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Immuno-oncology

by | Mar 22, 2024 | Clone sets

Introduction

Immuno-oncology is a scientific field that studies the interactions between tumors and the immune system, revealing how tumors evade immune surveillance and elimination, as well as how they exploit the mechanisms of the immune system to promote their growth and spread. Cancer immunotherapy, developed on the theoretical foundation of immuno-oncology, represents a revolutionary approach to treatment. It activates or enhances the patient’s own immune system to recognize and destroy cancer cells, fundamentally differing from traditional cancer treatments such as surgery, radiation, and chemotherapy. Cancer immunotherapy comes in a variety of forms, including targeted antibodies, cancer vaccines, adoptive cell transfer, tumor-infecting viruses, checkpoint inhibitors, cytokines, and adjuvants.

Application

The Immuno-oncology clone set can be used in GSRA technology to perform high-throughput screening of various transmembrane or secreted proteins interacting with target proteins. The Genome-Scale Receptor Array (GSRA) is a semi-automated gene expression and detection system invented by Prof. Lieping Chen’s team, which is used to rapidly detect protein-protein interactions. This clone set fuels a number of research results. Screening of ligand proteins for LAG-3, revealing the role of this LAG-3-FGL1 pathway in tumour immunity and therapy[1]. Demonstrating that Siglec-15 inhibits antigen-specific T-cell responses in vitro and in vivo, and can serve as a potential target for cancer immunotherapy[2]. Identifying IGFBP7 interacts with its receptor CD93, and subsequently demonstrated that this interaction contributes to abnormal tumor vasculature[3]. And showing CD8α is critical for the maintenance of CD8+ T cells in a physiologically quiescent state in peripheral lymphoid organs[4].

Fig. 1 In this study, gain-of-function genetic screens were used to profile axon guidance proteins and their cognate ligands on human T cells. They identified fibronectin leucine-rich transmembrane protein 3 (FLRT3) as a ligand that inhibits T cell activity. (Prajapati et al. Sci Adv. 2024)

Genecopoeia also offers HEKT293-OKT3 stable cell line for activating T cells during co-culture. ⇒View Details

Reference
  1. Wang, F., et al., Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. Cell, 2018
  2. Wang J, Sun J, Liu L N, et al. Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Nature medicine, 2019
  3. Sun Y, Chen W, Torphy R J, et al. Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy. Science Translational Medicine, 2021
  4. Zheng, L., et al., The CD8α-PILRα interaction maintains CD8+ T cell quiescence. Science, 2022

Clone set information

 
Cat. No. Old Cat. No. Species Gene Vector Vector Type Price
OC-GF012-M02 OC-HIO-M02 Human 6592 pReceiver-M02 Expression-ready Non-viral Inquire
OC-GF012-M35 OC-HIO-M35 Human 6592 pReceiver-M35 Expression-ready Non-viral Inquire
OC-GF012-M98 OC-HIO-M98 Human 6592 pReceiver-M98 Expression-ready Non-viral Inquire
OC-GF012-Lv105 OC-HIO-Lv105 Human 6592 pReceiver-Lv105 Expression-ready Lentiviral Inquire
OC-GF012-Lv242 OC-HIO-Lv242 Human 6592 pReceiver-Lv242 Expression-ready Lentiviral Inquire

