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Chemokines and chemokine receptors

by | May 29, 2024 | Clone sets

Introduction

Cancer is a collection of diseases characterized by abnormal and uncontrolled cellular growth caused primarily by genetic mutations. Based on their role in cancer progression, driver genes can be classified into two main categories: oncogenes and tumor suppressor genes. Oncogene addiction refers to the phenomenon that certain tumours depend on one or more activated oncogenes, also known as driver oncogenes, to maintain their malignant biological phenotype.
Chemokines, or chemotactic cytokines, are a family of small cytokines or signaling proteins secreted by cells that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells. In addition to playing a major role in the activation of host immune responses, chemokines are important for biological processes, including morphogenesis and wound healing, as well as in the pathogenesis of diseases like cancers.
Chemokines have been classified into four main subfamilies: CXC, CC, CX3C and C. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, includes CCL14, CCL19, CCL20, CCL21, CCL25, CCL27, CXCL12 and CXCL13. This classification is not strict, for example, CCL20 can act also as pro-inflammatory chemokine. Others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. These chemokines are formed under pathological conditions (on pro-inflammatory stimuli, such as IL-1, TNF-alpha, LPS, or viruses) and actively participate in the inflammatory response attracting immune cells to the site of inflammation, such as CXCL-8, CCL2, CCL3, CCL4, CCL5, CCL11, CXCL10.
Chemokine receptors are G protein-coupled receptors containing 7 transmembrane domains that are found on the surface of leukocytes. Chemokine receptors associate with G-proteins to transmit cell signals following ligand binding. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production

Clone set information

Cat. no. Species Gene Vector Vector Type Price
OC-GF023-M02 Human 69 pReceiver-M02 Expression-ready Non-viral Inquire
OC-GF023-M35 Human 69 pReceiver-M35 Expression-ready Non-viral Inquire
OC-GF023-M98 Human 69 pReceiver-M98 Expression-ready Non-viral Inquire
OC-GF023-Lv105 Human 69 pReceiver-Lv105 Expression-ready Lentiviral Inquire
OC-GF023-Lv242 Human 69 pReceiver-Lv242 Expression-ready Lentiviral Inquire

