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Validated All-in-One™ qPCR Primer for AGTR1(NM_000685.4) Search again
Product ID:
HQP004522
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, ATR1, HAT1R
Gene Description:
angiotensin II receptor type 1
Target Gene Accession:
NM_000685.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq].
Gene References into function
- Generated a new transgenic rat model that exhibits an upregulated myocardial AT1 receptor density and demonstrates augmented cardiac hypertrophy and contractile response to angiotensin II after volume and pressure overload.
- Stimulation of cardiac apoptosis in essential hypertension: potential role of angiotensin II.
- Lys(199) mutation of the human angiotensin type 1 receptor differentially affects the binding of surmountable and insurmountable non-peptide antagonists.
- role in familial hyperaldosteronism
- Polymorphisms of genes encoding the AT1 receptor as risk factors for orthostatic hypotension.
- angiotensinogen T174M and M235T and the AT1-receptor A1166C polymorphisms were related to the change in LVH during antihypertensive treatment with an AT1-receptor antagonist
- Adenine/cytosine1166 polymorphism is not associated with mitral valve prolapse syndrome in Taiwan Chinese.
- angiotensin IV is a potent agonist for constitutive active human AT1 receptor
- Stimulation of the Ang II type 1 receptor by Ang II reduced adipose conversion, whereas blockade of this receptor markedly enhanced adipogenesis.
- Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
- AT1R gene contributes to the development of essential hypertension.
- AT1 receptor antagonism improves endothelial function during hypercholesterolemia.
- Type I Ang II receptor subtype (AT1) mediates Ang II-dependent [Ca2+]i increase in cancerous breast cells in culture
- explore the relation among myocardial AT(1)-/AT(2)- receptor expression, myocardial remodeling and cardiac function in patients with congestive heart failure
- that the presence of C allele of the AT1R locus polymorphism might be associated with faster deterioration of renal function in renal failure
- A1166C polymorphism of the angiotensin II type 1 receptor gene and essential hypertension in Han, Tibetan and Yi populations.
- AT1R gene contributed to T2DM complicated by hypertension, but is only associated with cases of elevated systolic blood pressure.
- results suggest that the caveolin-binding-like motif of the angiotensin II type 1 receptor may act as a docking site for regulatory proteins modulating the routing and the functionality of the receptor
- The angiotensin II (Ang II) molecule must adopt an extended structure when ligand incorporation occurs on the C-terminal Ang II fragment at residues Phe-293 and Asn-294 of the seventh transmembrane domain of the AT1 receptor.
- in this large cohort of older adults, the A1166C polymorphism was not associated with BP control or incident cardiovascular events
- The results for the AT1R gene polymorphism revealed significant differences in allele and genotype frequencies.
- Analysis of A1166C polymorphism in Serbian hypertensives showed significant association between hypertension and CC genotype in the males only.
- Tyr-319 of the AT1 receptor is phosphorylated in response to Ang II and plays a key role in mediating Ang II-induced transactivation of EGFR and cell proliferation, possibly through its interaction with SHP-2 and EGFR
- angiotensin II AT(1) receptor autoantibodies (anti-AT(1)-AABs) in preeclamptic women
- Association of ACE I/D and AT(1)R-A C polymorphisms with BP in a healthy normotensive primary care population. Although synergistic effect of both polymorphisms on BP does not seem to be present, an additive effect on DBP is likely.
- Importance of alternative splicing as an additional post-transcriptional mechanism regulating human AT(1) receptor number and function. (review)
- Our findings suggest that maternal autoantibody with the ability to activate AT1 receptors may account for two features of preeclampsia, increased PAI-1 production and shallow trophoblast invasion
- Polymorphism in essential arterial hypertension in childhood.
- the A1166C polymorphism of AT1 receptor is unlikely to influence blood pressure status in the Japanese population.
- that AT1 A/C1166 polymorphism was not associated with any clinical parameters associated with hypertension or atherosclerosis in the Japanese population.
- In young healthy subjects, there is an important interaction between gender, the AGT1R A1166-->C gene polymorphism, and blood pressure.
- mRNA levels as well as the protein production of angiotensin II receptors of type 1 was monitored during differentiation of primary human preadipocytes in culture and in mature adipocytes.
- Polymorphism is associated with diabetic retinopathy in NIDDM in Chinese patients.
- Susceptibility to faster progression to ESRD is associated with the AT1R A1166C polymorphism.
