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Validated All-in-One™ qPCR Primer for HTR2A(NM_000621.4) Search again
Product ID:
HQP009120
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
5-HT2A, HTR2
Gene Description:
5-hydroxytryptamine receptor 2A
Target Gene Accession:
NM_000621.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Gene References into function
- polymorphism of 5-HT2A receptor gene promoter may be causally related to the development of bipolar disorder
- promoter region of the 5-HT2A receptor gene does not contribute to a predisposition to anorexia nervosa for Japanese
- A multicenter European family-based transmission disequilibrium study found no evidence for a significant role of the 5-HT(2A) gene in anorexia nervosa.
- Patients carrying 5-HT(2A)-C allele had more than five times the risk for attempting suicide than noncarriers.
- Differential expression of the "C" and "T" alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics.
- Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues.
- possible influence of monoamine oxydase A (MAO-A), catechol-O-methyltransferase (COMT), serotonin receptor 2A (5-HT2A), dopamine receptor D2 (DRD2), and dopamine receptor D4 (DRD4) gene variants on timing of recurrence in mood disorders
- no association seen between T102C polymorphism of 5-HT2a receptor gene and onset of schizophrenia in Kuwaiti Arabs
- association between polymorphism of serotonin-2A receptor gene and schizophrenia among south Indians
- possible association seen between variation in HTR2a, childhood ADHD, and later development of SAD in women
- The A allele of the 5-HT 2A gene has bee associated with anorexia nervosa.
- For the ADHD combined subtype, the T102T genotype is a protective factor and the T102C genotype is a risk factor.
- THe promotr is -1438G/A polymorphic in children and adolescents with obsessive-compulsive disorders.
- In upper epidermis in eczematous skin; more evenly distributed in epidermis of control skin. In inflammatory dermal mononuclear cells and vessel walls. In basal epidermal layer of eczematous and control skin.
- The results did not support the association between the 5-HTR2A polymorphism and verbal fluency in normalcy, and agree with the assumed contribution of genotype A2A2 to the severity of schizophrenia
- The interaction of a constitutively active arrestin with the arrestin-insensitive 5-HT(2A) receptor induces agonist-independent internalization.
- An association was found between the presence of major depressive illness in Alzheimer's disease and both the 5-HT2A and 5-HT2C polymorphisms.
- A generally decreased neocortical binding potential of 5-HT2A receptor is found in Alzheimer's brains with a significant regional reduction in orbitofrontal, prefrontal, lateral frontal, cingulate, sensorimotor, parietal inferior, and occipital region.
- The study showed a positive association between panic disorder and the HTR2A gene, suggesting that HTR2A plays an important role in the pathogenesis of panic disorder.
- An association was found between the HTR2A gene promoter polymorphism and depressed mood in elderly Swedish males.
- -1438 G/A and T102C polymorphisms of the 5-HT2A receptor gene are not associated with increased risk of obsessive-compulsive disorder. The TT genotype of T102C and the AA genotype of the -1438 G/A polymorphism might be a factor in clinical severity
- No association of the HTR2A polymorphism has been found in the overall sample of 142 unipolar affective disorder-control pairs regarding allele and genotype frequencies and homo-heterozygote distributions.
- Review. Hyperactive platelet 5-HT2A receptor signal transduction occurs in depression. A possible mechanism for increased cardiac morbidity & mortality in depression may be this hyperreactivity & serotonin hyperresponsiveness of the platelet 5-HT2AR.
- To examine whether variation at two common polymorphisms, T102C and -1438AG, of the serotonin 2A gene (5HT2A) are involved in the puerperal triggering mechanism of bipolar affective puerperal psychosis
- This study investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant.
- 5-HT(2A) receptor gene polymorphism (A-1438G) appears to be associated with self-determinism and self-transcendence
- absence of any interindividual variability in relative mRNA allele ratio suggests that the HTR2A locus is unlikely to contain common polymorphisms or epigenetic modification that alter HTR2A mRNA levels in adult brain
- The results of this study support the hypothesis that the -1438A/G polymorphism of the promoter region of the 5-HTR2A gene is associated with MDD patients in a Korean population.
