Toll-Like Receptor Pathway

Toll-like receptors (TLRs) are a family of transmembrane proteins that play a key role in the innate immune system. Upon activation, TLRs recruit adapter proteins within the cytoplasm to propagate a signal. The adapter proteins in turn activate other proteins within the cell, including some protein kinases that amplify the signal, and ultimately lead to the activation or suppression of genes that regulate inflammatory response.

Click gene symbol on the map to view ORF/cDNA clone.

Data source: KEGG, BioCarta