Clone list

The form only shows 50 clones of the whole set. Please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.
Symbol Accession Species Description ORF length(bp) Product ID
TNFRSF9 NM_001561.6 Human Homo sapiens TNF receptor superfamily member 9 (TNFRSF9), mRNA. 768 GC-A0225
A1BG NM_130786.4 Human Homo sapiens alpha-1-B glycoprotein (A1BG), mRNA. 1488 GC-T3535
A2M NM_000014.5 Human Homo sapiens alpha-2-macroglobulin (A2M), transcript variant 1, mRNA. 4425 GC-A3521
A2ML1 NM_144670.6 Human Homo sapiens alpha-2-macroglobulin like 1 (A2ML1), transcript variant 1, mRNA. 4365 GC-D0701
A4GALT NM_017436.7 Human Homo sapiens alpha 1,4-galactosyltransferase (P blood group) (A4GALT), transcript variant 1, mRNA. 1062 GC-U0876
A4GNT NM_016161.3 Human Homo sapiens alpha-1,4-N-acetylglucosaminyltransferase (A4GNT), mRNA. 1023 GC-U0796
AAAS NM_015665.6 Human Homo sapiens aladin WD repeat nucleoporin (AAAS), transcript variant 1, mRNA. 1641 GC-V0141
AADAC NM_001086.3 Human Homo sapiens arylacetamide deacetylase (AADAC), mRNA. 1200 GC-A4273
ABCA5 NM_018672.5 Human Homo sapiens ATP binding cassette subfamily A member 5 (ABCA5), transcript variant 1, mRNA. 4929 GC-H4609
ABCA6 NM_080284.3 Human Homo sapiens ATP binding cassette subfamily A member 6 (ABCA6), mRNA. 4854 GC-I1895
ABCA8 NM_007168.4 Human Homo sapiens ATP binding cassette subfamily A member 8 (ABCA8), transcript variant 2, mRNA. 4746 GC-T0048
ABCB1 NM_000927.5 Human Homo sapiens ATP binding cassette subfamily B member 1 (ABCB1), transcript variant 3, mRNA. 3843 GC-E2266
ABCB1 NM_001348945.2 Human Homo sapiens ATP binding cassette subfamily B member 1 (ABCB1), transcript variant 1, mRNA. 4053 GC-E3923
ABCB11 NM_003742.4 Human Homo sapiens ATP binding cassette subfamily B member 11 (ABCB11), mRNA. 3966 GC-H5308
ABCB4 NM_000443.4 Human Homo sapiens ATP binding cassette subfamily B member 4 (ABCB4), transcript variant A, mRNA. 3840 GC-G0814
ABCB4 NM_018850.3 Human Homo sapiens ATP binding cassette subfamily B member 4 (ABCB4), transcript variant C, mRNA. 3699 GC-Z4744
ABCB5 NM_178559.6 Human Homo sapiens ATP binding cassette subfamily B member 5 (ABCB5), transcript variant 2, mRNA. 2439 GC-E2036
ABCB6 NM_005689.4 Human Homo sapiens ATP binding cassette subfamily B member 6 (Langereis blood group) (ABCB6), transcript variant 1, mRNA. 2529 GC-T1895
ABCB7 NM_001271696.3 Human Homo sapiens ATP binding cassette subfamily B member 7 (ABCB7), transcript variant 2, mRNA; nuclear gene for mitochondrial product. 2259 GC-Y5172
ABCB7 NM_004299.6 Human Homo sapiens ATP binding cassette subfamily B member 7 (ABCB7), transcript variant 1, mRNA; nuclear gene for mitochondrial product. 2262 GC-Y2039
ABCB8 NM_007188.5 Human Homo sapiens ATP binding cassette subfamily B member 8 (ABCB8), transcript variant 2, mRNA; nuclear gene for mitochondrial product. 2157 GC-U0894
ABCB9 NM_001243014.2 Human Homo sapiens ATP binding cassette subfamily B member 9 (ABCB9), transcript variant 5, mRNA. 2046 GC-I0755
ABCB9 NM_019625.4 Human Homo sapiens ATP binding cassette subfamily B member 9 (ABCB9), transcript variant 1, mRNA. 2301 GC-T0728
ABCC1 NM_004996.4 Human Homo sapiens ATP binding cassette subfamily C member 1 (ABCC1), mRNA. 4596 GC-Z4479
ABCC10 NM_033450.3 Human Homo sapiens ATP binding cassette subfamily C member 10 (ABCC10), transcript variant MRP7A, mRNA. 4395 GC-E2232
ABCC11 NM_033151.4 Human Homo sapiens ATP binding cassette subfamily C member 11 (ABCC11), transcript variant 2, mRNA. 4149 GC-W1207
ABCC2 NM_000392.5 Human Homo sapiens ATP binding cassette subfamily C member 2 (ABCC2), mRNA. 4638 GC-A8900
ABCC4 NM_001105515.3 Human Homo sapiens ATP binding cassette subfamily C member 4 (ABCC4), transcript variant 2, mRNA. 2580 GC-T9124
ABCC4 NM_005845.5 Human Homo sapiens ATP binding cassette subfamily C member 4 (ABCC4), transcript variant 1, mRNA. 3978 GC-T0262
ABCC8 NM_000352.6 Human Homo sapiens ATP binding cassette subfamily C member 8 (ABCC8), transcript variant 2, mRNA. 4746 GC-Y4894
ABCD1 NM_000033.4 Human Homo sapiens ATP binding cassette subfamily D member 1 (ABCD1), mRNA. 2238 GC-C0357
ABCD3 NM_001122674.2 Human Homo sapiens ATP binding cassette subfamily D member 3 (ABCD3), transcript variant 2, mRNA. 711 GC-T7842
ABCD4 NM_001353598.2 Human Homo sapiens ATP binding cassette subfamily D member 4 (ABCD4), transcript variant 13, mRNA. 1344 GC-L8576
ABCG1 NM_004915.4 Human Homo sapiens ATP binding cassette subfamily G member 1 (ABCG1), transcript variant 4, mRNA. 2037 GC-Z0825
ABCG1 NM_016818.3 Human Homo sapiens ATP binding cassette subfamily G member 1 (ABCG1), transcript variant 2, mRNA. 2001 GC-Z3287
ABCG1 NM_207628.1 Human Homo sapiens ATP binding cassette subfamily G member 1 (ABCG1), transcript variant 6, mRNA. 1935 GC-Z8089
ABCG2 NM_004827.3 Human Homo sapiens ATP binding cassette subfamily G member 2 (Junior blood group) (ABCG2), transcript variant 1, mRNA. 1968 GC-Q0668
ABCG4 NM_022169.5 Human Homo sapiens ATP binding cassette subfamily G member 4 (ABCG4), transcript variant 1, mRNA. 1941 GC-Z1538
ABCG8 NM_022437.3 Human Homo sapiens ATP binding cassette subfamily G member 8 (ABCG8), transcript variant 1, mRNA. 2022 GC-W1096
ABHD1 NM_032604.4 Human Homo sapiens abhydrolase domain containing 1 (ABHD1), mRNA. 1218 GC-W2844
ABHD12 NM_015600.5 Human Homo sapiens abhydrolase domain containing 12, lysophospholipase (ABHD12), transcript variant 2, mRNA. 1215 GC-T2637
ABHD13 NM_032859.3 Human Homo sapiens abhydrolase domain containing 13 (ABHD13), mRNA. 1014 GC-T8787
ABHD17A NM_001130111.2 Human Homo sapiens abhydrolase domain containing 17A, depalmitoylase (ABHD17A), transcript variant 2, mRNA. 933 GC-Z6406
ABHD17A NM_031213.4 Human Homo sapiens abhydrolase domain containing 17A, depalmitoylase (ABHD17A), transcript variant 1, mRNA. 1086 GC-Z9629
ABHD2 NM_152924.5 Human Homo sapiens abhydrolase domain containing 2, acylglycerol lipase (ABHD2), transcript variant 2, mRNA. 1278 GC-G0334
ABHD3 NM_138340.5 Human Homo sapiens abhydrolase domain containing 3, phospholipase (ABHD3), transcript variant 1, mRNA. 1230 GC-H4722
ABHD6 NM_001320126.2 Human Homo sapiens abhydrolase domain containing 6, acylglycerol lipase (ABHD6), transcript variant 1, mRNA. 1014 GC-V0321
ABI1 NM_001178119.2 Human Homo sapiens abl interactor 1 (ABI1), transcript variant 6, mRNA. 1443 GC-M0337
ABI1 NM_001178120.2 Human Homo sapiens abl interactor 1 (ABI1), transcript variant 7, mRNA. 1356 GC-Z8779
ABI1 NM_005470.4 Human Homo sapiens abl interactor 1 (ABI1), transcript variant 1, mRNA. 1527 GC-Z4495

Transcription factors

by | Mar 22, 2024 | Clone sets

Introduction

Transcription factors, also known as trans-acting factors, are proteins that can bind to specific nucleotide sequences upstream of a gene, and these proteins can regulate the transcription of its genes, including TFIIA, TFIIB, TFIID, HSF, HIF, SREBP, and so on.
Based on protein structure, these transcription factors generally consist of DNA-binding domains, transcription regulation domains (including activation and repression domains), oligomerization sites, and nuclear location signals (NLS). Transcription factors are not only related to a variety of major human diseases. For example, p53, myc, ER, Id are related to cancer; PPAR are related to obesity; MEF2, HIF1 are related to heart disease.
Transcription factors are also involved in the regulation of plant growth and development, as well as stress defense responses. Studying the functions of transcription factors and their interacting factors is essential for understanding their roles in signaling cascade reactions, providing a theoretical basis for both basic research and production applications.