- HTR2A gene is associated with schizophrenia
- 5-HT(2A) receptor binding in the hippocampus was reduced by 29% in depressed subjects
- Alterations in 5-HT(1A,) 5-HT(1B), and 5-HT(2A) mRNA levels in the brains of subjects with both mood disorders and schizophrenia add further support for hypothesis of dysregulation of the serotonergic system in these psychiatric disorders.
- Single nucleotid polymorphism is associated with serotonin induced platelet aggregation.
- A statistically significant difference between obsessive-compulsive patients and controls was observed on the genotypic distribution and allelic frequencies for the C516T variant of the serotonin receptor type gene.
- Impulsive subjects exhibited decreased serotonin-induced calcium release by platelets, while fenfluramine-induced prolactin release was not affected.
- These data did not provide evidence for a contribution of the 102T/C SNP of HTR2A gene to susceptibility to the southern Han Chinese schizophrenia.
- No clear association was found between 5-HT2A variants and psychosis.
- Study assessed genetic factors influencing antidepressant response to fluoxetine. Results implicate HTR2A in the specificity of response to fluoxetine.
- No allele differences were detected regardless of whether the bulimia nervosa patients had suffered prior anorexia nervosa episodes.
- 5-HT(2A) serotonin receptors are regulated by Caveolin-1
- genotype distribution suggests that T102C polymorphism is associated with maintenance, but not with initiation of the smoking habit. The CC genotype was more frequent in the current smokers
- Patients with homozygote C allele of the 102 T/C polymorphisms or homozygote A allele of the -1438 G/A polymorphism of the 5-HT2A receptor gene, have a high risk of IBS. T/T genotype of 102 T/C polymorphism may be associated with more severe pain.
- The 102T genotype of the 5-HT2A receptor was significantly associated with delusions and agitation/aggression in Alzheimer Disease patients with psychiatric symptoms.
- The results suggested that the 5-HT2A may play some roles in the effects of drug treatment on obsessive-compulsive disorder.
- the serotonergic receptor 5HT2A could act as the cellular receptor for JCV on human glial cells
- (+/-)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI), significantly increased arachidonic acid incorporation in widespread brain areas containing 5-HT2A/2C receptors.
- Single nucleotide polymorphism might not be associated with susceptibility to a risk factor for developing smoking behavior.
- In this first report on the T102C genetic polymorphism of the 5-HT2A receptor in Chinese hypertensive patients, no correlation exists between T102C polymorphism and hypertension.
- No evidence for statistically significant associations between 5-HT2A polymorphisms and personality traits.
- Potential genetic relationship between the serotonin receptor gene polymorphism and the HDL-cholesterol serum levels.
- genetic variability in HTR(2A) contributes a small but significant degree of risk for the expression of TD, particularly in older patients and specifically for the non-orofacial (limb-truncal) type.
- Age strongly modulates the effect of the 5-HT2a receptor polymorphism at residue 452 on episodic memory.
- the 5-HT(2A) receptor subtype is fully expressed in the human choriocarcinoma cell lines JEG-3 and BeWo as well as in normal human placental tissue
- Findings indicate that women with bulimia nervosa who are HT2A GG homozygotes on the -1438G/A promoter polymorphism are characterized by increased impulsiveness.
- PET study of the 5-HT2AR status in subjects at increased risk for schizophrenia; distribution volume ratios as a proxy for 5-HT(2A)R availability were reduced in prefrontal cortex regions of at-risk subjects
- 5-HTR2A gene -1438G/A polymorphism was probably not associated with APS-induced weight gain in Chinese Han patients with schizophrenia in the study.
- Genotypes and allele frequencies of 102T/C polymorphism of the HTR2A and 796G/C polymorphism of the HTR2C did not differ between controls and patients with obstructive sleep apnea.
- 5-HT(2A)-serotonin receptor SNPs exert statistically significant effects on the affinity and functional effects of several currently approved atypical antipsychotics.
- The C-allele of 5-HT2a was significantly associated with the hyperactivity/impulsivity scale and the total ASRS scale with highest scores in carriers of the TT genotype.