Clone list

For clone list please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.
Symbol Accession Species Description ORF length(bp) Product ID
CCL1 NM_002981.2 Human Homo sapiens C-C motif chemokine ligand 1 (CCL1), mRNA. 291 GC-A0176
CCL2 NM_002982.4 Human Homo sapiens C-C motif chemokine ligand 2 (CCL2), mRNA. 300 GC-Q0327
CCL3 NM_002983.3 Human Homo sapiens C-C motif chemokine ligand 3 (CCL3), transcript variant 1, mRNA. 279 GC-Z2490
CCL4 NM_002984.4 Human Homo sapiens C-C motif chemokine ligand 4 (CCL4), mRNA. 279 GC-A8645
CCL5 NM_001278736.2 Human Homo sapiens C-C motif chemokine ligand 5 (CCL5), transcript variant 2, mRNA. 465 GC-I2496
CCL5 NM_002985.3 Human Homo sapiens C-C motif chemokine ligand 5 (CCL5), transcript variant 1, mRNA. 276 GC-A3676
CCL7 NM_006273.4 Human Homo sapiens C-C motif chemokine ligand 7 (CCL7), mRNA. 300 GC-O0062
CCL8 NM_005623.3 Human Homo sapiens C-C motif chemokine ligand 8 (CCL8), mRNA. 300 GC-Z2678
CCL11 NM_002986.3 Human Homo sapiens C-C motif chemokine ligand 11 (CCL11), mRNA. 294 GC-Z7461
CCL13 NM_005408.3 Human Homo sapiens C-C motif chemokine ligand 13 (CCL13), mRNA. 297 GC-N0005
CCL14 NM_032962.5 Human Homo sapiens C-C motif chemokine ligand 14 (CCL14), transcript variant 2, mRNA. 330 GC-Z3767
CCL14 NM_032963.4 Human Homo sapiens C-C motif chemokine ligand 14 (CCL14), transcript variant 3, mRNA. 282 GC-N0003
CCL15 NM_032965.6 Human Homo sapiens C-C motif chemokine ligand 15 (CCL15), mRNA. 342 GC-X0728
CCL16 NM_004590.4 Human Homo sapiens C-C motif chemokine ligand 16 (CCL16), mRNA. 363 GC-N0036
CCL17 NM_002987.3 Human Homo sapiens C-C motif chemokine ligand 17 (CCL17), mRNA. 285 GC-N0017
CCL18 NM_002988.4 Human Homo sapiens C-C motif chemokine ligand 18 (CCL18), mRNA. 270 GC-N0039
CCL19 NM_006274.3 Human Homo sapiens C-C motif chemokine ligand 19 (CCL19), mRNA. 297 GC-I0009
CCL20 NM_001130046.2 Human Homo sapiens C-C motif chemokine ligand 20 (CCL20), transcript variant 2, mRNA. 288 GC-N0056
CCL20 NM_004591.3 Human Homo sapiens C-C motif chemokine ligand 20 (CCL20), transcript variant 1, mRNA. 291 GC-Z4471
CCL21 NM_002989.4 Human Homo sapiens C-C motif chemokine ligand 21 (CCL21), mRNA. 405 GC-M0488
CCL22 NM_002990.5 Human Homo sapiens C-C motif chemokine ligand 22 (CCL22), mRNA. 282 GC-Z9059
CCL23 NM_005064.6 Human Homo sapiens C-C motif chemokine ligand 23 (CCL23), transcript variant CKbeta8, mRNA. 414 GC-Z2590
CCL23 NM_145898.4 Human Homo sapiens C-C motif chemokine ligand 23 (CCL23), transcript variant CKbeta8, mRNA. 363 GC-N0012
CCL24 NM_002991.3 Human Homo sapiens C-C motif chemokine ligand 24 (CCL24), transcript variant 2, mRNA. 360 GC-A3100
CCL25 NM_001201359.2 Human Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant 2, mRNA. 450 GC-Z9647
CCL25 NM_005624.4 Human Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript variant 1, mRNA. 453 GC-N0051
CCL26 NM_006072.4 Human Homo sapiens C-C motif chemokine ligand 26 (CCL26), mRNA. 285 GC-N0034
CCL27 NM_006664.4 Human Homo sapiens C-C motif chemokine ligand 27 (CCL27), mRNA. 339 GC-N0035
CCL28 NM_001301875.2 Human Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 4, mRNA. 243 GC-A6116
CCL28 NM_148672.3 Human Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript variant 1, mRNA. 384 GC-W0559
CXCL1 NM_001511.4 Human Homo sapiens C-X-C motif chemokine ligand 1 (CXCL1), transcript variant 1, mRNA. 324 GC-G0095
CXCL2 NM_002089.4 Human Homo sapiens C-X-C motif chemokine ligand 2 (CXCL2), mRNA. 324 GC-A0267
CXCL3 NM_002090.3 Human Homo sapiens C-X-C motif chemokine ligand 3 (CXCL3), mRNA. 324 GC-N0068
PF4 NM_002619.4 Human Homo sapiens platelet factor 4 (PF4), transcript variant 1, mRNA. 306 GC-G0251
PF4 NM_001363352.1 Human Homo sapiens platelet factor 4 (PF4), transcript variant 2, mRNA. 333 GC-I8439
CXCL5 NM_002994.5 Human Homo sapiens C-X-C motif chemokine ligand 5 (CXCL5), mRNA. 345 GC-A1113
CXCL6 NM_002993.4 Human Homo sapiens C-X-C motif chemokine ligand 6 (CXCL6), mRNA. 345 GC-Y2027
PPBP NM_002704.3 Human Homo sapiens pro-platelet basic protein (PPBP), mRNA. 387 GC-G0161
CXCL8 NM_000584.4 Human Homo sapiens C-X-C motif chemokine ligand 8 (CXCL8), transcript variant 1, mRNA. 300 GC-I0329
CXCL9 NM_002416.3 Human Homo sapiens C-X-C motif chemokine ligand 9 (CXCL9), mRNA. 378 GC-A0353
CXCL10 NM_001565.4 Human Homo sapiens C-X-C motif chemokine ligand 10 (CXCL10), transcript variant 1, mRNA. 297 GC-T7063
CXCL11 NM_001302123.2 Human Homo sapiens C-X-C motif chemokine ligand 11 (CXCL11), transcript variant 2, mRNA. 321 GC-A6118
CXCL11 NM_005409.5 Human Homo sapiens C-X-C motif chemokine ligand 11 (CXCL11), transcript variant 1, mRNA. 285 GC-N0032
CXCL12 NM_000609.7 Human Homo sapiens C-X-C motif chemokine ligand 12 (CXCL12), transcript variant 2, mRNA. 282 GC-A0590
CXCL12 NM_001178134.2 Human Homo sapiens C-X-C motif chemokine ligand 12 (CXCL12), transcript variant 4, mRNA. 423 GC-Z9616
CXCL12 NM_001277990.2 Human Homo sapiens C-X-C motif chemokine ligand 12 (CXCL12), transcript variant 5, mRNA. 312 GC-A4545
CXCL12 NM_199168.4 Human Homo sapiens C-X-C motif chemokine ligand 12 (CXCL12), transcript variant 1, mRNA. 270 GC-Z1991
CXCL13 NM_006419.3 Human Homo sapiens C-X-C motif chemokine ligand 13 (CXCL13), transcript variant 1, mRNA. 330 GC-N0028
CXCL17 NM_198477.3 Human Homo sapiens C-X-C motif chemokine ligand 17 (CXCL17), transcript variant 1, mRNA. 360 GC-Y2390
XCL1 NM_002995.3 Human Homo sapiens X-C motif chemokine ligand 1 (XCL1), mRNA. 345 GC-N0006