- activation of the angiotensin II type 1 receptor alters the spatial proximity of transmembrane 7 to the ligand-binding pocket
- Placental AT1R expression and its normal vascular and endocrine activity plays a very important role in oxygenation and nutrition of the fetus and this ensures proper fetal development and growth.
- results confirmed that angiotensin II receptor type 1 immunoreactivity is elevated in vascular endothelial cells of human placenta from pregnancies complicated by preeclampsia
- Polymorphisms of the angiotensin II receptor, type 1 gene is associated with increased risk of coronary heart disease in hypertension.
- findings suggest that the angiotensinogen and angiotensin II type 1 receptor gene polymorphisms would not have an effect on hypertension or the end stage renal disease in autosomal dominant polycystic kidney disease
- the N111G-AT1 receptor maintains a high affinity conformation despite being uncoupled from the G protein Gq/11.
- Agonistic anatibodies targeting this receptor may participate in steroid-refractory acute vacular rejection of kidney tranplants.
- A1166C polymorphism of the AT1 receptor gene is associated with collagen type I synthesis and myocardial stiffness in patients with hypertensive heart disease.
- in patients with nephrotic syndrome due to biopsy proven focal segmental glomerulosclerosis, the AT1R-A1166C polymorphism was not associated with any of the parameters studied
- These results suggest that cap-independent translation initiation by internal ribosome entry may represent an important mechanism for the regulation of human angiotensin II type 1 receptor expression.
- Aberrant Ang II via AGTR1 may be involved in tissue fibrosis through excessive production of the extracellular matrix components in systemic sclerosis dermal fibroblasts.
- gene polymorphisms in Turkish hypertensive patients
- AT1 and AT2 receptors were found within the epidermis and in dermal vessel walls.
- The 1166 A->C AT1 receptor polymorphism does not confer any increased risk for MI in young South African Indians.
- Polymorphisms in angiotensin II type 1 receptor gene is associated with severe hypertension in pregnancy
- No significant differences in the distribution of any of these polymorphisms were found between patients with pre-eclampsia or eclampsia and the normal control
- A significant association was found between height and the C573T polymorphism in women. Allele dosage effect.
- Ang II stimulates IL-6 and IL-8 production and release from human adipocytes by a NF-kappaB-dependent pathway. This proinflammatory action of Ang II seems to be mediated by the AT1.
- expression of angiotensin II (ANG II) receptor subtype 1(AT(1)R) is statistically significantly increased in the syncytiotrophoblast layer and villous endothelium of human placenta with pregnancy-induced hypertension
- angiotensin II type 1 receptor is upregulated in cardiac donors with spontaneous intracerebral hemorrhage
- The vasoconstrictively acting genotype AT1R C/C is of similar prevalence in recurrent spontaneous abortions patients and in controls.
- CYP11B2 C-344T and AT1R A1166C polymorphisms affect the autonomic modulation of heart rate, but these genetic effects depend on sodium excretion.
- Results show that glucose response factor(s) acts as trans-acting factor(s) binding to the cis-acting repressor element in the angiotensin type-1 receptor promoter.
- ACE I/D and AT1R 1166A/C polymorphisms affect coronary artery stenosis in patients with Kawasaki disease (KD).
- Polymorphism of A1166C gene of AGTR1 contributes to formation of AH signs diversity in DM2 patients.
- Data show how the ability of receptors such as angiotensin type 1A to interact with beta-arrestin 2 determines both the mechanism of extracellular signal-regulated kinase 1 and 2 activation as well as the physiological consequences of this activation.
- EP24.15 associates with AT1 and B2 receptors both at the plasma membrane and after receptor internalization
- Polymorphism is not associated with increased risk of developing chronic kidney allograft dysfunction.
- there are key elements of TMD3 in the human type 1 angiotensin II receptor that contribute to the activation of class A G protein-coupled receptors through structural rearrangements
- common genetic variations in the AGTR1 gene may affect the risk of MI in Chinese males
- an imbalance of AT1R and AT2R activity in mesangial cells following exposure to pIgA plays a significant pathogenetic role in the inflammatory injury in IgA nephropathy.
- the AT1 gene variant exerted a major impact on ischemic stroke occurrence in the presence of hypertension.
- central arterial stiffness was significantly and independently associated with the AC polymorphism, increased pulse wave velocity being associated with the presence of the A allele
- AT1R/A1166C polymorphism is not a major genetic predisposing factor for hypertension in Japanese.
