All human and mice ORF clones and related Lentivirus, AAV particles and recombinant proteins provided by GeneCopoeia are fully sequenced using Sanger sequencing by capillary electrophoresis and Amino Acid Sequences are guaranteed to be matched with NCBI database.

Lentifect Purified Lentivirus Publications

View selected publications citing GeneCopoeia’s Lentifect™ purified lentiviral particles from the recent literature

2023

Bustos, M.A., et al (2023). MiR-181a targets STING to drive PARP inhibitor resistance in BRCA- mutated triple-negative breast cancer and ovarian cancer. Cell Biosci. doi: 10.1186/s13578-023-01151-y [Lentifect™ lentiviral particles]
Zeng, F., et al. (2023). MALAT1 promotes FOXA1 degradation by competitively binding to miR-216a-5p and enhancing neuroendocrine differentiation in prostate cancer. Transl Oncol. doi: 10.1016/j.tranon.2023.101807 [Lentifect™ lentiviral particles targeting MALAT1; Lentifect™ lentiviral particles expressing shRNA targeting MALAT1, ZFP91]
Elste, J., et al. (2023). Plant Cell-Engineered Gold Nanoparticles Conjugated to Quercetin Inhibit SARS-CoV-2 and HSV-1 Entry. Int J Mol Sci. doi: 10.3390/ijms241914792 [Lentifect™ SARS-CoV-2 D614G Spike-Pseudotyped Lentiviral Particles; Lenti-Pac™ HEK293T cell line]
Zhang, C., et al. (2023). Latexin deletion protects against radiation-induced hematopoietic damages via selective activation of Bcl-2 prosurvival pathway. Haematologica. doi: 10.3324/haematol.2022.282028 [Lentifect™ lentiviral particles expressing shRNAs targeting Rps3]
Wang, X., et al. (2023). m6A modified BACE1-AS contributes to liver metastasis and stemness-like properties in colorectal cancer through TUFT1 dependent activation of Wnt signaling. J Exp Clin Cancer Res. doi: 10.1186/s13046-023-02881-0 [Lentifect™ lentiviral particles expressing shRNA targeting BACE1-AS or BACE1-AS ]
WangX., et al. (2023). Novel insights into the ecDNA formation mechanism involving MSH3 in methotrexate-resistant human colorectal cancer cells. Int J Oncol. doi: 10.3892/ijo.2023.5582 [Lentifect™ lentiviral particles]
Dai, J., et al. (2023). SPOP regulates the expression profiles and alternative splicing events in human hepatocytes. Open Life Sci. doi: 10.1515/biol-2022-0755 [Lentifect™ lentiviral particles targeting SPOP]
Liu, R., et al. (2023). Tumor removal limits prostate cancer cell dissemination in bone and osteoblasts induce cancer cell dormancy through focal adhesion kinase. J Exp Clin Cancer Res. doi: 10.1186/s13046-023-02849-0 [Lentifect™ Lentiviral particles]
Gau, D., et al. (2023). Vascular endothelial profilin-1 drives a protumorigenic tumor microenvironment and tumor progression in renal cancer. J Biol Chem. doi: 10.1016/j.jbc.2023.105044 [Lentifect™ Lentiviral Particles]
Parween, F., et al. (2023). Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells. bioRxiv doi: 10.1101/2023.01.25.525561 [Lentifect™ lentiviral particles]
Singh, S.P., et al. (2023). Human CCR6+ Th cells show both an extended stable gradient of Th17 activity and imprinted plasticity. bioRxiv doi: 10.1101/2023.01.05.522630 [Lentifect™ lentiviral particles; OMICSLINK™ Lentiviral ORF expression clone]
Kim, G.S., et al. (2023). Single-cell analysis identifies Ifi27l2a as a novel gene regulator of microglial inflammation in the context of aging and stroke. Res Sq doi: 10.21203/rs.3.rs-2557290/v1 [Lentifect™ lentiviral particles]
Liu, Q., et al. (2023). A long non-coding RNA H19/microRNA-138/TLR3 network is involved in high phosphorus-mediated vascular calcification and chronic kidney disease. Cell Cycle doi: 10.1080/15384101.2022.2064957 [Lentifect™ lentiviral particles]
Han, W., et al. (2023). Exploiting the tumor-suppressive activity of the androgen receptor by CDK4/6 inhibition in castration-resistant prostate cancer. Mol Ther doi: 10.1016/j.ymthe.2022.01.039 [Lentifect™ shRNA lentiviral particles]
Zhang, X., et al. (2023). IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma. iScience doi: 10.1016/j.isci.2023.106639 [shIGFBP3 lentiviral particles and control (psi-LvRU6rLP) ; Lentifect™ shRNA lentiviral particles]
Fuller, M.J., et al. (2023). Investigating role of ASIC2 in synaptic and behavioral responses to drugs of abuse. Front Mol Biosci doi: 10.3389/fmolb.2023.1118754 [Lentifect™ Lentiviral particles expressing Asic2a and Asic2b]
Rao, X., et al. (2023). Dipeptidyl Peptidase 4/Midline‐1 Axis Promotes T Lymphocyte Motility in Atherosclerosis. Adv Sci (Weinh) doi: 10.1002/advs.202204194 [Lentifect™ Lentiviral particles expressing Mid1]
Zhang, X., et al. (2023). IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma. iScience doi: 10.1016/j.isci.2023.106639 [shIGFBP3 lentiviral particles and control (psi-LvRU6rLP) ; Lentifect™ shRNA lentiviral particles]
Han, W., et al. (2023). Exploiting the tumor-suppressive activity of the androgen receptor by CDK4/6 inhibition in castration-resistant prostate cancer. Mol Ther doi: 10.1016/j.ymthe.2022.01.039 [Lentifect™ shRNA lentiviral particles]
Liu, Q., et al. (2023). A long non-coding RNA H19/microRNA-138/TLR3 network is involved in high phosphorus-mediated vascular calcification and chronic kidney disease. Cell Cycle doi: 10.1080/15384101.2022.2064957 [Lentifect™ lentiviral particles]
Kim, G.S., et al. (2023). Single-cell analysis identifies Ifi27l2a as a novel gene regulator of microglial inflammation in the context of aging and stroke. Res Sq doi: 10.21203/rs.3.rs-2557290/v1 [Lentifect™ lentiviral particles]
Singh, S.P., et al. (2023). Human CCR6+ Th cells show both an extended stable gradient of Th17 activity and imprinted plasticity. bioRxiv doi: 10.1101/2023.01.05.522630 [Lentifect™ lentiviral particles; OMICSLINK™ Lentiviral ORF expression clone]
Parween, F., et al. (2023). Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells. bioRxiv doi: 10.1101/2023.01.25.525561 [Lentifect™ lentiviral particles]

