MicroRNA complete functional analysis tools

GeneCopoeia offers comprehensive tools for microRNA (miRNA) functional analysis so researchers can detect, express, validate or knockdown microRNA of interest confidently. All known human, mouse and rat microRNA in miRBase covered.

MicroRNA clones/constructs/plasmids
miExpress precursor microRNA expression clones — Lentiviral and non-viral miArrest microRNA inhibitor clones — Lentiviral and non-viral miTarget microRNA 3' UTR target clones — Dual reporter vector based

Figure 1: microRNA mechanism of action and comprehensive microRNA tools

Mechanism of action

MicroRNAs (miRNAs) are small, non-coding single stranded RNA molecules found in eukaryotic organisms. They are highly conserved and usually 21-23 nucleotides in length. miRNAs are involved in almost all cellular functions and regulate gene expression by binding to the 3' untranslated regions (3' UTRs) of targeted mRNAs. Irregularities in miRNA-regulated gene expression have been found to be associated with cancers, cardiovascular disorders and a variety of other diseases.

Applications of miRNA functional analysis and detection tools
Conduct single gene or pathway analysis Study gain-of-function or loss-of-function effects Discover pathways, study diseases and uncover developmental stages Identification and validation of diagnostic and therapeutic biomarkers and targets