- culture of coronary arteries induced down-regulation of the angiotensin AT1 receptor mRNA levels
- c-Src has a role in regulating the dissociation of AP-2 from agonist-occupied AT1R and beta-arrestin during the clathrin-mediated internalization of receptors
- protein kinase B/Akt phosphorylation is stimulated by mechanical stretch in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor
- may be polymorphic among mult=ethnic groups as a risk factor for hypertension.
- Significant role of the AT1R. Normal AT1R activity may be of fundamental significance for the normal course of pregnancy and proper fetal growth.
- beta-arrestin 2 can mediate chemotaxis through mechanisms which may be G-protein-independent (Ang II receptors) or -dependent (LPA receptors).
- AGTR1 A1166C genotypes may influence resting blood pressure (BP) response to strength training(ST)
- There are interactions between the angiotensin II type 1 receptor 1166 A/C as well as the angiotensinogen 235 M/T gene polymorphism and age with respect to the outcome after coronary artery bypass graft surgery.
- the G allele of AGTR1/A-153G is linked independently to urinary F2-isoprostanes level; data suggest that F2-isoprostane level depends at least in part on the A-153G polymorphism of the angiotensin II AT1 receptor gene.
- studies indicate that the angiotensin-converting enzyme-Angiotensin II-Angiotensin II receptor type 1 system serves as a positive feedback loop and fosters pulmonary artery adventitial fibroblasts proliferation under hypoxic conditions
- Angiotensin II activates mineralocorticoid-receptor-mediated gene transcription via the AT1 receptor.
- the systemic and renal hemodynamic responses to acute AT1R blockade are, at least in part, genetically determined
- a maternal autoantibody with the ability to activate AT(1) receptors may account for the development of renal damage seen in preeclamptic patients.
- The non-AA allele of ATR1 1166 gene is associated with an anti-inflammatory state and may predict renal outcome in transplant patients.
- an evidence-based molecular model of interactions with human AT1 that is very similar to the rhodopsin-retinal interaction
- AT1R A1166C polymorphism showed no consistent association with blood pressure (load).
- the interaction between Ang II and AT2R causes expression of cleaved poly[ADP-ribose] polymerase through downregulation of the mitogen-activated protein kinase pathway
- No influence of AGTR1 genetic polymorphisms in the development of lupus nephropathy.
- Diabetic nephropathy patients homozygous for the wild type AGTR1 1166A allele had increased all cause mortality risk for treatment with Renin-Angiotensin-System inhibitors
- Depression patients with a haplotype combining the CC and DD/ID genotypes respond better to treatment than those with either single allele.
- report associates severe congenital uropathies and renal hypodysplasia with decreased renin-angiotensin system activity associated with the ACE II genotype and a possible functional imbalance among ATR1 receptors.
- AT1/B2 receptor heterodimerization contributes to angiotensin II hyperresponsiveness of mesangial cells in experimental hypertension.
- Double homozygous combinations for normal alleles (MM of AGT, II of ACE and AA of AGTR1) had a lower risk of AMI (odds ratio<0.38), indicating a protective effect in these individuals.
- Significant association between AT1-receptor AA genotype and decreased risk of premature coronary heart disease.
- Polymorphisms of ACE and AT1R genes additively contribute to QTc prolongation found in a great majority of end stage renal disease patients
- AT1 receptor blockade in obese men does not reveal a major tonic ANG II effect on interstitial glucose supply, lipolysis, or glycolysis in skeletal muscle, either at rest or during beta-adrenergic stimulation
- the AGTR1 A1166C and the NOS3 G894T polymorphisms are associated with silent white matter lesions in the subcortical area in essential hypertension
- Abundant expression of AT1 receptors in all human fibroblasts studied, and in vascular smooth muscle cells.
- Podocytes express mRNA for angiotensin II receptor, type 1.
- a cross-talk exists between the AGE-RAGE system and the angiotensin II receptor (renin-angiotensin system), and serum levels of sRAGE may reflect endothelial RAGE expression
- Mediates downstream signaling mechanisms through G-protein-dependent and -independent mechanisms, which induce cardiac hypertrophy with a distinct phenotype.
- Addition of BK or AngII to the cell line expressing WT AT1aR and BKB2R downregulated the expression of collagen alpha1(I) (COL1A1) mRNA. However, these effectors did not have this effect in cells expressing the mutant receptors.