Synaptic genes in autoimmune disease of nervous system

by | May 29, 2024 | Clone sets

Introduction

The nervous system includes the central nervous system (CNS) and the peripheral nervous system (PNS). Viral infections, poisoning, genetic defects, immune damage, and metabolic disorders may trigger the development of neurological diseases. Neurological autoimmune diseases are diseases in which the body’s immune system mistakenly attacks its own nervous system, causing damage to the tissue structure and function of the nervous system. This kind of disease has a wide range of damage, and the clinical manifestations are complex and varied, which can involve the central nervous system, peripheral nervous system and nerve-muscle joints, resulting in neuronal or axonal damage, myelin loss, nerve-muscle joint destruction and other pathological changes.
Examples of CNS autoimmune diseases include optic neuromyelitis optica spectrum disease (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), multiple sclerosis (MS), acute disseminated encephalomyelitis (ADEM), autoimmune encephalitis (AE), and vasculitis of the CNS. These diseases have relatively independent clinical features, and some specific antibodies play an indispensable role in the diagnosis and differential diagnosis of the diseases. For example, patients with NMOSD may be positive for AQP4 antibodies, and patients with ADEM may be positive for MOG antibodies.
This clone set can be used for the development of biomarkers for neuroimmune diseases, expanding and improving the spectrum of humoral markers for neuroimmune diseases, which can be further used for differential diagnosis, disease course monitoring, efficacy and prognosis assessment, and drug target screening.

Clone set information

Cat. no. Species Gene Vector Vector Type Price
OC-GF021-M02 Human 2137 pReceiver-M02 Expression-ready Non-viral Inquire
OC-GF021-M35 Human 2137 pReceiver-M35 Expression-ready Non-viral Inquire
OC-GF021-M98 Human 2137 pReceiver-M98 Expression-ready Non-viral Inquire
OC-GF021-Lv105 Human 2137 pReceiver-Lv105 Expression-ready Lentiviral Inquire
OC-GF021-Lv242 Human 2137 pReceiver-Lv242 Expression-ready Lentiviral Inquire