Clone set information

Cat. No. Old Cat. No. Species Gene Vector Vector Type Price
OC-GF020-M02 OC-HTF-M02 Human 2412 pReceiver-M02 Expression-ready Non-viral Inquire
OC-GF020-M35 OC-HTF-M35 Human 2412 pReceiver-M35 Expression-ready Non-viral Inquire
OC-GF020-M98 OC-HTF-M98 Human 2412 pReceiver-M98 Expression-ready Non-viral Inquire
OC-GF020-Lv105 OC-HTF-Lv105 Human 2412 pReceiver-Lv105 Expression-ready Lentiviral Inquire
OC-GF020-Lv242 OC-HTF-Lv242 Human 2412 pReceiver-Lv242 Expression-ready Lentiviral Inquire

Clone list

The form only shows 50 clones of the whole set. Please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.
Symbol Accession Species Description ORF length(bp) Product ID
VDR NM_001017535.2 Human Homo sapiens vitamin D receptor (VDR), transcript variant 2, mRNA. 1284 GC-A0043
ESR1 NM_000125.3 Human Homo sapiens estrogen receptor 1 (ESR1), transcript variant 1, mRNA. 1788 GC-A0322
RXRB NM_021976.5 Human Homo sapiens retinoid X receptor beta (RXRB), transcript variant 2, mRNA. 1602 GC-A0346
AHR NM_001621.5 Human Homo sapiens aryl hydrocarbon receptor (AHR), mRNA. 2547 GC-A0474
RXRA NM_002957.6 Human Homo sapiens retinoid X receptor alpha (RXRA), transcript variant 1, mRNA. 1389 GC-A0529
NR0B1 NM_000475.5 Human Homo sapiens nuclear receptor subfamily 0 group B member 1 (NR0B1), mRNA. 1413 GC-A0573
NR1D1 NM_021724.5 Human Homo sapiens nuclear receptor subfamily 1 group D member 1 (NR1D1), mRNA. 1845 GC-A0803
THRA NM_001190919.2 Human Homo sapiens thyroid hormone receptor alpha (THRA), transcript variant 4, mRNA. 1473 GC-A0835
NR3C1 NM_001024094.2 Human Homo sapiens nuclear receptor subfamily 3 group C member 1 (NR3C1), transcript variant 7, mRNA. 2337 GC-A0857
NR1I3 NM_005122.5 Human Homo sapiens nuclear receptor subfamily 1 group I member 3 (NR1I3), transcript variant 3, mRNA. 1047 GC-A0964
NR2F1 NM_005654.6 Human Homo sapiens nuclear receptor subfamily 2 group F member 1 (NR2F1), mRNA. 1272 GC-A1000
NR1H3 NM_005693.4 Human Homo sapiens nuclear receptor subfamily 1 group H member 3 (NR1H3), transcript variant 1, mRNA. 1344 GC-A1306
MYBL2 NM_002466.4 Human Homo sapiens MYB proto-oncogene like 2 (MYBL2), transcript variant 1, mRNA. 2103 GC-B0073
HMGB2 NM_001130688.1 Human Homo sapiens high mobility group box 2 (HMGB2), transcript variant 2, mRNA. 630 GC-B0079
RUNX1 NM_001122607.2 Human Homo sapiens RUNX family transcription factor 1 (RUNX1), transcript variant 3, mRNA. 753 GC-B0083
TP53 NM_000546.6 Human Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA. 1182 GC-B0105
ELK1 NM_005229.4 Human Homo sapiens ELK1, ETS transcription factor (ELK1), transcript variant 2, mRNA. 1287 GC-B0214
SMAD4 NM_005359.6 Human Homo sapiens SMAD family member 4 (SMAD4), mRNA. 1659 GC-B0219
FOS NM_005252.4 Human Homo sapiens Fos proto-oncogene, AP-1 transcription factor subunit (FOS), mRNA. 1143 GC-B0247
RUNX3 NM_004350.3 Human Homo sapiens RUNX family transcription factor 3 (RUNX3), transcript variant 2, mRNA. 1248 GC-B0301
NME2 NM_001018139.2 Human Homo sapiens NME/NM23 nucleoside diphosphate kinase 2 (NME2), transcript variant 4, mRNA. 459 GC-C0166
NR2F2 NM_021005.4 Human Homo sapiens nuclear receptor subfamily 2 group F member 2 (NR2F2), transcript variant 1, mRNA. 1245 GC-C0221
ARNT NM_001668.4 Human Homo sapiens aryl hydrocarbon receptor nuclear translocator (ARNT), transcript variant 1, mRNA. 2370 GC-C0312
HDAC9 NM_014707.4 Human Homo sapiens histone deacetylase 9 (HDAC9), transcript variant 3, mRNA. 1773 GC-E0013
GTF2I NM_001518.5 Human Homo sapiens general transcription factor IIi (GTF2I), transcript variant 4, mRNA. 2874 GC-E0033
RFX4 NM_032491.6 Human Homo sapiens regulatory factor X4 (RFX4), transcript variant 1, mRNA. 1926 GC-E0092
ZNF232 NM_001320954.2 Human Homo sapiens zinc finger protein 232 (ZNF232), transcript variant 4, mRNA. 1254 GC-E0203
ESRRG NM_001438.4 Human Homo sapiens estrogen related receptor gamma (ESRRG), transcript variant 1, mRNA. 1377 GC-E0424
MYOCD NM_153604.4 Human Homo sapiens myocardin (MYOCD), transcript variant 2, mRNA. 2817 GC-E0450
GSC NM_173849.3 Human Homo sapiens goosecoid homeobox (GSC), mRNA. 774 GC-E0453
GATAD2B NM_020699.4 Human Homo sapiens GATA zinc finger domain containing 2B (GATAD2B), mRNA. 1782 GC-E0581
ZNF41 NM_001324140.2 Human Homo sapiens zinc finger protein 41 (ZNF41), transcript variant 4, mRNA. 2340 GC-E0596
FOXL1 NM_005250.3 Human Homo sapiens forkhead box L1 (FOXL1), mRNA. 1038 GC-E0843
TP63 NM_003722.5 Human Homo sapiens tumor protein p63 (TP63), transcript variant 1, mRNA. 2043 GC-E0955
HOXC12 NM_173860.3 Human Homo sapiens homeobox C12 (HOXC12), mRNA. 849 GC-E0972
CREM NM_182769.3 Human Homo sapiens cAMP responsive element modulator (CREM), transcript variant 13, mRNA. 738 GC-E1258
TCF7 NM_003202.5 Human Homo sapiens transcription factor 7 (TCF7), transcript variant 1, mRNA. 1155 GC-E1346
TCF20 NM_005650.4 Human Homo sapiens transcription factor 20 (TCF20), transcript variant 1, mRNA. 5883 GC-E1417
MTUS1 NM_020749.5 Human Homo sapiens microtubule associated scaffold protein 1 (MTUS1), transcript variant 5, mRNA. 1311 GC-E1441
TRERF1 NM_033502.4 Human Homo sapiens transcriptional regulating factor 1 (TRERF1), transcript variant 2, mRNA. 3603 GC-E1475
HOXC6 NM_004503.4 Human Homo sapiens homeobox C6 (HOXC6), transcript variant 1, mRNA. 708 GC-E1530
SOX5 NM_152989.5 Human Homo sapiens SRY-box transcription factor 5 (SOX5), transcript variant 2, mRNA. 2253 GC-E1597
TBX22 NM_016954.2 Human Homo sapiens T-box 22 (TBX22), transcript variant 2, mRNA. 1563 GC-E1621
ZNF26 NM_019591.4 Human Homo sapiens zinc finger protein 26 (ZNF26), transcript variant 2, mRNA. 1602 GC-E1630
ZNF398 NM_170686.3 Human Homo sapiens zinc finger protein 398 (ZNF398), transcript variant 1, mRNA. 1929 GC-E1852
SOX5 NM_001261414.3 Human Homo sapiens SRY-box transcription factor 5 (SOX5), transcript variant 4, mRNA. 1929 GC-E1940
HSF1 NM_005526.4 Human Homo sapiens heat shock transcription factor 1 (HSF1), mRNA. 1590 GC-F0013
GATA2 NM_001145661.2 Human Homo sapiens GATA binding protein 2 (GATA2), transcript variant 1, mRNA. 1443 GC-F0016
YY1 NM_003403.5 Human Homo sapiens YY1 transcription factor (YY1), mRNA. 1245 GC-F0023
ELK4 NM_021795.3 Human Homo sapiens ETS transcription factor ELK4 (ELK4), transcript variant b, mRNA. 1218 GC-F0031