- Interaction between AT1 and TGFbeta1 is a novel observation in trophoblast and suggests new avenues for the study of placentation.
- Robust interaction is demonstrated between the AT1 receptor and quality control chaperones calnexin and Hsp70 in the endoplasmic reticulum
- Genetic polymorphisms of the angiotensin II Type 1 Receptor is associated with end-stage renal disease
- angiotensin II receptor haplotype transmission is distorted in fetal growth restriction
- AT1R correlated with tumour angiogenesis and poor patient outcome in ovarian cancer, suggesting its clinical potential for a novel molecular target in strategies for ovarian cancer treatment
- Candesatran monoterapy is more effective for treatment of patients having C allele.
- TGF-beta up-regulated hAT(1)R mRNA splice variants which harbor exon 2.
- AT(1) receptor-mediated activation of PI 3-K/Akt cascades occurs at least partially via the transactivation of EGF receptor, which is under a negative control by AT(2) receptor in hypertrophic scar fibroblasts.
- The genotype distributions or allele frequencies of angiotensin II receptor, type 1 were significantly different between the samples of the She and Han populations in China.
- AT1R mRNA was expressed in polymorphonuclear leukocytes (PMNs), monocytes, B-lymphocytes, and, to a lesser extent, T-lymphocytes.
- No episodes of coronary heart disease and heart failure were detected in T-A carriers with hypertension. Haplotypes of G/T rs5193-G/A rs5194 are not associated with essential hypertension
- NO decreased the binding affinity of the AT1 receptor for angiotensin II by S-nitrosylation of cysteine 289.
- Restenosis after percutaneous coronary intervention is associated with AGTR1.
- the ability of MAS to up-regulate AT(1) receptor levels reflects the constitutive capacity of MAS to activate Galpha(q)/Galpha(11) and hence stimulate PKC-dependent phosphorylation of the AT(1) receptor
- Direct AT(1) inhibition and indirect AT(2) receptor stimulation are associated factors normalizing cerebrovascular compliance, reducing cerebrovascular inflammation and decreasing the vulnerability to brain ischemia.
- AT1R genotype is an independent predictor of both plasma protein carbonyls and myeloperoxidase levels in heart failure.
- miR-155 can bind to the 3'-untranslated region of hAT(1)R mRNAs and translationally repress the expression of this protein in vivo. Importantly, the translational repression mediated by miR-155 can be regulated by physiological stimuli
- An inducible expression system is used to insert AngII receptor 1 (AT1R) and to obtain a signal level in response to angiotensin II at the magnitude of bradykinin.
- angiotensin II, via AT1-R signaling, decreases system A activity by suppressing Na(+)-K(+)-ATPase in human placental villi
- findings provide evidence that, in breast cancer cells, oestrogen can signal through AT1 to activate early cell survival mechanisms in an ER-independent manner
- Data describe the role of angiotensin II type 1A receptor phosphorylation, phospholipase D, and extracellular calcium in isoform-specific protein kinase C membrane translocation responses.
- AT1R gene polymorphism influences Doppler blood flow parameters of both BA and CCA, and IMT of CCA.
- Blockade may increase risk of myocardial infarct
- A/C1166 polymorphism of AT1R did not influence the risk of either acute MI or biventricular function after anterior MI.
- analysis of the G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor
- AT1 receptor expression in myocardium of type 2 diabetic patients is dynamic, depending on the level of glycaemic control and the activity of the renin angiotensin system.
- This is the first report to describe increased mRNA expression of AGTR1 in response to recurrent cellular rejection in heart transplantations.
- Analysis of 43 receptors mutants in the N111G-hAT1 series, photolabeled and CNBr digested, showed that there were only subtle structural changes between the wt-receptor and its constitutively active form.
- Several selective proteolyses of the labeled receptor indicate that the new photolabel forms three simultaneous contact regions on the hAT1 receptor
- exogenous human angiotensin II increases the blood pressure more potently in subjects with 1166A/C than in those with 1166A/A polymorphism of angiotensin II type 1 receptor
- Mutations were not detected in the AGTR1 and AGTR2 genes in patients with premature adrenarche; however, two polymorphisms were identified in the AGTR1 gene: the C573T (exon 5) and the A1166C (3' untranslated region).
- Polymorphism A1166C contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy. The mutated receptor has changed sensitivity to Angiotensine II.
