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Validated All-in-One™ qPCR Primer for CTLA4(NM_005214.3) Search again
Product ID:
HQP003500
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12
Gene Description:
cytotoxic T-lymphocyte associated protein 4
Target Gene Accession:
NM_005214.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer.
Gene References into function
- CTLA4 gene polymorphisms are associated with, and linked to, insulin-dependent diabetes mellitus in a Russian population.
- effect on cytokine production by antigen-stimulated T cells
- CTLA4 gene region is associated with genetic susceptibility to celiac disease in UK families.
- The B7-CD28/CTLA-4 costimulatory pathway has a dominant role in regulating T-cell activation. Antagonists enable graft survival and suppress autoimmunity.
- results suggest that the CTLA-4 gene region on chromosome 2q33 is a susceptibility locus for autoimmune hypothyroidism in the United Kingdom
- The CTLA-4 49 Ala allele confers an increased risk of type 1 diabetes, independent of age and HLA-DQ genetic markers
- the strongest association between CTLA4 gene polymorphisms and RA susceptibility occurs with the 3' UTR polymorphism
- results support the concept that CTLA-4 plays a critical role in the autoimmune process in Graves' disease
- polymorphism in type 1 diabetics in a Romanian population
- CTLA-4 gene polymorphism contributes to the genetic risk for latent autoimmune diabetes in adults.
- Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation.
- association of Wegener's granulomatosis (WG) with 2 single nucleotide polymorphisms (SNP), a +49 A/G polymorphism in coding sequence (CDS) 1 and a C/T base exchange in the promoter region at position -318.
- Long-term therapy with recombinant human erythropoietin decreases percentage of T-cells in primary glomerulonephritis haemodialysis patients.
- evidence against the +49 A/G transition as the aetiological polymorphism within the CTLA4 gene
- segregation analysis supports the hypothesis of a modulation by CTLA-4 49 G/A dimorphism of the susceptibility to type 1 diabetes conferred by maternal HLA-DRB1*03 inheritance
- Remission of Graves' hyperthyroidism and A/G polymorphism at position 49 in exon 1 of cytotoxic T lymphocyte-associated molecule-4 gene.
- The -318T allele is associated with a higher promoter activity than the -318C allele.
- Cell surface expression of the HIV-1 envelope glycoproteins is directed from intracellular CTLA-4-containing regulated secretory granules. (CTLA-4)
- exon 1 polymorphism of the cytotoxic T lymphocyte antigen 4 gene influences on thyroid antibody production in patients with newly diagnosed Graves' disease.
- Reduced expression of CTLA-4 may contribute to favorable umbilical cord blood T lymphocyte allogeneic responses
- The results showed that the CTLA4 dimorphism does not affect susceptibility to MS in ethnic Russians, be these stratified or not with regard to DRB1 alleles corresponding to serologic specificities DR1 to DR16.
- Among Filipinos, the CTLA-4 genotypes are associated with type I diabetes only in the presence of the predisposing DR3, 4, and 9 haplotypes (P=0.012).
- role of ligation in modulating TCR-induced transcriptional profiles
- Results suggest that the linkage of the CTLA-4 A49G single nucleotide polymorphism to autoimmune thyroid disease is most likely secondary to linkage disequilibrium.
- HTLV-1 infection is not associated with CTLA-4 polymorphisms in patients with Hashimoto's thyroiditis
- Levels of sCTLA-4 increase with the serum concentration of antibodies against the acetylcholine receptor. The (AT)(n) polymorphism in the 3'-untranslated region causes decreased mRNA stability and reduced levels of CTLA-4.
- common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele
- CTLA-4 upregulation during aging
- CD80 and CD86 differ in their interactions with CTLA-4 and that CD80 appears to be the preferential inhibitory ligand for CTLA-4 working via a population of CD4(+) CD25(+) CTLA-4(+) regulatory T cells.
