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Validated All-in-One™ qPCR Primer for DRD1(NM_000794.4) Search again
Product ID:
HQP004445
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
D1R, DADR, DRD1A
Gene Description:
dopamine receptor D1
Target Gene Accession:
NM_000794.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
This gene encodes the D1 subtype of the dopamine receptor.
Gene References into function
- peripheral dopamine D1 and D2 receptors are present in the seminal vesicle tissue
- Patterns of cyclic AMP formation by coexpressed D1 and D2L dopamine receptors in HEK 293 cells.
- dopamine depletion does not result in increased neostriatal binding
- critical role of GRK4, relative to GRK2, in the homologous desensitization of D1 receptors in renal proximal tubule cells.
- mechanism of activation as evidenced by molecular interplay between the third extracellular loop and the cytoplasmic tail
- Significant age-related decline was observed for dopamine receptor mRNAs in the hippocampus and entorhinal cortex
- regulation of trafficking and desensitization by oligomerization with glutamate N-methyl-D-aspartate receptors
- D1 dopamine receptors have a role in inducing nitric-oxide synthase activation and cytotoxicity
- Among type 1 alcoholics dopamine transporters are lower in nucleus accumbens and dopamine D(2), but not D(1) or D(3) receptors in nucleus accumbens and amygdala. Lower dopamine receptor density is specific for D(2) receptor and for type 1 alcoholism.
- This is the first report of a male-limited association between the DRD1 gene restriction fragment length polymorphism and sensation-seeking score in alcohol-dependent subjects.
- DRD1 is involved in ADHD. Haplotype 3 contains a potential risk factor for the inattentive symptom dimension of the disorder. The putative DRD1 risk variant for ADHD resides outside of the coding region of the gene.
- stimulation of co-expressed D1 and D2 receptors resulted in an increase of intracellular calcium levels via a signaling pathway not activated by either receptor alone
- have identified a sequence present in the carboxyl-terminal cytoplasmic domain of the human D1 dopamine receptor that is specifically required for the efficient recycling of endocytosed receptors back to the plasma membrane
- role of ERK in the cytotoxicity mediated upon activation of the D1 dopamine receptor.
- the interrelationship between D1 and D2 receptor-mediated control of motor activity, food intake, and gastrointestinal functions
- D1 receptors are mainly localized on smooth muscle cells in corpus cavernosum
- These data suggest that DRD1 gene is not a useful marker for prediction of the susceptibility of Tourette syndrome.
- Heterologously and endogenously expressed D1Rs in renal cells are associated with and regulated by caveolin-2.
- Racial differences may play an important role concerning the association of variants in the dopamine receptor type 1 gene with essential hypertension.
- importance of dopamine D(1) receptors in reward and/or alcoholism.
- Results suggest an association between the DRD1 gene and bipolar I disorder (BP I) in the Sardinian population.
- This study provides support for an association between attention deficit hyperactivity disorder (ADHD) and polymorphisms in dopamine D1 receptor gene.
- GRK4 constitutively phosphorylates the D1 receptor in the absence of agonist activation.
- (11)C-NNC 112 displays a favorable radiation dose profile in humans and would allow multiple PET examinations per year to be performed on the same subject.
- The -48A/G polymorphism of DRD1 was estimated in patients with schizophrenia or bipolar disorder. No association was found with schizophrenia. The G/G genotype and G allele were significantly more frequent in patients with bipolar disorder, type 2.
- dopamine D(1) and D(2) receptors can form hetero-oligomers in the plasma membrane. The degree of receptor protein-protein interaction is significantly enhanced by concomitant addition of D(1) and D(2) receptor subtype-specific agonists.
- dopamine receptor type 1 and Gs protein alpha subunit loci contribute to blood pressure regulation at rest
- The fact that the same haplotype shows a similar trend for association in samples originating from different ethnic backgrounds seems to imply that the -800C/-48G/1403T haplotype may be considered as a risk factor for bipolar type I disorder.
- The association of DRD1 with inattention, but not with reading disabilities, or the other reading and reading-related phenotypes analysed, suggests that DRD1 contributes uniquely to inattention, without overlap for reading ability.
- D1 and D2 dopamine receptor expression is regulated by direct interaction with the chaperone protein calnexin
- The information derived from this study could be valuable for understanding the genetic factors involved in alcoholic phenotypes and genetic distribution of the DRD gene family, and could facilitate further investigation in other ethnic groups.
- Single-nucleotide polymorphisms of the dopamine D(1) receptor gene is associated with nicotine dependence
- Discovery of differential regulation by D1and D5 receptors opens new avenues for development of agonists selective to either receptor subtype as targeted antihypertensive agents that can decrease AT(1)R-mediated antinatriuresis.
- Preferential haplotype transmission of markers at the DRD1 locus and an increased frequency of a specific haplotype support the DRD1 gene as a risk gene for core symptoms of autism spectrum disorders in families having only affected males.
- The observation that the hD1R mutations induce significant alterations in pharmacologic properties may have implications both for disease susceptibility and/or therapeutic response to dopaminergic ligands.
- receptor hetero-oligomer complex formed resulted in a significantly enhanced surface expression of mu-opioid receptor. This hetero-oligomer formation involved the interaction of mu-opioid receptor with the dopamine D1 receptor carboxyl tail
- DRD1 is a susceptibility gene in alcohol dependence, specifically haplotype rs686*T-rs4532*G.
- renal sodium handling and blood pressure were associated with genetic variation in the DRD1 promoter
- Reciprocal regulation of DRD1 and DRD3 function and trafficking by heterodimerization is reported.
- Genetic polymorphism of the gene is substantially involving in individual variation of susceptibility to alcohol dependence.
- The predicted structure of the human D1 dopamine receptor is used to understand the mechanism of interactions between scorpion neurotoxins through the protein-protein docking method.
- D(3) receptor stimulation potentiates D(1) receptor-mediated behavioral effects by a different mechanism than D(2) receptor stimulation
- analysis of the reciprocal modulation of function between the D1 and D2 dopamine receptors and the Na+,K+-ATPase
- Our findings suggest that orchestration of prefrontal D(1) receptors and hippocampal D(2) receptors might be necessary for human executive function including working memory.
- D(2)R and cyan fluorescent protein-tagged D(1)R may result from differing localization of these proteins in the cell rather than from the possible role of the D(2)R basic domain in the mechanism of D(1)-D(2) receptor heterodimerization
- The p21 codon 31*C- and DRD2 codon 313*T-related genotypes/alleles, but not XRCC1 codon 399, hOGG1 codon 326, and DRD1-48 polymorphisms, are correlated with the presence of leiomyoma.
- findings show that the training of working memory, which improves working memory capacity, is associated with changes in the density of cortical dopamine D1 receptors