Clone list

For clone list please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.
Symbol Accession Species Description ORF length(bp) Product ID
HTR3B NM_006028.5 Human Homo sapiens 5-hydroxytryptamine receptor 3B (HTR3B), transcript variant 1, mRNA. 1326 GC-U0382
KCNH1 NM_172362.3 Human Homo sapiens potassium voltage-gated channel subfamily H member 1 (KCNH1), transcript variant 1, mRNA. 2970 GC-Z2907
PCDH8 NM_002590.4 Human Homo sapiens protocadherin 8 (PCDH8), transcript variant 1, mRNA. 3213 GC-A6372
MT3 NM_005954.4 Human Homo sapiens metallothionein 3 (MT3), mRNA. 207 GC-T3737
NR4A1 NM_001202233.2 Human Homo sapiens nuclear receptor subfamily 4 group A member 1 (NR4A1), transcript variant 3, mRNA. 1836 GC-A1310
NR4A1 NM_001202234.2 Human Homo sapiens nuclear receptor subfamily 4 group A member 1 (NR4A1), transcript variant 4, mRNA. 1959 GC-A4501
NR4A1 NM_173157.3 Human Homo sapiens nuclear receptor subfamily 4 group A member 1 (NR4A1), transcript variant 2, mRNA. 1797 GC-A1311
CAPRIN1 NM_005898.5 Human Homo sapiens cell cycle associated protein 1 (CAPRIN1), transcript variant 1, mRNA. 2130 GC-Y3977
CAPRIN1 NM_203364.3 Human Homo sapiens cell cycle associated protein 1 (CAPRIN1), transcript variant 2, mRNA. 2085 GC-Z5446
GPR176 NM_001271854.2 Human Homo sapiens G protein-coupled receptor 176 (GPR176), transcript variant 2, mRNA. 1545 GC-A3513
GPR176 NM_007223.3 Human Homo sapiens G protein-coupled receptor 176 (GPR176), transcript variant 1, mRNA. 1548 GC-A0542
GRM2 NM_000839.5 Human Homo sapiens glutamate metabotropic receptor 2 (GRM2), transcript variant 1, mRNA. 2619 GC-A0723
YBX1 NM_004559.5 Human Homo sapiens Y-box binding protein 1 (YBX1), transcript variant 1, mRNA. 975 GC-Z2227
FZD4 NM_012193.4 Human Homo sapiens frizzled class receptor 4 (FZD4), mRNA. 1614 GC-U0507
CORO1C NM_001276471.2 Human Homo sapiens coronin 1C (CORO1C), transcript variant 3, mRNA. 1425 GC-V0380
PDE7B NM_018945.4 Human Homo sapiens phosphodiesterase 7B (PDE7B), mRNA. 1353 GC-U0877
SLC40A1 NM_014585.6 Human Homo sapiens solute carrier family 40 member 1 (SLC40A1), mRNA. 1716 GC-U0652
RAB26 NM_001308053.1 Human Homo sapiens RAB26, member RAS oncogene family (RAB26), transcript variant 2, mRNA. 573 GC-U0581
RPS13 NM_001017.3 Human Homo sapiens ribosomal protein S13 (RPS13), mRNA. 456 GC-F0132
RPS18 NM_022551.3 Human Homo sapiens ribosomal protein S18 (RPS18), mRNA. 459 GC-F0609
RPS14 NM_001025071.2 Human Homo sapiens ribosomal protein S14 (RPS14), transcript variant 1, mRNA. 456 GC-F0356
RPS16 NM_001020.6 Human Homo sapiens ribosomal protein S16 (RPS16), transcript variant 1, mRNA. 441 GC-F0306
RPS15A NM_001030009.2 Human Homo sapiens ribosomal protein S15a (RPS15A), transcript variant 1, mRNA. 393 GC-F0583
RTN3 NM_006054.4 Human Homo sapiens reticulon 3 (RTN3), transcript variant 1, mRNA. 711 GC-V0138
RTN3 NM_201428.3 Human Homo sapiens reticulon 3 (RTN3), transcript variant 2, mRNA. 3042 GC-Z3044
UNC5C NM_003728.3 Human Homo sapiens unc-5 netrin receptor C (UNC5C), mRNA. 2796 GC-A3946
DNAJB1 NM_001300914.2 Human Homo sapiens DnaJ heat shock protein family (Hsp40) member B1 (DNAJB1), transcript variant 2, mRNA. 723 GC-I2174
DNAJB1 NM_006145.3 Human Homo sapiens DnaJ heat shock protein family (Hsp40) member B1 (DNAJB1), transcript variant 1, mRNA. 1023 GC-T0399
GABARAP NM_007278.2 Human Homo sapiens GABA type A receptor-associated protein (GABARAP), mRNA. 354 GC-I0146
ARF1 NM_001658.4 Human Homo sapiens ADP ribosylation factor 1 (ARF1), transcript variant 4, mRNA. 546 GC-A0306
NETO2 NM_018092.5 Human Homo sapiens neuropilin and tolloid like 2 (NETO2), transcript variant 1, mRNA. 1578 GC-H0314
ATAD1 NM_032810.4 Human Homo sapiens ATPase family AAA domain containing 1 (ATAD1), transcript variant 1, mRNA; nuclear gene for mitochondrial product. 1086 GC-E1659
CALM3 NM_001329925.2 Human Homo sapiens calmodulin 3 (CALM3), transcript variant 6, mRNA. 342 GC-A8631
CALM3 NM_005184.4 Human Homo sapiens calmodulin 3 (CALM3), transcript variant 1, mRNA. 450 GC-A0377
GJD2 NM_020660.3 Human Homo sapiens gap junction protein delta 2 (GJD2), mRNA. 966 GC-T1262
STX10 NM_001271611.2 Human Homo sapiens syntaxin 10 (STX10), transcript variant 4, mRNA. 603 GC-Z0174
STX10 NM_003765.3 Human Homo sapiens syntaxin 10 (STX10), transcript variant 1, mRNA. 750 GC-U0157
SPARCL1 NM_001128310.3 Human Homo sapiens SPARC like 1 (SPARCL1), transcript variant 1, mRNA. 1995 GC-Z6357
SPARCL1 NM_001291977.2 Human Homo sapiens SPARC like 1 (SPARCL1), transcript variant 4, mRNA. 1620 GC-A5795
SPARCL1 NM_004684.6 Human Homo sapiens SPARC like 1 (SPARCL1), transcript variant 2, mRNA. 1995 GC-D0257
FBXL20 NM_032875.3 Human Homo sapiens F-box and leucine rich repeat protein 20 (FBXL20), transcript variant 1, mRNA. 1311 GC-Z1248
BLOC1S6 NM_012388.4 Human Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 6 (BLOC1S6), transcript variant 2, mRNA. 519 GC-U0952
MKLN1 NM_001321316.2 Human Homo sapiens muskelin 1 (MKLN1), transcript variant 3, mRNA. 1587 GC-T2699
MKLN1 NM_013255.5 Human Homo sapiens muskelin 1 (MKLN1), transcript variant 2, mRNA. 2208 GC-T9061
TTYH1 NM_020659.4 Human Homo sapiens tweety family member 1 (TTYH1), transcript variant 1, mRNA. 1353 GC-U1041
NQO1 NM_000903.3 Human Homo sapiens NAD(P)H quinone dehydrogenase 1 (NQO1), transcript variant 1, mRNA. 825 GC-Z0563
NQO1 NM_001025433.2 Human Homo sapiens NAD(P)H quinone dehydrogenase 1 (NQO1), transcript variant 2, mRNA. 723 GC-Z3579
KCNN2 NM_170775.3 Human Homo sapiens potassium calcium-activated channel subfamily N member 2 (KCNN2), transcript variant 2, mRNA. 696 GC-L8848
SLC12A5 NM_001134771.1 Human Homo sapiens solute carrier family 12 member 5 (SLC12A5), transcript variant 1, mRNA. 3420 GC-Y4646
SLC12A5 NM_020708.4 Human Homo sapiens solute carrier family 12 member 5 (SLC12A5), transcript variant 2, mRNA. 3351 GC-Y4733

