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Validated All-in-One™ qPCR Primer for FCGR2A(NM_001136219.3) Search again
Product ID:
HQP153673
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, FcgammaRIIa, IGFR2
Gene Description:
Fc gamma receptor IIa
Target Gene Accession:
NM_001136219.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq].
Gene References into function
- REVIEW: In FcgRIIA humanized transgenic mice there is an important interplay of platelet activation and splenic clearance. Reduction of splenic clearance or antibody activation of platelets in an FcgRIIA-dependent manner leads to thrombosis, shock, death
- Early events that follow Fc gamma RIIA cross-linking include translocation to a detergent-insoluble fraction rapidly followed by degradation of the receptor--events which occur in parallel to those leading to signal transduction though Fc gamma RIIA.
- implicated as a possible disease modifying gene in rheumatoid arthritis
- Role of the Fcgamma receptor IIa polymorphism in susceptibility to systemic lupus erythematosus and lupus nephritis
- Polymorphism of this receptor correlates with renal allograft survival.
- The results suggest that Fc gamma RIIa polymorphism is not a risk factor for rheumatoid arthritis.
- regulation of FcgammaR-mediated activation of human myeloid cells by the expression and function of the inositol phosphatase SHIP-2
- SHP-1 associates with this protein to modulate signaling events in myeloid cells.
- putative susceptibility and severity factor [for periodontitis]
- The FcgammaRIIA-R/H131 polymorphism is an important determinant of predisposition to antiphospholipid syndrome, with different influences on SLE and APS susceptibility per se.
- FcgammaRIIa cross-linking causes irreversible aggregation of human platelets
- Polymorphism of the Fc gamma IIa receptor influences neither susceptibility nor clinical disease course of multiple sclerosis.
- PECAM-1 and Fc gamma RIIa are colocalized on the platelet membrane and PECAM-1 down-regulates Fc gamma RIIa-mediated platelet responses.
- Fc gamma RIIa on natural IFN-alpha-producing cells/plasmacytoid dendritic cells is involved in the activation of IFN-alpha production by interferogenic immune complexes, but it may also mediate inhibitory signals.
- A skewed distribution of Fc gamma RIIA genotypes is reported in Dutch myasthenia gravis patients.
- Fc gamma RIIA-mediated binding of murine IgG1 immune complexes to apoptotic human neutrophils profoundly augments phagocytosis by human macrophages but leads to proinflammatory cytokine production.
- An abnormal distribution of the FcgRIIa allotypes may contribute to the pathogenesis of renal disease in Brazilian systemic lupus erythematosus patients.
- conclude that the G507A polymorphism does not contribute to risk of myocardial infarction, either alone of in combination with established cardiovascular risk factors
- H/H131 genotype may be associated with chronic periodontitis risk (and disease severity) in Caucasian smokers
- evaluated the association between Fc gamma RIIa polymorphism and acute kidney graft rejection
- fusion of cross-linked FcgammaRII and rafts requires generation of cell surface ceramide
- study suggests that the IgG2-binding Fc gamma RIIa-His/His131 genotype is associated with enhanced susceptibility to placental malaria in HIV-positive women but not in HIV-negative women
- a sustained rise in [Ca 2+ ]i due to an increase in the frequency and amplitude of transient calcium spiking in single platelets was dependent upon engagement of both P-selectin and FcgammaRIIA
- Variations in Fcgamma receptor IIA is associated with susceptibility to Pseudomonas aeruginosa infection in patients with cystic fibrosis
- FcgammaRIIA gene polymorphisms is associated with rheumatic fever
- Polymorphism could be useful markers for potential risk of rejection in kidney transplantation.
- the H131 allele of FcgammaRIIa protects against advanced peripheral atherosclerosis
- analysis of C-reactive protein binding to FcgammaRI, FcgammaRIIa, and C1q
- decreased FcR expression could potentially represent a form of compensatory biological response to an adverse lipid profile in which sensitivity of platelets to collagen may be relatively down regulated in type 2 diabetes.
- These results indicate that FcgammaRIIA can be activated in human platelets downstream [of]G-protein-coupled receptors by low concentrations of agonists.
- Phosphorylation of FcgammaRIIA is required for efficient binding of IgG-opsonized particles to receptors; inhibition of FcgammaRIIA phosphorylation correlates with impairment of FcgammaRIIA clustering.