- NLS (KKFKKY; aa307-312) is located within the cytoplasmic tail of the AT(1A) receptor and that nuclear localization of the receptor corresponds with specific activation of transcription for the COX-2 gene PTGS-2.
- The present study suggests that none of the major genetic polymorphisms in the RAA system (angiotensinogen, angiotensin-converting enzyme, angiotensin II type 1 receptor, and aldosterone synthase) strongly influence the onset of essential hypertension.
- pressor response induced by intracisternally infused angiotensin II is substantially mediated by activation of Rho/Rho-kinase pathway via AT1 receptors of the brainstem in WKY; this pathway might be involved in the hypertensive mechanisms of SHR.
- A novel approach to quantitation of transcript haplotypes (QTH) of AGTR1 is desctibed. Linkage disequilibrium (LD) and genomic haplotype associations with metabolic syndrome were examined.
- We found an association between AGT and blood pressure, atherosclerosis and white matter lesions (WML). Also, we found synergistic effects between AGT and AT1R on the development of WML.
- In conclusion, the frequency of 1166C polymorphism is similar among Malay hypertensive and normotensive subjects; the polymorphism has no association with BP but may have an influence on aortic pulse wave velocity in Malays.
- Transfected into mice, blockade by olmesartan may be bseneficial in treaatment of HIV-associated nephropathy.
- Our data suggest that in cirrhosis-induced vasodilation, the AT1-R is desensitized by GRK-2 and beta-arrestin-2 and that changed patterns of phosphorylated Ca(2+) sensitizing proteins decrease Ca(2+) sensitivity.
- Homozygotes of the C-allele in the AT2-R A/C(3123) polymorphism were associated with small but significant increases in BMI levels in Japanese women
- Polymorphism A11166C of AT1R gene does not predispose to myocardial infarction and higher left ventricular mass in the Polish population.
- Meta-analysis research finds an association between AT1R+1166A/C polymorphism and an increased risk of myocardial infarction for the "C" allele.
- human embryonic stem cells can be differentiated effectively into the epithelial lineage and that when differentiated express functional, signaling AT1 and BKB2 receptors
- the X-linked AT2 (-1332 G/A) polymorphism may have a role in premature coronary artery disease and possibly stenotic atherosclerosis requiring revascularization
- results suggest a correlation between AT1 A1166C gene polymorphism and risk of cardiovascular disease
- The A1166C polymorphism of AGTR1 might affect insulin resistance by altering the responsiveness to angiotensin II signaling, though this mechanism is as yet inconclusive.
- The up-regulation of angiotensin II receptor type 1 and the consequent increase of CTGF expression, independently of TGFbeta1, participate
- angiotensin II, the main product of the renin-angiotensin system, is mediated by the AT1 receptor [review]
- AT1 an AT2 receptors are developmentally regulated in fetal skin, suggesting theh possible diverse actions that angiotensin II might play in development and maturation of skin
- Activation of the angiotensin II type 1 receptor leads to movement of the sixth transmembrane domain.
- AT(1)PRE3 is responsible for the tissue-specific expression of the human AT(1) gene, and that AT(1)PRE (positvely regulating elements)1, AT(1)PRE2 and AT(1)PRE4 function as a general enhancer in liver-derived cells.
- AT1R is involved in the progression of gastric cancer and may promote the angiogenesis of gastric cancer cell line (MKN-28).
- Angiotensin II directly stimulates MCP-2 expression through AT1-receptors in activated macrophages
- the incidence of recurrent in-stent restenosis was not associated with the polymorphism A1166C of the angiotensin-II receptor 1 (AGTR1.
- The polymorphism of TGF beta1 gene is associated with hereditary susceptibility to liver cirrhosis and severity of HBV-induced liver cirrhosis; the polymorphism of AT1R gene is not associated with hereditary susceptibility to HBV-induced liver cirrhosis.
- Review. The presence of AT1/bradykinin-B2-receptor heterodimers is involved in the hypertensive and oxidative stress states in pre-eclampsia.
- In the presence of other coexisting risk factors the AGTR1 A(1166)C polymorphism increased the risk of stroke.
- study reports an association between the A1166C polymorphism in the gene AGTR1 and treatment outcome in geriatric major depression
- biochemical mechanism by which the +1166 A/C polymorphism can lead to increased AT1R densities and possibly cardiovascular disease.