Secretory proteins

by | Mar 22, 2024 | Clone sets

Introduction

Secretory proteins are proteins that are synthesized inside the cell and then secreted outside the cell to play a role, such as salivary amylase, pepsin, digestive enzymes, antibodies and some hormones. Protein secretion is one of the most important ways of information transfer between cells. General secretory proteins have a signal peptide at their N-terminus, which can be transported through the conventional secretory pathway and eventually secreted to the outside of the cell. These are conventional secretory proteins.
In recent years, it has been found that there exists another class of secretory proteins in the cell that can be secreted to the outside of the cell to play a role without signal peptides, and these proteins with unique secretion mechanisms are called unconventional secretory proteins. They are often used in the study of human body immunity changes caused by bacterial infections and their interaction mechanism with the host, which can provide a theoretical basis for the prevention of diseases and the development of targeted drugs.

Clone set information

Cat. No. Old Cat. No. Species Gene Vector Vector Type Price
OC-GF019-M02 OC-HSP-M02 Human 2334 pReceiver-M02 Expression-ready Non-viral Inquire
OC-GF019-M35 OC-HSP-M35 Human 2334 pReceiver-M35 Expression-ready Non-viral Inquire
OC-GF019-M98 OC-HSP-M98 Human 2334 pReceiver-M98 Expression-ready Non-viral Inquire
OC-GF019-Lv105 OC-HSP-Lv105 Human 2334 pReceiver-Lv105 Expression-ready Lentiviral Inquire
OC-GF019-Lv242 OC-HSP-Lv242 Human 2334 pReceiver-Lv242 Expression-ready Lentiviral Inquire