Cancer driver gene

by | May 29, 2024 | Clone sets

Introduction

Cancer is a collection of diseases characterized by abnormal and uncontrolled cellular growth caused primarily by genetic mutations. Based on their role in cancer progression, driver genes can be classified into two main categories: oncogenes and tumor suppressor genes. Oncogene addiction refers to the phenomenon that certain tumours depend on one or more activated oncogenes, also known as driver oncogenes, to maintain their malignant biological phenotype.
For example, EGFR gene mutation is a common mutation in lung cancer, which makes the EGFR receptor persistently activated and the signalling process aberrant, leading to long-term uncontrolled cell proliferation and growth, and becoming one of the driver genes of lung cancer cells. Cancer cells require driver oncogenes for sustained function, whereas normal cells do not.
Therefore, targeting oncogenes as therapeutic targets allows targeted drugs to specifically kill tumour cells without damaging normal cells. Martínez-Jiménez et al. present the Integrative OncoGenomics (IntOGen) pipeline, which applies to somatic mutations of more than 28,000 tumours of 66 cancer types reveals 568 cancer genes and points towards their mechanisms of tumorigenesis. These cancer driver genes’ identification has led to the development of the paradigm of targeted anticancer therapies and, more generally, to the search for genomic biomarkers of prognosis and response to treatments.

Clone set information

Cat. no. Species Gene Vector Vector Type Price
OC-GF022-M02 Human 620 pReceiver-M02 Expression-ready Non-viral Inquire
OC-GF022-M35 Human 620 pReceiver-M35 Expression-ready Non-viral Inquire
OC-GF022-M98 Human 620 pReceiver-M98 Expression-ready Non-viral Inquire
OC-GF022-Lv105 Human 620 pReceiver-Lv105 Expression-ready Lentiviral Inquire
OC-GF022-Lv242 Human 620 pReceiver-Lv242 Expression-ready Lentiviral Inquire