2022

Zhang, Z., et al. (2022). N6‐methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation. Clin Transl Med doi: 10.1002/ctm2.940 [Lentifect™ Lentiviral particles expressing shRNAs targeting ALKBH5; Lenti-PAC™ HIV Expression Packaging Kit]
Wang, Q., et al. (2022). Post-translational control of beige fat biogenesis by PRDM16 stabilization. Nature doi: 10.1038/s41586-022-05067-4 [Lentifect™ Lentiviral particles expressing shRNAs targeting Cul2, Klhdc2, Lrrc14]
Su, L.H., et al. (2022). CAR-T Engager proteins optimize anti-CD19 CAR-T cell therapies for lymphoma. Oncoimmunology doi: 10.1080/2162402X.2022.2111904 [Lentifect™ Lentiviral particles]
Liu, X., et al. (2022). HER2 drives lung fibrosis by activating a metastatic cancer signature in invasive lung fibroblasts. J Exp Med doi: 10.1084/jem.20220126 [Lentifect™ Lentiviral particles]
Hyroššová, P., et al. (2022). Glycosylation defects; offset by PEPCK-M; drive entosis in breast carcinoma cells. Cell Death Dis doi: 10.1038/s41419-022-05177-x [Lentifect™ Lentiviral particles expressing PCK2]
Varney, M.J., et al. (2022). G protein–coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin. J Biol Chem doi: 10.1016/j.jbc.2022.102421 [Lentifect™ Lentiviral particles expressing GRK6 or GRK6-P384S]
Marimuthu, S., et al. (2022). MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion. Mol Cancer Res doi: 10.1158/1541-7786.MCR-21-0888 [Firefly Luciferase Lentifect™ Purified Lentiviral Particles]
Shia, D.W., et al. (2022). Targeting PEA3 transcription factors to mitigate small cell lung cancer progression. Oncogene doi: 10.1038/s41388-022-02558-6 [Lentifect™ shRNA lentiviral particles]
Wang, C., et al. (2022). RNA N6-Methyladenosine (m6A) Methyltransferase-like 3 Facilitates Tumorigenesis and Cisplatin Resistance of Arecoline-Exposed Oral Carcinoma. Cells doi: 10.3390/cells11223605 [METTL3 (ULP-A8711-Lv105-A00); HIF-1α (ULP-T0096-Lv105-A00); MYC (LPP-B0255-Lv105-050);Lentifect™ Lentiviral particles]
Le, Q., et al. (2022). CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target. J Clin Invest doi: 10.1172/JCI157101 [Lentifect™ Lentiviral particles expressing FOLR1]
Kan, X.F., et al. (2022). Enhanced efficacy of direct immunochemotherapy for hepatic cancer with image-guided intratumoral radiofrequency hyperthermia. J Immunother Cancer doi: 10.1136/jitc-2022-005619 [Lentifect™ Lentiviral particles expressing Luc/RFP]
Yoshimoto, T., et al. (2022). Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection. Nat Commun doi: 10.1038/s41467-022-34352-z [Lentifect™ Lentiviral particles expressing Fbxl19; Lentifect™ Lentiviral particles expressing Pdlim2]
Kanyomse, Q., et al. (2022). KLF15 suppresses tumor growth and metastasis in Triple-Negative Breast Cancer by downregulating CCL2 and CCL7. Sci Rep doi: 10.1038/s41598-022-23750-4 [Lentifect™ Lentiviral particles]
Hu, Y.J., et al. (2022). Delta-catenin attenuates medulloblastoma cell invasion by targeting EMT pathway. Front Genet doi: 10.3389/fgene.2022.867872 [Lentifect™ Lentiviral particles]
Roshini, A., et al. (2022). The extracellular matrix protein fibulin-3/EFEMP1 promotes pleural mesothelioma growth by activation of PI3K/Akt signaling. Front Oncol doi: 10.3389/fonc.2022.1014749 [Lentiviral particles carrying firefly Luciferase fLuc (LPP-hLUC-LV206) ]
Seenappa, L.M., et al. (2022). Amphiphile-CpG vaccination induces potent lymph node activation and COVID-19 immunity in mice and non-human primates. NPJ Vaccines doi: 10.1038/s41541-022-00560-3 [Lentifect™ SARS-CoV2 Spike-pseudotyped Lentiviral particles]
Olivia McGinn, et al. (2022). Cytokeratins 5 and 17 maintain an aggressive epithelial state in basal-like breast cancer. Mol Cancer Res doi: 10.1158/1541-7786.MCR-21-0866 [Lentifect™ purified lentiviral particles]
Summer Y. Y. Ha, et al. (2022). An enzymatically cleavable tripeptide linker for maximizing the therapeutic index of antibody-drug conjugates. Mol Cancer Ther doi: 10.1158/1535-7163.MCT-22-0362 [Firefly Luciferase Lentifect™ Purified Lentiviral Particles]
Li, Z-X., et al. (2022). WTAP-mediated m6A modification of lncRNA DIAPH1-AS1 enhances its stability to facilitate nasopharyngeal carcinoma growth and metastasis. Cell Death & Differentiation doi: 10.1038/s41418-021-00905-w 3 [Lentifect™ Lentiviral particles expressing shRNAs targeting WTAP]
Rao, T.C., et al. (2022). ST6Gal-I-mediated sialylation of the epidermal growth factor receptor modulates cell mechanics and enhances invasion. Journal of Biological Chemistry doi: 10.1016/j.jbc.2022.101726 [Lentifect™ Lentiviral particles expressing ST6Gal1]
Man, L., et al. (2022). Chronic superphysiologic AMH promotes premature luteinization of antral follicles in human ovarian xenografts. Science Advances doi: 10.1126/sciadv.abi7315 [Lentifect™ Lentiviral particles expressing AMH]
Wang, H., et al. (2022). BET inhibitor JQ1 enhances anti-tumor immunity and synergizes with PD-1 blockade in CRC. Journal of Cancer doi: 10.7150/jca.69375 [Lentifect™ Lentiviral particles expressing shRNAs targeting BRD4]
Jones, T.M., et al. (2022). Targeted CUL4A inhibition synergizes with cisplatin to yield long-term survival in models of head and neck squamous cell carcinoma through a DDB2-mediated mechanism. Cell Death & Disease doi: 10.1038/s41419-022-04798-6 [Lentifect™ Lentiviral particles expressing the promoter for DB2]
Wang, L., et al. (2022). Long non-coding RNA UCA1 promotes retinoblastoma progression by modulating the miR-124/c-myc axis. American Journal of Translational Research v.14(3); 2022 [Lentifect™ Lentiviral particles expressing EGFP]
Fan, N., et al. (2022). Hierarchical self-uncloaking CRISPR-Cas13a–customized RNA nanococoons for spatial-controlled genome editing and precise cancer therapy. Science Advances doi: 10.1126/sciadv.abn7382 [Lentifect™ Lentiviral particles expressing EGFRvIII, EGFP]
Shi, D., et al. (2022). RGS20 Promotes Tumor Progression through Modulating PI3K/AKT Signaling Activation in Penile Cancer. Journal of Oncology doi: 10.1155/2022/1293622 [Lentifect™ Lentiviral particles expressing RGS20; Lentifect™ Lentiviral particles expressing shRNA targeting RGS20]
Hong, X., et al. (2022). Host cell-dependent late entry step as determinant of hepatitis B virus infection. PLOS Pathogens doi: 10.1371/journal.ppat.1010633 [Lentifect™ Lentiviral particles expressing huNTCP]
Paidi, R.K., et al. (2021). Selective Inhibition of the Interaction between SARS-CoV-2 Spike S1 and ACE2 by SPIDAR Peptide Induces Anti-Inflammatory Therapeutic Responses. Journal of Immunology doi: 10.4049/jimmunol.2100144 [Lentifect™ SARS-CoV2 Spike-pseudotyped Lentiviral particles]
Travis, B.J., et al. (2022). Significance of chlorine-dioxide-based oral rinses in preventing SARS-CoV-2 cell entry. Oral Diseases doi: 10.1111/odi.14319 [Lentifect™ SARS-CoV2 Spike-pseudotyped Lentiviral particles]
Hsu, M.A., et al. (2022). Cancer-targeted photoimmunotherapy induces antitumor immunity and can be augmented by anti-PD-1 therapy for durable anticancer responses in an immunologically active murine tumor model. Cancer Immunology, Immunotherapy doi: 10.1007/s00262-022-03239-9 [Lentifect™ Lentiviral particles expressing Ephrin A2]
Kou, B., et al. (2022). LKB1 inhibits proliferation, metastasis and angiogenesis of thyroid cancer by upregulating SIK1. Journal of Cancer doi: 10.7150/jca.72021 [Lentifect™ Lentiviral particles expressing LKB1]
Singh, K., et al. (2022). Genome-wide DNA hypermethylation opposes healing in patients with chronic wounds by impairing epithelial-mesenchymal transition. The Journal of Clinical Investigation doi: .1172/JCI157279 [Lentifect™ Lentiviral particles expressing Adam17]
Wang, Y., et al. (2022). Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells. Molecular Cell doi: 10.1016/j.molcel.2022.07.007 [Lentifect™ Lentiviral particles expressing MDH1]
Varney, M.J., et al. (2022). G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin. Journal of Biological Chemistry doi: 10.1016/j.jbc.2022.102421 [Lentifect™ Lentiviral particles expressing wild type and mutant GRK6]