- No significant difference was found in the 5-HTTLPR frequency between AN patients and controls; however, there was a statistical trend towards a higher frequency of the A allele of the -1438 A/G polymorphism in patients.
- it is unlikely that the--1438 G/A polymorphism of serotonin receptor 2A gene may influence obesity in a Spanish children population
- N376 to D mutation in the conserved NPxxY motif within the carboxy terminal tail domain (CT) of the 5-HT2A receptor alters the binding preference of GST-fusion protein constructs of the CT domain from ARF1 to an alternative isoform, ARF6.
- 5-HT exerts this positive growth effect on MCF-7 cells through, in part, the 5-HT(2A) receptor subtype, which is fully expressed in this cell line.
- In normal aging patients, 5-HT2A label was observed in large pyramidal cells, but to a lesser in small pyramidal cells and in stellate cells of cortical layers II-VI. In AD, density of positive cells was significantly reduced by 33%.
- Taken together with prior neurobiological findings, these new genetic data make a compelling case for a key role of HTR2A in the mechanism of antidepressant action.
- Persons with a GG genotype of the 5HT2A -1438 single nucleotide polymorphisms (SNP) were significantly more likely to be categorized as having sexual dysfunction than persons with a GA or AA genotype
- The -1438A>G polymorphism was found to be related to remission in attention-deficit/hyperactivity disorder.
- results suggest that the 5HTR2A -1438 A/G polymorphism is possibly related to seasonality in the Korean population
- results suggest the possible involvement of the A-1438A polymorphism of the 5-HT2A receptor gene in impulsive behavior
- the 5-HT2A T102C and ET-1 G/T polymorphisms are interactively associated with hypertension
- The results suggest a possible role for the 5-HT(2A)T102C polymorphism in the development of social anxiety disorder.
- No evidences for biased transmissions of both HTR2A -1438 A > G and SLC6A4 polymorphisms to ADHD youths were observed.
- lack of influence of the T102C polymorphism of the 5HT-2A receptor on the emergence of psychotic symptoms in Alzheimer's disease
- Results suggest that a polymorphism of a gene related to the serotonergic system affects eating behavior, influencing food choices in a population with a stable diet.
- The phosphorylation of Galpha protein represents a novel mechanism involved in regulation of receptor signaling.
- 5-HT2A receptors are involved spatial memory function.
- investigate seven genetic variants in three genes (serotonin transporter (5-HTT), serotonin receptor 1B (5-HTR1B) and serotonin receptor 2A (5-HTR2A)), which have previously been shown to be associated with ADHD
- No association between the 5-HT2A C102T polymorphism and suicidal behavior in major psychoses.
- investigation of association between the T102C polymorphism on the 5HT2A gene and cognitive function in patients with schizophrenia; findings suggest that the TC genotype might be related to certain cognitive impairments in patients with schizophrenia
- this replication study provides further evidence for association between the 5-HTR2A receptor T102C polymorphism and schizophrenia
- Haplotype analysis and global chi(2) test for haplotype transmission revealed a significant association between some SNPs of HTR2A and autism.
- The 5-HT2A -1438A (or 102T) allele was significantly more frequent in patients than controls (0.53 and 0.45, respectively; corrected p=0.028, OR=1.39 (95% CI=1.11-1.75)).
- The 102T/C sinngle nucleotide polymorphism in the 5-HT2A receptor gene may be an independent risk factor for developing stroke.
- no genetic association between HTR2A T102C with either schizophrenia or bipolar disorder under the assumption of a parent-of-origin effect
- Results suggest that the C516T polymorphism of the 5-HT2A receptor gene is not related to the susceptibility for schizophrenia in a Brazilian sample.
- 15 single nucleotide polymorphisms (SNPs) within the gene coding for the serotonin-receptor 2A (HTR2A) in patients suffering from PD and a control sample, is reported.
- T102C polymorphism of the HTR2A gene may be involved in the development of temperament by moderating the influence of environmental conditions.
- Male carriers of T/T genotype of 5HTR2A who were rated hyperactive by their mothers expressed a high level of hostility, especially that of cynicism, in adulthood. For men with other genetic variants, such an association was not seen.
