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Validated All-in-One™ qPCR Primer for FCGR1A(NM_000566.3) Search again
Product ID:
HQP005251
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CD64, CD64A, FCG1, FCGR1, FCRI, FcgammaRI, IGFR1
Gene Description:
Fc gamma receptor Ia
Target Gene Accession:
NM_000566.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq].
Gene References into function
- At least two alternate mechanisms of internalization of Fc gamma RI are influenced by the presence or absence of ligand and demonstrate the receptor's physiologic potential to transport a large antigenic load into antigen presenting cells for processing.
- Distinct functions for STAT1 and PU.1 in transcriptional activation of Fc gamma receptor I promoter.
- CY domain alters gamma-chain tyrosine-based signaling and phagocytosis
- Activation of mast cells through the high affinity IgG receptor.
- cross-linking FcgammaRI and -II but not FcgammaRIII activates transcription factor NF-kappaB
- FcgammaRI plays a major role in anti-HPA-1a-mediated platelet phagocytosis by monocytes while FcgammaRIIa, is of little or minor importance only.
- specific sequences in the FcgammaRIIIA and FcgammaRI transmembrane domains govern their different interactions with the gamma chain in cell surface expression and phagocytosis
- The levels of peripheral blood neutrophil CD(64) may help us distinguish infection from disease activation in systemic lupus erythematosus (SLE).
- FcgammaRI intracellular signaling cascades require iPLA(2)beta
- periplakin (PPL) as a selective interacting protein for the intracellular tail of FcgammaRI but no other activatory FcRs
- FcgammaRIIa polymorphism is not an important genetic risk factor for chronic rejection of kidney allografts.
- Fc fragments of IgG from healthy donors or purified monoclonal anti-human Fc gamma receptor (FcgammaR) antibody strengthen the participation of FcgammaRI (CD64) in HIV-1 inhibition on monocyte-derived macrophages.
- analysis of C-reactive protein binding to FcgammaRI, FcgammaRIIa, and C1q
- results imply a novel functional role of CD13 and Fc gamma receptors (CD32 and CD64)as members of a multimeric receptor complex
- Thus, these results suggest that the lipid raft-associated 67LR plays an important role in mediating the FcepsilonRI-suppressive action of EGCG.
- in human aortic endothelial cells, CRP upregulates monocyte-endothelial adhesion by activation of NF-kappaB through engaging the Fcgamma receptors CD32 and CD64
- findings showed that that both Fcgamma RIA and FcgammaRIIA mediated enhanced dengue virus immune complex infectivity but that FcgammaRIIA appeared to do so far more effectively
- Fcgamma receptor I Ab and Fcgamma receptor I play an important role in the regulation of alopecia areata (AA), are useful for a marker of the disease prognosis and are worth intense research for the reasonable and specific therapy of AA.
- finding documents the capacity of FcgammaRI to mediate potent antimalaria immunity
- kinetics of neutrophil membrane CD64 expression were examined during a standardized inflammatory response, using a human endotoxemia model
- In platelets, GPVI-FcRgamma has evolved to transmit sustained signals in order to maintain spreading over several hours, as well as facilitating rapid activation through release of feedback agonists and integrin activation.
- FcgammaRI is hyperexpressed in the intestinal mast cells of Crohn disease patients.
- An alternatively spliced 4.1G product is shown to be associated with increased Fc gamma RI binding in yeast two-hybrid assays, and to be selectively enriched in most immune cells at the transcript level.
- the response to vascular injury provoked by human C-Reactive Protein in ovariectomized C-reactive protein transgenic mice depends on Fc gamma RI and probably requires its expression by F4/80+ cells
- Activation of mast cells through aggregation of Fc-gamma receptor I leads to degranulation, induction of prosurvival gene bfl-1, and promotion of cell survival.
- FcgammaRI predominantly resides in thin detergent-insoluble buoyant membranes, together with FcRgamma-chain, but independent of cross-linking ligand
- RAGE could also behave as a receptor for Mycobacterium tuberculosis
- Data show that in cardiac surgical patients the expression of activation marker FcgammaR1 (CD64) on monocytes is increased earlier in comparison with granulocytes in both "on-pump" and "off-pump" patients.
- Data show that CD64 indexes for neutrophils and monocytes, and CD163 index for neutrophils can all be used for discrimination of SIRS and sepsis in critically ill neonates and children.
- These results provide a mechanism by which Fcgamma receptors can elevate circulating BLyS levels and promote autoantibody production in immune complex-mediated autoimmune diseases.
- Aspartic acid at position 265 of IgG is a residue critically implicated in triggering the Fc-associated effector functions of IgG, probably by defining a crucial three-dimensional structure of the Fc region.
- Data suggest that flagellin-specific IgG/Fc gamma receptor I complex immune responses activate mast cells in the intestine and play important roles in the pathogenesis of intestinal immune inflammation.