- role of genotypes at the -1722 locus in susceptibility to systemic lupus erythematosus
- analysis of expression on leukocytes, hematopoietic cell lines, and a variety of myeloid and lymphoid leukemias
- at least two novel signal pathways regulate CTLA-4 gene expression and CD152 molecule up-regulation in human CD4(+) T lymphocytes, in the absence of full T cell activation
- CTLA4 exon 1 dimorphism is associated with primary progressive multiple sclerosis.
- C-318T and A+49G CTLA4 gene polymorphisms and their haplotypes are not associated in Dutch Caucasian patients with IBD and in Chinese patients with UC.
- In Japanese patients, the +49A allele of CTLA-4 increased in the presence of systemic sclerosis with the anti-RNP antibody.
- Allele G and G/G genotype confer genetic susceptibility to Grave's disease; (ii) CTLA-4 A49G polymorphism is not associated with the development of Grave's ophthalmopathy; (iii) different non-genetic factors may contribute to GO in different populations.
- prevalence of the A and G alleles of the CTLA-4 gene in autoimmune hemolytic anemia, AIHA and CLL, and immune thrombocytopenic purpura indicate that the G allele predisposes to the development of AIHA, particularly among patients with CLL
- CTLA-4 is a predisposing gene for celiac disease in an Italian population with a prominent role in patients not carrying the high-risk human leukocyte antigen-DQ2 molecules.
- Length of exposure and microfilarial antigen status are both important factors in determining the level of CTLA-4 expression in filarial infections and may provide insight into its role in diminished parasite antigen-specific T cell responsiveness.
- distinct association exists between the G allele of CTLA-4 and high values of GAD Ab, residual beta-cell function, and the absence of HLA-DRB1*0405.
- Association of variations of the CTLA4 promoter region with type 1 diabetes.
- Role of polymorphism at this site in immunologic response to chronic hepatitis C therapy with interferon alfa and ribavirin.
- apoptosis mediated by Fas-FasL and engagement of CTLA-4 are involved in modulation of the immune response in patients infected with Paracoccidioides brasiliensis
- candidates for primary determinants of risk of the common autoimmune disorders Graves' disease, autoimmune hypothyroidism and type 1 diabetes
- increased expression of soluble CTLA-4 molecule in patients with systemic lupus erythematosus
- CTLA4-FasL fusion protein inhibits the primary mixed leukocyte reaction (MLR), induces specific hyporesponsiveness in the secondary MLR, and may potentially induce hyporesponsiveness by promoting both anergy and apoptosis of alloresponsive clones.
- CTLA-4 is an important molecule regulating tolerance to "self" antigens in humans. CTLA-4 blockade may have a role in breaking tolerance to human cancer antigens for cancer immunotherapy.
- interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility
- Polymorphisms of CTLA4 (CTLA-4-318 and CTLA-4 + 49) do not affect the risk of developing multiple sclerosis and have no influence on the course and progression of disease.
- Susceptibility to autoimmune hepatitis-1 and -2 in Brazilian patients is not influenced by exon 1 CTLA-4 gene polymorphisms at position 49.
- CTLA-4 exon polymorphism is not causative in multiple sclerosis
- Polymorphisms occur in the pathogenic mechanism of autoimmune thyroid diseases (REVIEW)
- CTLA-4 dimorphisms has no association in the development of systemic lupus erythematosus in Japanese.
- CTLA-4 49 A-G polymorphism is associated with rheumatoid arthritis in Chinese patients from Taiwan.
- No association found between exon 1 (+49) polymorphism of CTLA4 gene and bipolar disorder in Korean population
- the exon 1 (+49) polymorphism of the CTLA-4 gene is associated with systemic sclerosis in African Americans.
- concluded that the A/G polymorphism of the cytotoxic T lymphocyte-associated molecule-4 gene affects the progress of Graves" disease
- involvement of CTLA4 polymorphisms on systemic lupus erythematosis susceptibility
- Length of the AT-repeat allele correlated inversely with augmentation of proliferation after CTLA-4 blockade in Grave's disease(GD). Long AT-repeat allele associated with reduced control of T-cell proliferation and thus contributes to pathogenesis of GD.