Clone list

The form only shows 50 clones of the whole set. Please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.
Symbol Accession Species Description ORF length(bp) Product ID
IFNA1 NM_024013.3 Human Homo sapiens interferon alpha 1 (IFNA1), mRNA. 570 GC-A0001
PTN NM_002825.7 Human Homo sapiens pleiotrophin (PTN), transcript variant 1, mRNA. 507 GC-A0004
IL10 NM_000572.3 Human Homo sapiens interleukin 10 (IL10), transcript variant 1, mRNA. 537 GC-A0007
TMPRSS2 NM_001135099.1 Human Homo sapiens transmembrane protease, serine 2 (TMPRSS2), transcript variant 1, mRNA. 1590 GC-H3842
BMP5 NM_021073.4 Human Homo sapiens bone morphogenetic protein 5 (BMP5), transcript variant 1, mRNA. 1365 GC-A0015
BMP6 NM_001718.6 Human Homo sapiens bone morphogenetic protein 6 (BMP6), mRNA. 1542 GC-A0016
EDN2 NM_001956.5 Human Homo sapiens endothelin 2 (EDN2), transcript variant 1, mRNA. 537 GC-A0032
IL12B NM_002187.3 Human Homo sapiens interleukin 12B (IL12B), mRNA. 987 GC-A0033
IL12A NM_000882.4 Human Homo sapiens interleukin 12A (IL12A), transcript variant 1, mRNA. 762 GC-A0034
IGFALS NM_004970.3 Human Homo sapiens insulin like growth factor binding protein acid labile subunit (IGFALS), transcript variant 2, mRNA. 1818 GC-A0066
AGER NM_001136.4 Human Homo sapiens advanced glycosylation end-product specific receptor (AGER), transcript variant 1, mRNA. 1215 GC-A0070
NPY NM_000905.4 Human Homo sapiens neuropeptide Y (NPY), mRNA. 294 GC-A0089
ANG NM_001145.4 Human Homo sapiens angiogenin (ANG), transcript variant 1, mRNA. 444 GC-A0098
GIP NM_004123.3 Human Homo sapiens gastric inhibitory polypeptide (GIP), mRNA. 462 GC-A0106
TGFB2 NM_001135599.4 Human Homo sapiens transforming growth factor beta 2 (TGFB2), transcript variant 1, mRNA. 1329 GC-A0107
NMB NM_021077.4 Human Homo sapiens neuromedin B (NMB), transcript variant 1, mRNA. 366 GC-A0109
ACHE NM_000665.5 Human Homo sapiens acetylcholinesterase (Cartwright blood group) (ACHE), transcript variant E4-E6, mRNA. 1845 GC-A0120
CSF3R NM_156039.3 Human Homo sapiens colony stimulating factor 3 receptor (CSF3R), transcript variant 3, mRNA. 2592 GC-A0126
IFNA14 NM_002172.3 Human Homo sapiens interferon alpha 14 (IFNA14), mRNA. 570 GC-A0136
IFNB1 NM_002176.4 Human Homo sapiens interferon beta 1 (IFNB1), mRNA. 564 GC-A0137
PRL NM_001163558.3 Human Homo sapiens prolactin (PRL), transcript variant 2, mRNA. 684 GC-A0139
IL4R NM_000418.4 Human Homo sapiens interleukin 4 receptor (IL4R), transcript variant 1, mRNA. 2478 GC-A0144
TAC1 NM_013997.3 Human Homo sapiens tachykinin precursor 1 (TAC1), transcript variant gamma, mRNA. 345 GC-A0149
IGF1 NM_000618.5 Human Homo sapiens insulin like growth factor 1 (IGF1), transcript variant 4, mRNA. 462 GC-A0153
FGF3 NM_005247.4 Human Homo sapiens fibroblast growth factor 3 (FGF3), mRNA. 720 GC-A0154
CRHBP NM_001882.4 Human Homo sapiens corticotropin releasing hormone binding protein (CRHBP), mRNA. 969 GC-A0155
IL11 NM_000641.4 Human Homo sapiens interleukin 11 (IL11), transcript variant 1, mRNA. 600 GC-A0158
IFNW1 NM_002177.3 Human Homo sapiens interferon omega 1 (IFNW1), mRNA. 588 GC-A0159
IL5 NM_000879.3 Human Homo sapiens interleukin 5 (IL5), mRNA. 405 GC-A0169
PPY NM_002722.5 Human Homo sapiens pancreatic polypeptide (PPY), transcript variant 1, mRNA. 288 GC-A0172
IL4 NM_000589.4 Human Homo sapiens interleukin 4 (IL4), transcript variant 1, mRNA. 462 GC-A0173
NPPB NM_002521.3 Human Homo sapiens natriuretic peptide B (NPPB), mRNA. 405 GC-A0175
CCL1 NM_002981.2 Human Homo sapiens C-C motif chemokine ligand 1 (CCL1), mRNA. 291 GC-A0176
IFNG NM_000619.3 Human Homo sapiens interferon gamma (IFNG), mRNA. 501 GC-A0177
CSF3 NM_172219.3 Human Homo sapiens colony stimulating factor 3 (CSF3), transcript variant 2, mRNA. 615 GC-A0178
INHBA NM_002192.4 Human Homo sapiens inhibin subunit beta A (INHBA), mRNA. 1281 GC-A0186
EBI3 NM_005755.3 Human Homo sapiens Epstein-Barr virus induced 3 (EBI3), mRNA. 690 GC-A0215
BMP2 NM_001200.4 Human Homo sapiens bone morphogenetic protein 2 (BMP2), mRNA. 1191 GC-A0241
BMP4 NM_001347916.1 Human Homo sapiens bone morphogenetic protein 4 (BMP4), transcript variant 8, mRNA. 1227 GC-A0242
AVP NM_000490.5 Human Homo sapiens arginine vasopressin (AVP), mRNA. 495 GC-A0259
CXCL2 NM_002089.4 Human Homo sapiens C-X-C motif chemokine ligand 2 (CXCL2), mRNA. 324 GC-A0267
PDGFA NM_002607.6 Human Homo sapiens platelet derived growth factor subunit A (PDGFA), transcript variant 1, mRNA. 636 GC-A0278
GSN NM_000177.5 Human Homo sapiens gelsolin (GSN), transcript variant 1, mRNA. 2349 GC-A0279
PTHLH NM_198964.2 Human Homo sapiens parathyroid hormone like hormone (PTHLH), transcript variant 3, mRNA. 528 GC-A0295
GCG NM_002054.5 Human Homo sapiens glucagon (GCG), mRNA. 543 GC-A0296
TTR NM_000371.4 Human Homo sapiens transthyretin (TTR), mRNA. 444 GC-A0298
IL6 NM_000600.5 Human Homo sapiens interleukin 6 (IL6), transcript variant 1, mRNA. 639 GC-A0301
STATH NM_003154.3 Human Homo sapiens statherin (STATH), transcript variant 1, mRNA. 189 GC-A0302
BMP7 NM_001719.3 Human Homo sapiens bone morphogenetic protein 7 (BMP7), mRNA. 1296 GC-A0309
IL1RN NM_173842.3 Human Homo sapiens interleukin 1 receptor antagonist (IL1RN), transcript variant 1, mRNA. 534 GC-A0332

Protease

by | Mar 22, 2024 | Clone sets

Introduction

Proteases are widely distributed in animals, plants, and microorganisms, and their main role is to catalyze the hydrolysis of proteins and peptides. Proteases play an important role in organisms, and their activities are tightly regulated and controlled, because the overexpression of proteases could be detrimental to the health of the organisms. Together, proteases and their inhibitors are involved in the regulation of many physiological responses in the organism, such as the human pancreatic rennet protease (CTRC) that regulates the balance between trypsin activation and hydrolysis, the HIV-1 protease that plays an important role in viral replication, and the extracellular matrix metalloproteinase MT1-MMP mutation that affects bone tissue development.
Proteases are key factors in cellular health and viability and are involved in a variety of physiological processes such as replication, transcription, cell proliferation, differentiation, remodeling of the extracellular matrix, and processing of hormones and bioactive peptides. Proteases are implicated in many diseases, such as cancer, Alzheimer’s disease, arthritis, clotting disorders, allergies and infections.