2021

Joshi, S., et al. (2021). ACE2 Gene Transfer Ameliorates Vasoreparative Dysfunction in CD34+ Cells Derived from Diabetic Older Adults. Clinical Science doi: 10.1042/CS20201133 [Lentifect™ Lentiviral particles expressing ACE2 promoter]
Hyroššová, P., et al. (2021). PEPCK-M recoups tumor cell anabolic potential in a PKC-ζ-dependent manner. Cancer and Metabolism doi: 10.1186/s40170-020-00236-3 [Lentifect™ Lentiviral particles expressing PCK1 ORF]
Baroni, M., et al. (2021). Musashi1 Contribution to Glioblastoma Development via Regulation of a Network of DNA Replication, Cell Cycle and Division Genes. Cancers doi: 10.3390/cancers13071494 [Lentifect™ Lentiviral particles expressing Msi1 ORF]
Meylan, P., et al. (2021). Low expression of the PPARγ-regulated gene thioredoxin-interacting protein accompanies human melanoma progression and promotes experimental lung metastases. Scientific Reports doi: 10.1038/s41598-021-86329-5 [Lentifect™ Lentiviral particles expressing shRNAs targetingTXNIP]
Tito, A., et al. (2021). Pomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs. Frontiers in Chemistry doi: 10.3389/fchem.2021.638187 [Lentifect™ Lentiviral particles expressing Firefly luciferase; SARS-CoV-2 Spike-pseudotyped lentiviral particles]
Zhang, G., et al. (2021). Reduced hyaluronan cross-linking induces breast cancer malignancy in a CAF-dependent manner. Cell Death & Disease doi: 10.1038/s41419-021-03875-6 [Lentifect™ Lentiviral particles expressing TSG6]
Liu, Z., et al. (2021). miR-30a/SOX4 Double Negative Feedback Loop is modulated by Disulfiram and regulates EMT and Stem Cell-like properties in Breast Cancer. Journal of Cancer doi: 10.7150/jca.57752 [Lentifect™ Lentiviral particles]
Mo, J., et al. (2021). TFPI2 Promotes Perivascular Migration in an Angiotropism Model of Melanoma. Frontiers in Oncology doi: 10.3389/fonc.2021.662434 [Lentifect™ Lentiviral particles expressing shRNA against TFPL2]
Huang, Z., et al. (2021). MCTS1 promotes invasion and metastasis of oral cancer by modifying the EMT process. Annals of Translational Medicien doi: 10.21037/atm-21-2361 [Lentifect™ Lentiviral particles expressing MCTS1]
Ma, S., et al. (2021). CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance. Cell Reports doi: 10.1016/j.celrep.2021.109549 [Lentifect™ Lentiviral particles expressing firefly luciferase]
Faria, R.S., et al .(2021). Liposomal paclitaxel induces apoptosis, cell death, inhibition of migration capacity and antitumoral activity in ovarian cancer. Biomedicine & Pharmacotherapy doi: 10.1016/j.biopha.2021.112000 [Lentifect™ Lentiviral particles expressing firefly luciferase and GFP]
Crouchet, E. ,et al. (2021). A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery. Nature Communications doi: 8/s41467-021-25468-9 [Lentifect™ Lentiviral particles expressing NTCP]
Zhang, X., et al. (2021). Interleukin enhancer-binding factor 2 promotes cellproliferation and DNA damage response in metastaticmelanoma. Clinical and Translational Medicine doi: 10.1002/ctm2.608 [Lentifect™ Lentiviral particles expressing ILF2]
Xie, L., et al. (2021). MYO1B enhances colorectal cancer metastasis by promoting the F-actin rearrangement and focal adhesion assembly via RhoA/ROCK/FAK signaling. Annals of Translational Medicine doi: 10.21037/atm-21-4702 [Lentifect™ Lentiviral particles expressing shRNA against MYO1B]
Hu, X., et al. (2021). LncRNA NEAT1 Recruits SFPQ to Regulate MITF Splicing and Control RPE Cell Proliferation. Investigative Ophthalmology & Visual Science doi: 10.1167/iovs.62.14.18 [Lentifect™ Lentiviral particles expressing SPFQ ORF]
Liu, T., et al. (2021). In vivo visualization of murine melanoma cells B16-derived exosomes through magnetic resonance imaging. Biochimica et Biophysica Acta (BBA) – General Subjects doi: 10.1016/j.bbagen.2021.1300628 [Lentifect™ Lentiviral particles expressing FTH1 ORF]
Guan, J., et al. (2021). Clinical significance and biological f unctions of chemokine CXCL3 in head and neck squamous cell carcinoma. Bioscience Reports doi: 10.1042/BSR20212403 [Lentifect™ Lentiviral particles expressing CXCL3 ORF and shRNA against CXCL3]

2020

Corbet, C., et al. (2020), TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells. Nature Communications doi: 10.1038/s41467-019-14262-3 [Lentifect™ Lentiviral particles expressing eGFP and mCherry]
Lin, Z., et al. (2020). Translationally controlled tumor protein promotes liver regeneration by activating mTORC2/AKT signaling. Cell Death & Disease doi: 10.1038/s41419-020-2231-8 [Lentifect™ Lentiviral particles expressing mTOR]
Wang, W., et al. (2020). Lipopolysaccharide inhibits osteogenic differentiation of periodontal ligament stem cells partially through toll-like receptor 4-mediated ephrinB2 downregulation. Cinical Oral INvestigation doi: 10.1007/s00784-020-03211-w [Lentifect™ Lentiviral particles expressing EfnB2]
Zhao, Y. and Sun, M. (2020). Metformin rescues Parkin protein expression and mitophagy in high glucose-challenged human renal epithelial cells by inhibiting NF-κB via PP2A activation. Life Sciences doi: 10.1016/j.lfs.2020.117382 [Lentifect™ Lentiviral particles expressing shRNA]
Wang, W., et al. (2020). EphrinB2 overexpression enhances osteogenic differentiation of dental pulp stem cells partially through ephrinB2-mediated reverse signaling. Stem Cell Research and Therapy doi: 10.1186/s13287-019-1540-2 [Lentifect™ Lentiviral particles expressing human and dog EfnB2]
Banan, B., et al.. (2020). Development of a novel murine model of lymphatic metastasis. Clinical & Experimental Metastasis doi: 10.1007/s10585-020-10025-3 [Lentifect™ Lentiviral particles]
Pan, Y-R., et al. (2020). mTOR may interact with PARP-1 to regulate visible light-induced parthanatos in photoreceptors. Cell Communication and Signaling doi: 10.1186/s12964-019-0498-0 [Lentifect™ Lentiviral particles expressing shRNA targeting PARP-1]
Pothuraju, R., et al. (2020). Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance. Molecular Cancer doi: 10.1186/s12943-020-01156-y [Lentifect™ Lentiviral particles expressing shRNA targeting luciferase + GFP]
Qie, Y., et al. (2020). TACC3 promotes prostate cancer cell proliferation and restrains primary cilium formation. Experimental Cell Research doi: 10.1016/j.yexcr.2020.111952 [Lentifect™ Lentiviral particles expressing shRNA targeting TACC3]
Huang, R., et al. (2020). CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling. Cell Death & Disease doi: 10.1038/s41419-020-2435-y [Lentifect™ Lentiviral particles expressing Firefly luciferase]
Huang, Y., et al. (2020).Resveratrol increase the proportion of oxidative muscle fiber through the AdipoR1-AMPK-PGC-1α pathway in pigs. Journal of Funcitonal Foods doi: 10.1016/j.jff.2020.104090 [GeneHero™ leniviral particles expressing sgRNA clones targeting AdipoR1]
Nicolas, S., et al. (2020). Enduring effects of an unhealthy diet during adolescence on systemic but not neurobehavioural measures in adult rats. Nutritional Neurosciences doi: 10.1080/1028415X.2020.1796041 [Lentifect™ Lentiviral particles expressing IL1β]
Xiong, B., et al. (2020). Ubiquitin-specific protease 2a promotes hepatocellular carcinoma progression via deubiquitination and stabilization of RAB1A. Cellular Oncology doi: 10.1007/s13402-020-00568-8 [Lentifect™ Lentiviral particles expressing shRNA against RAB1A]
Hu, D., et al. (2020). Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells. Proceedings of the National Academy of Scinces of the United States of America doi: 10.1073/pnas.2007935117 [Lentifect™ Lentiviral particles expressing shRNA against USF2]