Clone list

For clone list please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.
Symbol Accession Species Description ORF length(bp) Product ID
ABCC4 NM_001105515.3 Human Homo sapiens ATP binding cassette subfamily C member 4 (ABCC4), transcript variant 2, mRNA. 2580 GC-T9124
ABCC4 NM_005845.5 Human Homo sapiens ATP binding cassette subfamily C member 4 (ABCC4), transcript variant 1, mRNA. 3978 GC-T0262
ABL1 NM_005157.6 Human Homo sapiens ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1), transcript variant a, mRNA. 3393 GC-B0076
ABL1 NM_007313.3 Human Homo sapiens ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1), transcript variant b, mRNA. 3450 GC-T1921
ABL2 NM_005158.5 Human Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant c, mRNA. 3504 GC-Z1255
ACKR3 NM_020311.3 Human Homo sapiens atypical chemokine receptor 3 (ACKR3), mRNA. 1089 GC-H4618
ACSL3 NM_004457.5 Human Homo sapiens acyl-CoA synthetase long chain family member 3 (ACSL3), transcript variant 1, mRNA. 2163 GC-I1896
ACSL6 NM_001009185.3 Human Homo sapiens acyl-CoA synthetase long chain family member 6 (ACSL6), transcript variant 2, mRNA. 2169 GC-H1464
ACSM3 NM_005622.4 Human Homo sapiens acyl-CoA synthetase medium chain family member 3 (ACSM3), transcript variant 1, mRNA; nuclear gene for mitochondrial product. 1761 GC-H1838
ACSM3 NM_202000.3 Human Homo sapiens acyl-CoA synthetase medium chain family member 3 (ACSM3), transcript variant 2, mRNA; nuclear gene for mitochondrial product. 1317 GC-T2661
ACVR1 NM_001105.5 Human Homo sapiens activin A receptor type 1 (ACVR1), transcript variant 1, mRNA. 1530 GC-T8297
ACVR1B NM_004302.5 Human Homo sapiens activin A receptor type 1B (ACVR1B), transcript variant 1, mRNA. 1518 GC-Y2812
ACVR1B NM_020327.5 Human Homo sapiens activin A receptor type 1B (ACVR1B), transcript variant 2, mRNA. 1362 GC-Y4814
ACVR1B NM_020328.4 Human Homo sapiens activin A receptor type 1B (ACVR1B), transcript variant 3, mRNA. 1641 GC-Z8332
ACVR2A NM_001616.5 Human Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 2, mRNA. 1542 GC-A0075
AFDN NM_001207008.2 Human Homo sapiens afadin, adherens junction formation factor (AFDN), transcript variant 1, mRNA. 5232 GC-A2202
AFDN NM_001291964.2 Human Homo sapiens afadin, adherens junction formation factor (AFDN), transcript variant 4, mRNA. 5346 GC-I3276
AJUBA NM_032876.6 Human Homo sapiens ajuba LIM protein (AJUBA), transcript variant 1, mRNA. 1617 GC-T1556
AJUBA NM_198086.3 Human Homo sapiens ajuba LIM protein (AJUBA), transcript variant 2, mRNA. 366 GC-H1000
AKT1 NM_001014431.2 Human Homo sapiens AKT serine/threonine kinase 1 (AKT1), transcript variant 3, mRNA. 1443 GC-Z5980
AKT1 NM_005163.2 Human Homo sapiens AKT serine/threonine kinase 1 (AKT1), transcript variant 1, mRNA. 1443 GC-A0022
AKT3 NM_001206729.2 Human Homo sapiens AKT serine/threonine kinase 3 (AKT3), transcript variant 3, mRNA. 1398 GC-Z3429
AKT3 NM_005465.7 Human Homo sapiens AKT serine/threonine kinase 3 (AKT3), transcript variant 1, mRNA. 1440 GC-R0021
ALDH2 NM_000690.4 Human Homo sapiens aldehyde dehydrogenase 2 family member (ALDH2), transcript variant 1, mRNA; nuclear gene for mitochondrial product. 1554 GC-C0231
