TGF beta signaling pathway

The transforming growth factor beta (TGFβ) signaling controls diverse cellular responses and is critically involved in animal development.

The TGFβ signaling pathway is relatively straightforward. TGFβ ligands bind to a type II receptor, which in turn recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs). Phosphorylated R-SMADs bind to the coSMAD. The R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and control the target gene expression.

Click gene symbol on the map to view ORF/cDNA clone.

Data source: KEGG, BioCarta