2019

Al-Khadairi, G., et al. (2019). PRAME promotes epithelial-to-mesenchymal transition in triple negative breast cancer. Journal of Translational Medicine doi: 10.1186/s12967-018-1757-3 [Lentifect™ Lentiviral particles expressing PRAME]
Wang, L., et al. (2019). GLRX inhibition enhances the effects of geftinib in EGFR-TKI-resistant NSCLC cells through FoxM1 signaling pathway. Journal of Cancer Research and Clinical Oncology doi: 10.1007/s00432-019-02845-y [Lentifect™ Lentiviral particles expressing FoxM1]
Zhou, X-L., et al. (2019). The oncoprotein HBXIP competitively binds KEAP1 to activate NRF2 and enhance breast cancer cell growth and metastasis. Oncogene doi: 10.1038/s41388-019-0698-5 [Lentifect™ Lentiviral particles expressing CRE]
Sukonina,, V., et al. (2019). FOXK1 and FOXK2 regulate aerobic glycolysis. Nature doi: 10.1038/s41586-019-0900-5 [Lentifect™ Lentiviral particles expressing FOXK1, FOXK2]
Fitchman, B., et al. (2019). Combined loss of LAP1B and LAP1C results in an early onset multisystemic nuclear envelopathy. Nature Comunications doi: 10.1038/s41467-019-08493-7 [Lentifect™ Lentiviral particles expressing LAP1B, LAP1C]
Xie, X., et al. (2019). MiR -192- 5p reverses cisplatin resistance by targeting ERCC3 and ERCC4 in SGC7901/DDP cells. Journal of Cancer doi:10.7150/ jca .25814 [Lentifect™ Lentiviral particles expressing miR-192-5p]
Barnawi, R., et al. (2019). β1 Integrin is Essential for Fascin‐Mediated Breast Cancer Stem Cell Function and Disease Progression. International Journal of Cancer doi: 10.1002/ijc.32183 [Lentifect™ Lentiviral particles expressing fascin]
Goncalves, M.B., et al. (2019). Regulation of myelination by exosome associated retinoic acid release from NG2-positive cells. The Journal of Neuroscience doi: 10.1523/JNEUROSCI.2922-18.2019 [Lentifect™ Lentiviral particles]
Yoon, J-H, et al. (2019). Error-Prone Replication through UV Lesions by DNA Polymerase θ Protects against Skin Cancers. Cell doi: 10.1016/j.cell.2019.01.023 [Lentifect™ Lentiviral particles expressing SV40 large T antigen]
Qin, Y., et al. (2019). CCL18 promotes the metastasis of squamous cell carcinoma of the head and neck through MTDH‐NF‐κB signalling pathway. Journal of Cellular and Molecular Medicine doi: 10.1111/jcmm.14168 [Lentifect™ Lentiviral particles expressing shRNA targeting MTDH]
Zhou, X., et al. (2019). Inhibition of MEK suppresses hepatocellular carcinoma growth through independent MYC and BIM regulation. Cellular Oncology doi: 10.1007/s13402-019-00432-4 [Lentifect™ Lentiviral particles expressing MYC antigen]
Zhou, J., et al. (2019). Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway. Journal of Experimental & Clinical Cancer Research doi: 10.1186/s13046-019-1057-7 [Lentifect™ Lentiviral particles expressing GK5, SCD1]
Ning, Y., et al. (2019). CK2-mediated CCDC106 phosphorylation is required for p53 degradation in cancer progression. Journal of Experimental & Clinical Cancer Research doi: 10.1186/s13046-019-1137-8 [Lentifect™ Lentiviral particles expressing shRNA targeting CCDC106]
Cassaletto, J.B., et al. (2019). MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM. Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.1819085116 [Lentifect™ Lentiviral particles expressing HGF]
Dinamarca, M.C., et al. (2019). Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing. Nature Communications doi: 10.1038/s41467-019-09164-3 [Lentifect™ Lentiviral particles expressing GB1a, GB1b]
Warren, C.S., et al. (2019). EXAMINING THE MARKERS OF VITAMIN C CYTOTOXICITY IN PANCREATIC DUCTAL ADENOCARCINOMA. Masters Thesis, The UNiversity of British Columbia [Lentifect™ Lentiviral particles expressing KRAS wild type and G12D mutant]
Ma, X., et al. (2019). Identification of Tumor Specific Peptide as EpCAM Ligand and Its Potential Diagnostic and Therapeutic Clinical Application. Molecular Pharmacutics doi: 10.1021/acs.molpharmaceut.9b00185 [Lentifect™ Lentiviral particles expressing luciferase]
Yung, K.L., et al. (2019). Biocompatible Sculptured Extracellular Nanomatrix enables self assembly of neural stem cells into miniature brain organoids of substantia nigra . United States Patent Application 20190106676 [Lentifect™ Lentiviral particles expressing GFP]
Chen, H., et al. (209). CDCA5, Transcribed by E2F1, Promotes Oncogenesis by Enhancing Cell Proliferation and Inhibiting Apoptosis via the AKT Pathway in Hepatocellular Carcinoma. International Journal of Cancer doi: 10.7150/jca.28809 [Lentifect™ Lentiviral particles expressing CDCA5]
Wang, L., et al. (2019). Down-regulation of lncRNA GAS5 attenuates neuronal cell injury through regulating miR-9/FOXO3 axis in cerebral ischemic stroke. RSC Advances doi: 10.1039/C9RA01544B [Lentifect™ Lentiviral particles expressing shRNA targeting MCAO]
Flaherty, E., et al. (2019). Neuronal impact of patient-specific aberrant NRXN1α splicing. Nature Genetics doi: 10.1038/s41588-019-0539-z [Lentifect™ Lentiviral particles expressing NRXN1α]
Baltazar, T., et al. (2019). Three Dimensional Bioprinting of a Vascularized and Perfusable Skin Graft Using Human Keratinocytes, Fibroblasts, Pericytes, and Endothelial Cells. Tissue Engineering Part A doi: 10.1089/ten.tea.2019.0201 [Lentifect™ Lentiviral particles expressing RFP]
Tan, G., et al. (2019). Type-I-IFN-Stimulated Gene TRIM5γ Inhibits HBV Replication by Promoting HBx Degradation. Cell Reports doi: 10.1016/j.celrep.2019.11.041 [Lentifect™ Lentiviral particles expressing TRIM5γ ORF]
Tang, j., et al. (2019). Protein phosphatase Mg2+/Mn2+ dependent‐1A and PTEN deregulation in renal fibrosis: Novel mechanisms and co‐dependency of expression . The FASEB JOurnal doi: 10.1096/fj.201902015RR [Lentifect™ Lentiviral particles expressing PPM1A, PTEN ORFs]
Li, Y., et al. (2019). CASC15 promotes epithelial to mesenchymal transition and facilitates malignancy of hepatocellular carcinoma cells by increasing TWIST1 gene expression via miR-33a-5p sponging. European Journal of Phamacology doi: 10.1016/j.ejphar.2019.172589 [Lentifect™ Lentiviral particles expressing CASC15 ORF]

