingivalis
- IL-1RN*2 and IL-1beta -511*T in various combinations of genotypes and haplotypes are associated with higher susceptibility for cervical cancer.
- rhIL1beta and rhTNF alpha inhibited glucagon-stimulated signal transduction at the site of cAMP formation.
- Genotyping of the (+3954C/T) polymorphism of IL-1beta could be useful in patients starting highly active antiretroviral therapy, especially in potential users of stavudine, to predict their risk of developing lipodystrophic syndrome
- Results suggest that the simultaneous presence of IL-1B and TNF-alpha two-positions risk haplotypes enhances the susceptibility for celiac disease.
- IL-1B-511 polymorphism could be involved in the risk of developing restenosis after coronary stent placement
- IL1B promoter haplotypes characterized by homozygosity for the common allele at -3737, were associated with raised serum levels of C-reactive protein
- A significant increase was observed after plaque accumulation around the teeth gingival crevicular fluid whereas in the peri-implant crevicular fluid the increase was not statistically significant
- IL-1B -511*T-IL-1RN *1 (T1) haplotype carriers were at decreased risk for gastritis and no significant association was observed for precancerous lesions in North Indians
- data indicate that the IL-1beta-induced increase in MLCK protein expression and Caco-2 TJ permeability was mediated by an increase in MLCK expression and activity and by an NF-kappaB-dependent increase in MLCK gene transcription
- in the IL1B (interleukin 1 beta) T-31C T/T genotype, the rate of radiographis osteoarthritis was significantly higher than that with the C/C and C/T genotypes
- High levels of IL-1beta, IL-10, IL-17 and TNF-alpha (in the serum and synovial fluid) were observed in arthritis compared to the healthy controls.
- subjects with IL-1 beta -511TT genotype had lower risk for middle third tumor location of EC in a northern Indian population
- Epistatic interactions among IL-1 gene complex SNPs and clinical or environmental factors are more important than the singe attributes in the development of severe ventilatory restriction in systemic sclerosis patients.
- Patients with irritant contact dermatitis with the polymorphism IL1B-31 (T-->C)had lower concentrations of IL-1 alpha. The authors conclude that altered expression may lead to differences in the inflammatory response of the skin
- These results indicate that there may be aberrant control of the activity of the IL-1 family in sJIA patients causing the increased susceptibility to the disease.
- chronic periodontitis group had a significantly higher total amount [in gingival crevicular fluid] compared with control group
- activation of the TRPM8 variant in human lung epithelial cells leads to increased expression of IL-1alpha, -1beta, -4, -6, -8, and -13, granulocyte-macrophage colony-stimulating factor (GM-CSF), and TNF-alpha.
- study indicates that the IL-1B-511C/T and ACE I/D polymorphisms may be useful genetic markers of EPO requirement in hemodialysis patients
- Interleukin-1beta levels in gingival crevicular fluid were positively correlated with probing depth and clinical attachment loss in children with gingivitis.
- In overweight women, an association is found between the +3953 C/T polymorphism in the interleukin-1 beta gene and body mass index.
- Down-regulation in the release of the pro-inflammatory cytokine IL-1beta and the up-regulation of its antagonist (IL-1Ra) may be a part of the inflammatory response to infection in human term, but not preterm, placentae.
- Type 2 diabetes in this study seems not to increase gingival crevicular fluid levels of the evaluated inflammatory mediators IL-1beta.
- polymorphism may determine susceptibility to invasive pulmonary aspergillosis infection
- in a Korean ankylosing spondylitis (AS) cohort, haplotype analysis revealed associations of AS with IL1 locus polymorphisms
- Data show that IL-1 beta is overexpressed in experimental models of seizures in brain areas of seizure generation and propagation, prominently by glia and to a lesser extent by neurons.
- These data suggest that glucose- and IL-1beta-induced beta-cell secretory dysfunction and apoptosis are Ca(2+) influx and ERK dependent in rat islets.
- IL-1beta caused a distinct suppression of t-PA transcript, mediated primarily by NF-kappaB signaling.
