T Cell Receptor Signaling Pathway

The T cell receptor (TCR) is found on the surface of T cells. It is a complex of integral membrane proteins that participates in the activation of T cells in response to the presentation of an antigen. TCR is responsible for recognizing antigens bound to the major histocompatibility complex (MHC) molecules.

Ligation of the TCR/CD3 results in the activation of Src and Syk family PTKs associated with the intracellular CD3 domains, which in turn activate PLCγ1 and Ras-dependent pathways.

Click gene symbol on the map to view ORF/cDNA clone.

Data source: KEGG, BioCarta