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AAVPrime™ Adeno-associated Viral (AAV) Particles

20% off AAV particles

Introduction

GeneCopoeia’s AAVPrime™ Adeno-associated virus (AAV) products are the ideal tools for inserting genes into a broad range of cell types with high efficiency and enhanced safety. GeneCopoeia’s optimized helper-free human AAV system allows viral packaging without potentially pathogenic helper adenovirus. Many pre-made particles are available in 7 different serotypes, such as fluorescent reporters (Figure 1). You can also request us to produce custom AAV particles for genes up to 3 kb in length. Particle preparations are available in either standard (for in vitro use only; Figure 1) or purified (suitable for in vivo use; Figure 2) formats. 

 

Advantages

  • High titers. Titer of purified particles can be up to 10^14 GC/ml (genome copies/ml)
  • Versatile. Usable in a broad range of host cell types
  • Low toxicity. Does not integrate into the host genome.
  • Low immunogenicity. Minimal host immune response.
  • High adaptability. All serotypes are available.
  • Safe. Not associated with any human disease

 

GeneCopoeia's AAVPrime™ standard AAV particles expressing fluorecent reporters

A B C
图片A 图片B 图片C

Figure 1. HT1080 cells in 24-well plates were transduced with 0.5 µL of standard purity AAV particles expressing either eGFP (A), RFP (B), or mCherry (C)). Cells were visualized with a fluorescence microscope (Exposure time: 400 ms).

 

GeneCopoeia's AAVPrime™ purified AAV particles expressing eGFP

0.005 μl 0.05 μl 0.5 μl

Figure 2. HT1080 cells in 24-well plates were transduced with the indicated amounts of purified AAV particles expressing eGFP. Cells were visualized with a fluorescence microscope (Exposure time: 400 ms).

To order

Order custom AAV particles

Custom AAV particles production services are currently available for ORF expression. GeneCopoeia' s scientific expertise can deliver AAV particles with titers starting from 10^11 GC/mL or higher depending upon the request.

For all AAV particles not covered in the premade particles collection, request a custom quote here.

 

Order premade AAV particles

By default, all options for AAV particle serotype, purity level (standard or purified) and volume are listed in the table below. Use the drop-down menus to narrow down the number of options displayed.

Serotype: Grade: Size:

