|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for ICOSLG(NM_015259.5) Search again
Product ID:
HQP005977
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
B7-H2, B7H2, B7RP-1, B7RP1, B7h, CD275, GL50, ICOS-L, ICOSL, LICOS
Gene Description:
inducible T cell costimulator ligand
Target Gene Accession:
NM_015259.5(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- ICOS-L is a ligand for ICOS and plays an important functional role in the activation of memory T cells by endothelial cells [review]
- These results demonstrate that airway epithelial cells express the costimulatory molecule B7-H2, and suggest the possibility that B7-H2 may participate in antigen presentation by epithelial cells.
- ICOS-B7H costimulatory pathway may be involved in the negative regulation of cell-mediated immune responses.
- A critical role of the B7-like protein-ICOS costimulatory pathway is demonstrated in the pathogenesis of lupus nephritis.
- ICOSL protein and mRNA was expressed in 7 of 12 glioma cell lines and expression is upregulated by the inflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha), whereas interferon-gamma (IFN-gamma) has no such effect
- Expression of B7-H3 by nasal epithelial. Expands range of potential costimulatory signals through which these cells may interact with activated mucosal T lymphocytes. Extent of mucociliary differentiation of cultured cells may influence this capability.
- B7h-ICOS protein costimulatory pathway may be important in intestinal epithelial cell(iec):T-cell interactions. IEC expressed B7h and B7-H1.
- Results indicate the expression of functional B7-H2 molecule may facilitate progression of acute myeloid leukemia.
- Interaction of tubular epithelial cells and kidney infiltrating T cells via ICOS-L and B7-H1 may change the balance of positive and negative signals to the T cells
- ICOSL receptor binding site is mediated solely by the immunoglobulin (Ig) variable domain but requires the Ig constant domain for maintaining structural integrity of the protein.
- ICOS-L may be relevant in inducing an acute immune response and may be critically involved in perpetuating inflammation in chronically immune-mediated disorders of the peripheral nervous system.
- The generated a 3T3 cellular library retrovirally expressing mutants of the murine B7h gene. Screening of this unbiased cellular library identified residues of murine B7h. These residues are located on the same of human B7h by mutagenesis.
- Genetic variation in this protein affects the outcome and failure of kidney tranplantation.