- FcgammaRIIa is a very important factor in the pathogenesis of autoimmune inflammation
- Polymorphisms of FcgammaRIIa influence the severity of IgAN in Japanese patients but not the incidence, suggesting that IgG-IC may play important roles in the progression and prognosis of this disease via FcgammaRs.
- The Patelet FcgammaRIIA is stably overexpressed in type 2 diabetes and may also play a role in collagen-mediated platelet activation.
- FcgammaRIIa gene polymorphism is associated with recurrent infectious diseases in children
- The response to either dimeric IgG or aggregated IgG (aIgG) was assessed and related to differences in the ratio of FcgammaRIIa to FcgammaRIIb2 mRNA in granulocytes
- FCGR2A from rheumatoid arthritis sera and synovial fluid influence tnf-alphaproduction by peripheral blood mononuclear cells.
- CREB activation is involved in up-regulation of Fc gammaRIIA expression in myeloid lineages.
- Organized association of FcgammaRIIa monomers is essential for optimal receptor signaling.
- Skin-derived mast cells express functional Fc gamma RIIa receptors and consequently can release mediators in an IgG-dependent, IgE-independent manner.
- FcgammaRIIA recognizes Mac-1 via the alpha(M)I-domain but not the lectin domain, a distinct feature from other FcRs
- Increased association with FCGR2A-FCGR3A haplotype suggests presence of additional genetic polymorphisms in linkage disequilibrium with this haplotype that may contribute to disease susceptibility.
- This study identifies a role for p40(phox) and PI(3)P in coupling FcgammaR-mediated phagocytosis to activation of the NADPH oxidase.
- findings showed that that both Fcgamma RIA and FcgammaRIIA mediated enhanced dengue virus immune complex infectivity but that FcgammaRIIA appeared to do so far more effectively
- Susceptibility to type 1 autoimmune hepatitis in Japanese patients is not influenced by FcgammaRIIA, FcgammaRIIB, or FCRL3 polymorphisms.
- Our data indicate that platelet FcgammaRIIA binds and internalizes IgG complexes and suggest that human platelets may function to clear soluble IgG complexes from the circulation.
- result demonstrated that ACC haplotype of IL-10 gene & FcgammaRIIa R131 polymorphism can be used as marker for genetic susceptibility & severity to systemic lupus erythematosus in Thai population, particularly individuals carrying both specific genotypes
- checked for prevalence of the PTPN22 R620W polymorphism in multiplex families affected with systemic lupus erythematosus & other autoimmune diseases; its association with other polymorphisms in mannose binding lectin & FcgammaRIIa genes was also studied
- These results revealed that the absent CD3zeta chain in cancer T lymphocytes was not replaced by FcRgamma either in fresh T cells or T-cell lines, in contrast to lupus T cells.
- expression of the phagocytic receptor FCGR2A is preserved in immature and mature DCs at comparable levels with macrophages; phagocytosis of antigenic peptides directed to FcgR2a on DCs leads to increases in Ag cross-presentation and T cell activation.
- Study shows that Fc gammaRIIa gene 131R allele represents an important genetic risk factor for bronchial asthma and allergic rhinitis susceptibility.
- There is wide linkage within and between polymorphisms in FcgammaRIIa and FcgammaRIIIa and might provide an explanation for why polymorphisms at FcgammaRIIa are associated with rituximab responses despite a lack of impact on IgG1 binding.
- The Fc gamma receptor 2A (FCGR2A)-His/Arg131 polymorphism is critical to the binding of IgG2 immune complexes to phagocytes.
- study showed that the FcgammaRIIa-R/R131 genotype is associated with increased susceptibility to severe malaria in a Sudanese population & that the H/H131 genotype is less likely associated with severe malaria
- Human neutrophils from peripheral blood express the ITIM containing CD300a (also known as IRp60 and CMRF-35H) receptor. Co-ligation of CD300a with (FcgammaRIIa) activation receptor inhibited CD32a mediated signalling.
- FcgammaRIIIa and FcgRIIa polymorphisms did not influence response, event-free or overall survival in treatment of diffuse large B-cell lymphoma
- There was no significant difference in the distribution of Fc gamma RIIa genotypes and the two allelic forms between the patients and controls; study indicates that Fc gamma RIIa polymorphism is not decisive for the acquisition of brucellosis
- This is the first report that the FcgRIIa*519GG genotype predisposes to type 1 diabetes and celiac disease.