Clone set information

Cat. No. Old Cat. No. Species Gene Vector Vector Type Price
OC-GF018-M02 OC-HPR-M02 Human 596 pReceiver-M02 Expression-ready Non-viral Inquire
OC-GF018-M35 OC-HPR-M35 Human 596 pReceiver-M35 Expression-ready Non-viral Inquire
OC-GF018-M98 OC-HPR-M98 Human 596 pReceiver-M98 Expression-ready Non-viral Inquire
OC-GF018-Lv105 OC-HPR-Lv105 Human 596 pReceiver-Lv105 Expression-ready Lentiviral Inquire
OC-GF018-Lv242 OC-HPR-Lv242 Human 596 pReceiver-Lv242 Expression-ready Lentiviral Inquire
OC-GF018-GC OC-HPR-GC Human 596 pDONR™ Vector Gateway shuttle Inquire

Clone list

The form only shows 50 clones of the whole set. Please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.
Symbol Accession Species Description ORF length(bp) Product ID
IDE NM_004969.4 Human Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA. 3060 GC-A0272
BMP1 NM_001199.4 Human Homo sapiens bone morphogenetic protein 1 (BMP1), transcript variant 1, mRNA. 2193 GC-A0384
CMA1 NM_001836.5 Human Homo sapiens chymase 1 (CMA1), transcript variant 1, mRNA. 744 GC-A0570
HGF NM_000601.6 Human Homo sapiens hepatocyte growth factor (HGF), transcript variant 1, mRNA. 2187 GC-A0820
BIRC2 NM_001256163.1 Human Homo sapiens baculoviral IAP repeat containing 2 (BIRC2), transcript variant 2, mRNA. 1857 GC-B0151
ENO1 NM_001428.5 Human Homo sapiens enolase 1 (ENO1), transcript variant 1, mRNA. 1305 GC-C0061
UQCRC2 NM_003366.4 Human Homo sapiens ubiquinol-cytochrome c reductase core protein 2 (UQCRC2), mRNA; nuclear gene for mitochondrial product. 1362 GC-C0188
LTA4H NM_000895.3 Human Homo sapiens leukotriene A4 hydrolase (LTA4H), transcript variant 1, mRNA. 1836 GC-C0282
THOP1 NM_003249.5 Human Homo sapiens thimet oligopeptidase 1 (THOP1), mRNA. 2070 GC-C0488
UQCRC1 NM_003365.3 Human Homo sapiens ubiquinol-cytochrome c reductase core protein 1 (UQCRC1), mRNA; nuclear gene for mitochondrial product. 1443 GC-C0542
PROC NM_000312.4 Human Homo sapiens protein C, inactivator of coagulation factors Va and VIIIa (PROC), transcript variant 10, mRNA. 1386 GC-D0023
CTSV NM_001333.4 Human Homo sapiens cathepsin V (CTSV), transcript variant 1, mRNA. 1005 GC-E0001
QPCT NM_012413.4 Human Homo sapiens glutaminyl-peptide cyclotransferase (QPCT), mRNA. 1086 GC-E0292
ADAMTS15 NM_139055.4 Human Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 15 (ADAMTS15), mRNA. 2853 GC-E0438
CPO NM_173077.3 Human Homo sapiens carboxypeptidase O (CPO), mRNA. 1125 GC-E0472
LONP2 NM_031490.5 Human Homo sapiens lon peptidase 2, peroxisomal (LONP2), transcript variant 1, mRNA. 2559 GC-E1718
PCSK6 NM_002570.5 Human Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 1, mRNA. 2910 GC-F0024
CASP1 NM_001257118.3 Human Homo sapiens caspase 1 (CASP1), transcript variant 6, mRNA. 1215 GC-F0035
CTSE NM_001910.4 Human Homo sapiens cathepsin E (CTSE), transcript variant 1, mRNA. 1191 GC-F0059
CTSD NM_001909.5 Human Homo sapiens cathepsin D (CTSD), mRNA. 1239 GC-F0069
CELA2A NM_033440.3 Human Homo sapiens chymotrypsin like elastase 2A (CELA2A), mRNA. 810 GC-F0075
DPP4 NM_001935.4 Human Homo sapiens dipeptidyl peptidase 4 (DPP4), transcript variant 1, mRNA. 2301 GC-F0106
KLK2 NM_005551.5 Human Homo sapiens kallikrein related peptidase 2 (KLK2), transcript variant 1, mRNA. 786 GC-F0110
PCSK2 NM_002594.5 Human Homo sapiens proprotein convertase subtilisin/kexin type 2 (PCSK2), transcript variant 1, mRNA. 1917 GC-F0126
DPEP1 NM_001128141.3 Human Homo sapiens dipeptidase 1 (DPEP1), transcript variant 2, mRNA. 1236 GC-F0127
MMP8 NM_002424.3 Human Homo sapiens matrix metallopeptidase 8 (MMP8), transcript variant 1, mRNA. 1404 GC-F0129
GZMH NM_033423.5 Human Homo sapiens granzyme H (GZMH), transcript variant 1, mRNA. 741 GC-F0137
ANPEP NM_001150.3 Human Homo sapiens alanyl aminopeptidase, membrane (ANPEP), transcript variant 1, mRNA. 2904 GC-F0169
ENDOU NM_006025.4 Human Homo sapiens endonuclease, poly(U) specific (ENDOU), transcript variant 2, mRNA. 1110 GC-F0178
MMP1 NM_002421.4 Human Homo sapiens matrix metallopeptidase 1 (MMP1), transcript variant 1, mRNA. 1410 GC-F0186
CPN1 NM_001308.3 Human Homo sapiens carboxypeptidase N subunit 1 (CPN1), mRNA. 1377 GC-F0189
HPN NM_002151.5 Human Homo sapiens hepsin (HPN), transcript variant 2, mRNA. 1254 GC-F0204
CAPN1 NM_001198868.2 Human Homo sapiens calpain 1 (CAPN1), transcript variant 1, mRNA. 2145 GC-F0216
FURIN NM_002569.4 Human Homo sapiens furin, paired basic amino acid cleaving enzyme (FURIN), transcript variant 1, mRNA. 2385 GC-F0229
PSMA6 NM_002791.3 Human Homo sapiens proteasome 20S subunit alpha 6 (PSMA6), transcript variant 1, mRNA. 741 GC-F0241
PSMB9 NM_002800.5 Human Homo sapiens proteasome 20S subunit beta 9 (PSMB9), mRNA. 660 GC-F0246
CPA1 NM_001868.4 Human Homo sapiens carboxypeptidase A1 (CPA1), mRNA. 1260 GC-F0257
MMP7 NM_002423.5 Human Homo sapiens matrix metallopeptidase 7 (MMP7), mRNA. 804 GC-F0265
PSMA2 NM_002787.5 Human Homo sapiens proteasome 20S subunit alpha 2 (PSMA2), mRNA. 705 GC-F0270
PSMA3 NM_152132.3 Human Homo sapiens proteasome 20S subunit alpha 3 (PSMA3), transcript variant 2, mRNA. 747 GC-F0272
PSMA4 NM_002789.6 Human Homo sapiens proteasome 20S subunit alpha 4 (PSMA4), transcript variant 1, mRNA. 786 GC-F0273
UCHL3 NM_006002.5 Human Homo sapiens ubiquitin C-terminal hydrolase L3 (UCHL3), transcript variant 2, mRNA. 693 GC-F0304
TPSAB1 NM_003294.4 Human Homo sapiens tryptase alpha/beta 1 (TPSAB1), mRNA. 828 GC-F0305
ELANE NM_001972.4 Human Homo sapiens elastase, neutrophil expressed (ELANE), mRNA. 804 GC-F0319
PLAT NM_000930.5 Human Homo sapiens plasminogen activator, tissue type (PLAT), transcript variant 1, mRNA. 1689 GC-F0362
PRSS8 NM_002773.5 Human Homo sapiens serine protease 8 (PRSS8), mRNA. 1032 GC-F0438
GZMK NM_002104.3 Human Homo sapiens granzyme K (GZMK), mRNA. 795 GC-F0481
MMP10 NM_002425.3 Human Homo sapiens matrix metallopeptidase 10 (MMP10), mRNA. 1431 GC-F0613
PRSS1 NM_002769.5 Human Homo sapiens serine protease 1 (PRSS1), transcript variant 1, mRNA. 744 GC-F0615
MMP12 NM_002426.6 Human Homo sapiens matrix metallopeptidase 12 (MMP12), mRNA. 1413 GC-F0675

