WNT Signaling Pathway

The WNT (Wingless-Type MMTV Integration Site Family) genes encode a large family of secreted proteins and growth factors that have been identified in animals from Hydra to Human. The name WNT denotes the relationship of this family to the Drosophila segment polarity gene Wg (Wingless) and to its vertebrate ortholog, Int1, a mouse protooncogene. At present, close to 100 WNT genes have been isolated from various species. In humans, 19 WNT proteins have been identified that share 27% to 83% Amino-acid sequence identity and a conserved pattern of 23 or 24 cysteine residues. Wnt members can play a role in the expression of many genes by interacting with multiple disparate signaling pathways.

Click gene symbol on the map to view ORF/cDNA clone.

Data source: KEGG, BioCarta