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Validated All-in-One™ qPCR Primer for NFASC(NM_001005388.3) Search again
Product ID:
HQP170778
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
NEDCPMD, NF, NRCAML
Gene Description:
neurofascin
Target Gene Accession:
NM_001005388.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Neurofascin is an L1 family immunoglobulin cell adhesion molecule (see L1CAM; MIM 308840) involved in axon subcellular targeting and synapse formation during neural development (Ango et al., 2004 [PubMed 15479642]).[supplied by OMIM].
Gene References into function
- different splicing variants of NF expressed on neurons and glia play distinct roles during neural development
- raft-association of NF155 is essential for the assembly of the paranodal junction and reduced association to lipid rafts is accompanied by the disassembly of the paranodal junction and contributes to the demyelination process in multiple sclerosis
- antibodies to neurofascin selectively targeted nodes of Ranvier, resulting in deposition of complement, axonal injury, and disease exacerbation