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Validated All-in-One™ qPCR Primer for GLP1R(NM_002062.4) Search again
Product ID:
HQP007708
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
GLP-1, GLP-1-R, GLP-1R
Gene Description:
glucagon like peptide 1 receptor
Target Gene Accession:
NM_002062.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Gene References into function
- In vitro folding, functional characterization, and disulfide pattern of the extracellular domain
- Missenses mutations in Japaneses type 2 diabetes patients.
- analysis of the glucagon-like peptide-1 receptor beta-arrestin 2 interaction
- Experimental evidence indicates that the GLP-1 receptor gene is expressed in human brain as a protein, with binding properties similar to those of the GLP-1R located in peripheral tissues.
- glucagon-like peptide-1 receptor polymorphism results in reduced agonist responsiveness
- GLP-1R stimulation does not modify the growth or survival of human pancreatic cancer cells.
- The interaction of the GLP-1R with caveolin-1 regulates subcellular localization, trafficking, and signaling activity.
- results suggest that the differential affinity of nGLP-1R is explained almost entirely by divergent residues in the central part of the ligands: Leu10-Gly30 of Exendin-4 and Val16-Arg36 of GLP-1.
- For GLP-1 receptor scintigraphy, a low-background signal can be expected, on the basis of the low receptor expression in the normal tissues surrounding tumors.
- analysis of the crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain
- Structural basis of endogenous agonist activation of family B G protein-coupled receptors.
- Our data suggest that the GLP-1 receptor is restricted to the pancreatic beta cells.