- Interleukin 1beta and tumor necrosis alpha regulate IL-6-type cytokines in gingival fibroblasts
- Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1
- Stimuli acting on different pathogen-sensing receptors converge on a common pathway where ATP externalization is the first step in the cascade of events leading to inflammasome activation and IL-1beta and IL-18 secretion.
- Report IL-1beta gene polymorphisms in gastric cancer cases' and controls' family members from Chinese areas at high cancer prevalence.
- CK2 triggers the IFN regulatory factor-4 and p65 pathways independently to serve as a master regulator of IL-1beta transcription
- fixed orthodontic appliances result in an increase in the expression of IL-1beta and IL-8. This may reflect biologic activity in the periodontium during orthodontic tooth movement.
- Our results provide evidence that, in the majority of cases, polymorphism in IL1A and IL1B is not a major contributor to genetic susceptibility to RA.
- HuR plays an important role in suppression of TM protein synthesis in IL-1beta treatment and sepsis
- While homozygous allele 1 of IL-1beta(+3954) was the most frequent genotype in cases (62%), no controls were homozygous. In this Turkish population, susceptibility to LAgP is increased by homozygosity for allele 1 of IL-1beta(R+3954).
- High endogenous IL-1Ra (interleukin 1 receptor antagonist) /IL-1beta ratio occurs in synovial fluid from knee osteoarthritis; it does not correlate with pain or Lequesne index
- HCC risk associated with heavy alcohol intake and current smoking differed by this polymorphism among CLD patients. IL-1B -31T/C polymorphism may modify HCC risk in relation to alcohol intake or smoking
- Pravastatin immunomodulates IL-6 and C-reactive protein, but not IL-1 and TNF-alpha, in cardio-pulmonary bypass
- Salivary IL-1 beta levels were significantly higher in children with Langerhans cell histiocytosis than in normal children.
- treatment of cells with carcinogens induced the promoter significantly above the control level and the cells with wild-type allele T in position -31 showed the stronger induction when compared with the promoter with variant allele C in this position
- A combined effect of APOE and IL1B allelic variants has been discovered indicating the increased risk of the disease development in the carriers of APOE*4 and IL1B*T/*T alleles (OR = 4.76).
- IL-1beta mRNA expression is up-regulated in beta-cells of patients with T2DM;glucose-promoted IL-1beta autostimulation may be a possible contributor.
- To test whether polymorphisms in IL-1, NF-KB, FAS, and FASL genes are associated with risk of silicosis
- Thalidomide suppressed IL-1beta while enhancing TNF-alpha and IL-10, when cells in whole blood were stimulated with lipopolysaccharide.
- IL-1 beta plus interleukin-6 enhance the binding of transcription factor C/EBPbeta to the C-reactive protein promoter in Hep3B tumor cells.
- higher expression of IL1B mRNA in reflected amnion than in placental amnion at term only in the absence of labor
- we have shown that the IL-1B -31C allele promoter polymorphism is significantly associated with gastric stump cancer compared to the control group.
- Gestational diabetes is a state of insulin resistance associated with altered levels of proinflammatory cytokines, increased IL-1beta and decreased adiponectin values.
- LPS in the presence of soluble CD14 initiated splicing of unprocessed IL-1beta RNA, with translation and accumulation of IL-1beta protein in platelets
- We found no evidence that the gene polymorphism of IL-1 B (p = 0.182) and overall gene polymorphism in any of the genes (p = 0.752) correlate with periodontitis.
- IL-1beta may be an important triggering factor determining the silica-induced release in monocyte-endothelial cells of several of the other cytokines.
- in a coronary heart disease population IL-1 alpha and beta gene polymorphisms may be involved in increased central obesity, and the genetic influences are more evident among patients who have a higher level of obesity or inflammatory markers
- In a Canary Island population, IL-1 beta promoter polymorphism (-511 C/T) is an independent risk factor for Alzheimer disease.
- Single nucleotide polymorphisms in genes of the IL1 cluster: IL1A and IL1B are not associated with aggressive periodontitis in northern European Caucasian patients.