2018

Jones, L.E. (2018). Patient-Derived Models of IDH1-Mutant, Hypermutated Glioma. Ph.D. Thesis, University of Californa at San Francisco [Lentifect™ Lentiviral particles expressing luciferase]
Kenney, R.M., et al. (2018). A pH-Sensing Optode for Mapping Spatiotemporal Gradients in 3D Paper-Based Cell Cultures. Analytical Chemistry doi: 10.1021/acs.analchem.7b05015 [Lentiviral particles expressing mCherry]
Ali, M.M., et al. (2018). PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers. Nature Communications doi: 10.1038/s41467-018-03265-1 [Lentiviral particles expressing shRNA targeting SCAT7]
Xion, F., et al. (2018). Orthotopic hepatic cancer: radiofrequency hyperthermia-enhanced intratumoral herpes simplex virus-thymidine kinase gene therapy. Oncotarget doi: 10.18632/oncotarget.23586 [Lentiviral particles expressing luciferase and RFP]
Wang, X., et al. (2018). miR‑30a inhibits epithelial‑mesenchymal transition and metastasis in triple‑negative breast cancer by targeting ROR1. Oncology Reports doi: 10.3892/or.2018.6379 [Lentiviral particles expressing miR-30a]
Yu, j., et al. (2018). Epigenetic silencing of miR-483-3p promotes acquired gefitinib resistance and EMT in EGFR-mutant NSCLC by targeting integrin β3. Oncogene doi: 10.1038/s41388-018-0276-2 [Lentiviral particles expressing integrin β3]
Liu, H., et al. (2018). Downregulation of Glutathione S‑transferase A1 suppressed tumor growth and induced cell apoptosis in A549 cell line. Oncology Letters doi: 10.3892/ol.2018.8608 [Lentiviral particles expressing GSTA1 and shRNA against GSTA1]
Tran, A.P., et al. (2018). Modulation of receptor protein tyrosine phosphatase sigma increases chondroitin sulfate proteoglycan degradation through Cathepsin B secretion to enhance axon outgrowth. The Journal of Neuroscience doi: 10.1523/JNEUROSCI.3214-17.2018 [Lentifect™ Lentiviral particles expressing Crystatin-B]
Baumert, T., et al. (2018). CLINICAL GENE SIGNATURE-BASED HUMAN CELL CULTURE MODEL AND USES THEREOF. United States Patent Application 20180119096 [Lentifect™ Lentiviral particles expressing HDV, HBV]
Porello, A., et al. (2018). Factor XIIIA—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking. Nature Communications doi: 10.1038/s41467-018-04355-w [Lentifect™ Lentiviral particles expressing CCL2, Factor 13; Lentifect™ Lentiviral particles expressing shRNA against Factor 13]
Glumac, P.M/, et al. (2018). The identification of a novel antibody for CD133 using human antibody phage display. The Prostate doi: 10.1002/pros.23656 [Lentifect™ Lentiviral particles expressing PROM1]
Bi, Q-J., et al. (2018). LHX6 inhibits the proliferation, invasion and migration of breast cancer cells by modulating the PI3K/Akt/mTOR signaling pathway. European Review for Medical and Pharmacological Sciences 2018; 22: 3067-3073 [Lentifect™ Lentiviral particles expressing LHX6]
Bai, P-s., et al. (2018). Hepatitis B virus promotes proliferation and metastasis in male Chinese hepatocellular carcinoma patients through the LEF-1/miR-371a-5p/SRCIN1/pleiotrophin/Slug pathway. Experimental Cell Research doi: 10.1016/j.yexcr.2018.06.020 [Lentifect™ Lentiviral particles expressing miR-371a]
Kim, K. M., et al. (2018). SCAMP4 enhances the senescent cell secretome. Genes & Development doi: 10.1101/gad.313270.118 [Lentifect™ Lentiviral particles expressing SCAMP4-Myc]
Wang, K., et al. (2018). Hypoxia-stressed cardiomyocytes promote early cardiac differentiation of cardiac stem cells through HIF-1α/Jagged1/Notch1 signaling. Acta Pharmaceutica Sinica B doi: 10.1016/j.apsb.2018.06.003 [Lentifect™ Lentiviral particles expressing HIF-1α]
Gril, B., et al. (2018). Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases. Nature Communications doi: 10.1038/s41467-018-05030-w [Lentifect™ Lentiviral particles expressing SIP3]
Kalimuthu, S., et al. (2018). Migration of mesenchymal stem cells to tumor xenograft models and in vitro drug delivery by doxorubicin. International Journal of Medical Sciences doi: 10.7150/ijms.25760 [Lentifect™ Lentiviral particles expressing eGFP, mCherry, and Renilla luciferase]
Helsen, C.W., et al. (2018). The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity. Nature Communications doi: 10.1038/s41467-018-05395-y [Lentifect™ Lentiviral particles expressing HER2]
Cai, M., et al. (2018). Inhibiting homologous recombination decreases extrachromosomal amplification but has no effect on intrachromosomal amplification in methotrexate‐resistant colon cancer cells. International Journal of Cancer doi: 10.1002/ijc.31781 [Lentifect™ Lentiviral particles expressing BRCA1]
Hui, K., et al. (2018). The expression and function of RASAL2 in renal cell carcinoma angiogenesis. Cell Death & Disease doi:10.1038/s41419-018-0898-x [Lentifect™ Lentiviral particles expressing RASAL2]
Guo, Y-C., et al. (2018). Ubiquitin‐specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling. EMBO Journal doi: 10.15252/embj.201899398 [Lentifect™ Lentiviral particles expressing shRNA against USP34]
Shigemura, M., et al. (2018). Hypercapnia increases airway smooth muscle contractility via caspase-7–mediated miR-133a–RhoA signaling. Science Translational Medicine doi: 10.1126/scitranslmed.aat1662 [Lentifect™ Lentiviral particles expressing mir-133a inhibitor]
Hueston, C.M., et al. (2018). Chronic interleukin-1β in the dorsal hippocampus impairs behavioural pattern separation. Brain, Behavior, and Immunity doi: 10.1016/j.bbi.2018.09.015 [Lentifect™ Lentiviral particles expressing IL1β]
Franke, F.C., et al. (2018). The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial Q1 – Mesenchymal Transition and Metastasis in Colorectal Cancer. Cellular and Molecular Gastroenterology and Hepatology doi: ol Gastroenterol Hepatology doi: 10.1016/j.jcmgh.2018.08.007 [Lentifect™ Lentiviral particles expressing luciferase]
Gangadaran, P., et al. (2018). New Optical Imaging Reporter-labeled Anaplastic Thyroid Cancer-Derived Extracellular Vesicles as a Platform for In Vivo Tumor Targeting in a Mouse Model. Scientific Reports doi: 10.1038/s41598-018-31998-y [Lentifect™ Lentiviral particles expressing RLuc]
Zhang, M., et al. (2018). Long non-coding RNA BRE-AS1 represses non-small cell lung cancer cell growth and survival via up-regulating NR4A3. Archived of Biochemistry and Biophysics doi: 10.1016/j.abb.2018.09.013 [Lentifect™ Lentiviral particles expressing STAT3]
Luo, F., eat al. (2018). Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis. Nature Communications doi: 10.1038/s41467-018-06505-610.1038/s41467-018-06505-6 [Lentifect™ Lentiviral particles expressing shRNA targeting MMP-2]
Kenney, R.M., et al. (2018). Paper-based Transwell assays: an inexpensive alternative to study cellular invasion. Analyst doi: 10.1039/C8AN01157E [Lentifect™ Lentiviral particles expressing shRNA targeting mCherry]
Yang, G., et al. (2017). MicroRNA-195 protection against focal cerebral ischemia by targeting CX3CR1. Journal of Neurosurgery doi: 10.3171/2018.5.JNS173061 [Lentifect™ Lentiviral particles]
Yeung, T-L., et al. (2018). ISG15 Promotes ERK1 ISGylation, CD8+ T Cell Activation and Suppresses Ovarian Cancer Progression. Cancers doi: 10.3390/cancers10120464 [Lentifect™ Lentiviral particles expressing ISG15 ORF]
Kozareva, D.A., et al. (2018). TLX knockdown in the dorsal dentate gyrus of juvenile rats differentially affects adolescent and adult behaviour. Behavioural Brain Research doi: 10.1016/j.bbr.2018.11.034 [Lentifect™ Lentiviral particles expressing shRNA]
Liu, Z., et al. (2018). Muscular proteomic profiling of deep pressure ulcers reveals myoprotective role of JAK2 in ischemia and reperfusion injury. Am J Transl Res 2018;10(11):3413-3429 [Lentifect™ Lentiviral particles expressing JAK2 ORF]
Miura, N., et al. (2018). Inhibitors for methylation-related enzymes hat1 and kat8. United Stated Patent Application 15/771,958 [Lentifect™ Lentiviral particles expressing shRNA targeting HAT1, KAT8]
Xue, Y., et al. (2018). IL-17A modulates osteoclast precursors’ apoptosis through autophagy-TRAF3 signaling during osteoclastogenesis. Biochemical and Biophysical Research Communications doi: 10.1016/j.bbrc.2018.12.029 [Lentifect™ Lentiviral particles expressing Beclin]
Cheng, F., et al. (2018). Conversion of human adipose-derived stem cells into functional and expandable endothelial-like cells for cell-based therapies. Stem CEll Research and Therapy doi: 10.1186/s13287-018-1088-6 [Lentiviral particles expressing sgRNA targeting MVPEGM-2]
Offenhäuser, C., et al. (2018). EphA3 Pay-Loaded Antibody Therapeutics for the Treatment of Glioblastoma. Cancers doi: 10.3390/cancers10120519 [Lentifect™ Lentiviral particles expressing luciferase]
Li, S., et al. (2018). IL-17A inhibits autophagic activity of HCC cells by inhibiting the degradation of Bcl2. Biochemical and Biophysical Research Communications doi: 10.1016/j.bbrc.2018.12.103 [Lentifect™ Lentiviral particles expressing Beclin]
Li, J., et al. (2018). HIF1A and VEGF regulate each other by competing endogenous RNA mechanism and involve in the pathogenesis of peritoneal fibrosis. Pathology- Research & Practice doi: 10.1016/j.prp.2018.12.022 [Lentifect™ Lentiviral particles for overexpression and shRNA of HIF1A, VEGF]