ALDH2 NM_001204889.2 Human Homo sapiens aldehyde dehydrogenase 2 family member (ALDH2), transcript variant 2, mRNA; nuclear gene for mitochondrial product. 1413 GC-Z9566
ALK NM_004304.5 Human Homo sapiens ALK receptor tyrosine kinase (ALK), transcript variant 1, mRNA. 4863 GC-T1863
ALK NM_001353765.2 Human Homo sapiens ALK receptor tyrosine kinase (ALK), transcript variant 2, mRNA. 1659 GC-I5740
ALPK1 NM_025144.4 Human Homo sapiens alpha kinase 1 (ALPK1), transcript variant 1, mRNA. 3735 GC-Z6155
AMER1 NM_152424.4 Human Homo sapiens APC membrane recruitment protein 1 (AMER1), mRNA. 3408 GC-H2338
ANK1 NM_000037.4 Human Homo sapiens ankyrin 1 (ANK1), transcript variant 3, mRNA. 5643 GC-Z5852
ANK1 NM_020476.3 Human Homo sapiens ankyrin 1 (ANK1), transcript variant 1, mRNA. 5646 GC-Z7807
AR NM_000044.6 Human Homo sapiens androgen receptor (AR), transcript variant 1, mRNA. 2763 GC-E2325
AR NM_001011645.3 Human Homo sapiens androgen receptor (AR), transcript variant 2, mRNA. 1167 GC-E2336
AR NM_001348061.1 Human Homo sapiens androgen receptor (AR), transcript variant 3, mRNA. 1935 GC-I5618
ARAF NM_001256196.2 Human Homo sapiens A-Raf proto-oncogene, serine/threonine kinase (ARAF), transcript variant 2, mRNA. 1830 GC-Z0699
ARAF NM_001654.5 Human Homo sapiens A-Raf proto-oncogene, serine/threonine kinase (ARAF), transcript variant 1, mRNA. 1821 GC-B0257
ARHGAP35 NM_004491.5 Human Homo sapiens Rho GTPase activating protein 35 (ARHGAP35), mRNA. 4500 GC-H1821
ARHGEF12 NM_015313.3 Human Homo sapiens Rho guanine nucleotide exchange factor 12 (ARHGEF12), transcript variant 1, mRNA. 4635 GC-T0327
ARID2 NM_152641.4 Human Homo sapiens AT-rich interaction domain 2 (ARID2), transcript variant 1, mRNA. 5508 GC-E2538
ARNT NM_001197325.2 Human Homo sapiens aryl hydrocarbon receptor nuclear translocator (ARNT), transcript variant 4, mRNA. 2322 GC-Z8721
ARNT NM_001668.4 Human Homo sapiens aryl hydrocarbon receptor nuclear translocator (ARNT), transcript variant 1, mRNA. 2370 GC-C0312
ARNT NM_178427.3 Human Homo sapiens aryl hydrocarbon receptor nuclear translocator (ARNT), transcript variant 3, mRNA. 2325 GC-Z5281
ASXL1 NM_015338.6 Human Homo sapiens ASXL transcriptional regulator 1 (ASXL1), transcript variant 1, mRNA. 4626 GC-E2820
ASXL2 NM_018263.6 Human Homo sapiens ASXL transcriptional regulator 2 (ASXL2), transcript variant 1, mRNA. 4308 GC-H1988
ATG7 NM_001136031.3 Human Homo sapiens autophagy related 7 (ATG7), transcript variant 2, mRNA. 2031 GC-T7632
ATG7 NM_001144912.2 Human Homo sapiens autophagy related 7 (ATG7), transcript variant 3, mRNA. 1872 GC-H4078
ATG7 NM_006395.3 Human Homo sapiens autophagy related 7 (ATG7), transcript variant 1, mRNA. 2112 GC-T0275
ATP1A1 NM_000701.8 Human Homo sapiens ATPase Na+/K+ transporting subunit alpha 1 (ATP1A1), transcript variant 1, mRNA. 3072 GC-T0533
ATP1A1 NM_001160234.2 Human Homo sapiens ATPase Na+/K+ transporting subunit alpha 1 (ATP1A1), transcript variant 4, mRNA. 2979 GC-H4345
AXIN1 NM_003502.4 Human Homo sapiens axin 1 (AXIN1), transcript variant 1, mRNA. 2589 GC-E2160