- caspase-8 has a role in the production of biologically active IL-1beta in response to TLR3 and TLR4 stimulation
- study concludes that IL-1beta upregulates HKalpha transcription by inducing Sp1 binding to HKalpha Sp1 & NF-kappaB sites & that Helicobacter pylori perturbation of HKalpha expression is independent of Sp1-mediated basal HKalpha transcription
- Variation in IL-1beta promoter conditions susceptibility to severe malarial anemia and functional changes in circulating IL-1beta levels.
- Overexpression of human interleukin-1beta in the transgenic murine pancreas induces chronic pancreatitis.
- Significantly higher levels of IL-1beta were found in the supernatants of Rheumatoid arthritis pannus compared to osteoarthritis pannus
- These studies demonstrate a synergistic role between TNFalpha and IL-1 family members, including IL-1beta, in the induction of interferon-gamma production.
- IL-1beta and IL-3 stimulated endothelium induces proliferation and differentiation of myeloid precursors, while IL-6 treatment induced a benefit of HPC survival.
- Interleukin-1beta mediates human airway epithelial cell migration via NF-kappaB
- Individuals with 1/C and 2/C haplotypes of IL-1RN VNTR and -511IL-1B C --> T polymorphisms were more susceptible to develop gallbladder cancer with gallstones compared to healthy controls in north India.
- There was no significant difference in the genotype or allele distributions of the IL1A -889 C/T and IL1B +3954C/T polymorphisms in patients with toxoplasmic retinochoroiditis when compared with controls.
- the correlation between the IL1beta-511T allele polymorphism and gastric cancer risk is not statistically significant in the Asian, but is strongly correlated in the Caucasian subgroup.
- the myelosuppressive cytokines TNFalpha and IL-1beta are secreted by bone marrow (BM) cells in a p38 MAPK-dependent manner
- Polymorphisms in the cytokine genes TNFA and IL1B may increase the risk of preterm birth, possibly by a dysregulation of the immune system in pregnancy.
- SOCS3 negatively regulates IL-1beta-induced MUC8 gene expression.
- Non-surgical periodontal treatment was effective in reducing the levels of IL-1beta in gingival crevicular fluid from diabetic patients with chronic periodontitis.
- IL-1Beta-511 (C/T), IL-1Beta+3953 (C/T) polymorphisms are not associated with the development of amyloid in familial Mediterranean fever patients
- IL1B impedes neutral lipid turnover in macrophage-derived foam cells.
- TNFalpha and IL-1 genetic polymorphisms contribute to the development of juvenile dermatomyositis and may also be indicators of disease severity
- Humans with this genotype were shown to have increased levels of anti-hepatitis B antibodies.
- This is the first report of IL1 gene cluster mutation screening in Korean keratoconus patients.
- Data suggest that graft-derived IL-1 can promote T cell intimal recruitment and IL-17 production during human artery allograft rejection, and suggest that targeting IL-1 in the perioperative transplant period may modulate host alloreactivity.
- serum IL-1beta level determination during the symptomatic phase of the diseases may help to differentiate asthmatics from patients with chronic obstructive pulmonary disease
- These results demonstrated that in A549 cells, activation of p50/p65 heterodimer through sequential activation of PKC alpha-JNK-NIK-IKK beta-NF-kappaB was required for IL-1 beta-induced uPA expression associated with migration of tumor cells.
- The genotype of IL-1B3954 T/T may protect against gastric cancer and gastric ulcer in Chinese Han population.
- These findings showed that HDAC inhibition antagonized FGF2 and IL-1beta induced MMP expression in articular chondrocytes.
- analysis of TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL
- IL1B can affect all the key steps in OP-1 signaling in chondrocytes
- IL-1B(+3954) and FcgammaRIIa (CD32) gene polymorphisms are not associated with an increased risk of Aggressive and chronic periodontitis.
- Interleukin-1 and tumor necrosis factor-alpha induce collagenolysis and bone resorption by regulation of matrix metalloproteinase-2 in mouse calvarial bone cells.
- This study introduces IL-32 as a critical regulator of endothelial function, expanding the properties of this cytokine relevant to coagulation, endothelial inflammation, and atherosclerosis.
- Administration of IL-1 or long-lasting insulin results in different changes in food intake and in neuroendocrine mechanisms 8 h following induction of the same degree of hypoglycemia.