2017

Teng, Y., et al. (2017). MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression. Nature Communications doi: 10.1038/ncomms14448 [Lentiviral particles expressing sgRNA targeting MVP]
Jay, A. (2017). STUDIES OF CD36 INTERACTING WITH FATTY ACIDS, OXIDIZED LOW DENSITY LIPOPROTEIN, AND THE CELLULAR PLASMA MEMBRANE. Thesis Dissertation, Boston University [CD36 ORF lentiviral particles]
Liu, Y., et al. (2017). Latexin Inactivation Enhances Survival and Long-Term Engraftment of Hematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice. Stem Cell Reports doi: 10.1016/j.stemcr.2017.02.009 [Lentifect™ lentviral particles]
Shih Y.P., et al. (2017). Down-regulation of DLC1 in endothelial cells compromises the angiogenesis process. 10.1016/j.canlet.2017.04.004 [lentivirus expressing SV40 large T antigen]
Wu, M., et al. (2017). Immunomodulators Targeting MARCO Expression Improve Resistance to Post-influenza Bacterial Pneumonia. Lung Cellular and Molecular Physiology doi: 10.1152/ajplung.00075.2017 [lentivirus expressing TFEB ORF]
Qi, W., et al. (2017). Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. Nature Medicine doi: 10.1038/nm.4328 [Lentifect™ Human PKM1 and PKM2 lentivirus]
Burenkova, O., et al. (2017). BIOMARKERS FOR PREDICTING OUTCOMES OF CANCER THERAPY WITH ERBB3 INHIBITORS. United States Patent Application 20170101480 [Lentifect™ ErbB4 JMaCYT1 and ErbB4 JMaCYT2 isoform cDNA lentivirus]
Liu, L., et al. (2017). CRY2 is suppressed by FOXM1 mediated promoter hypermethylation in breast cancer. Biochemical and Biophysical Research Communications doi: 10.1016/j.bbrc.2017.06.003 [FOXM1 Human Lentifect™ Purified Lentiviral Particles]
Chen, X., et al. (2017). MicroRNA-195 prevents dendritic degeneration and neuron death in rats following chronic brain hypoperfusion. Cell Death & Disease doi: 10.1038/cddis.2017.243 [Lentifect™ lentiviral particles expressing miR-195 miRNA precursors]
Tian, F.M., et al. (2017). PDE3A is hypermethylated in cisplatn resistant non-small cell lung cancer cells and is a modulator of chemotherapy response. European Review for Medical and Pharmacological Sciences 2017; 21: 2635-2641 [Lentifect™ lentiviral particles expressing PDE3A]
Yang, G., et al. (2017). CD11b promotes the differentiation of osteoclasts induced by RANKL through the spleen tyrosine kinase signalling pathway. Jounral of Cellular and Molecular Medicine doi: 10.1111/jcmm.13254 [Lentifect™ lentiviral particles expressing Itgam shRNA (shCD11b-1, shCD11b-2)]
Kalimuthu, S., et al. (2017). In Vivo Tracking of Chemokine Receptor CXCR4-Engineered Mesenchymal Stem Cell Migration by Optical Molecular Imaging. Stem Cells International doi: /10.1155/2017/8085637 4 [Lentifect™ lentiviral particles expressing mCherry-RLuc]
dos Santos, A.L., et al. (2017). Acid-sensitive lipidated doxo…prodrug entrapped in nanoemulsion impairs lung tumor metastasis in a breast cancer model. Furure Medicine doi: 10.2217/nnm-2017-0091 [Lentifect™ lentiviral particles expressing Firefly luciferase]
Han, M., et al. (2017). EMP3 is induced by TWIST1/2 and regulates epithelial-to-mesenchymal transition of gastric cancer cells. Tumor Biology doi: 10.1177/1010428317718404 [TWIST1 and TWIST2 Lentifect™ purified lentiviral particles]
Mondal, G., et al. (2017). EGFR-Targeted Cationic Polymeric Mixed Micelles for Codelivery of Gemcitab…and miR-205 for Treating Advanced Pancreatic Cancer. Molecular Pharmaceutics doi: 10.1021/acs.molpharmaceut.7b00355 [Lentiviral particles expressing luciferase]
Wu, D., et al. (2017). SLC39A4 expression is associated with enhanced cell migration, cisplatn resistance, and poor survival in non-small cell lung cancer. Scientific Reports doi: 10.1038/s41598-017-07830-4 [Lentifect™ purified lentiviral particles]
Li, Y., et al. (2017). Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis. Stem Cell Reports doi: 10.1016/j.stemcr.2017.07.011 [Lentifect™ purified lentiviral particles expressing HEBCan]
Man, L., et al. (2017). Engineered endothelium provides angiogenic and paracrine stimulus to grafted human ovarian tissue. Scientific Reports doi: 10.1038/s41598-017-08491-z [Lentifect™ purified lentiviral particles]
Wang, W., et al. (2017). P2Y6 Regulates cytoskeleton reorganization and cell migration of C2C12 myoblasts via ROCK pathway. Journal of Cellular Biochemistry doi: 10.1002/jcb.26350 [Lentifect™ purified lentiviral particles expressing P2Y6]
Kim, K.M., et al. (2017). Identification of senescent cell surface targetable protein DPP4. Genes & Development doi: 10.1101/gad.302570.117 [Lentifect™ purified lentiviral particles expressing DPP-4]
Guo, N. et al. (2017). Mesenchymal Stem Cells Overexpressing Interleukin-35 Propagate Immunosuppressive Effects in Mice. Scandinavian Journal of Immunology doi: 10.1111/sji.12613 [Lentifect™ purified lentiviral particles]
Wang, W., et al. (2017). Tumor-suppressive miR-145 co-repressed by TCF4-β-catenin and PRC2 complexes forms double-negative regulation loops with its negative regulators in colorectal cancer. International Journal of Cancer doi: 10.1002/ijc.31056 [Lentifect™ purified lentiviral particles expressing miR-145]
Wang, J.X., et al. (2017). GLI2 induces PDGFRB expression and modulates cancer stem cell properties of gastric cancer. European Review for Medical and Pharmacological Sciences 2017; 21: 3857-3865 [Lentifect™ purified lentiviral particles expressing anti-GLI2 and anti-PDGFRB shRNA]
Zhou, C., et al. (2017). AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs. Bone Reseach doi: 10.1038/boneres.2017.44 [Lentifect™ purified lentiviral particles expressing HA-AFF1, HA-AFF4]
Sun, S., et al. (2017). Advanced oxidation protein products induce S-phase arrest of hepatocytes via the ROS-dependent, β-catenin-CDK2-mediated pathway. Redox Biology doi: 10.1016/j.redox.2017.09.011 [Lentifect™ purified lentiviral particles expressing β-catenin]
Holland, C., et al. (2017). GITR Antibodies, Methods, and Uses. United States Patent Application 20170260282 [Lentifect™ purified lentiviral particles expressing GITR]
Zhao, L., et al. (2017). miR-149 suppresses human non-small cell lung cancer growth and metastasis by inhibiting the FOXM1/cyclin D1/MMP2 axis. Oncology Reports doi: 10.3892/or.2017.6047 [Lentifect™ purified lentiviral particles expressing miR-149]
Krummel, M., et al. (2017). MODULATION OF STIMULATORY AND NON-STIMULATORY MYELOID CELLS. United States Patent Application 20170291946 [Lentifect™ purified lentiviral particles]
Schregel, K., et al. (2017). Characterization of glioblastoma in an orthotopic mouse model with magnetic resonance elastography. NMR in Biomedicine doi: 10.1002/nbm.3840 [Lentifect™ purified lentiviral particles expressing luciferase]
Yang, H., et al. (2017). KLF4 protects brain microvascular endothelial cells from ischemic stroke induced apoptosis by transcriptionally activating MALAT1. Biochemical and Biophysical Research Communications doi: 10.1016/j.bbrc.2017.11.205 [Lentifect™ purified lentiviral particles expressing KLF4]
Berger, G., et al. (2017). Anticancer activity of osmium(VI) nitrido complexes in patient-derived glioblastoma initiating cells and in vivo mouse models. Cancer Letters doi: 10.1016/j.canlet.2017.11.041 [Lentifect™ purified lentiviral particles expressing luciferase]
Tang, J.C., et al. (2017). Efficacy of Shikonin against Esophageal Cancer Cells and its possible mechanisms in vitro and in vivo. Journal of Cancer doi: 10.7150/ jca .21224 [Lentifect™ purified lentiviral particles expressing PKM2]
Gangadaran, P. et al. (2017). A new bioluminescent reporter system to study the biodistribution of systematically injected tumor-derived bioluminescent extracellular vesicles in mice. Oncotarget doi: 10.18632/oncotarget.22493 [Lentifect™ purified lentiviral particles expressing Renilla luciferase]
Feng, Y., et al. (2017). Alpha-1-antitrypsin functions as a protective factor in preeclampsia through activating Smad2 and inhibitor of DNA binding 4. Oncotarget doi: 10.18632/oncotarget.22949 [Lentifect™ purified lentiviral particles expressing AAT]
Zang, X., et al. (2018). MAEL contributes to gastric cancer progression by promoting ILKAP degradation. Oncotarget doi: 10.18632/oncotarget.22970 [Lentifect™ purified lentiviral particles expressing shRNA targeting MAEL]
Britain, C.M., et al. (2018). Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death. Journal of Ovarian Research doi: 10.1186/s13048-018-0385-0 [Lentifect™ purified lentiviral particles expressing ST6Gal-I]
Hai, L., et al. (2018). Notch1 is a prognostic factor that is distinctly activated in the classical and proneural subtype of glioblastoma and that promotes glioma cell survival via the NF-κB(p65) pathway. Cell Death & Disease doi: 10.1038/s41419-017-0119-z [Lentifect™ purified lentiviral particles expressing shRNA targeting Notch1]
Wang, J., et al. (2018). Targeting dual specificity protein kinase TTK attenuates tumorigenesis of glioblastoma. Oncotarget doi: 10.18632/oncotarget.23152 [Lentifect™ purified lentiviral particles expressing shRNA targeting TTK]
Mu, N., et al. (2018). PRL- 3 is a potential glioblastoma prognostic marker and promotes glioblastoma progression by enhancing MMP7 through the ERK and JNK pathways. Theranostics doi: 10.7150/ thno .22699 [Lentifect™ purified lentiviral particles expressing sh-PRL-3]
Wang, K., et al. (2018). Hypoxia-stressed cardiomyocytes promote early cardiac differentiation of cardiac stem cells through HIF-1α/Jagged1/Notch1 signaling. Acta Pharmaceutica Sinica B doi: 10.1016/j.apsb.2018.06.003 [Lentifect™ purified lentiviral particles expressing HIF-1α]