Buy Catalog Size Product Description Gene of Interest Type Price
AA00125µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 2.   Promoter: CMV.
eGFPPurified$350
AA002100µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 2.   Promoter: CMV.
eGFPPurified$500
AA008500µl
≥ 1x10^11 GC/ml
eGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: 2.   Promoter: CMV.
eGFPStandard$300
AA0091ml
≥ 1x10^11 GC/ml
eGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: 2.   Promoter: CMV.
eGFPStandard$400
AA01125µl
≥ 5x10^12 GC/ml
IRES-hrGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 2.   Promoter: CMV.
IRES-hrGFPPurified$350
AA012100µl
≥ 5x10^12 GC/ml
IRES-hrGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 2.   Promoter: CMV.
IRES-hrGFPPurified$500
AA018500µl
≥ 1x10^11 GC/ml
IRES-hrGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: 2.   Promoter: CMV.
IRES-hrGFPStandard$300
AA0191ml
≥ 1x10^11 GC/ml
IRES-hrGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: 2.   Promoter: CMV.
IRES-hrGFPStandard$400
AA02125µl
≥ 5x10^12 GC/ml
LacZ AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 2.   Promoter: CMV.
LacZPurified$350
AA022100µl
≥ 5x10^12 GC/ml
LacZ AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 2.   Promoter: CMV.
LacZPurified$500
AA028500µl
≥ 1x10^11 GC/ml
LacZ AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: 2.   Promoter: CMV.
LacZStandard$300
AA0291ml
≥ 1x10^11 GC/ml
LacZ AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: 2.   Promoter: CMV.
LacZStandard$400
AA03125µl
≥ 5x10^12 GC/ml
CRE AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 2.   Promoter: CMV.
CREPurified$350
AA032100µl
≥ 5x10^12 GC/ml
CRE AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 2.   Promoter: CMV.
CREPurified$500
AA038500µl
≥ 1x10^11 GC/ml
CRE AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: 2.   Promoter: CMV.
CREStandard$300
AA0391ml
≥ 1x10^11 GC/ml
CRE AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: 2.   Promoter: CMV.
CREStandard$400
AA04325µl
≥ 5x10^12 GC/ml
mCherry AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 2.   Promoter: CMV.
mCherryPurified$350
AA062100µl
≥ 5x10^12 GC/ml
mCherry AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 2.   Promoter: CMV.
mCherryPurified$500
AA068500µl
≥ 1x10^11 GC/ml
mCherry AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: 2.   Promoter: CMV.
mCherryStandard$300
AA0691ml
≥ 1x10^11 GC/ml
mCherry AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: 2.   Promoter: CMV.
mCherryStandard$400
AA07125µl
≥ 5x10^12 GC/ml
FLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 2.   Promoter: CMV.
FLucPurified$350
AA072100µl
≥ 5x10^12 GC/ml
FLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 2.   Promoter: CMV.
FLucPurified$500
AA078500µl
≥ 1x10^11 GC/ml
FLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: 2.   Promoter: CMV.
FLucStandard$300
AA0791ml
≥ 1x10^11 GC/ml
FLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: 2.   Promoter: CMV.
FLucStandard$400
AA09125µl
≥ 5x10^12 GC/ml
GLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: 2.   Promoter: CMV.
GLucPurified$350
AA092100µl
≥ 5x10^12 GC/ml
GLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: 2.   Promoter: CMV.
GLucPurified$500
AA098500µl
≥ 1x10^11 GC/ml
GLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: 2.   Promoter: CMV.
GLucStandard$300
AA0991ml
≥ 1x10^11 GC/ml
GLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: 2.   Promoter: CMV.
GLucStandard$400
AA20125µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ.   Promoter: CMV.
eGFPPurified$350
AA202100µl
≥ 5x10^12 GC/ml
eGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ.   Promoter: CMV.
eGFPPurified$500
AA208500µl
≥ 1x10^11 GC/ml
eGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ.   Promoter: CMV.
eGFPStandard$300
AA2091ml
≥ 1x10^11 GC/ml
eGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ.   Promoter: CMV.
eGFPStandard$400
AA21125µl
≥ 5x10^12 GC/ml
IRES-hrGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ.   Promoter: CMV.
IRES-hrGFPPurified$350
AA212100µl
≥ 5x10^12 GC/ml
IRES-hrGFP AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ.   Promoter: CMV.
IRES-hrGFPPurified$500
AA218500µl
≥ 1x10^11 GC/ml
IRES-hrGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ.   Promoter: CMV.
IRES-hrGFPStandard$300
AA2191ml
≥ 1x10^11 GC/ml
IRES-hrGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ.   Promoter: CMV.
IRES-hrGFPStandard$400
AA22125µl
≥ 5x10^12 GC/ml
LacZ AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ.   Promoter: CMV.
LacZPurified$350
AA222100µl
≥ 5x10^12 GC/ml
LacZ AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ.   Promoter: CMV.
LacZPurified$500
AA228500µl
≥ 1x10^11 GC/ml
LacZ AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ.   Promoter: CMV.
LacZStandard$300
AA2291ml
≥ 1x10^11 GC/ml
LacZ AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ.   Promoter: CMV.
LacZStandard$400
AA23125µl
≥ 5x10^12 GC/ml
CRE AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ.   Promoter: CMV.
CREPurified$350
AA232100µl
≥ 5x10^12 GC/ml
CRE AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ.   Promoter: CMV.
CREPurified$500
AA238500µl
≥ 1x10^11 GC/ml
CRE AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ.   Promoter: CMV.
CREStandard$300
AA2391ml
≥ 1x10^11 GC/ml
CRE AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ.   Promoter: CMV.
CREStandard$400
AA26125µl
≥ 5x10^12 GC/ml
mCherry AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ.   Promoter: CMV.
mCherryPurified$350
AA262100µl
≥ 5x10^12 GC/ml
mCherry AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ.   Promoter: CMV.
mCherryPurified$500
AA268500µl
≥ 1x10^11 GC/ml
mCherry AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ.   Promoter: CMV.
mCherryStandard$300
AA2691ml
≥ 1x10^11 GC/ml
mCherry AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ.   Promoter: CMV.
mCherryStandard$400
AA27125µl
≥ 5x10^12 GC/ml
FLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ.   Promoter: CMV.
FLucPurified$350
AA272100µl
≥ 5x10^12 GC/ml
FLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ.   Promoter: CMV.
FLucPurified$500
AA278500µl
≥ 1x10^11 GC/ml
FLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ.   Promoter: CMV.
FLucStandard$300
AA2791ml
≥ 1x10^11 GC/ml
FLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ.   Promoter: CMV.
FLucStandard$400
AA29125µl
≥ 5x10^12 GC/ml
GLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 1 vial).
Serotype: DJ.   Promoter: CMV.
GLucPurified$350
AA292100µl
≥ 5x10^12 GC/ml
GLuc AAVPrime™ Purified Adeno-associated Viral Particles (25 µl x 4 vials).
Serotype: DJ.   Promoter: CMV.
GLucPurified$500
AA298500µl
≥ 1x10^11 GC/ml
GLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ.   Promoter: CMV.
GLucStandard$300
AA2991ml
≥ 1x10^11 GC/ml
GLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ.   Promoter: CMV.
GLucStandard$400
AA408500µl
≥ 1x10^11 GC/ml
eGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ/8.   Promoter: CMV.
eGFPStandard$360
AA4091ml
≥ 1x10^11 GC/ml
eGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ/8.   Promoter: CMV.
eGFPStandard$480
AA418500µl
≥ 1x10^11 GC/ml
IRES-hrGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ/8.   Promoter: CMV.
IRES-hrGFPStandard$360
AA4191ml
≥ 1x10^11 GC/ml
IRES-hrGFP AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ/8.   Promoter: CMV.
IRES-hrGFPStandard$480
AA428500µl
≥ 1x10^11 GC/ml
LacZ AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ/8.   Promoter: CMV.
LacZStandard$360
AA4291ml
≥ 1x10^11 GC/ml
LacZ AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ/8.   Promoter: CMV.
LacZStandard$480
AA438500µl
≥ 1x10^11 GC/ml
CRE AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ/8.   Promoter: CMV.
CREStandard$360
AA4391ml
≥ 1x10^11 GC/ml
CRE AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ/8.   Promoter: CMV.
CREStandard$480
AA468500µl
≥ 1x10^11 GC/ml
mCherry AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ/8.   Promoter: CMV.
mCherryStandard$360
AA4691ml
≥ 1x10^11 GC/ml
mCherry AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ/8.   Promoter: CMV.
mCherryStandard$480
AA478500µl
≥ 1x10^11 GC/ml
FLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ/8.   Promoter: CMV.
FLucStandard$360
AA4791ml
≥ 1x10^11 GC/ml
FLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ/8.   Promoter: CMV.
FLucStandard$480
AA498500µl
≥ 1x10^11 GC/ml
GLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 5 vials).
Serotype: DJ/8.   Promoter: CMV.
GLucStandard$360
AA4991ml
≥ 1x10^11 GC/ml
GLuc AAVPrime™ Standard Adeno-associated Viral Particles (100 µl x 10 vials).
Serotype: DJ/8.   Promoter: CMV.
GLucStandard$480