- the CTLA4 gene is involved in the susceptibility for Graves' disease and autoimmune thyroid disease in the Japanese
- suppressive effect was related to a significant increase in the percentage of T-cells expressing CTLA-4
- evidence for post-translational modification of human CTLA-4 after T cell activation
- No evidence for association of CTLA-4 with RA was detected using family or case-control methods.
- Interaction between the HLA-DRB4 and CTLA-4 genes determines the thyroid function of TPO-positive goitrous Japanese Hashimoto's thyroiditis patients.
- CTLA-4 gene polymorphism may have a role in genetic susceptibility to Non-Hodgkin Lymphoma
- The cytoplasmic domain of CTLA-4 has the capacity to assemble two different signalosomes on the T-cell surface, one inhibitory and the other activating, in response to two different types of ligands.
- Genetic and functional analyses of the CTLA-4 locus in autoimmune endocrinopathies and recent efforts in fine-mapping this locus. Review.
- CTLA-4 may play a critical role in the induction of T-cell anergy induced by superantigens.
- The CTLA-4 polymorphic G allele, probably by interfering with the immune response, may confer susceptibility to alcoholic liver disease and, in homozygous state, to alcoholic cirrhosis.
- Results do not suggest an association of the known polymorphism in exon 1 of the CTLA-4 gene with type 1 diabetes mellitus (DM1).
- Polymorphisms in CTLA4 confer general risk to develop autoimmunity and identifies a potential therapeutic target in the prevention of autoimmune endocrine disorders.
- The 3'-UTR of the CTLA4 gene is involved in susceptibility to systemic lupus erythematosus.
- CTLA4 is a candidate susceptibility gene for Type 1 diabetes.
- CTLA4 influences recovery from Hepatis B, which is consistent with the emerging role of T regulatory cells in the pathogenesis of disease
- The above findings suggest that the polymorphisms of CTLA-4 gene probably confer susceptibility to AIH and PBC in the Chinese population.
- CTLA-4 monoclonal antibodies enhance the expansion of human T cells in mice
- Expression of CTLA-4 as a transgene completely prevents lymphoaccumulation and autoimmune hemolytic anemia in IL-2-deficient mice.
- These findings suggest allelic variation in this region of CTLA4 is not major independent risk factor for systemic lupus erythematosus, but may contribute to risk of disease in younger African-Americans or in presence of certain immunogenetic markers.
- There are positive correlations between disease progression and the percentage of CD19+/CD5+ cells coexpressing CTLA-4 both on the surface and intracellularly.
- The +6230G>A cannot be the sole functional variant. Either the two polymorphisms define a haplotype carrying the (yet unexamined) functional variant or the -319C>T contributes to the genetic association independently.
- genetic interaction between the CTLA4 and CBLB genes in type 1 diabetes
- Association between CTLA-4 gene polymorphism and childhood onset Graves' disease(GD) is similar to that in adult onset GD in Japanese, but association is weak.
- In an expanded data set of 133 Japanese patients with conventional multiple sclerosis (MS), CTLA-4 gene polymorphisms are neither conclusively related to susceptibility nor to the clinical characteristics of MS.
- Single Nucleotide polymorphism is associated with celiac Disease
- this meta-analysis supports the idea that CTLA-4 exon-1 +49(A/ g) polymorphism influencing the risk for developing SLE, especially in Asians
- Role of the CTLA-4 locus in the susceptibility to Graves disease
- CTLA-4 may be stored in a specialized compartment in regulatory T cells that can be triggered rapidly for deployment to the plasma membrane in a phospholipase D- and ADP ribosylation factor-1-dependent manner
- CTLA-4 gene might be involved in the susceptibility to rheumatoid arthritis in the Chinese Han population
- Study showed that CTLA-4 +49 A/G polymorphism is significantly associated with type 1 diabetes, particularly in younger individuals.
- Exon-3 polymorphism of CTLA-4 gene in Turkish patients with vitiligo.
- The CTLA4 +49 A/G*G-CT60*G haplotype is associated with susceptibility to multiple sclerosis in Flanders.
