Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies against post-translational modified proteins, with the rheumatoid factor (RF) and antibodies against citrullinated proteins (ACPA) being the most acknowledged ones. A broad range of autoantibodies with different antigen specificities have been identified from RA patients’ serum and joint fluid. The autoantibodies are valuable biomarkers for study of disease pathogenesis, diagnosis, evaluation of drug efficacy and prognosis. The routine method for RA autoantibody detection is ELISA which is single-plex with limited sensitivity.
GeneCopoeia’s OmicsArray™ Rheumatoid Arthritis (RA) Antigen Array panel contains 32 antigens including modified (citrullinated, Carbamylated, and MAA-modified) and un-modified antigens. The 32-plex RA antigen array is a highly sensitive protein microarray that offers powerful antibody profiling capabilities for quantitative detection of over sixty antibodies from small amounts of various biological specimens.The 32 antigens included in the Rheumatoid Arthritis (RA) Antigen Array panel were chosen based on the published studies. The superior-quality modified or non-modified antigens were coated onto the 3D surface of microchips to ensure that antigens retain their natural conformations. Internal Ig and anti-Ig controls are included in each array for normalization and quantification purposes. Additionally, the utilization of fluorescent 2nd antibodies in our microarrays allows for the detection of two types (IgG, IgM, IgA) of antibodies on the same array, minimizing the requirement of sample needed.
In addition to premade arrays, arrays containing customized sets of antigens are available, as well as array processing kits, array profiling services and data analysis. To order premade or custom arrays, please contact us.
GeneCopoeia’s OmicsArray™ Rheumotoid Arthritis (RA) 32-plex Antigen Array is part of the GeneCopoeia OmicsArray™ Antigen Microarray family.
Premade Antigen Arrays
The listed chip prices apply to academic customers. For custom arrays and services pricing, please contact us.
Prices are for customers from the U.S. and Canada only. For other customers, please contact your local distributor for details.
Antigen microarray processing kits and accessories
Prices are for customers from the U.S. and Canada only. For other customers, please contact your local distributor for details.
Custom services
GeneCopoeia offers custom antigen microarray services in the following areas:- Custom array printing. GeneCopoeia will create custom antigen microarrays built to your specifications.
- Sample processing. Send us your blood, plasma, tissue, or other biological sample and we will prepare it for processing and incubation with any of our premade antigen microarrays or custom-built antigen microarrays for autoantibody profiling and other applications. For information on sample types to submit, consult the FAQ
- Data analysis. Once samples are processed and incubated with an antigen microarray, we will analyze the raw data. The standard analysis service includes: 1) An Excel file of the Net Signal Intensity (NSI) for each antigen on the array, normalized to internal controls; and 2) a heat map
