Recombinant Human IL1B Protein Data Sheet

Catalog #	hRP-A0180-ES131
Size	25 μg
Protein Name	Human interleukin-1 beta
Protein Symbol	IL1B
Original Source	Homo sapiens
Expression System	E.coli
GenBank Accession #	X02532.1
Uniprot Accession #	P01584
Description	The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Application	WB, ELISA, IP, antibody production, protein array
Fusion tag	Trx-His-SUMO
Peptide Length	493aa(including fusion tag)
Molecular Weight	55.6kDa(including fusion tag)
pI	4.8
Activity	NA
Storage	Storage buffer: 1XPBS. Store at -80°C and avoid repeated freeze-thaw cycles.

Reference:	Interleukin-1 beta targeted therapy for type 2 diabetes Interleukin-1 beta and interleukin-18: regulation and activity in local inflammation Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells Association study between interleukin 1 beta gene and epileptic disorders: a HuGe review and meta-analysis Structural and functional comparison of cytokine interleukin-1 beta from chicken and human Role of interleukin 1 beta in esophageal squamous cell carcinoma

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