- Because AII receptors are present in tumor tissue, it can be hypothesized that AII may be an additional factor responsible for testicular adrenal rest tumor growth.
- These results suggest an important role for cross talk among Smad, p38 MAPK, JNK, and PI3K pathways in mediating the augmented expression of hAT(1)R following TGF-beta1 treatment in human fetal pulmonary fibroblasts.
- The C allele of AT1R A1166C is associated with significantly lower endothelial response to statin treatment
- findings show that hsa-miR-155 down-regulates the expression of only the 1166A, and not the 1166C, allele of rs5186 in the 3' UTR of the AGTR1 gene
- Antagonists of AGTR1 in transgenic rats prevent renin-angiotensin system inhibition and prevent damage in an angiotensin ii model of hypertenion.
- frequency of genotypes similar in preeclampsia and normal pregnancy
- These results suggest that the cycling of ARF6 between its GDP-and GTP-bound states coordinates the recruitment of AP-2 and clathrin to activated receptors during the endocytic process.
- signaling to the small G-protein Rap-1 is regulated by Kv4.3
- Data suggest that the combination of homozygous MTHFR 677T and angiotensin II type-1 receptor 1166C variants confers the risk of small-vessel-associated ischemic stroke.
- in conclusion, combination of A(1166)C of AGTR(1) and T(786)C of eNOS mutations increased stiffness of muscular-type arteries
- Review of recent studies indicates that women with preeclampsia have autoantibodies that activate the angiotensin receptor, AT1, and that autoantibody-mediated AT1 receptor activation contributes to pathophysiology associated with preeclampsia.
- AGTR1 A1166C polymorphism was associated with left-ventricular hypertrophy (LVH), dependent on concomitant renal dysfunction. A weaker renal function dependent association between the angiotensin-converting enzyme polymorphism and LVH was also observed.
- Polymorphisms in angiotensin II type 1 receptor did not affect renal allograft function.
- Angiotensin II type 1 receptor gene polymorphisms were associated with age-related left ventricle remodeling and hypertrophy.
- the DD genotype of ACE and CC genotype of AT1R may have roles in renal rejection
- Angiotensin II type 1 receptor gene expression was significantly increased after stimulation with native low-density lipoprotein (nLDL) and oxidized LDL.
- Reduction in cutaneous NO-dependent vasodilation in low-flow postural tachycardia syndrome is corrected by AT(1)R blockade.
- beta-arrestin2 supported protein kinase C-independent ERK1/2 activation by the AT1a rceptor
- AT1R expression in the premalignant pancreatic lesions suggests its involvement in tumor progression and angiogenesis.
- Ascorbic acid decreases the binding affinity of the AT(1) receptor.
- Transfection of CD4-positive lymphocytes with PPARgamma small interfering RNA abolished telmisartan's effect on migration, whereas blockade of the AT1R had no such effect.
- Discovery of differential regulation by D1and D5 receptors opens new avenues for development of agonists selective to either receptor subtype as targeted antihypertensive agents that can decrease AT(1)R-mediated antinatriuresis.
- Data show that glial as well as neuronal AT1 receptors can mediate the brain's responses to angiotensins.
- These results show that the AT(1) receptor undergoes a conformational switch that couples mechanical stress-induced activation and inverse agonist-induced inactivation.
- association of the polymorphisms of the genes of the renin-angiotensin system in preterm delivery and premature rupture of membranes
- identified a strong and repeated association between the AGTR1 1166C allele and susceptibility to abdominal aortic aneurysm
- A1166C polymorphism not associated with atrial fibrillation in single-locus analyses, but part of multigene effect
- Overexpression of AGT1R in the myocardium leads to increased incidence of cardiac arrhythmia associated with delayed repolarization.
- These data indicates that the expression of AT1 receptors is altered in adrenal cancer and in pheochromocytomas. The expression of AT2 receptors, in turn, may be connected with the process of tumoral neo-angiogenesis.
- Roles of BMP-6 in aldosterone breakthrough induced by long-term treatment with agtr1 stimulated aldosterone production by adrenocortical cells.
- TNF-alpha induces renal tubular cell damage and AT1/AT2 receptor blockers showed cytoprotective effects probably via at least partly different mechanisms.
- allow identification of specific RNA-binding proteins possibly involved in the control of the hAT1-receptor mRNA stability and in the regulation of their expressions
- the AT1R [1166A > C] and AGT [-6G > A] polymorphisms do not influence repolarization parameters in this Chinese population in Taiwan.