UltraHiPF® DNA Polymerase Kit

by | May 21, 2024 | Products

UltraHiPF® DNA Polymerase Kit
UltraHiPF® DNA Polymerase Kit
UltraHiPF® DNA Polymerase Kit
UltraHiPF® DNA Polymerase Kit

UltraHiPF® DNA Polymerase Kit UltraHiPF® DNA Polymerase Kit

Price: $135.00 $541.00
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  • PC019
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Product Information

UltraHiPF® DNA Polymerase is a heat-resistant ultra-fidelity DNA polymerase with 5′-3′ polymerase activity and 3′-5′ exonuclease activity. The polymerase can amplify uracil- and hypoxanthine- containing templates, GC- or AT- rich templates, genomes as low as one copy, and DNA fragments of more than 12 kb from different species. UltraHiPF® DNA Polymerase can specifically amplify 2 kb fragments at 1sec denaturation, annealing, and elongation, and can expand complex templates at 15-30 sec/kb. With Sanger sequencing, the mutation rate of this enzyme was 55 times lower than that of Taq DNA polymerase. The PCR product obtained by using the product has the Blunt-end.

Advantages
  • 55X higher fidelity than Taq
  • Robust Reactions – maximal success with minimal optimization
  • Most templates can be expanded up to 0.5 sec/kb
  • Superior performance for a broad range of amplicons
 

AAV ORF cDNA, sgRNA and Cas9, precursor microRNA, microRNA inhibitor clones

by | May 16, 2024 | Products

Introduction

GeneCopoeia offers the largest collection of AAV vector-based expression clones for ORF cDNA, CRISPR, shRNA, precursor microRNA, and microRNA inhibitor.

In addition to the AAV clones, GeneCopoeia also provides optimized AAV serotype testing kits, as well as high quality AAV packaging services as a part of a comprehensive suite of AAV solutions.

Need AAV? Buy pre-made controls, serotype testing kits, or custom-made AAV

Advantages of AAV ORF cDNA, CRISPR, shRNA, and microRNA clones

  • Highest quality clones to ensure your AAV quality

All clones offered by Genecopoeia are fully sequenced using Sanger sequencing by capillary electrophoresis and the Amino Acid Sequences are guaranteed to match with NCBI database.

  • A variety of promoters are available for tissue-specific assays

GeneCopoeia provides ubiquitous promoters, such as CMV, EF1a, CAG, and tissue-specific promoters, such as CaMKIIa, hSyn, GFAP, aMHC, MHCK7, cTnT, and more.

  • Fast turnaround time for faster AAV packaging 

Most GeneCopoeia clones are ready within 2-3 weeks and are sequence guaranteed.