Protease inhibitors

by | Mar 22, 2024 | Clone sets

Introduction

Protease inhibitors are molecules that inhibit the function of proteases, and many naturally occurring protease inhibitors are proteins. Protease inhibitors can be used as antiviral drugs and the FDA has approved the marketing of 7 protease inhibitor drugs, including SQV, RTV, IDV, NFV, and APV, etc.
Protease inhibitors are further categorized into serine protease inhibitors, cysteine protease inhibitors, aspartate protease inhibitors, and metalloproteinase inhibitors based on homology of amino acid sequences and target proteases. Mutations in the key amino acids of proteases and their inhibitors can affect their physiological functions, stability, catalytic activity, inhibitory specificity, and so on.
It has become one of the current hotspots to explore various mutants of proteases and their inhibitors in nature, analyze their key active sites, and use protein engineering to modify and design proteases and their inhibitors with stronger activity, higher stability, better specificity, more environmentally friendly, and lower cost.

Clone set information

Cat. No. Old Cat. No. Species Gene Vector Vector Type Price
OC-GF017-M02 OC-HPI-M02 Human 154 pReceiver-M02 Expression-ready Non-viral Inquire
OC-GF017-M35 OC-HPI-M35 Human 154 pReceiver-M35 Expression-ready Non-viral Inquire
OC-GF017-M98 OC-HPI-M98 Human 154 pReceiver-M98 Expression-ready Non-viral Inquire
OC-GF017-Lv105 OC-HPI-Lv105 Human 154 pReceiver-Lv105 Expression-ready Lentiviral Inquire
OC-GF017-Lv242 OC-HPI-Lv242 Human 154 pReceiver-Lv242 Expression-ready Lentiviral Inquire
OC-GF017-GC OC-HPI-GC Human 154 pDONR™ Vector Gateway shuttle Inquire