 

 

 

Serotypes & Vectors

Order custom AAV particles

Custom AAV particles production services are currently available for ORF expression. GeneCopoeia' s scientific expertise can deliver AAV particles with titers starting from 10^11 GC/mL or higher depending upon the request.

For all AAV particles not covered in the premade particles collection, request a custom quote here.

 

AAV serotypes available

GeneCopoeia provides AAV particles for all the commonly-occurring AAV serotypes. The intensity of gene expression and tissue tropism depends highly on the AAV serotype used in different tissues. 

Different serotypes differ mainly in surface protein (capsid). Carefully choosing the serotype enables robust gene expression in specific tissues with minimal immune response. Refer to the table below to compare the essential differences between different serotypes.

Serotype Primary Target Tissues Description
AAV-1 Muscle Best for cardiac muscle, skeletal muscle, neuronal and glial tissue.
AAV-2 Muscle, Liver, Retina Oldest and most commonly-used serotype. Best for neurons, muscle, liver, and brain.
AAV-3 Megakaryocytes Best for megakaryocytes, muscle, liver, lung, and retina.
AAV-4 Retina Best for neurons, muscle, brain, and retina.
AAV-5 Lung Best for lung, neurons, synovial joint, retina, and pancreas.
AAV-6 Muscle, Lung Best for lung, liver, and heart.
AAV-7 Muscle, Retina, Neurons Best for muscle, neurons, and liver.
AAV-8 Liver Best for muscle, brain, liver, and retina.
AAV-9 Various Best for muscle, heart, liver, lung, and brain.
AAV-10 Pleura, CNS Cloned from Cynomolgus, almost identical with AAVrh10 except for 12 amino acids in VP1. Best for lung, muscle, heart, NCS and liver.
AAV-DJ Various A mixture of 8 naturally-occurring serotypes. Efficiently transduces a wide variety of cell types in vitro.
AAV-DJ/8 Various A variant of AAV-DJ with a mutation that permits infection of liver as well as other tissues in vivo.

 

 

Vector choices

GeneCopoeia’s AAV vector collection enables efficient gene expression in a broad range of cell types. For insert lengths up to 3kb.

Vector name Promoter Promoter description Reporter gene Length of insertion
pEZ-AV01 CMV Strong promoter, broad scope of application. N/A 3 kb
pEZ-AV02 EF-1α Broad scope of application. Better choice than CMV for in vivo applications. N/A 3 kb
pEZ-AV04 CAG Ubiquitous. Better choice than CMV for in vivo applications. N/A 3 kb
pEZ-AV06 CBh Hybrid chicken beta actin promoter. Provides better long-term expression than CMV in neural cells. N/A 3 kb
pEZ-AV07 CMV Strong promoter, broad scope of application. IRES-eGFP 2 kb
pEZ-AV08 EF-1α Broad scope of application. Better choice than CMV for in vivo applications. IRES-eGFP 2 kb
pEZ-AV09 CAG Ubiquitous. Better choice than CMV for in vivo applications. IRES-eGFP 2 kb
pEZ-AV11 CBh Hybrid chicken beta actin promoter. Provides better long-term expression than CMV in neural cells. IRES-eGFP 2 kb
pEZ-AV12 CAMKlla Highly-speciffic expression in excitatory neurons in the neocortex and hippocampus. N/A 2.3 kb
pEZ-AV13 hSYN Human synapsin-1 gene promoter, neuronal-specific. N/A 2.5 kb
pEZ-AV15 MHC Cardiac muscle-specific human promoter. N/A 2.5 kb

* More vectors are coming soon!

 

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