- results suggest that the 5-HT(2A) gene polymorphism (102T/C) is not involved in genetic susceptibility to suicidal behavior in schizophrenic patients
- replicate the association between 5-HT2A T102C polymorphism and response to typical neuroleptics in schizophrenia patients
- Psychosis onset in Alzheimer disease is strongly associated with severity of depressive symptoms, an association that may be modified by HTR2A polymorphism
- We conclude that widespread reductions in 5-HT(2A) receptor binding were found in amnestic MCI, pointing at the presence of serotonergic dysfunction in prodromal AD.
- This studt conclude that 5-HT(2A) SNPs may marginally modulate personality traits.
- These data might suggest that 5-HT2A polymorphisms are not major susceptibility factors of psychotic symptoms in PD patients.
- study demonstrates a higher frequency of 5-HTR2A -1438A and 102T alleles in schizophrenia patients compared to healthy volunteers
- sarpogrelate, a selective 5-HT(2A) receptor antagonist, inhibited platelet aggregation in patients with ischemic stroke.
- Human serum albumin-advanced glycation end products stimulate phosphatidylserine externalization in platelets via 5-HT 2A/2C receptors.
- The results of the present study seem to indicate that HTR2A gene polymorphism influences the tendency to express tardive dyskinesia following prolonged antipsychotic drug exposure in Turkish schizophrenia patients.
- An independent significant association was found between the TT genotype (35.7%) and urinary incontinence (OR = 2.06, 95%CI = 1.16-3.65).
- The relative importance of two serine residues located near the top of transmembrane helix 5 of the human 5-HT(2A) receptor, comparing the wild type with S5.43(239)A or S5.46(242)A mutations, was assesed
- association between polymorphisms in this serotonin gene suggests that these genetic factors can modulate vulnerability to puerperal psychosis in female bipolar participants.
- Although the -1438G>A polymorphism in the serotonin 2A receptor is not a relevant marker for obesity risk, this variant may play a role in determining BMI in obese subjects
- These results suggest a progressive reduction of cortical 5-HT(2A)R density as a surrogate biological measure of increased risk for schizophrenia, irrespective of conversion.
- the HTR2A T102C could be a potential indicator of clinical improvement after risperidone treatment in patient with schizophrenia.
- 5-HT2A and MAOA genes, regulating activity of serotonin, influence on subjective time flow.
- Long-term estrogen replacement therapy in postmenopausal women may be associated with lower 5-HT(2A) receptor availability in hippocampus.
- genetic polymorphisms at the HTR2A gene are associated with susceptibility for RA, suggesting possible links between the serotonergic system and development of the disease.
- A significant association was found between the serotonin receptor 2A C516T polymorphism and "Mania" (a possessive and dependent romantic attachment, characterized by self-defeating emotions).
- Sequence variation in HTR2A, potentially resulting in its enhanced activity, may be involved in the pathophysiology of chronic fatigue syndrome.
- Possible genes for antipsychotic treatment response were the dopamine D2 receptor gene (DRD2), the serotonin 2A and 2C receptor genes (HTR2A and HTR2C), the P-glycoprotein gene (ABCB1 or MDR1) and the drug-metabolizing cytochrome P450 2D6 gene (CYP2D6).
- The T102C polymorphism may be associated with suicide attempts and/or with psychiatric disorders and do not support an association between the C1354T (His452Tyr) polymorphism and suicidal behavior
- The number of 5-HT2AR-positive cells was increased in atopic dermatitis skin.
- Our findings support a contribution of the 5-HT(2A) gene to susceptibility to heroin dependence, as well as a possible synergistic effect of 5-HT(2A) and 5-HTT genes on susceptibility to heroin dependence.
- No significant differences were found with respect to A-1438G and 5-HTTLPR polymorphisms.
- Cases (controls or alcoholics) with a family history of alcoholism have less 5-HT2A receptor binding throughout the prefrontal cortex than subjects without a family history of alcoholism.