- Additional non-HLA loci contribute to the joint susceptibility to type I diabetes and autoimmune thyroiditis, and two potential candidates include the CTLA-4 and insulin VNTR loci.
- CTLA4 is implicated in regulatory T cell development
- C-318T polymorphism in the promotor region and A+49G polymorphism in exon 1 of the CTLA-4 gene are not associated with UC in the Chinese Han population.
- developed a novel strategy to inhibit expression of B7 molecules (CD80/86) by transfecting antigen-presenting cells with a gene construct encoding a modified cytotoxic T lymphocyte antigen 4 (CTLA4) molecule (CTLA4-KDEL)
- B7 binding ultimately determines the formation of dimer-dependent CTLA-4 lattices that may be necessary for triggering B7-dependent T cell inactivation.
- This study could not confirm association with the CD28/CTLA4/ICOS gene region in multiple sclerosis.
- CTLA4 located at 2q33 is a determinant of ulcerative colitis and responsible for fistula formation in Crohn disease in the Japanese.
- Effect of HLA class II, insulin and cytotoxic T-lymphocyte-associated protein CTLA4genes on the appearance of beta-cell-specific autoantibodies.
- Haplotype tagging efficiency was studied in worldwide populations in CTLA4.
- We provide evidence that CT60 SNP in CTLA-4 gene is associated with susceptibility to Grave's disease in the Taiwanese population
- expression of CTLA-4 was significantly upregulated in peripheral blood CD3+ T cells (36.8%), CD4+ T cells (21.7%) and CD8+ T cells (18.7%) of patients with atopic dermatitis
- Linkage disequilibrium between CD28 +17 C and CTLA4 -319 T alleles was observed in white (p < 0.0001), mulatto (p = 0.0001), and black (p = 0.0002) Brazilian populations.
- upregulated in acute HIV infections of Jurkat cells, and acquisition by HIV positively affects HIV attachment and replication
- A CTLA4high genotype is associated with myasthenia gravis in thymoma patients.
- Exon-1 polymorphism of CTLA4 gene is not associated with systemic sclerosis in Iranian patients.
- Hydrodynamics-based transfection of plasmid encoding CTLA4-Ig chimera dramatically prevented experimental autoimmune myocarditis.
- CTLA-4 and PD-1 inhibit T-cell activation through distinct and potentially synergistic mechanisms.
- Review summarizes recent developments and current understanding of the way in which cytotoxic T lymphocyte-associated 4 (CTLA4)contributes to T-cell activation, and how aberrant function of CTLA4 might trigger autoimmunity.
- The extended haplotype incorporating CD28/CTLA4 and 5' ICOS is more strongly associated with disease than haplotypes of individual genes, and suggests a causal variant associated with this haplotype may be associated with disease in the Irish population.
- CTLA-4 gene is involved in predisposition to inflammatory arthropathies in the Northern Irish population.
- insulin and HLA-DR-DQ polymorphisms, but nto CTLA-4, may have a role in development of diabetes in Brazil
- Association of CTLA4 with type 1 diabetes in previous studies may have been secondary to autoimmune thyroid disease.
- no association between migraine with aura and migraine without aura and CTLA-4 polymorphism
- There is strong support for an association of CTLA4 with the development of rheumatoid arthritis (RA). There is a stronger association with the development of RA in both cohorts who are seropositive for anti-citrulline antibodies.
- interaction of INS I/I and CTLA4 G/G genotypes was more common in older children with type 1 diabetes mellitus
- The abnormal level of CTLA-4 was confirmed at both the transcription and translation levels in malignant T-cells from patients with mycosis fungoides
- Kidney graft rejection is greater in CTLA4 single nucleotide polymorphism.
- CTLA-4 polymorphism is not associated with UC in the Iranian population.
- an imbalance in CTLA-4/CD28 expression or suppressed T-cell activity at the maternal-fetal interface may confer susceptibility to unexplained pregnancy loss.
