Monthly Archives: June 2020

COVID-19 Coronavirus CRISPR and shRNA Solutions

General information Webinars General information GeneCopoeia provides CRISPR-Cas9 solutions for gene knockout, knock-in, mutagenesis, tagging and more. Cas9 and sgRNA are available as either transfection-ready plasmid DNA, ready-to-use lentiviral and AAV particles, or as components for assembling ribonucleoprotein (RNP) complexes. In addition, we provide a collection of 7 lung cancer cell lines with the Cas9 nuclease stably integrated, which are ideal for lentiviral CRISPR or CRISPR knockout library screens, and one lung cancer cell line for CRISPR-mediated gene activation, which ......
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COVID-19 Coronavirus Receptor Stable Cell Lines

General information Performance data Resources General information GeneCopoeia has produced HEK293T cell lines expressing ACE2 and TMPRSS2, two human host factors needed for efficient infection by SARS-CoV-2, the virus responsible for the COVID-19 pandemic.  These cell lines express ACE2 and/or TMPRSS2 mRNA at high levels on the cell surface, and are amenable to infection by viruses expressing SARS-CoV-2 Spike protein in their envelopes. Refer to the "Performance data" tab for more information. ACE2-expressing cell lines are great for use with either native SARS-CoV......
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COVID-19 Coronavirus Lentiviral and AAV Solutions

General information Webinars General information GeneCopoeia carries complete suites of state-of-the-art products for gene delivery using lentivirus and adenoassociated virus (AAV). GeneCopoeia's lentiviral solutions include: Lentiviral plasmids. Available for expressing ORF cDNAs, gene promoters, miRNA precursors and inhibitors, CRISPR sgRNAs, and shRNAs for do-it-yourself, 3rd generation lentiviral packaging. Use the "Plasmids" tab for ordering information. Ready-to-use particles. For infection of most mammalian cell types with either standard VSV-G pseudotypi......
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COVID-19 Coronavirus Plasmid Clones

General information Related products Resources General information GeneCopoeia is the industry leader in expression-ready ORF cDNA clones, and we also carry reporter plasmid clones carrying gene promoters and 3' UTR microRNA (miRNA) binding site targets. OmicsLink™ SARS-CoV-2-related ORF cDNA plasmid clones can be constructed in any of our more than 250 ready-to-go vector types expressing both SARS-CoV-2 viral proteins as well as host proteins, which you can select using the drop-down menus below. OmicsLink™ SARS-CoV-2-related ORF cDNA plasmid clones are part of Gen......
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Lentifect™ SARS-CoV-2 Spike-Pseudotyped Lentivirus

GeneCopoeia's Lentifect™ SARS-CoV-2 Spike-pseudotyped lentivirus products produce a specially-packaged version of standard lentivirus, whereby the vesicular stomatitis G (VSV-G) envelope glycoprotein is replaced by the Spike (S) protein from SARS-CoV-2, the virus responsible for the COVID-19 pandemic. These particles, also known as "pseudoviruses", are typically used to infect cultured cells expressing ACE2, the receptor for SARS-CoV-2 on multiple  tissue types (Figure 1).. Lentifect™ SARS-CoV-2 Spike-pseudotyped lentivirus and our ACE2- and TMPRSS2-expres......
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Molecular & cell biology

        EZShuttle™ Recombination Cloning System Fast-Fusion™ Cloning Kit Smart-Join™ Blunt-end PCR Cloning Kit Molecular Cloning Systems         Nucleic Acid dye and quantitation products Nucleic Acid Quantitation Nucleic Acid Gel Stains         Cell Proliferation and Viability Assays Cell Biology Assays Cell Apoptosis Assays   Cell ......
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Drug/target screening

          Clone Libraries OmicsLink™ Expression-Ready ORF cDNA Clones               Cas9 Stable Cell CRISPR human sgRNA libraries               sgRNA Libraries CRISPR human sgRNA libraries           qPCR/Antigen arrays Antigen Microarrays E......
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Cancer research

    GeneHero™ CRISPR Products and Services GeneHero™ CRISPR-Cas9 stable cell lines GeneHero™ CRISPRa Stable Cell Lines GeneHero™ CRISPRi Stable Cell Lines CRISPR stable cell lines             Cancer research cell lines Luciferase/GFP-Labeled Cancer Cell Lines     OncoSpot™ Cancer Biomarker Mutant Cell Lines           ......
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Gene delivery

The addition of exogenous nucleic acids to cells is a fundamental component of nearly every field of biological research. Scientists use nucleic acid delivery for many purposes, including editing or disrupting genes, overexpressing proteins for purification, and gene therapy. GeneCopoeia carries an extensive suite of reagents, from viral solutions to transfection reagents, that greatly aid your gene delivery applications.             Lentivirus system Lentifect™ Lent......
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Gene Delivery

The addition of exogenous nucleic acids to cells is a fundamental component of nearly every field of biological research. Scientists use nucleic acid delivery for many purposes, including editing or disrupting genes, overexpressing proteins for purification, and gene therapy. GeneCopoeia carries an extensive suite of reagents, from viral solutions to transfection reagents, that greatly aid your gene delivery applications.   Lentivirus Infect most cell types Lentiviral-based clones and cloning vectors Purified le......
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