2016

Emery, AC. et al. (2016) C-terminal amidation of PACAP-38 and PACAP-27 is dispensable for biological activity at the PAC1 receptor. Peptides,doi:10.1016/j.peptides.2016.03.003. [human PAC1hop receptor with a C-terminal V5 epitope tag was encoded in the pLx304 lentiviral vector]
Huang, Z. et al. (2016) Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway. Cell Death & Disease,Cell Death and Disease (2016) 7, e2142; doi:10.1038/cddis.2016.51. [Lentiviral packaging wild-type YAP or YAP S112A mutation plasmids (CS-Mm06093-Lv128)]
Hoang, B. et al. (2016) SGK kinase activity in multiple myeloma cells protects against ER stress apoptosis via a SEK-dependent mechanism.. Molecular Cancer Research, doi:10.1158/1541-7786.MCR-15-0422. [pReceiver SEK1(EX-A0727-Lv105), pReceiver-Lv105 (EX-NEG-Lv105)]
Jiang, Z. et al. (2016) The effects and mechanisms of SLC34A2 on tumorigenicity in human non-small cell lung cancer stem cells. Tumor Biology,doi:10.1007/s13277-016-4928-y. [NC-si-RNA, SLC34A2-si-RNA lentiviral knock- downs, or Bmi1-si-RNA lentiviral knockdowns]
Pan, X. et al. (2016) Quinalizarin enhances radiosensitivity of nasopharyngeal carcinoma cells partially by suppressing SHP-1 expression. International Journal of Oncology,Pages: 1073-1084 DOI: 10.3892/ijo.2016.3338. [lentivirus-mediated SHP-1 overexpression]
Choi, YJ. et al. (2016) Visualization of the Biological Behavior of Tumor-Associated Macrophages in Living Mice with Colon Cancer Using Multimodal Optical Reporter Gene Imaging. Neoplasia,doi:10.1016/j.neo.2016.01.004. [lentivirus coexpressing the Rluc and mCherry genes]
Carter , SL. et al. (2016) IκBα mediates prostate cancer cell death induced by combinatorial targeting of the androgen receptor. BMC Cancer,DOI: 10.1186/s12885-016-2188-2. [NFKBIA-IRES-eGFP lentiviral ORF plasmid]
You, A. et al. (2016) Metformn sensitizes sorafenb to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models. Journal of Hematology & Oncology,DOI: 10.1186/s13045-016-0253-6. [EX-M0910-Lv105-5, overexpress control (EX-eGFP-Lv-105), and Lenti-Pac™HIV Expression Packaging Kit (Cat. No. HPK-LvTR-20)]
Eno, MR. et al. (2016) P450 3A Catalyzed O-dealkylation of Lapatinib Induces Mitochondrial Stress and Activates Nrf2. Chemical Research in Toxicology,DOI: 10.1021/acs.chemrestox.5b00524. [Lentiviruses, lentiviral plasmids, and reagents]
Jiang, P. et al. (2016) Proaggregant nuclear factor (s) trigger rapid formation of α-synuclein aggregates in apoptotic neurons. Acta Neuropathologica,DOI: 10.1007/s00401-016-1542-4. [Lentiviral plasmids and virus preparation Lentiviral plasmids carrying Αs (EX-G0543-Lv105)]
Layek , B. et al. (2016) Glycoengineered Mesenchymal Stem Cells as an Enabling Platform for Two-Step Targeting of Solid Tumors. Biomaterials,doi:10.1016/j.biomaterials.2016.02.024. [Firefly Luciferase Lentifect™ Purified Lentiviral Particles]
Wilkinson, D.C., et al. (2016). Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling Stem Cells Translational Medicine doi: 10.5966/sctm.2016-0192 [ACTA2-mCherry lentiviral particles]
González-Mariscal, I., et al. (2016). Human CB1 Receptor Isoforms, present in Hepatocytes and β-cells, are Involved in Regulating Metabolism. Scientific Reports doi: 10.1038/srep33302 [Lentifect™ Lentiviral particles]
Kalimuthu, S., et al. (2016). In Vivo therapeutic potential of mesenchymal stem cell-derived extracellular vesicles with optical imaging reporter in tumor mice model. Scientific Reports doi: 10.1038/srep30418 [Renilla luciferase-expressing lentiviral particles]
Vishnubalaji, R., et al. (2016). Bone morphogenetic protein 2 (BMP2) induces growth suppression and enhances chemosensitivity of human colon cancer cells. Cancer Cell International doi: 10.1186/s12935-016-0355-9 [human BMP2 and GFP control lentiviral particles]
Barnawi, R., et al. (2016). Fascin is Critical for the Maintenance of Breast Cancer Stem Cell Pool Predominantly via the Activation of the Notch Self-Renewal Pathway. Stem Cells doi: 10.1002/stem.2473 [Lentifect™ Fascin ORF-expressing lentiviral particles]
Ilmer, M., et al. (2016). Cell surface galectin-3 defines a subset of chemoresistant gastrointestinal tumor-initiating cancer cells with heightened stem cell characteristics. Cell Death & Disease doi: 10.1038/cddis.2016.239 [Lentifect™ mCherry-expressing lentiviral particles]
Lai, Y., et al. (2016). MiR-384 regulated IRS1 expression and suppressed cell proliferation of human hepatocellular carcinoma. Tumor Biology doi: 10.1007/s13277-016-5233-5 [Lentifect™ lentiviral particles expressing shRNA targeting IRS1]
Zhang, H., et al. (2016). CXCL2/MIF-CXCR2 signaling promotes the recruitment of myeloid-derived suppressor cells and is correlated with prognosis in bladder cancer. Oncogene doi: 10.1038/onc.2016.367 [Lentifect™ lentiviral particles expressing MyD88]
Voloshin, T., et al. (2016). Alternating electric fields (TTFields) in combination with paclitaxl are therapeutically effective against ovarian cancer cells in vitro and in vivo. International Journal of Cancer doi: 10.1002/ijc.30406 [Lentifect™ firefly luciferase-expressing lentiviral particles]
Zhu, S., et al. (2016). Helicobacter pylori-induced cell death is counteracted by NF-κB-mediated transcription of DARPP-32 . Gut doi: 10.1136/gutjnl-2016-312141 [DARPP-32 shRNA lentiviral particles]
Ghosh, S., et al. (2016). Targeted proteomics of cannabinoid receptor CB1 and the CB1b isoform. Journal of Pharmaceutical and Biomedical Analysis doi: 10.1016/j.jpba.2016.11.003 [Lentifect™ lentviral particles]
Wu, J., et al. (2016). Umbilical cord blood-derived non-hematopoietic stem cells retrieved and expanded on bone marrow-derived extracellular matrix display pluripotent characteristics. Stem Cell Research and Theraoy doi: 10.1186/s13287-016-0437-6 [Lentifect™ lentviral particles expressing eGFP]
Cheung, M.B., et al. (2016). Respiratory Syncytial Virus-Infected Mesenchymal Stem Cells Regulate Immunity via Interferon Beta and Indoleamine-2,3-Dioxygenase. PLOS ONE doi: 10.1371/journal.pone.0163709 [Lentifect™ lentviral particles expressing CRISPR sgRNA targeting IDO]