- CTLA-4 is a major thyroid autoantibody diathesis susceptibility gene in patients with Hashimoto's thyroiditis.
- Genetic variation associated with type 1 diabetes in a Czech Republic population with childhood onset.
- There are no major effects of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis but minor contributions cannot be excluded.
- There is strong support for an association of CTLA4 with the development of rheumatoid arthritis (RA).
- The results of the present study indicate that the presence of G allele at -1661 locus at the CTLA-4 gene (IDDM12 locus) is associated with increased susceptibility to type 1 diabetes in North Indians, whereas A allele is protective.
- findings reveal that CD80 is a superior ligand for CD28, but that its interaction with CTLA-4 attenuates T cell responses; CD86 is a relatively weak costimulator but lacks inhibitory CTLA-4 interactions, leading to enhanced T cell expansion
- CTLA-4 acts in the predisposition to Graves' disease by switching off the protective DRB1*07 influence, whereas DRB1*03 has an independent effect
- CTLA4(AT)n 106 bp may be the susceptible gene in Grave's disease patients of Zhuang nationality in Guangxi.
- There us an assoiciation of CTLA-4 gene promoter polymorphisms with systemic sclerosis in the Iranian population.
- prolonged kidney graft survival when tranfected into rats.
- Transgenic overexpressed CTLA-4 inhibits T cell responses both in vitro and in vivo during the initial stages of T cell activation, probably by competing with CD28 for B7 binding or by interfering with CD28 signaling.
- These results indicate a genetic link of CTLA4 gene polymorphisms to development of gastric MALT lymphoma and indirectly support the crucial role of host activated T cells in the MALT lymphomagenesis.
- no difference in levels of CTLA4 expression between mRNAs carrying an 88bp repeat allele or 106bp
- results from this study suggested that the -318T allele might play a protective role in Graves ophthalmopathy susceptibility for Graves disease patients at least in the Chinese population
- The association of CTLA-4 gene polymorphisms with allergic asthma is still controversial and therefore was the subject of this study.
- findings show that CTLA-4 increases T cell motility and overrides the T cell receptor (TCR)-induced stop signal required for stable conjugate formation between T cells and antigen-presenting cells
- CTLA4 -318 (C,T) and 49 (A,G) polymorphisms do not play a major role in endemic pemphigus foliaceus development
- The distribution of CTLA-4 exon 1-promoter genes did not reach significance between kidney transplantation recipients and controls.
- family-based study provides good evidence for a unique association signal with CTLA4 in systemic lupus erythematosus
- taken together, the loss of HIV-specific CD4+ T cells during primary HIV-1 infection is associated with a combination of an infection of CCR5+ CD127+ memory CD4+ T cells, possibly in gut-associated lymphoid tissue and a high expression of CTLA-4
- Expansion of T IL-10 cells during col-V stimulation in vitro involved CTLA-4 on Tregs
- Human cytotoxic T-lymphocyte antigen 4-immunoglobulin (hCTLA4I g) fusion protein was expressed in transgenic rice cell suspension culture. hCTLA4IgP was biologically active and was confirmed to suppress T-cell proliferation.
- The hyporesponsiveness of T lymphocytes induced by antibody targeting of TIRC7 is mediated, at least to a substantial degree, by CTLA-4.
- The frequency of the CTLA4 single nucleotide polymorphism in Japanese type 1 diabetics does not appear to be affected by either the VDR gene Bsm I large B polymorophism or HLA-DR9.
- CTLA4 polymorphisms are associated with the resolution of HCV infection.
- There were no significant associations between CTLA-4 exon-1 +49 A/G polymorphism and autoimmune or lymphoid hyperplasia and granulomatous disease in this mostly Caucasian CVID patient population.
- With multiethnic DNA panels that represent a wide spectrum of ethnic groups, we demonstrate long-range linkage disequilibrium among CD28, CTLA4, and ICOS costimulatory genes.
- The evidence of a statistical interaction with the known T1D susceptibility-associated CTLA4 polymorphism rs3087243 was reported (P<0.0001), and the CBLB SNP rs3772534 G allele was overtransmitted to offspring with the CTLA4 rs3087243 G/G genotype.