- Our results confirm other in vivo findings of no difference in cortical 5-HT(2A) receptor binding between first-episode antipsychotic-naive schizophrenic patients and age- and gender-matched healthy control subjects.
- In post-mortem human brain from untreated schizophrenic subjects, the 2AR is upregulated and the mGluR2 is downregulated, a pattern that could predispose to psychosis
- Examination of genetic variants at the HTR2A locus indicated no association between the selected polymorphisms and childhood-onset mood disorder.
- Three polymorphisms with theoretical and/or empirical ties to ASB or related traits (i.e., tryptophan hydroxylase-A218C, 5HT(2A) His452Tyr, and the DAT1 variable nucleotide tandem repeat) were genotyped.
- The serotonin-induced PGE(2) overexpression appeared to be mediated by 5-HT(2A) and 5-HT(3) receptors in macrophage like synovial cells
- Prepulse inhibition (PPI, sensorimotor gating) and habituation of the acoustic startle response are modulated by the serotonin-2A (5-HT(2A)) receptor A-1438G and T102C polymorphisms in schizophrenia.
- The findings of this study suggest that PPI and habituation are modulated by 5-HT(2A)R A-1438G and T102C genotype in schizophrenia.
- In the human internal thoracic artery, 5-hydroxytryptamine (5-HT)-induced vasoconstriction is mediated by activation of both 5-HT2A and 5-HT1B receptors.
- This result suggests that 5HTR2A 1438A/G and 102T/C polymorphic regions can be associated with the phenotype or the pathogenesis of panic disorder.
- Attention was assessed using a modified version of the Munsterberg test. The significant interaction effect of the BDNF, 5-HTR2A and diagnosis on attention characteristics was found (p=0,04).
- Because ARI displays high affinity for 5-HTR2A AND D2 receptors and CYD2D6 is involved in its metabolism, polymorphisms were analyzed.
- the HTR2A polymorphisms may not be associated with susceptibility to suicidal behavior in our Korean population.
- We evaluated the co-occurrence of serotonergic and dopaminergic dysfunctions in OCD subjects, all drug-naive, with no co-morbidity and homogeneous for symptoms.
- A/G polymorphism tags a subgroup of schizophrenic patients with greater chance of improvement with antipsychotics of either type.
- Genetic polymorphism of the gene is substantially involving in individual variation of susceptibility to alcohol dependence.
- Data show that central 5-HT2A receptors do not mediate stress-induced pressor and tachycardic responses, and are not involved in cardiovascular control at rest.
- Embryonic stem cell-derived oligodendrocyte progenitor cells express the serotonin receptor, 5-HT2A
- Results suggest a possible role of 5-HT2A receptors in memory consolidation
- These observations suggest a possible role of 5-HT2A T102-->C SNP in the development of SS.
- The His452Tyr substitution in the serotonin 2A receptor gene may influence susceptibility to systemic sclerosis by altering platelet aggregation in response to serotonin.
- Development of the human insular cortex: differentiation, proliferation, cell death, and appearance of 5HT-2A receptors.
- The observed gene expression signature contains a prefrontal cortical downregulation of the HTR2A serotonin receptor transcript, strengthening previously reported genetic susceptibility reports.
- 5-HT2a-mediated remodeling mechanism for maintenance of normal cytoarchitecture is present in normal human myometrium
- findings suggest that the serotonin 2A receptor -1438A allele may predispose for nonimpulsive suicidal behavior
- Lower prefrontal 5-HT2A binding potential is related to violent aggression
- 5HTR2A polymorphism is unlikely to be associated with susceptibility of dyspeptic symptoms.
- Both HTR2C and HTR2A gene polymorphisms seem to be associated with the occurrence of metabolic abnormalities in patients treated with olanzapine or clozapine.
- Lesser reduction of symptoms after multi-modal therapy in bulimic women who carried low-function alleles of 5-HTTLPR or 5-HT(2A)receptor gene (-1438G/A)promoter
- We identified genetic variants of 5-HT(2A) and 5-HT(2C) receptors, the G-protein beta-3 subunit, and the adrenergic receptor beta-3, as genetic risk factors for olanzapine-induced weight gain.