Jak-STAT signaling pathway

The JAK-STAT signaling pathway transmits information from chemical signals outside the cell, through the cell membrane, and into gene promoters on the DNA in the cell nucleus, which causes DNA transcription and activity in the cell. STATs (Signal Transducers and Activators of Transcription) are transcription factors that are phosphorylated by JAK (Janus kinases) in response to cytokine activation, then dimerize and move into the nucleus to activate transcription of cytokine-responsive genes. There are at least 3 JAK kinases and at least six STATs, with different cytokines inducing different patterns of JAK and STAT activation.

Click gene symbol on the map to view ORF/cDNA clone.

Data source: KEGG, BioCarta