- there was an increase in the -1661A/G dimorphorism of CTLA4 (CD152 antigen)in systemic sclerosis patients with anti-RNP antibodies
- Analysis of sCTLA-4 protein levels in serum showed no correlation between sCTLA-4 protein levels and disease status or CT60 genotype.
- These results may suggest that CD28 IVS3 +17TC genotype may be a risk factor for the development of BD, on the contrary CTLA-4 +49GG genotype may be protective in the studied Turkish population.
- may represent a candidate gene for disease susceptibility in Fuchs heterochromic cyclitis
- a subgroup of type 1 diabetic patients has a female bias, a failure in tolerance to thyroid peroxidase, and is sensitive to allelic variation of the negative regulatory molecule CTLA-4
- a lack of association between CTLA-4 CT60 or +49A/G polymorphisms and primary Sjogren syndrome
- -318 C/T variant in the promoter region of the CTLA-4 gene is associated with human papillomavirus-16-associated cervical squamous cell carcinoma in Taiwanese women.
- study confirmed that the exon1 +49 A/G SNP CLTA-4 is related to recurrence of Graves'disease after withdrawing medication
- CTLA-4 gene polymorphisms are not associated with susceptibility of primary biliary cirrhosis in Japan
- Meta-analysis found no evidence for association of the various contrasts of genotypes (or allele frequencies) with the risk of developing multiple sclerosis
- maternal but not paternal atopy has significant impacts on cord blood IgE elevation depending on gender and CTLA-4+49A/G polymorphism of newborns
- in Italian systemic sclerosis (SSc) patients the CTLA-4 -318C/T promoter polymorphism appears to be associated with the susceptibility to develop SSc without thyroid involvement
- Carriage of the +49G single nucleotide polymorphism of the cytotoxic T-lymphocyte antigen 4 gene in heterozygous or in homozygous form does not confer risk either for Crohn's disease or for ulcerative colitis in the Hungarian population.
- Polymorphisms in the CTLA-4 gene likely confer susceptibility to atopic asthma in Korean children.
- Thorough analysis of extended haplotypes shows that the CTLA4 gene does not play a major role in either disease susceptibility or disease progression in primary biliary cirrhosis.
- CT60 polymorphism of CTLA-4 maps an important genetic determinant for the risk of both Graves' disease and Hashimoto thyroiditis
- The data of this study showed the CTLA4 +49 A/G and 3'UTR polymorphisms as potential modifiers of disease course in MS.
- G allele at position 49 of exon 1 increased the risk of Graves disease recurrence
- study of the prevalence of four polymorphisms, CTLA-4 -318 C/T, 159 C/T, 3' STR and SUMO4 163 AG in latent autoimmune diabetes in adults; no association with either of the polymorphisms has been found
- The G/G genotype polymorphism of the CTLA-4 gene is associated with increased risk of AMI.
- the increased IFN-gamma response and lower IL-4 response toward diabetes-related autoantigens shown in CTLA-4 +49 GG risk subjects show a possible mechanism for the association between CTLA-4 and type 1 diabetes
- our data suggest the CTLA-4 gene may be a candidate as a renal adenocarcinoma susceptibility gene, but does not play an important role in colon cancer.
- CTLA-4 49A polymorphism and -318C/+49A/CT60G haplotype are associated with AIP in a Chinese population.
- CD4+CD25+CTLA-4+FoxP3+ T cells have roles in patients with systemic lupus erythematosus and are impaired after conventional treatments
- study concluded that both the CELIAC1 and CELIAC3 regions, besides the TNF-alpha locus, confer susceptibility for celiac disease
- Ligation of CTLA-4 with either soluble B7.1 immunoglobulin (Ig) (but not B7.2 Ig) or with a recombinant bispecific in-tandem single chain Fv antibody induces T cell receptor-independent T cell activation and has important therapeutic implications.
- The proximal promoter of CTLA-4 contains an NFAT consensus sequence critical for activating the CTLA-4 gene in human lymphocytes.
