Monthly Archives: June 2014

Transgenic Mouse Services

  Introduction Applications To Order Related Services Introduction GeneCopeia provides transgenic mouse services using CRISPR-Cas9. Many applications are readily within reach, including constitutive and conditional gene knockout, mutagenesis, correction of disease mutations, transgene knockin, and in-frame fusion tagging. Advantages Track record of success (Figure 1). Fast mouse line creation using CRISPR-Cas9 and pronuclear injection (Figure 2). F1 modified mice in as little as 6 months. In-depth project......
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GeneHero™ HDR Donor Clones and Cloning Vectors

For convenient selection and flexible applications Introduction HDR Donor Vectors HDR Donor Services Related Products Resources Introduction Homology-directed repair (HDR) is a natural DNA repair mechanism that is induced by DNA double-strand breaks (DSBs). Site-specific TALENs or CRISPR Cas9-sgRNA complexes generate DSBs in the chromosome, leading to DNA repair. In the presence of donor DNA, HDR occurs and replaces genetic information in the chromosome with new information from the donor gene. Donor-mediated HDR makes many applications possible, su......
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