- risk of having overt diabetic nephropathy was increased in patients homozygous for the angiotensin II type 1 receptor (AGTR1) A1166 allele, and smoking seemed to enhance the effect of the AGTR1 genotype.
- Ang II produces an inhibitory effect on I(Kr)/hERG currents via AT(1) receptors linked to the PKC pathway in ventricular myocytes.
- Roles of ACE vs. non-ACE and AT1 vs. AT2 in placental vessel cells.
- Angiotensin II and its type 1 receptor play a profibrogenic role in idiopathic interstitial pneumonias, particularly in usual interstitial pneumonia.
- effect of ANG II on NHE-1 activity is associated with ligand binding to AT(1) receptor and intracellular signaling events related to AT(1) translocation.
- Report an association between plasma concentrations of irbesartan and the blood pressure response for hypertensive patients with AT1R 5245 TT polymorphism.
- Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells
- Simvastatin induces down-regulation
- Data show that after silencing HCMV UL83 gene, gene expression of human brain vascular smooth muscle cell AT1 receptor is down-regulated.
- Homozygosity for the AT1R A1166C polymorphism was associated with hypertension in women.
- there was an association between A1166C polymorphism in the angiotensin II receptor gene and ischemic stroke.
- Treatment with ACE inhibitors in hypertensive subjects significantly reduces the occurrence of diabetes in homozygous 1166A carriers of the AGTR1 gene and carriers of the ACE I allele.
- The human angiotensin AT(1) receptor supports G protein-independent extracellular signal-regulated kinase 1/2 activation and cellular proliferation.
- The A1166C polymorphism of the AT1 receptor gene is not associated with reduction of blood pressure after treatment with ACEI in patients with essential hypertension
- Polymorphism in AGTR1 may increase sensitivity to candesartan in heart failure patients.
- Expression of AT1 and AT2 is associated with high grade of malignancy, increased cellular proliferation, and angiogenesis, and is thus related to poor prognosis.
- The CC AT1R genotype was associated with poor prognostic markers and increased mortality in heart failure
- overproduction of AT1-autoantibody is a novel risk factor in pregnant women and may play a causative role in the development of hypertension and vascular injury in preeclamptic patients
- There is an interacting effect of genetic variants of angiotensin II type 1 receptor on susceptibility to essential hypertension in Northern Han Chinese.
- there is insufficient evidence that polymorphisms in the AGTR1 gene are risk factors for hypertension
- binds to prorenin and stimulates a non RA- system-dependent intracellular signal by tyrosine phosphorylation. (review)
- Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction.
- patients with hypertension and congestive heart failure demonstrated the DD angiotensin-converting enzyme genotype and the CC angiotensin II type 1 receptor genotype
- the 1166C allele in angiotensin II type 1 receptor increases the risk of CAD associated with the presence of cigarette smoking and hypercholesterolemia.
- alpha-adducin (ADD1) and angiotensin II type 1 receptor (AT1R) interactively determine the elastic properties of the femoral artery.
- The analysis of carriership of the alleles and genotypes combinations of the polymorphous regions has shown that genes CYP11B2, REN, ACE, CMA andA T2R1 participate in development of low-renin HA
- Angiotensin II enhances foam cell formation by upregulating ACAT1 expression predominantly through the actions of AT(1) receptor via the G protein/c-Src/PKC/MAPK pathway in human monocyte-macrophages
- AT1R/B2R heterodimerization does not occur as a natural consequence of their simultaneous expression in the same cell nor does the B2R influence the AT1R signaling.
- Interactions between AT(1) and 5-HT(2B) receptors coexpressed by noncardiomyocytes are limiting key events in adrenergic agonist-induced, angiotensin-dependent cardiac hypertrophy.
- The AGTR1 A1166C polymorphism may be considered a genetic marker predisposing to an increase in BP and the development of the metabolic syndrome in subjects screened for stage 1 hypertension.
- Association between the AGTR1 polymorphism +1166A>C and serum levels of high-sensitivity C-reactive protein.
- Autoantibodies against angiotensin II type 1 receptor (AT1-AAs) were common in patients with preeclampsia, although sFlt-1 was a superior biomarker.
- an independent protective dose-allele effect for the presence of C alleles of the AGTR1 polymorphism on pulse wave velocity.