- polymorphisms of the CTLA-4 gene may modify individual susceptibility to and progression of breast cancer in Chinese Han women.
- common allelic variants in promoter regions of genes encoding for molecules involved in either the innate (CD14) or adoptive (CTLA-4) immune reactions are associated with an increased risk of GVHD after allogeneic stem cell transplantation.
- Polymorphism in CTLA-4 +49 GG genotype was related to a reduced risk in the incidence of HBV recurrence
- CD152 exon 1 position 49 A/G dimorphism does not contribute significantly to the development of multiple sclerosis in this patient population.
- No significant association of CT60 and +49A/G polymorphisms or respective haplotypes with multiple sclerosis was found
- For susceptible genes, the CC genotype in the CD40, the GG genotype in the CTLA-4 exon 1, and the CC genotype in the CTLA-4 promoter region have shown no significant association with clinical outcome after antithyroid drug withdrawal in Grave's disease.
- The increase in Fas and CTLA4 molecules in multiple sclerosis patients may lead to lymphocyte apoptosis, which suggests possible mechanisms underlying the therapeutic response to IFN-beta.
- Despite the expression of CTLA-4 and Foxp3, tumors were incapable of suppressing the proliferation of autologous T8 cells. ATL cells are phenotypically Treg cells in at least some patients, but lack immunoregulatory functions toward T8 cells.
- examined a cohort of healthy individuals stratified by genotypes at CTLA4 to gain insight into the functional effects of allelic variation on T cell signaling
- Appearance of an adenosine allele in the CTLA-4 gene after kidney transplntation may be a permissive element for cyclosporine-induced gingival overgrowth.
- A positive association between CTLA-4 TACG haplotype and gastric and colorectal cancers was found in an Iranian population.
- CTLA4 AND PDCD1 are genes encoding coinhibitory immunoreceptors that harbor polymorphisms with demonstrated associations to multiple autoimmune disorders.
- CT60 A/G dimorphism within the 3'-UTR of CTLA4 gene, which encodes for reduced sCTLA4 production, influence acute rejection development in liver transplantation.
- The association of the CTLA4 -318C>T variation with chronic HBV infection and cryptogenic cirrhosis is described but find no association of the +49G>A variation with autoimmune liver disease.
- patients who received a graft from a donor with a GG genotype for +49A/G had a stronger risk of developing cGVHD compared with those having a donor with either AG or AA genotype
- In this family-based association study of the Han population in Taiwan, CTLA-4 confers susceptibility to Graves' disease across different ethnic backgrounds.
- 3' UTR of CTLA4 regulates firefly luciferase reporter gene expression, can confer instability to CTLA4 mRNA and can influence its translation efficiency in vitro.
- two SNPs in the promoter region are associated with myasthenia gravis and might cause abnormal alternative splicing and affect the expression of CD152, thereby contributing to the pathogenesis of MG
- CTLA-4 gene, CT60A>G and +49A>G SNPs were studied in psoriasis vulgaris patients; the haplotype +49G, CT60G was significantly less frequent in the patient group with disease onset between the ages of 21 and 40 years than in controls.
- a role for CTLA-4 in limiting the interaction between T cell and APC that is needed for optimal activation.
- Inhibition of T cells by CTLA-4 may be explained by reduction of CD28 on the cell surface, which might impede T cell response to stimulation.
- PTPN22 in mediating susceptibility to generalized vitiligo and associated autoimmune diseases, but do not support a role for CTLA4.
- No particular CTLA-4 genotypes were associated with CAID.
- dendritic cells from nonobliterative bronchiolitis lung transplant recipients induce a tolerant T-cell phenotype which is dependent on cytotoxic T-lymphocyte antigen-4(CTLA-4) engagement
- CTLA-4 genetic polymorphisms are associated with the susceptibility to Vogt-Koyanagi-Harada syndrome.
- The joint effect of multiple susceptibility loci such s CTLA4 confer a very high risk of type 1 diabetes, but applies to a very small proportion of the general population.