- Modelling of the peptide-C7C1 structure in complex with FcgammaRIIa suggests that Pro3 of C7C1 binds to FcgammaRIIa by inserting between Trp90 and Trp113 of FcgammaRIIa thereby mimicking the molecular interaction made between FcgammaRIIa and IgG.
- polymorphisms may markers to predict clinical outcome in metastatic CRC patients treated with be useful molecular cetuximab and that polymorphisms were independently associated with progression-free survival
- The FCGR2A 131RR and FCGR3A 158VV genotypes were over-represented [OR: 1.67 (1.05-2.63) and 2.04 (1.06-4.00), respectively] whereas the FCGR3B NA2NA2 was under-represented in patients with cryptococcosis (28% vs. 40% in controls).
- These results support the concept that FcgammaRIIa genotype may affect IL-1beta production, possibly leading to interindividual differences in periodontitis risk.
- simultaneous activation of distinct extracellular (metalloproteinase-mediated) and intracellular (calpain-mediated) proteolytic pathways irreversibly inactivating platelet GPVI/FcRgamma and FcgammaRIIa, respectively
- One of the genetic variants of the FcgammaRIIa, the 131 H/H, is associated with more periodontal breakdown than the R/R.
- Fcgamma receptor IIA is involved in the neutralization of lipopolysaccharide signaling via a potent novel anti-TLR4 monoclonal antibody 15C1
- for patients with onchocerciasis, the Fc gamma RIIa R/R131 genotype appears to be associated with severe dermatopathology; presence of the H131 allele appears to be associated with protection from severe dermatopathology, including the reactive form
- Results showed an association of specific FCGR2A SNPs with cytokine levels and disease severity/resistance in patients from areas with differential disease endemicity.
- Our model demonstrates the inflammatory potential of ACPA-containing ICs via engagement of FcgammaRIIa at the surface of macrophages, strongly supporting their pathophysiologic involvement.
- important role for FcgammaRIIa in regulating the CD1 antigen presentation machinery of human DCs.
- There was trend significance in objective response rate and progression free survival for the Fc gamma RIIa-131 H/H genotype in patients with metastastic breast cancer treated with trastuzumab..
- No association was found with the FCGR2A region in Scandinavian coeliac disease families.
- Role of a polymorphism in a specific Fc gamma receptor gene, FcgammaRIIa, in the clinical outcome of patients with non-Hodgkin lymphoma.
- leukocyte surface chondroitin sulfates promote neutrophil activation by enhancing immune-complex binding to CD32a
- Ligand binding to platelet alphaIIbbeta3 induces integrin cytoplasmic domain-dependent phosphorylation of FcgammaRIIa, which then enlists selected components of the immunoreceptor signaling cascade to transmit amplification signals into the cell.
- Activation of human plasmacytoid dendritic cells by TLR9 impairs Fc gammaRII-mediated uptake of immune complexes and presentation by MHC class II
- Neither activating receptors FcgammaRI and FcgammaRIII, nor FcgammaRIIB, all of which lack Phe(163), bound the peptide
- the genotype frequencies and allelic distributions of the Fcgamma R (receptor)IIa, FcgammaRIIIa and FcgammaRIIIb gene polymorphisms were significantly different between BD patients and healthy controls and associated with disease severity, age of onset
- The effect of LDL particles showing extensive or low oxidation (HoxLDL and LoxLDL) on the expression of CD36 and FcgammaRII in a human monocytic cell line and the involvement of PPARgamma, was investigated.
- IL-1B(+3954) and FcgammaRIIa (CD32) gene polymorphisms are not associated with an increased risk of Aggressive and chronic periodontitis.
- This study thus does not support a previous publication showing FcgammaR association with celiac disease.
- Combined FCGR2A/FCGR3A polymorphisms are prognostic factors for disease profression in metastatis colorectal cancer patients treated with cetuximab plus irinotecan.
- c-Cbl mediates the ubiquitination of stimulated FcgammaRIIa
- Data show that anti-glycoprotein VI monoclonal antibodies can induce metalloproteinase-dependent ectodomain shedding of human GPVI,and can induce platelet aggregation independently of FcgammaRIIa.