2015

Ginsberg, M. et al. (2015) Direct conversion of human amniotic cells into endothelial cells without transitioning through a pluripotent state. Nature Protocols,doi:10.1038/nprot.2015.126. [clone cDNAs encoding ETV2, ERG1 and FLI1 into the lentiviral backbone pCCL-PGK lentivirus vector]
Ahlenstiel, C. et al. (2015) Novel RNA duplex locks HIV-1 in a latent state via chromatin-mediated transcriptional silencing. Molecular Therapy Nucleic Acids,doi:10.1038/mtna.2015.31. [lentiviral vectors containing the reporter mCherry]
Zhao, Z. et al. (2015) RNA interference targeting PSCA suppresses primary tumor growth and metastasis formation of human prostate cancer xenografts in SCID mice. The Prostate,DOI: 10.1002/pros.23110. [lentiviral vector pEZ-Lv201]
Mazzone, M. et al. (2015) MODULATING TRANSENDOTHELIAL MIGRATION AND RECRUITMENT OF GRANULOCYTES BY MODULATING C-MET PATHWAY. US Patent ,US Patent 20,150,258,194, 2015. [luciferase-expressing lentivirus (EXhLUC-Lvl 14)]
Lisanti, MP. et al. (2015) MSF REPROGRAMS MYOFIBROBLASTS TOWARD LACTATE PRODUCTION AND FUEL ANAERBOIC TUMOR GROWTH. US Patent,US Patent 20,150,240,240. [[EX-NEG-Lv105 (empty vector), Ex- Z4998-Lv105 (human MSF),Ex-D0101-Lv105 (human SMA), Ex-A0247-Lv105 (human Rac1), Ex-X0047-Lv105 (human Cdc42)]
Zavattari, P. et al. (2015) Nrf2, but not β‐catenin, mutation represents an early event in rat hepatocarcinogenesis. Hepatology,DOI: 10.1002/hep.27790. [a NRF2 lentiviral construct (217EX- T3128-Lv157), KEAP1 encoding plasmid (pCDNA3- T7-Keap1)]
Chen, H. et al. (2015) Requirement for BUB1B/BUBR1 in tumor progression of lung adenocarcinoma. Genes & Cancer,Genes & Cancer, Vol. 6 (3-4), March 2015. [pReceiver-Lv141 lentiviral vector]
Mcmillan, M. et al. (2015) CELL THERAPY TECHNOLOGY TO DELIVER RADIO-PROTECTIVE PEPTIDES. US Patent ,US Patent 20,150,050,250. [pLV67 lentiviral vector]
Liu, X. et al. (2015) The Regulation and Function of miR-21-FOXO3a-miR-34b/c Signaling in Breast Cancer. International Journal of Molecular Sciences ,Int. J. Mol. Sci. 2015, 16, 3148-3162; doi:10.3390/ijms16023148. [Lentiviral plasmids expressing FOXO3a and PTEN]
Xu, Y. et al. (2015) Expression and functional role of miR-29b in renal cell carcinoma. International Journal of Clinical and Experimental Pathology,Int J Clin Exp Pathol. 2015; 8(11): 14161–14170.. [hsa-miR-29b lentivirus expression vector ]
Yuste‐Checa , P. et al. (2015) The Effects of PMM2‐CDG‐Causing Mutations on the Folding, Activity, and Stability of the PMM2 Protein. Human Mutation,doi: 10.1002/humu.22817. [human PMM2 lentiviral ORF (EX-M0134-Lv101)]
Wang , Z. et al. (2015) Syndecan-1 Acts in Synergy with Tight Junction Through Stat3 Signaling to Maintain Intestinal Mucosal Barrier and Prevent Bacterial Translocation.. Inflammatory Bowel Diseases,doi: 10.1097/MIB.0000000000000421. [lentiviral plasmid containing human Sdc1, constitu- tively active Stat3 (Stat3 C), or dominant-negative Stat3 (Stat3 DN)]
Barrault , C. et al. (2015) Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor. The Journal of Steroid Biochemistry and Molecular Biology,doi:10.1016/j.jsbmb.2015.04.005. [full length AR gene-expressing lentiviral vectors previously constructed with the expression plasmid vector EX-E2325]
Vitali , C. et al. (2015) SOCS2 controls proliferation and stemness of hematopoietic cells under stress conditions and its deregulation marks unfavourable acute leukemias.. Cancer Research,Published OnlineFirst April 9, 2015; doi: 10.1158/0008-5472.CAN-14-3625. [mouse Mef2c (NMB001170537) lentviral ORF and Ikzf1(NMB001025597) or the empty vector]
Allahverdi, A. et al. (2015) Lentiviral vectors titration using real-time PCR. Journal of Paramedical Sciences,. [Lentiviral vector EX-M0942-Lv105 plasmid]
PAN, XF. et al. (2015) SHP-1 overexpression increases the radioresistance of NPC cells by enhancing DSB repair, increasing S phase arrest and decreasing cell apoptosis. Oncology Reports,Pages: 2999-3005 DOI: 10.3892/or.2015.3939. [SHP-1 gene sequence and a negative oligo sequence were inserted into pEZ-Lv201-green fluorescent protein (gFP) lentiviral vectors]
Zhangi , P. et al. (2015) ILT4 drives B7-H3 expression via PI3K/AKT/mTOR signalling and ILT4/B7-H3 co-expression correlates with poor prognosis in non-small cell lung cancer. FEBS Letters,DOI: 10.1016/j.febslet.2015.06.037. [Pez-lv105-ILT4 (ILT4), and a negative control plasmid, Pez-lv105 (NC)]
Wu , W. et al. (2015) miR-30c negatively regulates the migration and invasion by targeting the immediate early response protein 2 in SMMC-7721 and HepG2 cells. American Journal of Cancer Research,Am J Cancer Res. 2015; 5(4): 1435–1446.. [The vectors expressing IER2 (pEZ- Lv105-IER2) and null (pEZ-Lv105-null)]
Takeuchi , A. et al. (2015) STAT5A regulates DNMT3A in CD34+/CD38− AML cells. Leukemia Research,doi:10.1016/j.leukres.2015.05.006. [control and STAT5A lentiviral vectors]
Yuan, H. et al. (2015) MicroRNA-1908 is upregulated in human osteosarcoma and regulates cell proliferation and migration by repressing PTEN expression. Oncology Reports,Oncol Rep. 2015 Nov;34(5):2706-14. doi: 10.3892/or.2015.4242. Epub 2015 Sep 1. [lentiviral plasmid pEZX- MR03 expressing 1908 (Cat,HmiR0274-MR03) or scrambled miRNA (Cat, CmiR0001-MR03) and Lenti-Pac HIV Expression Packaging mix]
Xie, H. et al. (2015) Nuclear EGFRvIII Resists Hypoxic Microenvironment Induced Apoptosis via Recruiting ERK1/2 Nuclear Translocation. Biochemical and Biophysical Research Communications,Volume 470, Issue 2, 5 February 2016, Pages 466–472. [EGFRvIII/EGFRvIIIdNLS in pReceiver-LV151, Lenti-Pac HIV Expression Packaging Kit]
Cao, M. et al. (2015) HIF-2α regulates CDCP1 to promote PKCδ-mediated migration in hepatocellular carcinoma. Tumor Biology,DOI
10.1007/s13277-015-3527-7. [lentiviral plasmid HIF-2α (Cat.No.EX-M0910-Lv105-5), overexpression control (Cat.No.EX-eGFP-Lv-105), and Lenti-Pac™ HIV Expression Packaging Kit (Cat.No. HPK-LvTR-20)]
Okada, M. et al. (2015) Abrogation of Age‐Induced Microrna‐195 Rejuvenates the Senescent Mesenchymal Stem Cells by Reactivating Telomerase. STEM CELLS,DOI: 10.1002/stem.2211. [Lenti-Pac HIV Expression Packaging System]
Rodriguez, AL. et al. (2015) Tailoring minimalist self-assembling peptides for localised viral vector gene delivery. Nano Research,March 2016, Volume 9, Issue 3, pp 674-684. [mCherry lentivirus]
Lin, T. et al. (2015) MicroRNA-378g enhanced radiosensitivity of NPC cells partially by targeting protein tyrosine phosphatase SHP-1. International Journal of Radiation Biology,DOI:10.3109/09553002.2015.1096028. [Lentiviruses containing the SHP-1 gene (LP-SHP-1) and negative oligomers (LP-Neg)]
Qadir, XV. et al (2015) miR-223 Deficiency Protects against Fas-Induced Hepatocyte Apoptosis and Liver Injury through Targeting Insuln-Like Growth Factor 1 Receptor. American Journal of Pathology,185(12):3141-3151. [lentiviral particle solution containing either scrambled control miRNA (L/control) or pre–miR-223 (L/miR-223)]
Hoffman, Jill M. et al. (2015) Corticotropin-Releasing Hormone Receptor 2 Signaling Promotes Mucosal Repair Responses after Colitis. The American Journal of PATHOLOGY,January 2016Volume 186, Issue 1, Pages 134–144. [MCS-IRES-Strawberry-hPGK-Puro lentiviral particles that contained a cytomegalovirus promoter driving expression of human CRHR2]
Kenney, RM. et al. (2015) Real-time imaging of cancer cell chemotaxis in paper-based scaffolds. Analyst,DOI: 10.1039/c5an01787d . [lentiviral particles (LPP-eGFP-Lv105-025)]
Truong, AS. et al. (2015) Tracking the invasion of small numbers of cells in paper-based assays with quantitative PCR. Analytical Chemistry,DOI: 10.1021/acs.analchem.5b02362. [lentiviral particles, LPP-EGFP-Lv105-025 and LPP-MCHR-Lv105-025 particles, Lenti-Pac HIV Expression Packaging Kit]
Zhu, S. et al. (2015) Regulation of CD44E by DARPP-32-dependent activation of SRp20 splicing factor in gastric tumorigenesis. Oncogene,Oncogene 35, 1847-1856 (07 April 2016) | doi:10.1038/onc.2015.250. [Lentivirus particles expressing DARPP-32 shRNA or control shRNA]
Samarakoon, R. et al. (2015) Loss of Tumour Suppressor PTEN Expression in Renal Injury Initiates SMAD3 and p53 Dependent Fibrotic Responses. The Journal of Pathology,DOI: 10.1002/path.4538. [PTEN human ORF cDNA or control Lentifect lentiviral particles]
Becker , S. et al. (2015) Allogeneic Transplantation of Müller-Derived Retinal Ganglion Cells Improves Retinal Function in a Feline Model of Ganglion Cell Depletion. Stem Cells Translational Medicine,http://dx.doi.org/
10.5966/sctm.2015-0125. [eGFP lentiviral particles]
Mondal , G. et al. (2015) EGFR Targeted Polymeric Mixed Micelles carrying Gemcitabne for treating Pancreatic Cancer. Biomacromolecules,DOI: 10.1021/acs.biomac.5b01419. [Lentiviral particle LP-hLUC-Lv201- 0200]
Brown , AR. et al. (2015) Krüppel-like Factor 9 (KLF9) prevents colorectal cancer through inhibition of interferon-related signaling. Carcinogenesis,Carcinogenesis (2015)
doi: 10.1093/carcin/bgv104. [lentiviral particles containing cDNA for green fluorescent protein (EGFP) or human KLF9]
Boyce, MW. et al. (2015) Quantifying oxygen in paper-based cell cultures with luminescent thin film sensors. Analytical and Bioanalytical Chemistry,DOI
10.1007/s00216-015-9189-x. [lentiviral particles (LPP-eGFP-Lv105-025)]
Truong, AS. et al. (2015) Tracking the invasion of small numbers of cells in paper-based assays with quantitative PCR. Analytical Chemistry,DOI: 10.1021/acs.analchem.5b02362. [lentiviral particles, LPP-EGFP-Lv105-025 and LPP-MCHR-Lv105-025 particles, Lenti-Pac HIV Expression Packaging Kit]
Chen, W. et al. (2015) Deletion of Mir155 Prevents Fas-Induced Liver Injury through Up-Regulation of Mcl-1. The American Journal of Pathology,Volume 185, Issue 4, April 2015, Pages 1033–1044. [pre-Mir155 lentivirus and scrambled control miRNA]