- Three SNPs and the AT repeat length in CTLA-4 conferred susceptibility to childhood Graves' Disease, whereas IL-13 polymorphisms did not. No association was found between CTLA-4 and IL-13 with Graves' Ophthalmopathy.
- Autoimmune pancreatitis is associated with a genetic polymorphism in CTLA4 and is positively correlated with serum sCTLA4 levels
- There were no significant (P<0.05) associations between the A49G genotype and risk of MS, either before or after stratification for presence of the DR15 haplotype.
- contribution of the CTLA4 gene to disease susceptibility is distinct between fulminant type 1 diabetes and classic type 1A diabetes.
- CTLA-4 +49 A/G polymorphism does not contribute to susceptibility to Henoch-Schonlein purpura; however, the presence of CTLA-4 AG genotype
- The CTLA-4 variant G allele was associated with an increased rheumatoid arthritis risk among women in the Nurses' Health Study (NHS)cohort but not in the NHSII cohort or pooled results (multivariable dominant model).
- There is no association of CTLA-4 with either -318C/T or 49A/G polymorphism in patients with Behet's disease or intermediate uveitis.
- CTLA4 blockade induces Treg proliferation and activation of effector T4 cells in prostate cancer patients
- The panenteritis associated with injection of alpha-CTLA-4 mAbs demonstrates histology resembling autoimmune enteropathy.
- CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors
- These results suggest that C-318T, A49G, CT60, and haplotypes tagged by these CTLA4 SNPs are not associated with JIA or major JIA subtypes.
- The G allele of both examined CTLA-4 gene polymorphisms predisposes to Hashimoto thyroiditis and type 1 diabetes mellitus , but not to celiac disease
- study reports the identification of two new isoforms of CTLA-4 mRNA and an abnormal splicing spectrum in myasthenia gravis patients
- acquisition of suppressive behavior by activated CD4(+)CD25(-) T cells requires the expression of CTLA-4, a feature that appears to be facilitated by, but is not dependent on, expression of FoxP3
- CTLA4 blockade with ipilimumab induces significant clinical benefit in a female with melanoma metastases to the CNS.
- CTLA-4 and CD28 gene polymorphisms did not play an important role in Turkish patients with Colorectal cancer
- The involvement of CTLA4 in the pathogenesis of multiple sclerosis may be subtle and related to the functional changes in its pathway rather than predisposing genetic polymorphisms
- no significant associations between CTLA4 exon 1 polymorphism and neither multiple sclerosis nor any of its subtypes.
- CTLA4 gene polymorphisms in children and adolescents with autoimmune thyroid disease was investigated. The A49G polymorphisms might increase the susceptibility for Hashimoto thyroiditis.
- found that the 49G>A polymorphism in the CTLA-4 leading sequence causing (17)Ala to (17)Thr amino acid substitution is associated with increased susceptibility to multiple cancers, including lung, breast, esophagus, and gastric cardia cancers
- CTLA4 has an impact on the risk of primary biliary cirrhosis and possibly plays a role in influencing antimitochondrial antibody development as well as progression to liver transplant among PBC patients
- Genotype G/G of ctla4 was significantly associated with Grave's disease
- Cytotoxic T lymphocyte-associated antigen 4 (CTLA4) vaccines may offers a potential strategy to enhance the immune responses generated by DNA vaccines against periodontitis.
- TRIM acts to chaperone CTLA-4 transport to the cell surface; this function would be required to account for the phenotypic and functional properties of CD8(+) Tregs.
- The variation in the SNPs tested does not appear to effect sCTLA-4 protein levels, despite reports that they affect sCTLA-4 mRNA
- CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) gene variants are not associated with Behcet's disease or its clinical manifestations
- defects in CTLA-4 could contribute to abnormal Treg function in rheumatoid arthritis
- study analyzed SNPs in PTPN22 and CTLA-4 in patients with acute anterior uveitis (AAU);there was no significant association between PTPN22 620W, CTLA-4 -318C/T, or CTLA-4 49A/G and AAU