Clone list

The form only shows 50 clones of the whole set. Please contact us at 1-301-762-0888 or inquiry@genecopoeia.com if you have any questions.
Symbol Accession Species Description ORF length(bp) Product ID
CD109 NM_133493.5 Human Homo sapiens CD109 molecule (CD109), transcript variant 1, mRNA. 4338 GC-E1159
SPINT1 NM_003710.4 Human Homo sapiens serine peptidase inhibitor, Kunitz type 1 (SPINT1), transcript variant 2, mRNA. 1542 GC-M0314
XIAP NM_001204401.2 Human Homo sapiens X-linked inhibitor of apoptosis (XIAP), transcript variant 2, mRNA. 1494 GC-T0104
KAZALD1 NM_030929.5 Human Homo sapiens Kazal type serine peptidase inhibitor domain 1 (KAZALD1), transcript variant 1, mRNA. 915 GC-V1110
WFDC5 NM_145652.4 Human Homo sapiens WAP four-disulfide core domain 5 (WFDC5), transcript variant 1, mRNA. 372 GC-Y2198
SERPINE1 NM_000602.5 Human Homo sapiens serpin family E member 1 (SERPINE1), transcript variant 2, mRNA. 1209 GC-F0606
WFDC2 NM_006103.4 Human Homo sapiens WAP four-disulfide core domain 2 (WFDC2), mRNA. 375 GC-Z1019
SPINT1 NM_181642.3 Human Homo sapiens serine peptidase inhibitor, Kunitz type 1 (SPINT1), transcript variant 1, mRNA. 1590 GC-Z5300
C3 NM_000064.4 Human Homo sapiens complement C3 (C3), mRNA. 4992 GC-E2587
CD109 NM_001159587.3 Human Homo sapiens CD109 molecule (CD109), transcript variant 2, mRNA. 4287 GC-E2721
CD109 NM_001159588.3 Human Homo sapiens CD109 molecule (CD109), transcript variant 3, mRNA. 4107 GC-E2722
XIAP NM_001167.4 Human Homo sapiens X-linked inhibitor of apoptosis (XIAP), transcript variant 1, mRNA. 1494 GC-H4489
SERPINB2 NM_001143818.2 Human Homo sapiens serpin family B member 2 (SERPINB2), transcript variant 1, mRNA. 1248 GC-Z6805
AMBP NM_001633.4 Human Homo sapiens alpha-1-microglobulin/bikunin precursor (AMBP), mRNA. 1059 GC-G0166
APLP2 NM_001642.3 Human Homo sapiens amyloid beta precursor like protein 2 (APLP2), transcript variant 1, mRNA. 2292 GC-Y2612
APLP2 NM_001142278.2 Human Homo sapiens amyloid beta precursor like protein 2 (APLP2), transcript variant 4, mRNA. 1569 GC-Y4654
APP NM_201414.3 Human Homo sapiens amyloid beta precursor protein (APP), transcript variant 3, mRNA. 2088 GC-F0776
APP NM_000484.4 Human Homo sapiens amyloid beta precursor protein (APP), transcript variant 1, mRNA. 2313 GC-Z2553
APP NM_201413.3 Human Homo sapiens amyloid beta precursor protein (APP), transcript variant 2, mRNA. 2256 GC-Z3473
APP NM_001136130.3 Human Homo sapiens amyloid beta precursor protein (APP), transcript variant 6, mRNA. 2145 GC-Z6628
BCL2L1 NM_001317921.2 Human Homo sapiens BCL2 like 1 (BCL2L1), transcript variant 5, mRNA. 702 GC-B0212
BCL2L1 NM_001191.4 Human Homo sapiens BCL2 like 1 (BCL2L1), transcript variant 2, mRNA. 513 GC-Z2522
BIRC5 NM_001012270.2 Human Homo sapiens baculoviral IAP repeat containing 5 (BIRC5), transcript variant 2, mRNA. 414 GC-Z3551
C4B NM_001002029.4 Human Homo sapiens complement C4B (Chido blood group) (C4B), mRNA. 5235 GC-E2592
CAST NM_001042444.3 Human Homo sapiens calpastatin (CAST), transcript variant 10, mRNA. 2004 GC-T9667
CRIM1 NM_016441.3 Human Homo sapiens cysteine rich transmembrane BMP regulator 1 (CRIM1), mRNA. 3111 GC-U1217
CST11 NM_130794.2 Human Homo sapiens cystatin 11 (CST11), transcript variant 1, mRNA. 417 GC-T3222
CST11 NM_080830.3 Human Homo sapiens cystatin 11 (CST11), transcript variant 2, mRNA. 312 GC-H0931
CST2 NM_001322.3 Human Homo sapiens cystatin SA (CST2), mRNA. 426 GC-Z2898
CST3 NM_001288614.1 Human Homo sapiens cystatin C (CST3), transcript variant 2, mRNA. 441 GC-F0113
CST4 NM_001899.3 Human Homo sapiens cystatin S (CST4), mRNA. 426 GC-F0420
CST6 NM_001323.4 Human Homo sapiens cystatin E/M (CST6), mRNA. 450 GC-M0688
CST7 NM_003650.4 Human Homo sapiens cystatin F (CST7), mRNA. 438 GC-U0145
CST8 NM_001281730.2 Human Homo sapiens cystatin 8 (CST8), transcript variant 2, mRNA. 429 GC-W0217
CST9 NM_001008693.3 Human Homo sapiens cystatin 9 (CST9), mRNA. 480 GC-H3350
CST9L NM_080610.3 Human Homo sapiens cystatin 9 like (CST9L), mRNA. 444 GC-T3229
CSTA NM_005213.4 Human Homo sapiens cystatin A (CSTA), mRNA. 297 GC-F0405
CSTB NM_000100.4 Human Homo sapiens cystatin B (CSTB), mRNA. 297 GC-F0136
CSTL1 NM_138283.1 Human Homo sapiens cystatin like 1 (CSTL1), mRNA. 438 GC-T3228
FETUB NM_014375.3 Human Homo sapiens fetuin B (FETUB), transcript variant 1, mRNA. 1149 GC-I0029
GPC3 NM_004484.4 Human Homo sapiens glypican 3 (GPC3), transcript variant 2, mRNA. 1743 GC-I0391
GPC3 NM_001164617.2 Human Homo sapiens glypican 3 (GPC3), transcript variant 1, mRNA. 1812 GC-Z7351
GPC3 NM_001164618.2 Human Homo sapiens glypican 3 (GPC3), transcript variant 3, mRNA. 1695 GC-Z7352
GPC3 NM_001164619.2 Human Homo sapiens glypican 3 (GPC3), transcript variant 4, mRNA. 1581 GC-Z7353
GPX1 NM_000581.4 Human Homo sapiens glutathione peroxidase 1 (GPX1), transcript variant 1, mRNA. 612 GC-Z2571
GPX1 NM_201397.3 Human Homo sapiens glutathione peroxidase 1 (GPX1), transcript variant 2, mRNA. 297 GC-Z3958
HMSD NM_001123366.2 Human Homo sapiens histocompatibility minor serpin domain containing (HMSD), mRNA. 420 GC-H3031
HRG NM_000412.5 Human Homo sapiens histidine rich glycoprotein (HRG), mRNA. 1578 GC-G0140
HSPA5 NM_005347.5 Human Homo sapiens heat shock protein family A (Hsp70) member 5 (HSPA5), mRNA. 1965 GC-T3592
ITIH2 NM_002216.3 Human Homo sapiens inter-alpha-trypsin inhibitor heavy chain 2 (ITIH2), mRNA. 2841 GC-Z5660